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Compound preparation used for joint care and preparation method thereof

A compound preparation and joint technology, which is applied in the field of glucosamine medical and health products, can solve the problems of low absorption utilization rate and single product efficacy, and achieve the effect of high absorption utilization rate, good disintegration performance and enhanced stability

Active Publication Date: 2010-02-17
盛锦合生物科技江苏有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a compound preparation for joint health care and its preparation method, which solves the problems of single product efficacy and low absorption and utilization rate in the existing glucosamine health food, creatively screens and determines the Composed of preparations, the stability of the product is enhanced, and it is more in line with human drug requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0024] Example: Glucosamine 500g

[0025] Chondroitin Sulfate 400g

[0026] Collagen 200g

[0027] Dimethylsulfone 300g

[0028] Microcrystalline Cellulose 121g

[0029] Sodium carboxymethyl starch 45g

[0030] Polyvinylpyrrolidone 15g

[0031] Magnesium Stearate 12g

[0032] Coating Premix 32g

[0033] Prepare as follows:

[0034] 1) Configure a 10% aqueous solution of the adhesive and fully dissolve until clear and transparent.

[0035] 2) Pulverize the glucosamine and pass through a 120-mesh sieve.

[0036] 3) Put glucosamine, chondroitin sulfate and collagen into the fluidized bed granulator and preheat for 10 minutes.

[0037] 4) The solution sprayed into the binder is granulated, the air inlet temperature is strictly controlled at 60°C and the material temperature at 45°C, dried, and passed through a 20-mesh sieve.

[0038] 5) Add dimethyl sulfone, excipients, disintegrants, and lubricant...

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PUM

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Abstract

The invention discloses a compound preparation used for joint care and a preparation method thereof. The compound preparation comprises active ingredients and auxiliary materials, wherein the active ingredients comprise glucosamine, chondroitin sulfate, dimethyl sulfone and collagen, and the glucosamine is glucosamine sulfate or glucosamine hydrochloride or glucosamine phosphate or mixture of theglucosamine sulfate and the glucosamine hydrochloride and the glucosamine phosphate; and the auxiliary materials comprise excipient, disintegrant, lubricant, bonding agent and wetting agent. The invention has better treatment and prevention functions on arthritis and joint injury; the prepared tablet has good disintegration property, rapid digestion, quick effect taking, strengthened stability andhigh absorption and utilization ratio; and the consumption of the raw materials and the auxiliary materials achieves the optimal proportion.

Description

technical field [0001] The invention belongs to the technical field of glucosamine medicine and health products, and in particular relates to a compound preparation for joint health care and a preparation method thereof. Background technique [0002] Osteoarthritis is a common chronic arthritis, and people have been looking for and exploring drugs for the development of osteoarthritis for many years. For a long time, people have used aspirin, non-steroidal analgesics, etc. to help patients relieve pain. These medicines are used for a long time, and some effects gradually decrease, and some produce side effects such as bloating and stomach pain. Arthritis is mainly the degeneration of articular cartilage and secondary hyperosteogeny. Because the mucous membrane at the joint joint is composed of sulfur-containing protein and glucosamine. Sulfur-containing proteins such as collagen and glucosamine can promote the production of collagen, increase water binding, and help repai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61K9/28A61K47/38A61K47/36A61K47/32A61P19/02A61K31/737A61K31/7008A61K31/10
Inventor 卢鹏飞张国栋毛剑萍倪艳红刘刚
Owner 盛锦合生物科技江苏有限公司
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