Curcumin nanosuspension and preparation method thereof

A nano-suspension and curcumin technology, applied in the field of medicine, can solve the problems such as the inability to fully satisfy the oral administration of curcumin, and achieve the effects of high bioavailability, mild conditions and low preparation cost

Inactive Publication Date: 2013-03-13
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Microemulsions, polymer micelles, liposomes, phospholipid complexes, supramolecular inclusions, hot-melt extrusion, solid dispersions, dropping pills, soft capsules, solubilization and other dosage forms and technologies due to stability, safety, and drug loading Quantity and other reasons, can not fully meet the requirements of oral administration of curcumin, so it is necessary to study more effective dosage forms and technology

Method used

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  • Curcumin nanosuspension and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Dissolve 1g of curcumin, 0.8g of piperine and 0.1g of zein in 50mL of 90% ethanol, slowly add to 100mL of water, evaporate at 40 degrees, and evaporate the ethanol to obtain curcumin nanosuspension. Measure the average particle diameter of curcumin nanosuspension, the result is 228nm, and the suspension remains stable within 48h.

Embodiment 2

[0019] Dissolve 1g of curcumin, 0.9g of piperine and 0.2g of zein in 50mL of 90% ethanol, slowly add to 100mL of water, evaporate at 40 degrees, and evaporate the ethanol to obtain curcumin nanosuspension. Measure the average particle diameter of curcumin nanosuspension, the result is 153nm, and the suspension remains stable within 48h. The transmission electron microscope picture of curcumin nanosuspension is shown in figure 1 .

[0020] The above-mentioned nano-suspension is spray-dried to obtain solidified curcumin nano-suspension; after the curcumin nano-suspension solidified powder is placed at room temperature for 18 months, the content of curcumin and piperine is detected, and no significant change is found. Add 20 After stirring with several times the amount of water, the average particle diameter of the curcumin nanosuspension was measured, and the result was 195nm, and the suspension remained stable within 48h.

Embodiment 3

[0022] Dissolve 1g of curcumin, 0.8g of piperine and 0.2g of zein in 50mL of 90% ethanol, slowly add to 100mL of water, evaporate at 40 degrees, and evaporate the ethanol to obtain curcumin nanosuspension. The average particle diameter of the curcumin nanosuspension was measured, and the result was 136nm, and the suspension remained stable within 48h.

[0023] Dissolve 1g of curcumin and 0.2g of zein in 50mL of 90% ethanol, slowly add to 300mL of water, evaporate at 40°C, evaporate the ethanol, measure the average particle size, and the result is 1.7μm.

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Abstract

The invention belongs to the technical field of medicine, and discloses curcumin nanosuspension and a preparation method of the curcumin nanosuspension. As curcumin is poor in stability, small in solubility and low in oral bioavailability, popularization and use of the curcumin are restricted. The curcumin nanosuspension disclosed by the invention is characterized by containing the curcumin, piperine, and zein, and the mass ratio of the curcumin to the piperine to the zein is 10 to (8-9) to (1-2). The preparation method of the curcumin nanosuspension disclosed by the invention is mild in condition, simple and controllable, and the curcumin achieves high oral bioavailability.

Description

technical field [0001] The invention relates to a curcumin nano-suspension and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Curcumin has a wide range of pharmacological activities such as anti-tumor, anti-mutation, anti-inflammation, anti-oxidation, liver protection, and treatment of senile dementia. However, due to curcumin's poor stability, low solubility, and extremely low bioavailability in vivo, the popularization and use of curcumin is limited. How to improve the above-mentioned shortcomings of curcumin and prepare a preparation with high bioavailability has become an urgent problem for pharmaceutical workers in recent years. Microemulsions, polymer micelles, liposomes, phospholipid complexes, supramolecular inclusions, hot-melt extrusion, solid dispersions, dropping pills, soft capsules, solubilization and other dosage forms and technologies due to stability, safety, and drug loading Quantity and other rea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61K9/107A61K47/42A61P1/16A61P25/28A61P29/00A61P35/00A61P39/06A61K31/4525
Inventor 黄厚才钟荣玲夏智张振海王大为
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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