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Method for preparing surface cladding super-micro traditional Chinese medicine material crude slice

A technology of surface coating and decoction pieces of traditional Chinese medicine, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of reducing the effective use of traditional Chinese medicines, and achieve improved fluidity and fast dissolution , Ease of use

Active Publication Date: 2008-03-19
GUANGZHOU XIANGXUE PHARMA CO LTD
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Problems solved by technology

However, the active ingredients of traditional Chinese medicine contained in the cells, such as: polysaccharides, total glycosides, polyterpenes, volatile oils and other medicinal ingredients can be quickly extracted, but they are also very easy to decompose, volatilize, oxidize or pollute, thus to a certain extent The effective use of traditional Chinese medicine has been reduced

Method used

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  • Method for preparing surface cladding super-micro traditional Chinese medicine material crude slice

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preparation example Construction

[0008] As shown in the accompanying drawings, the preparation method of the surface-coated ultrafine Chinese herbal decoction pieces of the present invention includes the steps of processing, coarse pulverization, ultrafine pulverization, tabletting or granulation. Coating modification to prevent the loss or oxidative decomposition of active ingredients, the specific preparation steps are as follows:

[0009] 1. First, wash and dry the traditional Chinese medicine, and then carry out standardized processing according to the conventional technology, which is the basis of the processing of Chinese herbal medicine slices.

[0010] 2. Coarsely pulverize the processed traditional Chinese medicine. The coarse pulverization is carried out by mechanical pulverization, and pulverized into coarse particles with a particle size of 20-80 mesh for ultramicroprocessing.

[0011] 3. Ultra-micro processing is based on the different crushable characteristics of Chinese herbal medicines, and th...

Embodiment 1

[0019] Take 500 grams of wolfberry, clean and dry according to the conventional processing method; adopt the method of mechanical crushing to carry out coarse crushing to 20 mesh; adopt airflow crushing process to carry out circular crushing to 1500 mesh (8 microns). The surface coating agent gelatin is introduced into the circulation crushing process, the dosage of the surface coating agent is 5%, the gelatin is mixed with the solvent in a certain proportion, and directly enters the circulation crushing system. Due to the high polysaccharide content of Lycium barbarum, the total sugar content reaches 35-45%, and the active polysaccharide content reaches 6-10%, it is difficult to carry out ultramicronization treatment, and it is very easy to absorb moisture and agglomerate. After being processed by the method of the present invention, the ultramicronized Lycium barbarum is not only easy to crush, but also has good fluidity, and can be conveniently processed for decoction pieces...

Embodiment 2

[0021] Get 500 grams of ganoderma lucidum spore powder, at first raw material is carried out quality control, to guarantee to meet relevant requirements. Because the particles of Ganoderma lucidum spore powder itself are very small, it can be directly subjected to ultramicronization processing to meet the requirement of wall breaking. However, after the Ganoderma lucidum spore powder is broken, the active ingredients such as Ganoderma lucidum polysaccharides and polypeptides, which are rich inside, adhere to the ultrafine pulverizer, which seriously affects the crushing flow field and reduces the crushing effect, and these active ingredients are also very easy to be polluted or decomposed. In this wall-breaking process, a surface coating agent is introduced, and starch and β-cyclodextrin are used for coating, and the dosage of the coating agent is 1%. After surface coating, the content of ganoderma lucidum polysaccharide and other components can be kept basically unchanged, up...

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Abstract

The invention discloses a preparation method of a decoction piece of superfine traditional Chinese medicine, the surface of which is coated, including the steps of processing, coarse crushing, superfine crushing, tablet forming and granulizing. When the step of the superfine crushing is executed, a surface coating agent is synchronously introduced, and the surface coating agent forms a protective layer at the surface of the traditional Chinese medicine. The method of the invention can retain the effective components of the raw materials of the traditional Chinese medicine and improve the fluidity of the superfine traditional Chinese medicine powder during the processes of traditional Chinese medicine crushing, tablet forming and storing. The decoction piece of superfine traditional Chinese medicine, which is prepared by the invention, can be conveniently used; the dissolution is fast; the biological utilization degree is high; the batch production can be realized.

Description

technical field [0001] The invention relates to a preparation method of ultrafine Chinese herbal decoction pieces, in particular to a preparation method of surface-coated ultrafine Chinese herbal decoction pieces. Background technique [0002] For a long time, due to the particularity of traditional Chinese medicine, such as the regionality of raw materials, the complexity of composition, and the diversity of compound compatibility, etc., the processing of traditional Chinese medicine lacks scientific and strict process operation parameters and systematic quantitative indicators, and most of the products are still traditional. The dosage forms of pills, powders, ointments, and pills make the market competitiveness poor and it is difficult to meet the needs of the international market. Therefore, on the basis of inheriting and carrying forward the advantages and characteristics of traditional Chinese medicine, how to make full use of modern scientific and technological means ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61K9/16A61K47/12A61K47/36A61K47/38A61K47/42A61K47/44A61K47/40
Inventor 王义明葛晓陵张卫东胡坪张川
Owner GUANGZHOU XIANGXUE PHARMA CO LTD
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