Ticagrelor solid dispersion and preparation method thereof

A technology of solid dispersion and ticagrelor, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., and can solve the problems of unpredictable anti-platelet effect and so on.

Active Publication Date: 2015-03-25
SUNCADIA PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, genetic polymorphism is one of the main reasons for the variability of clopidogrel response, making its antiplatelet effect difficult to predict

Method used

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  • Ticagrelor solid dispersion and preparation method thereof
  • Ticagrelor solid dispersion and preparation method thereof
  • Ticagrelor solid dispersion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] formula:

[0032]

[0033] Preparation:

[0034] The raw and auxiliary materials are weighed according to the formula amount, completely dissolved in ten times the amount of ethanol solution, the solvent is removed by rotary evaporation, and then dried under reduced pressure in a vacuum drying oven.

Embodiment 2

[0036] formula:

[0037]

[0038]

[0039] Preparation:

[0040] The raw and auxiliary materials are weighed according to the formula amount, completely dissolved in ten times the amount of ethanol solution, the solvent is removed by rotary evaporation, and then dried under reduced pressure in a vacuum drying oven.

Embodiment 3

[0042] formula:

[0043]

[0044] Preparation:

[0045] The raw and auxiliary materials are weighed according to the formula amount, completely dissolved in ten times the amount of ethanol solution, the solvent is removed by rotary evaporation, and then dried under reduced pressure in a vacuum drying oven.

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Abstract

A ticagrelor solid dispersion and preparation method thereof; the solid dispersion is prepared via dispersing the ticagrelor into a carrier material, the carrier material comprising one or more of polyvinylpyrrolidone, copovidone and crospovidone.

Description

technical field [0001] The invention relates to a solid dispersion of ticagrelor and a preparation method thereof. Background technique [0002] Thromboembolic disease is a common clinical disease, and the formation of thrombus is closely related to the vessel wall, platelets, blood flow velocity, blood viscosity and coagulation activity. High platelet count and elevated blood lipids are important factors causing thrombus: increased platelets will increase the chances of platelet adhesion, elevated blood lipids will increase blood viscosity, and platelet aggregation and changes in blood flow will promote blood coagulation and cause blood clots. Formation of thrombus, therefore, the drug antithrombotic therapy of anti-platelet aggregation and lowering blood lipid content plays an important role. [0003] Ticagrelor, English name ticagrelor, is an oral anti-platelet aggregation drug developed by AstraZeneca. Ticagrelor is a non-prodrug and can take effect directly without be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/519A61K47/32A61P7/02
CPCA61K31/519A61K9/146A61K47/32A61K47/38A61P7/02A61P9/10A61P9/14
Inventor 黄金昆梁力左佼
Owner SUNCADIA PHARM CO LTD
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