Ibuprofen fat emulsion injection and preparation method thereof

A technology for injection and fat emulsion, which can be used in emulsion delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. High bioavailability, prolonged duration of action, high stability and safety

Active Publication Date: 2014-01-01
ANHUI FENGYUAN PHARM CO LTD
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In summary, at present, the main technical means to solve the problem of ibuprofen insoluble in water is to use the mode of aiding dissolution, but using various alkaline inorganic salts to aid dissolution, the stability of the formed solution is not high, and in the solution The combined form of salt formation, the formed salt is not very stable, and will change with the change of solution pH, which has certain safety problems in clinical compatibility

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ibuprofen fat emulsion injection and preparation method thereof
  • Ibuprofen fat emulsion injection and preparation method thereof
  • Ibuprofen fat emulsion injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] prescription:

[0031]

[0032] Preparation process: filter soybean oil and lecithin with microporous membrane respectively, put them into the container according to the above amount, heat to about 50°C, stir evenly, and make the oil phase; add ibuprofen into the oil phase, mix homogeneously to obtain a mixed solution; put water for injection in another container, add glycerin, stir evenly, and filter through a 0.45 μm microporous membrane to make an aqueous phase; mix the mixed solution containing ibuprofen, soybean oil and lecithin with After high-speed stirring at 1800rpm, pour it into the aqueous phase containing glycerin to make colostrum, adjust the pH of the solution to 8.0 with sodium hydroxide solution; transfer the prepared colostrum into a high-pressure homogenizer, homogenize, and set the pressure at 880bar , under the condition of temperature 45±2°C, high-pressure cycle 3 times to obtain emulsion, filter the emulsion through 5μm microporous membrane, fil...

Embodiment 2

[0034] prescription:

[0035]

[0036] Preparation process: with embodiment 1.

Embodiment 3

[0038] prescription:

[0039]

[0040] Preparation process: with embodiment 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to an ibuprofen fat emulsion injection which is prepared from the following components in parts by weight: 50-150 parts of ibuprofen, 800-1,200 parts of soya bean oil, 60-120 parts of ovolecithin and 220-260 parts of glycerol; the water is injected for supplementation to 1,000 mL. According to the invention, the homogeneous-phase liquid ibuprofen fat emulsion injection is prepared by adopting a drug-loaded fat emulsion form, uniform emulsion droplet particles are formed in the long-term placing process of the ibuprofen fat emulsion injection, and stability and safety are higher.

Description

technical field [0001] The invention relates to an ibuprofen fat emulsion injection and a preparation method thereof, belonging to the field of medicament preparation. Background technique [0002] Ibuprofen, also known as ibuprofen, is a non-steroidal anti-inflammatory drug (NSAIDS). Its anti-inflammatory, analgesic, and antipyretic effects are good, and its adverse reactions are small. At present, it has been widely used in the world and has become one of the best-selling over-the-counter drugs in the world. It is listed as the three pillar products of antipyretic and analgesic drugs together with aspirin and paracetamol. In addition to being recorded in the Chinese Pharmacopoeia, it has also been included in the pharmacopoeias of the United States, Britain, Japan and other countries. Ibuprofen was first listed in the UK in 1968. The manufacturer is the British Boots Company, and the trade name is Brufen. Because it has both antirheumatic and antipyretic and analgesic e...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/107A61K31/192A61P29/00
Inventor 吕美红
Owner ANHUI FENGYUAN PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap