A novel pharmaceutical auxiliary material namely silicified microcrystalline cellulose and a preparation method thereof are disclosed. The preparation method comprises the following steps: preparing microcrystalline cellulose accounting for 98.15 to 99.45% of the total weight of raw materials and aerosil accounting for 0.55 to 1.85% of the total weight of raw materials, mixing microcrystalline cellulose with part of aerosil, processing the mixture by a high-speed shearing, dispersing, and homogenizing machine, adding the residual aerosil into the homogenized emulsion, evenly mixing, and carrying out spray-drying to prepare the silicified microcrystalline cellulose. The prepared silicified microcrystalline cellulose has good fluidity and compressibility, moreover the preparation properties such as disintegration property, dispersion uniformity, dissolution rate, and the like are effectively improved, and thus the silicified microcrystalline cellulose is especially suitable for the production of traditional Chinese medicine dispersible preparations. The silicified microcrystalline cellulose is used to prepare Fuyankang dispersible tablets, and the appearance, dispersion uniformity, and dissolution degree of the tablets are all effectively improved.