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Cetirizine hydrochloride tablet and preparation method thereof

A kind of technology of cetirizine hydrochloride and rizine tablet, applied in the field of medicine, can solve problems such as complicated process

Active Publication Date: 2020-06-02
广东彼迪药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The base needs to be prepared first, and then processed by rotary evaporation, the process is more complicated

Method used

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  • Cetirizine hydrochloride tablet and preparation method thereof
  • Cetirizine hydrochloride tablet and preparation method thereof
  • Cetirizine hydrochloride tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022]

[0023] Preparation Process:

[0024] Dissolve cetirizine hydrochloride and polytetramethylene oxide stearate in ethanol, add diatomaceous earth to the solution, stir evenly, and dry at 50°C to obtain a mixture, then sieve the mixture, and then mix with Silicified microcrystalline cellulose is mixed with sodium carboxymethyl starch and magnesium stearate, and compressed into tablets.

Embodiment 2

[0026]

[0027]

[0028] Preparation Process:

[0029] Dissolve cetirizine hydrochloride and polytetramethylene oxide stearate in ethanol, add diatomaceous earth to the solution, stir evenly, and dry at 55°C to obtain a mixture, then sieve the mixture, and then mix with Silicified microcrystalline cellulose mixed with crospovidone and magnesium stearate, and compressed into tablets.

Embodiment 3

[0031]

[0032] Preparation Process:

[0033] Dissolve cetirizine hydrochloride and polytetramethylene oxide stearate in ethanol, add diatomaceous earth to the solution, stir evenly, and dry at 60°C to obtain a mixture, then sieve the mixture, and then mix with Silicified microcrystalline cellulose is mixed with sodium carboxymethyl starch and magnesium stearate, and compressed into tablets.

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Abstract

The invention discloses a cetirizine hydrochloride tablet, which is prepared by the method that cetirizine hydrochloride and polyoxyl stearate are dissolved in ethyl alcohol, diatomite is added into asolution to be evenly stirred, drying is carried out to obtain a mixture, and then, the mixture is mixed with silicified microcrystalline celluloses, disintegrating agents and lubricating agents to carry out tableting. The cetirizine hydrochloride tablet prepared by the method can be quickly dissolved out, is free from sticking and does not corrode a trimming die.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a cetirizine hydrochloride tablet and a preparation method thereof. Background technique [0002] Cetirizine hydrochloride is a second-generation H1 antihistamine, a long-acting and selective oral potent antiallergic drug. H1 receptor antagonists have good anti-allergic effects, and are often used for allergic rhinitis, allergic skin itching, conjunctivitis, etc. Cetirizine hydrochloride sheet is a kind of medicine commonly used, and present cetirizine hydrochloride sheet has the shortcoming of unstable property, because cetirizine hydrochloride is an acidic drug, it is very easy to react chemically with other substances in the formula, The content prepared by the prior art is unstable, affects the dosage, has a short validity period, is not conducive to the transportation and storage of the product, and has potential safety problems. [0003] In addition, most of ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K47/34A61K31/495A61P37/08A61P11/02A61P17/04A61P27/02
CPCA61K9/2031A61K9/2054A61K31/495A61P11/02A61P17/04A61P27/02A61P37/08
Inventor 司徒卫彤杨松明
Owner 广东彼迪药业有限公司
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