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Doxycycline hydrochloride tablet, preparation method thereof, application and antibacterial drug

A doxycycline hydrochloride tablet technology, applied in the field of medicine, can solve the problems of poor safety and effectiveness of finished tablets, high loss rate of dry granulation, poor quality stability, etc., and achieve good fluidity and compressibility , Improve safety and effectiveness, high uniformity effect

Active Publication Date: 2019-10-25
FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The traditional preparation method of doxycycline hydrochloride is wet granulation, and finally compressed into tablets, but because doxycycline hydrochloride is unstable under high temperature and high humidity conditions, the poor quality stability will lead to the safety of finished tablets. Poor performance and effectiveness; and dry granulation has a high loss rate, resulting in low yield and high cost

Method used

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  • Doxycycline hydrochloride tablet, preparation method thereof, application and antibacterial drug
  • Doxycycline hydrochloride tablet, preparation method thereof, application and antibacterial drug
  • Doxycycline hydrochloride tablet, preparation method thereof, application and antibacterial drug

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preparation example Construction

[0075] According to another aspect of the present invention, a method for preparing the above-mentioned doxycycline hydrochloride tablet is provided, comprising: mixing all raw materials uniformly and then compressing the tablet to obtain the doxycycline hydrochloride tablet. The method has a simple process and can be directly pressed into tablets after the raw materials are evenly mixed without using wet or dry granulation procedures, avoiding high temperature and high humidity conditions, ensuring the stability of product quality, and improving the safety and effectiveness of tablets. The tablet has the advantages of high uniformity, high hardness and smooth surface. In addition, the method also has low requirements on production equipment, and can effectively save the consumption of various raw materials and the cost of manpower and equipment loss.

[0076] In a preferred embodiment, the mixing includes: first premixing the doxycycline hydrochloride, the glidant and the fir...

Embodiment 1

[0098] A doxycycline hydrochloride tablet, mainly prepared from the following raw materials in mass percentage: 10% doxycycline hydrochloride, 2% silicon dioxide, 0.5% magnesium stearate and 87.5% silicified microcrystalline cellulose %.

Embodiment 2

[0100] A doxycycline hydrochloride tablet, mainly prepared from the following raw materials in mass percentage: 30% of doxycycline hydrochloride, 5% of silicon dioxide, 4% of magnesium stearate and 61% of silicified microcrystalline cellulose %.

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Abstract

The invention relates to the technical field of medicines, and particularly provides a doxycycline hydrochloride tablet, a preparation method thereof, an application and an antibacterial drug. The doxycycline hydrochloride tablet is mainly prepared from, in weight percent, 10%-30% of doxycycline hydrochloride, 2%-5% of flow aids, 0.5%-4% of lubricants and the balance directly-pressable fillers. The fillers comprise silicified microcrystalline cellulose. All raw materials are scientifically matched with each other, and the doxycycline hydrochloride tablet can be directly formed by tableting andhas the advantages of high uniformity, high hardness, surface smoothness, good product quality stability, high safety and effectiveness, low raw material loss rare, high product yield and low cost.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a doxycycline hydrochloride tablet, a preparation method and application thereof, and an antibacterial drug. Background technique [0002] Doxycycline hydrochloride is a tetracycline broad-spectrum antibiotic with broad-spectrum antibacterial effect. Sensitive bacteria include pneumococcus, streptococcus, some staphylococcus, bacillus anthracis, bacillus tetanus, corynebacterium and other gram-positive bacteria and Escherichia coli Gram-negative bacteria such as Pasteurella, Salmonella, Brucella, Haemophilus, Klebsiella, and Bacillus melioides also have a certain degree of inhibitory effect on Rickettsia, Mycoplasma, Spirochetes, etc. Oral absorption Rapid, less affected by food, high bioavailability, long-lasting effective blood concentration, strong tissue penetration, wide distribution, easy to enter cells. [0003] The traditional preparation method of doxycycline hydrochlo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/38A61K47/04A61K47/02A61K47/14A61K47/26A61K47/10A61K47/36A61K31/65A61P31/04
CPCA61K9/2009A61K9/2013A61K9/2018A61K9/2054A61K9/2059A61K9/2095A61K31/65A61P31/04
Inventor 陶映娴林孝崇
Owner FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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