The invention discloses a preparation and detection method of an
abiraterone acetate
dimer compound, and relates to the of field
pharmacy. The
dimer compound is 3 beta-acetyl-16-(3 beta-acetyl
androstane-5,16-
diene-17-base)-17-(3-pyridyl) androsterone-5,16-
diene. The method is as follows: adding compounds I and II into a reactor; dissolving the compounds and adding a
palladium catalyst and alkali into the reactor; cooling to
room temperature; filtering; concentrating; adding water; extracting; concentrating to obtain a compound III crude product; placing the crude product in the reactor; adding
pyridine and an acetyl compound; stirring at
room temperature till complete reaction; concentrating to remove
pyridine and the acetyl compound; adding water, extracting and concentrating to obtain a
dimer compound crude; and dissolving the dimer compound crude, washing,
drying, filtering, concentrating and recrystallizing to obtain the
abiraterone acetate dimer compound. According to
high performance liquid chromatography detection and calculation by an area normalization method, the prepared dimer compound has a purity up to 98% and a yield higher than 80%.