Purification method of abiraterone

A technology of abiraterone and purification method, which is applied in the fields of organic chemistry and steroids, and can solve the problems of high cost, time-consuming, complicated operation, etc.
CN102816201AInactive Publication Date: 2012-12-12成都伊诺达博医药科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
成都伊诺达博医药科技有限公司
Publication Date
2012-12-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a purification method of abiraterone. The method comprises the following steps: salifying an abiraterone crude product and acid, recrystallizing in an appropriate solvent, and adding alkali for ionization to obtain the abiraterone pure product, of which the HPLC (high performance liquid chromatography) purity is higher than 99.5% and the single impurity content is less than 0.1%. The invention has the advantages of simple technique and high crystallization yield, and is easy to control.
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Description

technical field

[0001] The invention belongs to the technical field of pharmaceutical synthesis technology, and in particular relates to a purification method of abiraterone. Background technique

[0002] Prostate cancer is a malignant tumor that occurs in male prostate tissue and is the result of abnormal and disordered growth of prostate acinar cells. Prostate cancer incidence varies markedly by geographic and ethnic origin. In developed countries and regions such as Europe and the United States, it is the most common malignant tumor in men, and its mortality rate ranks second among various cancers; in Asia, its incidence rate is lower than that in Western countries, but it has shown a rapid upward trend in recent years. Studies have found that the male hormone testosterone can stimulate the growth of prostate tumors, so clinical treatment generally uses drugs or surgery to reduce the production of testosterone or block the effect of testosterone. But it has been clinica...

Claims

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