Oral solid composition of abiraterone and preparation method thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- CHONGQING PHARMA RES INST
- Publication Date
- 2013-12-18
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an oral solid pharmaceutical composition of abiraterone and a preparation method thereof. The composition comprises abiraterone acetate with a particle size of 1-30um and pharmaceutical auxiliary materials. technical background
[0002] Abiraterone acetate, chemical name: (3β)-17-(3-pyridyl)-androst-5,16-dien-3-ol acetate, its chemical structure is shown in formula I .
[0003]
[0004]
[0005] Abiraterone acetate can be converted into abiraterone in the body. Abiraterone is a cytochrome oxidase P450 (CYP450)c17 inhibitor, which reduces androgen levels by inhibiting the key enzyme in androgen synthesis-CYP450c17, so , Abiraterone not only inhibits the androgen produced by the testes but also other parts of the body such as the adrenal gland.
[0006] Androgens can promote the growth of prostate cancer cells. At present, castration therapy, including ...