Abiraterone acetate preparation method

A technology of abiraterone acetate and palladium acetate, applied in directions such as steroids and organic chemistry, can solve problems such as limiting industrial application, and achieve the effects of large application value, simple production method and low cost
CN110790809AActive Publication Date: 2020-02-14AURISCO PHARMACEUTICAL CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
AURISCO PHARMACEUTICAL CO LTD
Publication Date
2020-02-14

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Abstract

The invention provides an abiraterone acetate preparation method, which comprises: dissolving 17-iodoandrosta-5,16-dien-3 beta-hydroxyl and 3-pyridine zinc neopentanoate in an organic solvent, reacting at 50-80 DEG C for 3-12 h under the catalysis of a palladium catalyst, removing the solvent after the reaction is finished, and esterifying with acetic anhydride to obtain an abiraterone acetate product. According to the invention, the method overcomes the defects of expensive raw materials, high cost, harsh reaction conditions and the like in the prior art, is low in cost, mild in preparation conditions, simple and convenient in production method and suitable for industrial production, and has high application value.
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Description

technical field

[0001] The invention relates to medicine preparation, in particular to medicine preparation, in particular to a preparation method of abiraterone acetate. Background technique

[0002] Prostate cancer is one of the most common malignant tumors in men. In recent years, the incidence of prostate cancer in China has been on the rise, and most of them are in the middle and late stages when they are discovered. Studies have shown that androgens play an important role in the development of prostate cancer. At present, first-line endocrine therapy is the standard treatment mode for newly diagnosed advanced prostate cancer. This treatment method is effective for most patients in the initial stage, but after a median treatment time of 14 to 30 months, almost all patients have lesions All of them will gradually develop into castration-resistant prostate cancer (CRPC), with a median survival time of 1 to 2 years. Docetaxel has been approved for the first-line chemothe...

Claims

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