Azithromycin enteric dry suspension and preparation method thereof
An azithromycin enteric and dry suspension technology, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problems such as cross-linking reaction of pellets and capsules.
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[0020] Example 1: Prescription: Azithromycin crystal particles 400g
[0021] Hypromellose 20g
[0022] Acrylic resin L100 120g
[0023] Triethyl citrate 20g
[0024] Sucrose 4250g
[0025] Carboxymethyl cellulose 200g
[0026] Preparation process: azithromycin crystal particles (30-50 mesh) are placed in a coating granulator, and the isolation coating is coated with a 4% hypromellose aqueous solution. The host parameter speed: 120-200rpm; spraying liquid: 3-10rpm; Air volume: small; atomization pressure: 0.05~0.1mPa; enteric coating with 6% acrylic resin L100 (adding triethyl citrate) ethanol solution, host parameter control speed: 120~250rpm; spray: 4~10rpm Air volume: small; atomization pressure: 0.05~0.1mPa; until the enteric material is used up; then crush the sucrose through a 30-mesh sieve, and mix it with the prepared enteric particles and carboxymethyl cellulose.
[0027] The prepared azithromycin enteric...
Example Embodiment
[0028] Example 2: Prescription:
[0029] Azithromycin 200g Sucrose core: 200g
[0030] PVP 40g Hypromellose 20g
[0031] Acrylic resin L100 120g Triethyl citrate 20g
[0032] Sucrose 3000g Mannitol 1000g
[0033] Preparation process: Dissolve azithromycin and PVP in ethanol to obtain 8% PVP40% azithromycin ethanol solution as the application solution, take the prescription amount of sucrose pellets and place them in a fluidized bed for application. The control parameter is: material temperature 25 ~35℃; inlet air temperature: 35~40℃; liquid spraying 4~9rpm; fan frequency: 18~24HZ; atomization pressure: 0.02~0.1mPa. The azithromycin drug particles are prepared.
[0034] Coating: use 4% hypromellose aqueous solution to coat the isolation coating, the host parameter speed is 150~200rpm; spray: 3~10rpm; air volume: small; atomization pressure: 0.05~0.1mPa; with 6% acrylic resin L100 (Add triethyl citrate) enteric-coated in ethanol solution, host parameter control speed: 150~250rpm; spray:...
Example Embodiment
[0036] Example 3: Prescription: Azithromycin crystal particles 450g
[0037] Povidone 20g
[0038] Cellulose acetate phthalate 120g
[0039] Diethyl phthalate 20g
[0040] Sucrose 4250g
[0041] Carboxymethyl cellulose 200g
[0042] Preparation process: azithromycin crystal particles (30-50 mesh) are placed in a coating granulator, and the isolation coating is coated with a 4% povidone aqueous solution. The main machine parameter speed: 120-200rpm; spray: 3-10rpm; air volume: Small; atomization pressure: 0.05~0.1mPa; enteric coating with 6% cellulose acetate phthalate (adding diethyl phthalate) ethanol solution, host parameter control speed: 120~250rpm; spray liquid : 4~10rpm; air volume: small; atomization pressure: 0.05~0.1mPa; until the enteric materials are used up; then crush the sucrose through a 30-mesh sieve, and mix with the prepared enteric particles and carboxymethyl cellulose to obtain .
[0043] The...
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