Medicinal core substance and micro-capsule prepared by taking corn cob flour as core material

A technology of corn cob powder and capsule core, which is applied in the field of preparation of pharmaceutical preparations, can solve the problems of drug loss, insufficient cognition and research, and high energy consumption.

Inactive Publication Date: 2017-06-13
中农华威生物制药(湖北)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The disadvantages of using the above method to prepare the capsule core are: the preparation process takes a long time and the process is relatively complicated; some equipment invests a lot, and the preparation process consumes more energy; there are broken objects, the particle size is not uniform, and the whole particle needs to be sieved , thus reducing the yield of finished products and causing a certain loss of drugs; some produce dust, electrostatic adsorption or adhesion between particles
[0005] Using the existing method, there are still the following problems in the subsequent coating process of the capsule core: (1) special...

Method used

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  • Medicinal core substance and micro-capsule prepared by taking corn cob flour as core material
  • Medicinal core substance and micro-capsule prepared by taking corn cob flour as core material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1, the preparation of enrofloxacin and its acidic salt or basic salt microcapsules: enrofloxacin is a kind of special quinolone antibacterial drug for animals, and it is mainly used in preventing and treating animal digestive system, respiratory system and urinary system System infection. Because enrofloxacin tastes bitter, has poor palatability, and is irritating to the stomach, most pigs refuse to eat enrofloxacin and its preparations without taste masking. Therefore, enrofloxacin administered orally must be coated Made into microcapsules, it is possible to feed as a premix, granule or tablet. Since enrofloxacin is insoluble in water and almost all organic solvents with good biocompatibility, the present invention adopts dissolving enrofloxacin in water to make an aqueous solution after salting, and selects an equivalent or slightly more Lactic acid, sodium hydroxide or sodium carbonate aqueous solution reacts with enrofloxacin to convert enrofloxacin into...

Embodiment 2

[0046] Embodiment 2, preparation of tilmicosin or tilmicosin phosphate or tilmicosin tartrate microcapsules

[0047] Tilmicosin and its salts are special antibiotics for livestock and poultry synthesized from tylosin. It has inhibitory effect on bacteria (Gram-positive bacteria and some Gram-negative bacteria), mycoplasma and spirochete, especially has strong antibacterial activity on Actinobacillus pleuropneumoniae, Pasteurella and mycoplasma in pigs. Because the taste of tilmicosin is very bitter, the tilmicosin in the tilmicosin preparation for oral administration must be coated and processed into microcapsules, so that pigs and other livestock can eat automatically.

[0048] The microcapsule preparation process is as follows:

[0049] 1. Preparation of tilmicosin phosphate microcapsules

[0050] (1) Preparation of capsule core: 3 kg of tilmicosin phosphate is stirred and dissolved with 9 liters of water, or 3 kg of tilmicosin is mixed with 9 liters of water and 0.4 liter...

Embodiment 3

[0058] Embodiment 3, the preparation of colistin sulfate microcapsule

[0059] Colistin sulfate is a narrow-spectrum antibiotic that mainly has a strong antibacterial effect on Gram-negative bacteria. The sensitive bacteria include Pseudomonas aeruginosa, Escherichia coli, Enterobacter, Klebsiella, Salmonella, and Shigella , Pasteurella and Vibrio, etc. Colistin sulfate is rarely absorbed orally, and oral preparations are mainly used to treat intestinal diseases caused by Gram-negative bacteria. Because colistin sulfate is bitter and acidic (pH value of 1% aqueous solution is 4.0-6.5), it is easy to react with alkaline substances in feed (such as vitamins, trace elements, etc.), therefore, it will cause colistin sulfate The potency of the element decreases, and the reaction produces water to increase the humidity of the feed, which is prone to deterioration. In addition, because colistin sulfate itself has hygroscopicity, it is not conducive to the storage of the product. T...

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Abstract

The invention provides a medicinal micro-capsule taking corn cob flour as a core material and a preparation method of the medicinal micro-capsule. The preparation method comprises the following steps that 1, a core substance is prepared: a medicinal solvent is dissolved to prepare a medicinal solution, or a medicine and assistants such as an emulsifier are combined to prepare an emulsion; the medicinal solution or the emulsion and the corn cob flour are mixed, sufficiently stirred and dried to obtain the core substance taking the corn cob flour as a medicinal carrier; 2, bonding and fixing are performed: a bonding agent is dissolved by a solvent to obtain a bonding agent solution; the bonding agent solution and the core substance are mixed, sufficiently stirred, dried and sieved to obtain the secure core substance containing the bonding agent; 3, coating is performed: the core substance is coated with the core material to prepare the medicinal micro-capsule taking the corn cob flour as the core material, wherein coating methods include an air suspension method, a spray drying method, a pan coating method and a painting method; the painting coating method is preferable.

Description

technical field [0001] The invention relates to the technical field of preparation of pharmaceutical preparations, in particular to using corncob powder as a capsule core material to prepare oral medicine-containing capsule cores and microcapsules thereof. Background technique [0002] Common dosage forms for oral administration to animals include premixes, powders, powders, granules, tablets, pastes, and oral liquids, among which the use of premixes in feed is the most common way of administration. In the process of mixing the premix and the feed, the drug or dispersed drug dust on the surface of the premix particles will cause pollution to the mixing equipment, the dust will endanger the workers, and the exposed drug may also mix with various ingredients in the feed Chemical reactions such as acidifiers, high trace elements, electrolytes, etc., will reduce the efficacy of the medicine and cause the loss of nutrients in the feed. Moreover, the drugs adsorbed on the surface...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/36
Inventor 王玉万翁志飞李莹韩可可李蕾任亚楠沈力
Owner 中农华威生物制药(湖北)有限公司
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