Medicinal core substance and micro-capsule prepared by taking corn cob flour as core material

Abstract

The invention provides a medicinal micro-capsule taking corn cob flour as a core material and a preparation method of the medicinal micro-capsule. The preparation method comprises the following steps that 1, a core substance is prepared: a medicinal solvent is dissolved to prepare a medicinal solution, or a medicine and assistants such as an emulsifier are combined to prepare an emulsion; the medicinal solution or the emulsion and the corn cob flour are mixed, sufficiently stirred and dried to obtain the core substance taking the corn cob flour as a medicinal carrier; 2, bonding and fixing are performed: a bonding agent is dissolved by a solvent to obtain a bonding agent solution; the bonding agent solution and the core substance are mixed, sufficiently stirred, dried and sieved to obtain the secure core substance containing the bonding agent; 3, coating is performed: the core substance is coated with the core material to prepare the medicinal micro-capsule taking the corn cob flour as the core material, wherein coating methods include an air suspension method, a spray drying method, a pan coating method and a painting method; the painting coating method is preferable.

Description

technical field [0001] The invention relates to the technical field of preparation of pharmaceutical preparations, in particular to using corncob powder as a capsule core material to prepare oral medicine-containing capsule cores and microcapsules thereof. Background technique [0002] Common dosage forms for oral administration to animals include premixes, powders, powders, granules, tablets, pastes, and oral liquids, among which the use of premixes in feed is the most common way of administration. In the process of mixing the premix and the feed, the drug or dispersed drug dust on the surface of the premix particles will cause pollution to the mixing equipment, the dust will endanger the workers, and the exposed drug may also mix with various ingredients in the feed Chemical reactions such as acidifiers, high trace elements, electrolytes, etc., will reduce the efficacy of the medicine and cause the loss of nutrients in the feed. Moreover, the drugs adsorbed on the surface...

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Problems solved by technology

[0004] The disadvantages of using the above method to prepare the capsule core are: the preparation process takes a long time and the process is relatively complicated; some equipment invests a lot, and the preparation process consumes more energy; there are broken objects, the particle size is not uniform, and the whole particle needs to be sieved , thus reducing the yield of finished products and causing a certain loss of drugs; some produce dust, electrostatic adsorption or adhesion between particles

[0005] Using the existing method, there are still the following problems in the subsequent coating process of the capsule core: (1) special coating equipment is required; (2) the coating time is longer and the energy consumption is more; (3) the preparation conditions The requirements are strict. Therefore, the quality and yield of microcapsules are greatly affected by the proficiency of the operator. If the coating process is not grasped properly, more unqualified products will easily appear.

From the above, it can be seen that corn cob powder is an excellent material for preparing drug microcapsules and capsule cores, but it has not been fully recognized and researched. Therefore, it has not been used more scientifically and effectively in the pharmaceutical manufacturing industry

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