34 results about "Tilmicosin phosphate" patented technology

A method for synthesizing tilmicosin and tilmicosin phosphate through using a tylosin broth is disclosed. The method is characterized in that the method comprises the following process steps: preprocessing the tylosin broth to obtain a tylosin filtrate; allowing the tylosin filtrate to undergo extraction, ammonification, reextraction, hydrolysis, acidification liquid extraction and vacuum drying to obtain tilmicosin; and allowing the obtained tilmicosin to undergo phosphorylation and spray drying to obtain tilmicosin phosphate. The method, which directly extracts the tylosin broth which is the initial raw material to synthesize the tilmicosin and the tilmicosin phosphate, allows the production procedure to be simplified, the product production time to be shortened, reaction conditions of the whole technology to be mild, the operation to be simple, the production process to be safe and reliable, and the organic solvent loss to be less, and has the advantages of energy saving and consumption reduction, high finished product yield, low production cost, high working efficiency and the like.

The invention discloses a compound doxycycline hyclate suspension injection and a preparation process thereof. The suspension injection is prepared by taking doxycycline hyclate and tilmicosin phosphate as main medicines and adding appropriate medical accessories. The compound doxycycline hyclate suspension injection comprises the following components: 5-20 percent (W/V) of doxycycline hyclate, 5-20 percent (W/V) of tilmicosin phosphate, 0.5-2 percent (W/V) of a suspending aid, 0.01-0.2 percent (W/V) of an antioxidant, 0.1-2 percent (V/V) percent of a thickening agent and injection oil which supplements the balance to reach 100 percent. According to the invention, the doxycycline hyclate and the tilmicosin phosphate are evenly suspended into a solvent by a special process, and therefore the compound doxycycline hyclate suspension injection has good dispersibility and high bioavailability. Meanwhile, a feasible approach is provided for broadened production, and the advantages of increasing medical efficacy, reducing medication frequency and saving manpower and material resources are achieved.

The invention relates to an improved long-acting or extended-release tilmicosin formulation comprising: tilmicosin phosphate in a concentration between 35 and 50% by weight of the total composition; a first co-solvent in a concentration between 8 and 20% by volume, said first co-solvent being propylene glycol; a second co-solvent in a concentration between 5 and 15% by volume, said second co-solvent being ethyl alcohol; and an emulsifier in a concentration between 1.5 and 15% by weight of the total composition, said emulsifier being poloxamer. The invention also relates to the method for producing said improved long-acting tilmicosin formulation.

The invention relates to a milk fragrance type tilmicosin enteric microcapsule, and belongs to the technical filed of veterinary drugs. The tilmicosin enteric microcapsule is composes of a capsule core layer and a capsule coat layer; wherein the capsule core layer is composed of tilmicosin or tilmicosin phosphate and proper auxiliary materials, and the capsule coat layer is composed of a composite enteric material. The milk fragrance type tilmicosin enteric microcapsule can radically cover the bitterness of tilmicosin, and has a high encapsulation rate and a small microcapsule particle size.

The invention relates to a tilmicosin solution, mainly comprising injection water, tilmicosin and sodium bisulfite; 100ml of injection water contains 7.5-20g of tilmicosin and 0.05-0.2g of sodium bisulfite. The invention further relates to a preparation method of the tilmicosin solution, comprising partially weighing the injection water, regulating pH value, adding the tilmicosin, then adding the sodium bisulfite, supplying the injection water, adding active carbon, decarbonization and filtration. The invention solves the problem that tilmicosin phosphate is required to prepare the tilmicosin solution in the prior art and makes up for the shortage of the prior art.

The invention relates to a preparation method of a tilmicosin phosphate crystal. The method comprises the following steps of: firstly fully dissolving tilmicosin phosphate powder in ethyl acetate, then slowly dripping isopropyl ether under the temperature condition of 0-5 DEG C in a stirring state for mixing, keeping the stirring state for 30-60min after the end of dripping, and performing solid-liquid separation, leaching and vacuum drying. According to the preparation method disclosed by the invention, tilmicosin phosphate is prepared into crystal particles, and the crystal particles are used for replacing the powder; as the specific gravity of the crystal particles is lager, the dust pollution can be avoided during packaging and using processes; furthermore, drinking water for animals is added, the crystal particles are easy to settle down into the water bottom, the dispersion is better, the dissolution speed is higher, the content is higher, and the crystal particles can be directly added into animal feed or the drinking water for the animals; and in addition, a solvent is very easy to recover, and the tilmicosin phosphate crystal further has certain application prospects in production.

The invention discloses a tilmicosin-plant essential oil composition. The composition contains the following components in percentage by weight: 5%-30% of a tilmicosin raw material, 1%-10% of a plant essential oil raw material and the balance of auxiliary materials, wherein the tilmicosin raw material is tilmicosin or tilmicosin phosphate or tilmicosin tartrate or salt of other tilmicosin. By virtue of compatibility of the tilmicosin and one or more plant essential oil in use, the use amount of an antibiotic can be effectively reduced, drug pollution and residue can be reduced, furthermore, animal diseases can be effectively prevented and treated, the immunity of animals can be enhanced, the feed conversion ratio can be decreased, and the productivity of the animals can be improved, so that the use effect is greatly improved, the raising cost is lowered, and the tilmicosin-plant essential oil composition has wide application prospects in the animal breeding industry.

The invention belongs to the field of pharmacy and particularly discloses a method for producing tilmicosin and tilmicosin phosphate by utilizing a tylosin fermentation broth. The method comprises thefollowing steps of performing hydrolysis pretreatment and filtering on the tylosin fermentation broth to obtain a tylosin B filtrate, then performing extraction separation on the tylosin B filtrate,performing catalyzed synthesis to obtain the tilmicosin, performing water-phase extraction, decoloration, crystallization and solid-liquid separation to obtain a wet tilmicosin solid, and drying the wet tilmicosin solid to obtain a tilmicosin product, or dissolving the wet tilmicosin solid with strong phosphoric acid to prepare a tilmicosin phosphate product. In the method, by directly taking thetylosin fermentation broth as a starting material to extract and synthesize the tilmicosin product or the tilmicosin phosphate product, the production technology is simplified, the production time isremarkably shortened, the production efficiency is improved, the yield of the product is increased, the quality of the product is improved, the production cost is lowered, loss of an organic solvent is reduced, emission of the three wastes is remarkably reduced, and the method has the advantages of energy conservation, consumption reduction, safe environment, excellent quality, cost reduction andthe like.

The invention relates to a production method for improving the quality of tilmicosin phosphate, which is characterized in that anhydrous sodium sulfate is added into extract liquor for stirring treatment after butyl acetate extraction for 20-40 minutes and before amination synthesis, so that on one hand, the standing water separation time of butyl acetate extraction is greatly shortened, and the standing water separation time of the extraction in the original process needs 5-6 hours; and after the anhydrous sodium sulfate is added, the water separation time is 30-60 minutes, so that the production time is shortened. On the other hand, moisture in the extract liquor is greatly removed, and a specific amount of anhydrous sodium sulfate is added at a specific time, so that the moisture in the extract liquor is lower than 2.0%, the subsequent inadequate amination reaction is avoided, the amination reaction is thorough, the mass of tilmicosin phosphate is improved, and the total impurity content is reduced by 3.0%.

The invention discloses a compound tilmicosin phosphate-ambroxol nanoemulsion preparation and a preparation method thereof. The nanoemulsion preparation is oil-in-water type, has a particle size of 1-100nm, and is prepared from tilmicosin phosphate, ambroxol, a surfactant, a co-surfactant, ethyl acetate and distilled water. The drug is a light yellow clarified liquid, and ahs the characteristics of simple preparation process, low production cost, obvious absorption effect and high stability, and can improve the bioavailability of drugs.

The present invention discloses a three-stage composition for preventing and controlling porcine respiratory diseases. The composition comprises a composition A used in weaning period of piglets, a composition B used in conservation period and a composition C used in fattening period. The composition A comprises fermented licorice extract, folium artemisiae argyi extract, loquat leaf extract, a coated tilmicosin phosphate preparation and zeolite powder; the composition B comprises echinacea purpurea extract and radix astragali extract; and the composition C comprises corns, soybean meal, wheat bran and homemade special premixes. In addition, the present invention also discloses an application of the three-stage composition used for preparing feed additives or feeds for preventing and controlling the porcine respiratory diseases. According to the occurrence regularity of the respiratory diseases of live pigs, the different compositions in the three stages are firstly used to prevent and control the occurrence of the porcine respiratory diseases. The three-stage composition is very ideal in effects, can effectively prevent and control the occurrence of the respiratory diseases and has the characteristics of being accurate in curative effects, not easy to produce drug resistance and relapse, etc.

The invention provides a tilmicosin phosphate immune colloidal gold detection card and a preparation method thereof, and relates to the technical field of detection of antibiotics. According to the present invention, the tilmicosin phosphate immune colloidal gold detection card comprises a PVC glue plate, a sample pad, a colloidal gold conjugation pad, a coating membrane and a water absorbing pad, wherein the colloidal gold membrane is a glass cellulose membrane containing tilmicosin phosphate monoclonal antibody, the coating membrane is a nitrocellulose membrane and is provided with a T line and a C line, a tilmicosin phosphate protein conjugate is coated on the T line, and a goat anti-mouse IgG antibody is coated on the C line; and the detection card is effectively used for tilmicosin phosphate detection, and has advantages of convenience, rapidness, and accurate result.

The invention relates to a tilmicosin phosphate preparation method, which comprises: adding tilmicosin to a certain proportion of purified water, heating, adding phosphoric acid in a dropwise manner to adjust the pH value so as to dissolve, filtering, cooling, adding a sedimentation agent to precipitate a crystal, carrying out centrifugation, and drying, wherein the obtained product is tilmicosin phosphate. According to the present invention, the preparation method has advantages of safety, environmental protection, good product quality and low cost, and can be used for industrial production; and the produced product has advantages of high purity and good stability.

The invention relates to A61K, in particular to a method for preparing an efficient tilmicosin premixing agent through adsorption crystallization and application of the efficient tilmicosin premixing agent. Comprising the following steps: adsorption crystallization: spraying a tilmicosin mixed solution into a porous material, and carrying out boiling drying at 50-100 DEG C for 10-15 minutes; by controlling the water content and the adsorption capacity of the porous material, adsorption of the tilmicosin mixed solution is promoted, and meanwhile, solvent water and the like in the tilmicosin mixed solution are controlled to be taken out by sucking and discharging boiling dry airflow at a certain temperature in a pore channel of the porous material with high adsorption capacity; therefore, the tilmicosin or the tilmicosin phosphate is promoted to rapidly crystallize in a short time and is adsorbed in the pore channels of the porous material to form adsorption crystals. Plant extract components can be further added after adsorption and crystallization, so that the effects of enhancing immunity, resisting inflammation, resisting oxidation, improving drug effects, reducing side effects of drugs and the like are achieved, or the taste of the preparation is improved, and the first-mouth selectivity and the long-term feed intake are improved.