34 results about "Tilmicosin phosphate" patented technology

A detection method for a residual solvent in tilmicosin phosphate comprises: preparing a reference substance solution, preparing a to-be-detected sample solution, employing a gas chromatography method, injecting the reference substance solution and the to-be-detected sample solution into a gas chromatograph by a headspace sampling manner, and calculating the residual quantity according to an external standard method. Through optimization of chromatographic conditions and the tests on preparation methods of the to-be-detected sample and the reference substance, a gas chromatograph method is established for detecting residues such as butyl acetate and n-butanol possibly existing in tilmicosin phosphate; through optimization of the chromatographic separation system, the detection method for the residual solvent in the veterinary drug tilmicosin phosphate; methodological verification tests show that the established method is high in accuracy, strong in specificity and good in reproducibility; and by controlling the content of the residual solvent in the veterinary drug tilmicosin phosphate, the safety of the veterinary drug tilmicosin phosphate is guaranteed, and thus infectious diseases of animals such as cattle, goat, sheep, cow, pig, chicken and the like are relatively effectively controlled.

The invention relates to a preparation method of a tilmicosin phosphate crystal. The method comprises the following steps of: firstly fully dissolving tilmicosin phosphate powder in ethyl acetate, then slowly dripping isopropyl ether under the temperature condition of 0-5 DEG C in a stirring state for mixing, keeping the stirring state for 30-60min after the end of dripping, and performing solid-liquid separation, leaching and vacuum drying. According to the preparation method disclosed by the invention, tilmicosin phosphate is prepared into crystal particles, and the crystal particles are used for replacing the powder; as the specific gravity of the crystal particles is lager, the dust pollution can be avoided during packaging and using processes; furthermore, drinking water for animals is added, the crystal particles are easy to settle down into the water bottom, the dispersion is better, the dissolution speed is higher, the content is higher, and the crystal particles can be directly added into animal feed or the drinking water for the animals; and in addition, a solvent is very easy to recover, and the tilmicosin phosphate crystal further has certain application prospects in production.

The invention belongs to the technical field of preparation of animal drugs, and particularly discloses a preparation method of a tilmicosin phosphate microsphere specifically for use on animals. The preparation method comprises the steps of: solving acrylic resin into absolute ethyl alcohol to make up a solution with a certain concentration; adding the soybean oil solution of the tilmicosin phosphate to obtain uniformly mixed phase; slowly dropping the mixed phase into liquid paraffin comprising Span 80 (SP80) and silicon dioxide; bathing in water and stirring at 40 DEG C to fully volatilize the absolute ethyl alcohol so as to form cured microsphere; centrifuging; removing the liquid paraffin on the surface of the microsphere through washing for many times by use of few petroleum ether, and drying at 40 DEG C to obtain the tilmicosin phosphate microsphere specifically for use on animals. The preparation method of tilmicosin phosphate microsphere specifically for use on animals has the advantages of simple operation in preparation technology and low requirement on preparation equipment and conditions. The prepared microsphere better solves the problem of drug palatability.

The invention relates to a tilmicosin phosphate soluble powder preparation and a preparation method thereof. The soluble powder preparation is prepared from the following components in parts by weight: 5-30 parts of tilmicosin phosphate, 2-30 parts of a sweetening agent, 2-20 parts of an adhesive and 20-91 parts of parts of a water-soluble diluent. The tilmicosin phosphate soluble powder provided by the invention has mobility, solubility and palatability; moisture absorption and agglomeration are not easily generated; and the stability is obviously superior to that of existing soluble powder.

The invention relates to a tilmicosin phosphate preparation method. The preparation method comprises that through hydrolysis under acidic conditions, alkalization extraction, amination, phosphorylation with phosphoric pentoxide and a small amount of water, full stirring salification, centrifugation separation after solid precipitation and vacuum drying, tilmicosin phosphate is prepared from tylosin tartrate as a raw material. According to the preparation method, phosphoric pentoxide and a small amount of water are directly added into an amination liquid, the mixture undergoes a phosphorylation reaction and tilmicosin phosphate is precipitated from the organic solvent. The preparation method has a final mole yield of 95% or more and a simple process route, can be operated easily, is free of spray drying production equipment, has a low production cost and realizes recycle of an organic solvent.

A method for synthesizing tilmicosin and tilmicosin phosphate through using a tylosin broth is disclosed. The method is characterized in that the method comprises the following process steps: preprocessing the tylosin broth to obtain a tylosin filtrate; allowing the tylosin filtrate to undergo extraction, ammonification, reextraction, hydrolysis, acidification liquid extraction and vacuum drying to obtain tilmicosin; and allowing the obtained tilmicosin to undergo phosphorylation and spray drying to obtain tilmicosin phosphate. The method, which directly extracts the tylosin broth which is the initial raw material to synthesize the tilmicosin and the tilmicosin phosphate, allows the production procedure to be simplified, the product production time to be shortened, reaction conditions of the whole technology to be mild, the operation to be simple, the production process to be safe and reliable, and the organic solvent loss to be less, and has the advantages of energy saving and consumption reduction, high finished product yield, low production cost, high working efficiency and the like.

The invention discloses compound florfenicol injection and a preparation method thereof. The compound florfenicol injection comprises the following components: 500g of florfenicol, 500g of doxycycline hyclate, 500g of tilmicosin phosphate, 3,000g of polyvinylpyrrolidone, 4,000g of N, N-dimethylacetylamide, 200g of magnesium chloride, 20g of sodium formaldehyde sulphoxylate and 10,000 milliliters of water for injection. The preparation method comprises the following steps of: (1) preparing; (2) adding doxycycline into the polyvinylpyrrolidone, heating to 80 DEG C, stirring until a mixture is clarified, adding the tilmicosin phosphate, and stirring until a mixture is clarified; (3) heating dimethylacetylamide to 50 DEG C, adding the florfenicol, and stirring for dissolving; (4) adding 1,000 milliliters of water for injection, adding the magnesium chloride and the sodium formaldehyde sulphoxylate in turn, and stirring for dissolving; and (5) mixing solution prepared in the step (2) and the step (3), gradually adding solution prepared in the step (4) under stirring, replenishing the water for injection until the total volume of the water for injection is 10,000 milliliters, uniformly stirring, filtering, filling nitrogen, encapsulating, and sterilizing at the temperature of between 110 and 115 DEG C for 30 minutes to prepare the compound florfenicol injection.

The present invention discloses a three-stage composition for preventing and controlling porcine respiratory diseases. The composition comprises a composition A used in weaning period of piglets, a composition B used in conservation period and a composition C used in fattening period. The composition A comprises fermented licorice extract, folium artemisiae argyi extract, loquat leaf extract, a coated tilmicosin phosphate preparation and zeolite powder; the composition B comprises echinacea purpurea extract and radix astragali extract; and the composition C comprises corns, soybean meal, wheat bran and homemade special premixes. In addition, the present invention also discloses an application of the three-stage composition used for preparing feed additives or feeds for preventing and controlling the porcine respiratory diseases. According to the occurrence regularity of the respiratory diseases of live pigs, the different compositions in the three stages are firstly used to prevent and control the occurrence of the porcine respiratory diseases. The three-stage composition is very ideal in effects, can effectively prevent and control the occurrence of the respiratory diseases and has the characteristics of being accurate in curative effects, not easy to produce drug resistance and relapse, etc.