Method for preparing efficient tilmicosin premixing agent through adsorption crystallization and application of efficient tilmicosin premixing agent

A technology of tilmicosin and tilmicosin phosphate, which is applied in the field of adsorption and crystallization to prepare high-efficiency tilmicosin premix, which can solve problems such as difficult crystallization, affecting use, and morphological changes of tilmicosin, so as to improve the taste , reduce drug side effects, improve selectivity and long-term feed intake

Active Publication Date: 2022-07-08
HUNAN DANWEI BILOGICALTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in the process of tilmicosin adsorption and drying, it is difficult to crystallize, and it is easy to change the shape of tilmicosin during storage, which affects subsequent use. Therefore, it is necessary to provide a method for rapid crystallization of tilmicosin while adsorbing, for animal husbandry

Method used

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  • Method for preparing efficient tilmicosin premixing agent through adsorption crystallization and application of efficient tilmicosin premixing agent
  • Method for preparing efficient tilmicosin premixing agent through adsorption crystallization and application of efficient tilmicosin premixing agent
  • Method for preparing efficient tilmicosin premixing agent through adsorption crystallization and application of efficient tilmicosin premixing agent

Examples

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Effect test

Embodiment 1

[0035] This example provides a method for preparing high-efficiency tilmicosin premix by adsorption crystallization, including:

[0036] Adsorption and crystallization: spray the tilmicosin mixture into the porous material, boil and dry at 60°C for 13 minutes to obtain crystalline tilmicosin particles; the water content of the porous material is less than 1.5wt%, and the adsorption capacity of the porous material is less than 1.5 wt%. It is between 60 and 70%, the mesh number of the porous material is 45 mesh, and the porous material is corncob flour; the tilmicosin mixed solution includes tilmicosin, and the tilmicosin accounts for The weight percent of the tilmicosin mixture is 28wt%, the tilmicosin mixture also includes citric acid, and the citric acid accounts for 14wt% of the tilmicosin mixture, and the tilmicosin and the porous material The weight ratio is 1:1;

[0037] Coating: spraying the coating solution into the crystalline tilmicosin granules obtained after adsorp...

Embodiment 2

[0039] This example provides a method for preparing high-efficiency tilmicosin premix by adsorption crystallization, including:

[0040]Adsorption and crystallization: spray the tilmicosin mixture into the porous material, boil and dry at 70° C. for 10 min to obtain crystalline tilmicosin particles; the water content of the porous material is less than 1.5wt%, and the adsorption capacity of the porous material is less than 1.5 wt%. It is between 60 and 70%, the mesh number of the porous material is 60 mesh, and the porous material is corncob flour; the tilmicosin mixture includes tilmicosin, and the tilmicosin accounts for tilmicosin The weight percentage of the tilmicosin mixture is 35wt%, the tilmicosin mixture also includes phosphoric acid, and the phosphoric acid accounts for 20wt% of the tilmicosin mixture, and the weight of the tilmicosin and the porous material is 20% by weight. The ratio is 3:4;

[0041] Coating: spray the coating solution into the crystalline tilmico...

Embodiment 3

[0043] This example provides a method for preparing high-efficiency tilmicosin premix by adsorption crystallization, including:

[0044] Adsorption and crystallization: spray the tilmicosin mixture into the porous material, boil and dry at 55°C for 15 minutes to obtain crystalline tilmicosin particles; the water content of the porous material is less than 1.5wt%, and the adsorption capacity of the porous material is less than 1.5 wt%. It is between 60 and 70%, the mesh number of the porous material is 45 mesh, and the porous material is corncob flour; the tilmicosin mixed solution includes tilmicosin phosphate, and the tilmicosin phosphate is used The weight percentage of the micosin mixed solution is 40wt%, and the weight ratio of the total weight of the tilmicosin phosphate to the porous material is 1:1;

[0045] Coating: spraying the coating solution into the crystalline tilmicosin granules obtained after adsorption and crystallization, boiling and drying at 55° C. for 15 m...

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Abstract

The invention relates to A61K, in particular to a method for preparing an efficient tilmicosin premixing agent through adsorption crystallization and application of the efficient tilmicosin premixing agent. Comprising the following steps: adsorption crystallization: spraying a tilmicosin mixed solution into a porous material, and carrying out boiling drying at 50-100 DEG C for 10-15 minutes; by controlling the water content and the adsorption capacity of the porous material, adsorption of the tilmicosin mixed solution is promoted, and meanwhile, solvent water and the like in the tilmicosin mixed solution are controlled to be taken out by sucking and discharging boiling dry airflow at a certain temperature in a pore channel of the porous material with high adsorption capacity; therefore, the tilmicosin or the tilmicosin phosphate is promoted to rapidly crystallize in a short time and is adsorbed in the pore channels of the porous material to form adsorption crystals. Plant extract components can be further added after adsorption and crystallization, so that the effects of enhancing immunity, resisting inflammation, resisting oxidation, improving drug effects, reducing side effects of drugs and the like are achieved, or the taste of the preparation is improved, and the first-mouth selectivity and the long-term feed intake are improved.

Description

technical field [0001] The present invention relates to A61K, and more particularly, the present invention relates to a method for preparing high-efficiency tilmicosin premix by adsorption crystallization and its application. Background technique [0002] As a semi-synthetic antibiotic for livestock and poultry, tilmicosin is a hydrolyzed product with fast absorption by oral administration and injection, and has a good control effect on various diseases such as gram pathogens. The main methods of administration of cosine are: injection, made into a premix for use with other feeds or beverages, or a solution, etc. Compared with direct injection or made into a solution, a solid premix is ​​more effective for tilmicol. The preservation, transportation and use of stars have unique advantages. [0003] CN111821264A provides a tilmicosin premix with good palatability and bioavailability. By uniformly adsorbing tilmicosin in the carrier, in the process of ensuring the dissolution ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/706A61K47/46A61K47/36A61P31/04
CPCA61K31/706A61K9/1664A61K9/167A61P31/04A61K9/1682Y02A40/818
Inventor 熊小军庞一林梁汉新
Owner HUNAN DANWEI BILOGICALTECH
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