60 results about "Drug side effects" patented technology

The embodiment of the invention discloses a medicine composition for preventing and / or treating heart system diseases of mammals. The medicine composition comprises a mitochondrial function optimizing substance and a medicine for treating heart system related diseases. According to the embodiment of the invention, the pharmaceutical composition has the beneficial effects of synergistic interaction or reduction of side effects of drugs in the aspect of preventing and / or treating heart system diseases of mammals.

The invention discloses a traditional Chinese medicine liniment for treating rheumatoid arthritis and a preparation process thereof, the traditional Chinese medicine liniment is composed of a wind-dispelling and pain-relieving liquid medicine and auxiliary materials, the wind-dispelling and pain-relieving liquid medicine contains eight traditional Chinese medicines of thorny elaeagnus root, erythrina bark, kadsura longepedunculata root, waxberry root, ardisia crenata, rose mallow root, glabrous sarcandra herb and wikstroemia canescens root, and is prepared by ultrasonic extraction; the auxiliary materials comprise polyvinyl alcohol, a chitosan-acetic acid solution, glycerol, azone, methylparaben, vanillyl butyl ether and ethanol. The liniment is short in film forming time and good in stability, has excellent transdermal absorption performance and antioxidant activity, can remarkably relieve joint swelling of RA model mice, improve the pain threshold value, improve joint pathological injuries, achieve local precise long-acting administration, reduce side effects of the whole body and improve patient compliance, is suitable for clinical treatment of RA, and has a wide application prospect. The problems that an existing rheumatoid arthritis treatment medicine is large in side effect, and a traditional Chinese medicine preparation is short in efficacy duration and inconvenient to use are solved.

This disclosure provides a secretion centric therapy to overcome muscle wasting. Provided are mesenchymal stem cell secretion-based therapies to overcome muscle wasting due to: old age; as a consequence of immobilization (e.g., mobility restricted or paralytics administered); due to use of ventilators (e.g., in an ICU or long-term immobilization); in microgravity during long space flights; or, resulting from drug side effects (e.g., the use of weight loss drugs, chemotherapies, etc.). Uris disclosure further provides methods and compositions for modulating, including regulating or altering, the structure and function of diaphragm muscle cells and / or diaphragm muscle fibers in particular, and skeletal muscle in general. In certain embodiments extracellular vesicles are applied to patients affected by muscle wasting.

The invention provides a full-automatic detection device and method for the concentration of free drugs in blood. The full-automatic detection method adopts a full-automatic detection device and comprises the following steps: (1) loading a blood sample to a protein purification chromatographic column by adopting a pump 1 and an automatic sampler, removing protein components in the blood sample, and retaining free drug components on the protein purification chromatographic column; (2) enabling free drug components in the protein purification chromatographic column to flow into a trapping column and enriching the free drug components in the trapping column; and (3) enabling the free drug components in the trapping column to flow into an analytical column, separating, and detecting in a triple quadrupole mass spectrometer. Through the specific full-automatic detection device, the problems that total drug concentration monitoring cannot meet clinical treatment requirements, and the free drug pretreatment process is complex, long in time and high in cost are solved, clinical individualized drug administration can be assisted, the drug curative effect is improved, and the toxic and side effects of drugs are reduced.

This invention application provides compositions containing red yeast rice pigment and their applications, compositions with α-glucosidase inhibitory activity and their applications, and further, their application in α-glucosidase inhibitors, belonging to the technical field of natural active compounds inhibiting α-glucosidase. The compositions of this invention comprise one or both of red yeast rice pigment and red yeast rice pigment: wherein the molar ratio of acarbose to red yeast rice pigment is 400:400-600:300; the molar ratio of acarbose to red yeast rice pigment is 400:200-600:150; and the molar ratio of red yeast rice pigment to red yeast rice pigment is 150:400-200:300. The compositions involved in this invention have a significant synergistic inhibitory effect on α-glucosidase, superior to using the above compounds alone, and can achieve reduced drug dosage and reduced drug side effects.

The application belongs to the technical field of biological medicine, and particularly relates to application of an active component of chamomile in preparation of an asthma treatment preparation. The chamomile active component is prepared by the following method: chamomile is subjected to reflux extraction with ethanol as an extraction solvent to obtain an extract; the extract is purified, eluted with water and ethanol in sequence, and the eluate of ethanol is collected and dried to obtain the chamomile active component. The chamomile active component provided in the application can regulate autophagy and apoptosis through multiple targets, inhibit airway inflammation, and improve immune imbalance, and can not only effectively relieve asthma symptoms, but also reduce airway epithelial damage and inhibit airway remodeling, thereby overcoming the defects of existing drugs, such as large side effects, limited efficacy on severe and hormone-resistant asthma patients, and difficulty in reversing airway damage. The active component is derived from a natural plant, is safe, and has a good application prospect in preparation of asthma treatment drugs.

The invention relates to the technical field of biological medicine, in particular to an exosome medicine preparation for treating knee osteoarthritis and a preparation method thereof, and the exosome medicine preparation is characterized in that an exosome is derived from mesenchymal stem cells subjected to three-dimensional culture in a first hydrogel matrix containing sodium alginate and hyaluronic acid; flurbiprofen or a pharmaceutically acceptable salt or ester thereof; and a pharmaceutically acceptable second gel matrix. Sodium alginate and hyaluronic acid composite hydrogel serves as a three-dimensional culture carrier of mesenchymal stem cells, a joint microenvironment is simulated to induce stem cells to secrete high-activity exosomes rich in key functional nucleic acid and active protein, meanwhile, the exosomes are scientifically compounded with flurbiprofen, and synergistic mechanisms of anti-inflammatory analgesia and tissue repair are achieved; and a local slow-release delivery system is constructed through the second gel matrix, so that long-acting stable release of active ingredients is realized, the systemic side effect of the medicine is reduced, the bioavailability of the exosome is improved, and the problems of obvious side effect, limited repair effect and the like in the prior art are solved.

To support the estimation of a suspect drug for a side effect expressing in a patient.SOLUTION: A suspect drug estimation support device 1 for a side effect according to the present invention is used to estimate a suspect drug having the possibility of a causative drug being the cause of an expression of a side effect expressing in an object patient from among a plurality of administering drugs administered to the object patient. An information processing device includes an information acquisition part 134 for acquiring candidate side effect information showing candidate side effects to be a candidate for the expression of the side effect, and administering drug information showing administering drugs, a probability calculation part 135 for calculating a conditional probability that an administering drug is a suspect drug in each of the plurality of administering drugs on condition that the candidate side effects are the expression of the side effect on the basis of the candidate side effect information and the administering drug information, and a storage part 12 for storing the calculated conditional probability.SELECTED DRAWING: Figure 2

The invention discloses a composition capable of inhibiting alpha-amylase and resisting oxidation and a preparation method thereof, and belongs to the field of traditional Chinese medicine extraction. The composition is prepared from the following components in percentage by mass: 20 to 30 percent of caulis polygoni multiflori, 20 to 40 percent of flos rosae rugosae, 10 to 30 percent of fructus amomi and 20 to 30 percent of rhizoma anemarrhenae. The preparation method comprises the following steps: crushing the medicinal materials, sieving with a 40-mesh sieve, adding 30-70% ethanol which is 10-20 times of the medicinal materials, carrying out 400-500W ultrasonic extraction for 2-3 times, and carrying out reduced pressure vacuum concentration and drying on the filtrate at 40-50 DEG C, thereby obtaining the traditional Chinese medicine composition. The alpha-amylase inhibition rate of the composition is 89.86%-96.07%, the ORAC value is 103238.56-184168.52 [mu] mol TE / L, the safety is high, the side effect is small, the process is convenient and fast, the composition can be used for assisting regulation and control of blood sugar, and the problems that existing chemical drugs are large in side effect, and traditional Chinese medicine combination effects are insufficient are solved.

The invention discloses a miRNA (micro Ribonucleic Acid)-drug-side effect triple association prediction method. In order to solve the problems of data sparse isomerism, insufficient high-order correlation modeling and limited prediction precision and generalization ability of MDS triple correlation prediction, the method comprises the following steps: integrating multi-source data to construct a reference data set for miRNA-drug-side effect triple identification; modeling the MDS association into a hypergraph, and learning triple representation by using a hypergraph convolutional network; generating an enhanced view which retains high-order topological semantics through a variational hypergraph automatic encoder; and finally, carrying out end-to-end training by adopting a joint loss function consisting of supervised binary cross entropy loss, contrast consistency loss and generation reconstruction loss to realize MDS triple association prediction. According to the method, the identification capability of MDS triple association is remarkably improved under the conditions of limited labels and data isomerism, efficient and low-cost technical support is provided for drug molecular mechanism research, safety evaluation and accurate medication, and the method has good generalization performance and application value.

The invention provides a rhinitis treatment method based on viscera meridian regulation, relates to the technical field of rhinitis treatment, and is characterized by comprising a moxibustion method, a fumigation method, a massage method and an application method. According to the moxibustion method, the Shenque acupoint is subjected to moxibustion by adopting hanging pot moxibustion or stale moxibustion, and the characteristic that the Ren meridian acupoint is communicated with the internal organs is utilized. The traditional Chinese medicine composition has the advantages that overall conditioning is achieved from the function of internal organs, local symptoms and the whole body state are considered, and the limitation of a single therapy is broken through; pure traditional Chinese medicines are combined with physical therapy, safety is high, and side effects of chemical medicines are avoided; clinical observation shows that the curative effect is remarkable, nasal obstruction, running nose, sneezing and other symptoms of a patient are obviously relieved, and the living quality is effectively improved; the operation process is clear and standard, and is easy to popularize and apply in community hospitals, traditional Chinese medicine clinics and family health care; the concept of'Huangdi internal acupuncture 'is combined with the modern traditional Chinese medicine external treatment method for the first time, and a systematized rhinitis conditioning system is constructed.

The invention discloses a topology-enhanced hypergraph learning and multi-graph converter driven drug-related side effect prediction method. The method comprises the following steps: constructing a multi-view heterogeneous graph, a drug-side effect hypergraph and a corresponding line graph; based on a cross-hypergraph and line graph learning strategy, node features of the hypergraph and the line graph are extracted and fused, and a first feature matrix is obtained; integrating node features of the multi-view heterogeneous graph by using an adaptive multi-graph Transform model to obtain a second feature matrix; performing multi-view feature fusion on the first feature matrix and the second feature matrix through a feature-level gating network; and splicing the fusion features and node features of the heterogeneous graph to form drug-side effect node pair feature representation, and performing model training based on a cross entropy loss function to obtain a drug-side effect association model. According to the method, the accuracy of predicting the relationship between the drug and the side effect is improved, and powerful technical support is provided for drug safety evaluation.

To provide a method for analyzing sequences of side effect-related HLA genes and pharmacokinetic-related 14 genes efficiently, accurately and comprehensively.SOLUTION: The present invention provides a data acquisition (gene sequence analysis) method for determining a side effect expression risk of a drug. The method includes the steps of: preparing a plurality of primer sets for amplifying 261-483bp regions including a pharmacokinetic mutation for each of human leukocyte antigen (HLA) genes, including HLA-A gene, HLA-B gene, HLA-DRB1 gene and HLA-DQA1 gene and specific 14 genes; using the plurality of primer sets to perform an amplification reaction in a plurality of reaction systems for each of the four types of HLA genes derived from a subject and pharmacokinetic-related 14 genes; and analyzing the sequences of resultant gene amplification products.SELECTED DRAWING: Figure 1

The present application relates to the field of biological medicine, and particularly relates to a recombinant fusion protein for targeted treatment of tumors and a preparation method thereof.The present application combines the protein transduction domain TAT with GLIPR1 to form a fusion protein to improve the targeting and penetration ability of GLIPR1 and optimize the defect that GLIPR1 protein mainly enters the cytoplasm by endocytosis.The recombinant fusion protein TAT-GLIPR1 prepared by the present application has significantly enhanced cell penetration ability compared with GLIPR1 protein, and improves the efficiency of GLIPR1 into tumor cells.The drug use concentration can be significantly reduced, and the drug side effects can be reduced;compared with traditional gene therapy, the problems of possible toxicity and immunogenicity can be avoided, and the recombinant fusion protein can be used as a drug for targeted treatment of tumors, and provides important technical support for the application of GLIPR1 targeted treatment of tumors.

The invention relates to a massage method for relieving pain symptoms of joints and surrounding tissues. The massage method comprises the following steps: (1) evaluating; (2) preparing; (3) cleaning and observing; (4) combined massage; and (5) observing and recording. Through scientific cooperation of a conditioning medium and a massage technique, the limitation of pure mechanical massage is broken through, the effect of relieving pain symptoms of joints and surrounding tissues is remarkably improved, and meanwhile, accompanying discomfort such as soreness and swell and stiffness is remarkably improved; during application, dependence on medicines is not needed, side effect risks of the medicines can be avoided, massage operation standardization design is easy to standardize and repeatable, and use safety and effect stability are both considered.

Disclosed in the present invention are a FAP-targeting compound and a preparation method therefor. By means of a meticulously designed molecular structure containing a plurality of variable substituents, the compound can precisely target fibroblasts in tumor stroma, thereby providing a new approach for cancer treatment. The Z group of the compound can be flexibly replaced by a radioactive agent, fluorescent agent or contrast agent, thus broadens the application range for tumor diagnosis and treatment. In the preparation method, starting from a starting material, a high-purity and high-yield FAP-targeting compound is ultimately obtained via a plurality of efficient reaction steps. Such compound has good metabolic stability and pharmacokinetic properties, which reduce the side effects of medications and increase the therapeutic effect. The diverse substituents and linker arms of the compound further optimize the physicochemical properties and improve the overall therapeutic effect. When combined with a pharmaceutical carrier, the compound achieves efficient delivery to tumor tissues and reduces non-target side effects, which provides a precise and effective personalized treatment regimen for cancer patients, and significantly improves the therapeutic effect and the quality of life of patients.

The invention discloses an external compound preparation for treating skin diseases as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation is prepared from the following raw materials in specific parts by weight: borneol, dipterex tablets, cantharides, huechys sanguinea, ephedra, calculus bovis, dragon's blood, centipedes and garter snakes. The preparation method comprises raw material pretreatment, mixing and blending, and sub-packaging and storage, and is simple in process and easy to operate; the ointment is externally applied to skin lesions every morning and evening, and is suitable for diseases such as eczema, psoriasis, neurodermatitis and the like. Through the synergistic effect of multiple components, the comprehensive curative effects of clearing heat, detoxifying, dredging collaterals, relieving itching and promoting tissue regeneration are achieved, the traditional Chinese medicine composition has the advantages of being rapid in effect taking, convenient to externally use and small in side effect, the problems that an existing skin disease treatment medicine is large in side effect and slow in effect taking are solved, and a new effective scheme is provided for clinical treatment of skin diseases.

This invention relates to the field of hair growth composition technology, specifically to an anti-hair loss and hair growth composition and its application in hair growth products. The active ingredients of the composition include GHK-Gu and Erigeron tiglium extract, and preferably also include Eclipta prostrata extract. Through in-depth research, this invention has for the first time discovered that GHK-Gu and Erigeron tiglium extract can produce a synergistic effect at a specific ratio. Based on this, a ternary compound system containing Eclipta prostrata extract was optimized. The composition significantly improves hair density, diameter, and color through multi-target synergistic effects, including inhibiting 5α-reductase activity, promoting dermal papilla cell proliferation, and activating tyrosinase. This invention solves the technical problems of significant side effects from existing chemical drugs and complex compositions of traditional Chinese medicine compound formulas, providing a highly efficient, safe, and simplified solution for hair loss treatment. In vitro and in vivo experiments have confirmed its significant anti-hair loss, hair growth, and hair darkening effects.

The invention discloses a periodontal brace for treating periodontitis in Uyghur medicine, and relates to the technical field of auxiliary devices for dental treatment. The tooth socket comprises a customized half-soft membrane tooth socket body, and a medicine storage groove is formed in the inner side of the tooth socket body corresponding to the periphery of gingiva and used for containing Uyghur medicine ointment. The tooth socket is ensured to be fit with the shape of the oral cavity through mold taking customization, the medicine storage groove can prolong the contact time of medicine and periodontium, the medicine storage groove is matched with pure natural Uyghur medicine to avoid the side effect of chemical medicine, and the tooth socket can be repeatedly used. The problems that an existing local treatment medicine is short in treatment effect and obvious in side effect are solved, the treatment effect and safety of chronic periodontitis are improved, and the traditional Chinese medicine composition is suitable for clinical periodontitis local medicine treatment scenes.

The invention provides a donkey milk exosome preparation, a preparation method and application, and belongs to the technical field of life sciences, the donkey milk exosome preparation comprises a donkey milk exosome and a complex microbial inoculant; wherein the complex microbial inoculant is prepared from clostridium butyricum, bacillus subtilis and enterococcus faecium. The scheme that the donkey milk exosome and the complex microbial inoculant are compounded for use is created for the first time, and the donkey milk exosome and the complex microbial inoculant can achieve synergistic interaction, so that inflammatory factors can be effectively reduced, the number of goblet cells is increased, and the intestinal mucosa is repaired; meanwhile, by utilizing the natural anti-inflammatory property of the donkey milk exosome and the micro-ecological regulation of the complex microbial inoculant, the side effects of chemical drugs are avoided, and an integrated scheme of'intestinal barrier repair-immune regulation 'is provided.

The invention relates to the field of medical treatment and health, and discloses a diabetic foot ulcer electrical stimulation and medicine synergistic treatment device and a using method, the diabetic foot ulcer electrical stimulation and medicine synergistic treatment device comprises a flexible main body belt, the two sides of the flexible main body belt are both provided with binding belts, the surface of the left binding belt is provided with a hook face hook-and-loop fastener, and the surface of the right binding belt is provided with a suede face hook-and-loop fastener; and the electrical stimulation drug delivery synergistic structure is used for integrating electrical stimulation and transdermal drug delivery, so that the rehabilitation treatment of the foot ulcer is enhanced. Organic fusion of treatment means is achieved through an electrical stimulation drug delivery synergistic structure, and the limitation of single treatment is broken through: a platinum composite flexible electrode and a gold composite flexible electrode are matched with an electrical stimulation control module, wound surface microcirculation can be improved through low-frequency electrical stimulation, and meanwhile, a blood vessel dilating agent stored in a drug storage chamber can further enhance the microcirculation improvement effect; the anti-inflammatory drug can reduce local inflammatory response possibly caused by electrical stimulation, and the synergistic effect of stimulation synergy and drug side effect reduction is achieved.

A method for automatically generating medicine safety information using generative AI according to an embodiment of the present invention comprises the steps of: receiving a user prompt; extracting a keyword on the basis of preconfigured keyword extraction reference by using a topic modeling model; calculating the similarity between the user prompt and the extracted keyword; extracting and summarizing information on the safety of a medicine having a similarity equal to or greater than a preconfigured threshold; classifying the summarized information on the safety of the medicine according to a medicine side effect report form; and generating a medicine side effect report for the corresponding medicine by using the classified information.

The invention provides an active peptide composition for regulating emotion and improving side effects of drugs, and relates to the technical field of active peptide compositions. The active peptide composition provided by the invention comprises an emotion regulating component and a nerve recovery promoting component, the emotion regulating component comprises theanine, gamma-aminobutyric acid (GABA), a perilla leaf extract, nano curcumin and a black pepper extract, and the components have a synergistic effect to jointly inhibit depression and central nervous system hyperexcitation and regulate emotion; the nerve recovery promoting component comprises N-acetylneuraminic acid, phosphatidylserine, brain peptide VVAVP and a perilla leaf extract, and the components cooperate with one another, so that brain recovery is promoted, anxiety is reduced, and memory is improved; the emotion regulating component and the nerve recovery promoting component cooperate with each other, the dosage of the components is optimized, depression and central nervous hyperexcitation are jointly inhibited, emotion is regulated, brain recovery is promoted, anxiety is reduced, memory is improved, the digestion and absorption effects are good, and burden on intestines and stomach is small.

This disclosure provides a secretion centric therapy to overcome muscle wasting. Provided are mesenchymal stem cell secretion-based therapies to overcome muscle wasting due to: old age; as a consequence of immobilization (e.g., mobility restricted or paralytics administered); due to use of ventilators (e.g., in an ICU or long-term immobilization); in microgravity during long space flights; or, resulting from drug side effects (e.g., the use of weight loss drugs, chemotherapies, etc.). This disclosure further provides methods and compositions for modulating, including regulating or altering, the structure and function of diaphragm muscle cells and / or diaphragm muscle fibers in particular, and skeletal muscle in general. In certain embodiments extracellular vesicles are applied to patients affected by muscle wasting.

The invention belongs to the technical field of biomedical informatics and drug safety assessment, and provides a drug side effect frequency prediction method and device, electronic equipment and a storage medium, and the method comprises the steps: carrying out the weighted fusion of one-dimensional sequence features and two-dimensional structure features through employing learnable weight parameters; constructing a side effect similar graph through known drug-side effects, and initializing side effect nodes into semantic feature vectors by adopting preset medical term embedding; calculating an attention coefficient between the side-effect node and a neighbor node thereof by adopting a graph attention network, and updating a semantic feature vector; and training the drug weighted fusion result and the semantic feature vector to obtain a model for predicting the side effect frequency of the target drug, and the technical scheme of the invention realizes the accuracy and efficiency of drug-side effect frequency prediction.

The invention relates to the technical field of emotion regulation, in particular to a method and system for regulating emotion and social behaviors based on terahertz radiation. According to the technical scheme, the method comprises the following steps: directionally irradiating a head target region of a mammal object with terahertz waves; according to the method, by establishing the clear corresponding relation between the specific terahertz frequency and the emotional behavior regulation effect, the long-standing core problems of parameter chaos and unpredictable effect in the field are solved; based on the characteristics of non-ionizing radiation, a safe novel intervention way capable of avoiding side effects of drugs is provided, and the effectiveness and biological safety of operation are ensured through a safety parameter window verified by experiments; the method provided by the invention can generate a stable and repeatable behavior regulation effect.

The utility model relates to scalp care equipment in the technical field of microneedle transdermal drug delivery, in particular to a head care cavity and a scalp care massage chair. The scalp care massage chair comprises a chair body and a head care cavity, the head care cavity is formed in the chair body, and the head care cavity comprises a shell, a sliding rail, a motion controller and a scalp care unit; the scalp nursing unit is arranged on the sliding rail in a sliding mode, and the motion controller can control the scalp nursing unit to move or stop on the sliding rail; the scalp care unit comprises a vibration module and a care element capable of being driven by the vibration module to vibrate. The scalp care unit further comprises a medicine applying module, a light-emitting unit and a distributing unit. According to the scalp care massage chair, intelligent automatic care of a scalp area can be achieved, and the comfort degree and the convenience degree of scalp care are improved; the absorption of scalp on active ingredients such as drugs is improved, the amount of drugs remaining on the skin surface is reduced, the stickiness and discomfort of the skin are relieved, and the side effects of the drugs are reduced.

The invention discloses liver-soothing and depression-relieving type medicinal and edible weight-reducing tea based on AMPK / SREBP-1c pathway regulation and control and a preparation method of the weight-reducing tea. A targeted extraction technology is introduced and comprises the steps of step-by-step extraction, embedding purification, liquid phase preparation and the like, key components, such as hawthorn flavone, nuciferine and the like, acting on an SREBP-1c pathway are accurately extracted, the key components and medicinal and edible components such as ginseng, poria cocos and the like in a formula have a synergistic effect, AMPK phosphorylation is effectively activated, SREBP-1c nuclear translocation is inhibited, and the SREBP-1c protein is prepared. Deeper lipid metabolism regulation and control and liver-intestinal axis balance are realized. Cell and animal experiments show that the tea can significantly reduce accumulation of triglyceride and has no side effects of drugs.

The application belongs to the technical field of biological medicine, and relates to application of mucinophilic Akkermansia or outer vesicles thereof in preparation of a schistosomiasis treatment drug. The application enhances host anti-infection immunity by regulating intestinal flora balance (restoring diversity and composition), improving immune response (regulating macrophages, CD8+ T cell recruitment and Th1 / Th2 balance), improving intestinal barrier function, reducing pathogen invasion and inflammation, significantly reducing liver granuloma and liver fibrosis caused by schistosome infection, and improving liver function. The application reveals the key role of MIF gene in immune regulation, and provides a new direction for schistosomiasis immunotherapy. In addition, the probiotic treatment has high safety, no obvious side effects, can be combined with chemotherapy, enhances the curative effect, reduces the side effects of chemical drugs and drug resistance, provides a persistent and comprehensive adjuvant treatment scheme for schistosomiasis, and has important clinical application potential.

The present application relates to the technical field of medicine, and relates to application of empentiv in preparation of a drug for resisting infection of Bungomkenya virus. Empentiv belongs to cyanamide dye compounds, is a very effective drug for treating oxyuriasis at present, has low side effects and good safety.