35 results about "Drug side effects" patented technology

The invention discloses a traditional Chinese medicine liniment for treating rheumatoid arthritis and a preparation process thereof, the traditional Chinese medicine liniment is composed of a wind-dispelling and pain-relieving liquid medicine and auxiliary materials, the wind-dispelling and pain-relieving liquid medicine contains eight traditional Chinese medicines of thorny elaeagnus root, erythrina bark, kadsura longepedunculata root, waxberry root, ardisia crenata, rose mallow root, glabrous sarcandra herb and wikstroemia canescens root, and is prepared by ultrasonic extraction; the auxiliary materials comprise polyvinyl alcohol, a chitosan-acetic acid solution, glycerol, azone, methylparaben, vanillyl butyl ether and ethanol. The liniment is short in film forming time and good in stability, has excellent transdermal absorption performance and antioxidant activity, can remarkably relieve joint swelling of RA model mice, improve the pain threshold value, improve joint pathological injuries, achieve local precise long-acting administration, reduce side effects of the whole body and improve patient compliance, is suitable for clinical treatment of RA, and has a wide application prospect. The problems that an existing rheumatoid arthritis treatment medicine is large in side effect, and a traditional Chinese medicine preparation is short in efficacy duration and inconvenient to use are solved.

The invention provides a full-automatic detection device and method for the concentration of free drugs in blood. The full-automatic detection method adopts a full-automatic detection device and comprises the following steps: (1) loading a blood sample to a protein purification chromatographic column by adopting a pump 1 and an automatic sampler, removing protein components in the blood sample, and retaining free drug components on the protein purification chromatographic column; (2) enabling free drug components in the protein purification chromatographic column to flow into a trapping column and enriching the free drug components in the trapping column; and (3) enabling the free drug components in the trapping column to flow into an analytical column, separating, and detecting in a triple quadrupole mass spectrometer. Through the specific full-automatic detection device, the problems that total drug concentration monitoring cannot meet clinical treatment requirements, and the free drug pretreatment process is complex, long in time and high in cost are solved, clinical individualized drug administration can be assisted, the drug curative effect is improved, and the toxic and side effects of drugs are reduced.

This invention application provides compositions containing red yeast rice pigment and their applications, compositions with α-glucosidase inhibitory activity and their applications, and further, their application in α-glucosidase inhibitors, belonging to the technical field of natural active compounds inhibiting α-glucosidase. The compositions of this invention comprise one or both of red yeast rice pigment and red yeast rice pigment: wherein the molar ratio of acarbose to red yeast rice pigment is 400:400-600:300; the molar ratio of acarbose to red yeast rice pigment is 400:200-600:150; and the molar ratio of red yeast rice pigment to red yeast rice pigment is 150:400-200:300. The compositions involved in this invention have a significant synergistic inhibitory effect on α-glucosidase, superior to using the above compounds alone, and can achieve reduced drug dosage and reduced drug side effects.

The application belongs to the technical field of biological medicine, and particularly relates to application of an active component of chamomile in preparation of an asthma treatment preparation. The chamomile active component is prepared by the following method: chamomile is subjected to reflux extraction with ethanol as an extraction solvent to obtain an extract; the extract is purified, eluted with water and ethanol in sequence, and the eluate of ethanol is collected and dried to obtain the chamomile active component. The chamomile active component provided in the application can regulate autophagy and apoptosis through multiple targets, inhibit airway inflammation, and improve immune imbalance, and can not only effectively relieve asthma symptoms, but also reduce airway epithelial damage and inhibit airway remodeling, thereby overcoming the defects of existing drugs, such as large side effects, limited efficacy on severe and hormone-resistant asthma patients, and difficulty in reversing airway damage. The active component is derived from a natural plant, is safe, and has a good application prospect in preparation of asthma treatment drugs.

The invention relates to the technical field of biological medicine, in particular to an exosome medicine preparation for treating knee osteoarthritis and a preparation method thereof, and the exosome medicine preparation is characterized in that an exosome is derived from mesenchymal stem cells subjected to three-dimensional culture in a first hydrogel matrix containing sodium alginate and hyaluronic acid; flurbiprofen or a pharmaceutically acceptable salt or ester thereof; and a pharmaceutically acceptable second gel matrix. Sodium alginate and hyaluronic acid composite hydrogel serves as a three-dimensional culture carrier of mesenchymal stem cells, a joint microenvironment is simulated to induce stem cells to secrete high-activity exosomes rich in key functional nucleic acid and active protein, meanwhile, the exosomes are scientifically compounded with flurbiprofen, and synergistic mechanisms of anti-inflammatory analgesia and tissue repair are achieved; and a local slow-release delivery system is constructed through the second gel matrix, so that long-acting stable release of active ingredients is realized, the systemic side effect of the medicine is reduced, the bioavailability of the exosome is improved, and the problems of obvious side effect, limited repair effect and the like in the prior art are solved.

The invention discloses a miRNA (micro Ribonucleic Acid)-drug-side effect triple association prediction method. In order to solve the problems of data sparse isomerism, insufficient high-order correlation modeling and limited prediction precision and generalization ability of MDS triple correlation prediction, the method comprises the following steps: integrating multi-source data to construct a reference data set for miRNA-drug-side effect triple identification; modeling the MDS association into a hypergraph, and learning triple representation by using a hypergraph convolutional network; generating an enhanced view which retains high-order topological semantics through a variational hypergraph automatic encoder; and finally, carrying out end-to-end training by adopting a joint loss function consisting of supervised binary cross entropy loss, contrast consistency loss and generation reconstruction loss to realize MDS triple association prediction. According to the method, the identification capability of MDS triple association is remarkably improved under the conditions of limited labels and data isomerism, efficient and low-cost technical support is provided for drug molecular mechanism research, safety evaluation and accurate medication, and the method has good generalization performance and application value.

The invention provides a rhinitis treatment method based on viscera meridian regulation, relates to the technical field of rhinitis treatment, and is characterized by comprising a moxibustion method, a fumigation method, a massage method and an application method. According to the moxibustion method, the Shenque acupoint is subjected to moxibustion by adopting hanging pot moxibustion or stale moxibustion, and the characteristic that the Ren meridian acupoint is communicated with the internal organs is utilized. The traditional Chinese medicine composition has the advantages that overall conditioning is achieved from the function of internal organs, local symptoms and the whole body state are considered, and the limitation of a single therapy is broken through; pure traditional Chinese medicines are combined with physical therapy, safety is high, and side effects of chemical medicines are avoided; clinical observation shows that the curative effect is remarkable, nasal obstruction, running nose, sneezing and other symptoms of a patient are obviously relieved, and the living quality is effectively improved; the operation process is clear and standard, and is easy to popularize and apply in community hospitals, traditional Chinese medicine clinics and family health care; the concept of'Huangdi internal acupuncture 'is combined with the modern traditional Chinese medicine external treatment method for the first time, and a systematized rhinitis conditioning system is constructed.

The invention discloses a topology-enhanced hypergraph learning and multi-graph converter driven drug-related side effect prediction method. The method comprises the following steps: constructing a multi-view heterogeneous graph, a drug-side effect hypergraph and a corresponding line graph; based on a cross-hypergraph and line graph learning strategy, node features of the hypergraph and the line graph are extracted and fused, and a first feature matrix is obtained; integrating node features of the multi-view heterogeneous graph by using an adaptive multi-graph Transform model to obtain a second feature matrix; performing multi-view feature fusion on the first feature matrix and the second feature matrix through a feature-level gating network; and splicing the fusion features and node features of the heterogeneous graph to form drug-side effect node pair feature representation, and performing model training based on a cross entropy loss function to obtain a drug-side effect association model. According to the method, the accuracy of predicting the relationship between the drug and the side effect is improved, and powerful technical support is provided for drug safety evaluation.

Disclosed in the present invention are a FAP-targeting compound and a preparation method therefor. By means of a meticulously designed molecular structure containing a plurality of variable substituents, the compound can precisely target fibroblasts in tumor stroma, thereby providing a new approach for cancer treatment. The Z group of the compound can be flexibly replaced by a radioactive agent, fluorescent agent or contrast agent, thus broadens the application range for tumor diagnosis and treatment. In the preparation method, starting from a starting material, a high-purity and high-yield FAP-targeting compound is ultimately obtained via a plurality of efficient reaction steps. Such compound has good metabolic stability and pharmacokinetic properties, which reduce the side effects of medications and increase the therapeutic effect. The diverse substituents and linker arms of the compound further optimize the physicochemical properties and improve the overall therapeutic effect. When combined with a pharmaceutical carrier, the compound achieves efficient delivery to tumor tissues and reduces non-target side effects, which provides a precise and effective personalized treatment regimen for cancer patients, and significantly improves the therapeutic effect and the quality of life of patients.

This invention relates to the field of hair growth composition technology, specifically to an anti-hair loss and hair growth composition and its application in hair growth products. The active ingredients of the composition include GHK-Gu and Erigeron tiglium extract, and preferably also include Eclipta prostrata extract. Through in-depth research, this invention has for the first time discovered that GHK-Gu and Erigeron tiglium extract can produce a synergistic effect at a specific ratio. Based on this, a ternary compound system containing Eclipta prostrata extract was optimized. The composition significantly improves hair density, diameter, and color through multi-target synergistic effects, including inhibiting 5α-reductase activity, promoting dermal papilla cell proliferation, and activating tyrosinase. This invention solves the technical problems of significant side effects from existing chemical drugs and complex compositions of traditional Chinese medicine compound formulas, providing a highly efficient, safe, and simplified solution for hair loss treatment. In vitro and in vivo experiments have confirmed its significant anti-hair loss, hair growth, and hair darkening effects.

The invention relates to the field of medical treatment and health, and discloses a diabetic foot ulcer electrical stimulation and medicine synergistic treatment device and a using method, the diabetic foot ulcer electrical stimulation and medicine synergistic treatment device comprises a flexible main body belt, the two sides of the flexible main body belt are both provided with binding belts, the surface of the left binding belt is provided with a hook face hook-and-loop fastener, and the surface of the right binding belt is provided with a suede face hook-and-loop fastener; and the electrical stimulation drug delivery synergistic structure is used for integrating electrical stimulation and transdermal drug delivery, so that the rehabilitation treatment of the foot ulcer is enhanced. Organic fusion of treatment means is achieved through an electrical stimulation drug delivery synergistic structure, and the limitation of single treatment is broken through: a platinum composite flexible electrode and a gold composite flexible electrode are matched with an electrical stimulation control module, wound surface microcirculation can be improved through low-frequency electrical stimulation, and meanwhile, a blood vessel dilating agent stored in a drug storage chamber can further enhance the microcirculation improvement effect; the anti-inflammatory drug can reduce local inflammatory response possibly caused by electrical stimulation, and the synergistic effect of stimulation synergy and drug side effect reduction is achieved.

A method for automatically generating medicine safety information using generative AI according to an embodiment of the present invention comprises the steps of: receiving a user prompt; extracting a keyword on the basis of preconfigured keyword extraction reference by using a topic modeling model; calculating the similarity between the user prompt and the extracted keyword; extracting and summarizing information on the safety of a medicine having a similarity equal to or greater than a preconfigured threshold; classifying the summarized information on the safety of the medicine according to a medicine side effect report form; and generating a medicine side effect report for the corresponding medicine by using the classified information.

This disclosure provides a secretion centric therapy to overcome muscle wasting. Provided are mesenchymal stem cell secretion-based therapies to overcome muscle wasting due to: old age; as a consequence of immobilization (e.g., mobility restricted or paralytics administered); due to use of ventilators (e.g., in an ICU or long-term immobilization); in microgravity during long space flights; or, resulting from drug side effects (e.g., the use of weight loss drugs, chemotherapies, etc.). This disclosure further provides methods and compositions for modulating, including regulating or altering, the structure and function of diaphragm muscle cells and / or diaphragm muscle fibers in particular, and skeletal muscle in general. In certain embodiments extracellular vesicles are applied to patients affected by muscle wasting.

The invention belongs to the technical field of biomedical informatics and drug safety assessment, and provides a drug side effect frequency prediction method and device, electronic equipment and a storage medium, and the method comprises the steps: carrying out the weighted fusion of one-dimensional sequence features and two-dimensional structure features through employing learnable weight parameters; constructing a side effect similar graph through known drug-side effects, and initializing side effect nodes into semantic feature vectors by adopting preset medical term embedding; calculating an attention coefficient between the side-effect node and a neighbor node thereof by adopting a graph attention network, and updating a semantic feature vector; and training the drug weighted fusion result and the semantic feature vector to obtain a model for predicting the side effect frequency of the target drug, and the technical scheme of the invention realizes the accuracy and efficiency of drug-side effect frequency prediction.

The invention relates to the technical field of emotion regulation, in particular to a method and system for regulating emotion and social behaviors based on terahertz radiation. According to the technical scheme, the method comprises the following steps: directionally irradiating a head target region of a mammal object with terahertz waves; according to the method, by establishing the clear corresponding relation between the specific terahertz frequency and the emotional behavior regulation effect, the long-standing core problems of parameter chaos and unpredictable effect in the field are solved; based on the characteristics of non-ionizing radiation, a safe novel intervention way capable of avoiding side effects of drugs is provided, and the effectiveness and biological safety of operation are ensured through a safety parameter window verified by experiments; the method provided by the invention can generate a stable and repeatable behavior regulation effect.

The utility model relates to scalp care equipment in the technical field of microneedle transdermal drug delivery, in particular to a head care cavity and a scalp care massage chair. The scalp care massage chair comprises a chair body and a head care cavity, the head care cavity is formed in the chair body, and the head care cavity comprises a shell, a sliding rail, a motion controller and a scalp care unit; the scalp nursing unit is arranged on the sliding rail in a sliding mode, and the motion controller can control the scalp nursing unit to move or stop on the sliding rail; the scalp care unit comprises a vibration module and a care element capable of being driven by the vibration module to vibrate. The scalp care unit further comprises a medicine applying module, a light-emitting unit and a distributing unit. According to the scalp care massage chair, intelligent automatic care of a scalp area can be achieved, and the comfort degree and the convenience degree of scalp care are improved; the absorption of scalp on active ingredients such as drugs is improved, the amount of drugs remaining on the skin surface is reduced, the stickiness and discomfort of the skin are relieved, and the side effects of the drugs are reduced.

This invention discloses an anionic surfactant-chitosan oligosaccharide composite assembly and its application, belonging to the field of mouthwash technology. The composite assembly provided by this invention is formed by the co-assembly of chitosan oligosaccharide and anionic surfactant through electrostatic interactions. The positive charge of the chitosan oligosaccharide can disrupt bacterial cell membranes, while the hydrophobic chain of the anionic surfactant can penetrate bacterial lipid membranes. The two synergistically significantly enhance broad-spectrum antibacterial activity against Gram-positive / negative bacteria and exhibit inflammation-induced pH-responsive antibacterial activity: reducing antibacterial strength in healthy oral environments, thereby reducing drug side effects; and significantly enhancing antibacterial ability in the slightly acidic, sub-healthy oral environment, thus effectively killing bacteria. Simultaneously, this invention avoids the use of pH adjusters, making it more suitable for the actual needs of mouthwashes in the oral care field for highly efficient and stable antibacterial agents.

The application belongs to the technical field of medicine, and discloses application of a sesquiterpenoid compound in preparation of a drug for regulating synovial cells. The application first discloses a triple regulation mechanism of CJB on fibroblast-like synovial cells, i.e. inhibiting cell proliferation, reducing inflammatory reaction, and regulating ferroptosis pathway. Compared with a single-target drug, the multi-target effect mode can more comprehensively control the pathological process of RA, not only inhibits abnormal proliferation of FLS and secretion of inflammatory factors, but also removes pathological synovial cells by regulating ferroptosis and apoptosis, significantly improves the treatment effect, and reduces disease recurrence. Moreover, CJB has low toxicity, raw materials are easy to obtain, and can be used in combination with existing anti-rheumatic drugs, thereby reducing drug side effects and treatment costs.

The invention discloses a metabolome and transcriptome analysis method and application in the aspect of traditional Chinese medicine eye masks.The metabolome and transcriptome analysis method comprises the following steps that S1, experimental grouping is conducted, and experimental animals are divided into a control group, a model group and a treatment group according to the standard; s2, after the experiment is finished, collecting a sample for detection; s3, metabonomics analysis is carried out, and specific metabolites related to treatment are screened out; s4, carrying out transcriptomics analysis, and screening out specific genes related to treatment; and S5, according to an analysis result, optimizing drug components so as to regulate and control the metabolic pathway and the gene in a targeted manner. A research method is provided for a treatment scheme of the xerophthalmia, the traditional Chinese medicine eye pad is further applied and developed, the xerophthalmia is treated more accurately, immunity is adjusted, metabolism is balanced, safety is high, and no chemical medicine side effect exists.

The invention discloses application of dihydrocoumarin to preparation of products for treating inflammatory bowel diseases, and belongs to the technical field of medicines. The invention aims to solve the technical problems that the existing inflammatory bowel disease treatment medicine is obvious in side effect, easy to generate drug resistance and high in disease recurrence rate, the specific effect of dihydrocoumarin in inflammatory bowel disease intervention is not clear yet, and related applications are not effectively developed. According to the key points of the technical scheme, the application of dihydrocoumarin in preparation of drugs for treating inflammatory bowel diseases, health-care foods and functional foods is provided, an inflammatory bowel disease model is intervened in a proper administration mode, the body weight loss, excrement abnormality, colon shortening and colon tissue pathological damage of a model animal are improved, the disease activity index is reduced, and the inflammatory bowel disease treatment effect is improved. Therefore, the intervention effect on the inflammatory bowel disease is achieved.

The application discloses a kind of construction methods of diabetic nephropathy combined with acute kidney injury rabbit comorbidity model, it is related to biological medicine technical field, the construction method includes the following steps: rabbit is fed with high-fat high-sugar feed, then injection tetraoxypyrimidine, constructs type 2 diabetes rabbit model, continue to feed high-fat high-sugar feed, detect rabbit blood sugar, blood fat and urine albumin / creatinine ratio, carries out pathological examination of kidney tissue, determines whether the diabetic nephropathy rabbit model is established successfully, to the diabetic nephropathy rabbit model that is successfully constructed injection folic acid-sodium bicarbonate solution, detect blood urea and creatinine level, carry out pathological examination of kidney tissue, determine whether the diabetic nephropathy combined with acute kidney injury rabbit comorbidity model is successfully constructed.The application provides effective animal model for the pathogenesis and new treatment target of diabetic comorbidity, effectively solves the problem that single animal model cannot comprehensively reflect complex disease and the influence of drug side effects on experimental animals.

The invention relates to a traditional Chinese medicine composition for treating autism spectrum disorder and application thereof, and belongs to the technical field of traditional Chinese medicines. The invention provides a traditional Chinese medicine composition for treating autism spectrum disorder. The traditional Chinese medicine composition comprises the following components in parts by mass: 5-15 parts of saffron crocus, 10-20 parts of wild chrysanthemum flowers, 5-15 parts of astragalus membranaceus, 5-15 parts of beautiful sweetgum fruits, 5-15 parts of medulla tetrapanacis, 5-15 parts of codonopsis pilosula, 1-10 parts of mint, 1-10 parts of agastache rugosus, 7-17 parts of albizia flowers, 0.5-1.5 parts of agilawood, 3-13 parts of sandalwood and 7-17 parts of tuber fleeceflower stems. The components of the traditional Chinese medicine composition are compatible and act together, the traditional Chinese medicine composition has the effect of treating autism spectrum disorder, the preparation method further improves the treatment effect, the effervescent tablets prepared from the traditional Chinese medicine composition are used for medicated bath, use is convenient and fast, the side effects of the medicine can be avoided, meanwhile, the medication conflict psychology of a patient can be prevented, and the curative effect is good. And a better treatment effect can be achieved.

This invention discloses a composition with weight-loss effects, relating to the fields of functional foods, health foods, or pharmaceuticals. The composition with weight-loss effects is prepared from components comprising the following parts by weight: 10-30 parts of Fat Burner™ Moroccan Cardamom Extract, 5-20 parts of Gingerol, 15-40 parts of Green Tea Extract, 20-50 parts of L-Carnitine, 30-60 parts of Dietary Fiber, 10-30 parts of Auxiliary Ingredients, and 1-10 parts of Lipid Metabolism Activator. This invention leverages the synergistic advantages of multi-target activation of fat metabolism, reduction of energy intake, and improvement of metabolic health, effectively overcoming the limitations of existing technologies such as insufficient synergistic effects of natural weight-loss ingredient combinations, limited fat metabolism promotion effects, and significant side effects of chemical drugs.

This invention discloses a nucleic acid delivery vector, its preparation method, and its applications, belonging to the field of drug delivery vector technology. The nucleic acid delivery vector provided by this invention is based on the LNP structure, retaining key lipids or lipid-like substances unchanged. By altering the surface composition of the LNP, it can effectively reduce the accumulation of LNP in the liver, achieving effective in-situ mRNA delivery and protein expression; thereby significantly improving LNP organ toxicity, reducing mRNA drug side effects, and enhancing mRNA drug tolerance; it achieves in-situ targeting and high nucleic acid expression by promoting in-situ uptake of the vector and enhancing endosome escape; by optimizing various components and parameters or adding active lipids, the in-situ expression level and stability of the prepared nucleic acid delivery vector can be enhanced; after use, sonication of the application site can also promote the in-situ expression level of the nucleic acid delivery vector.

This invention relates to the field of microbial technology, and in particular to a short-fermenting Lactobacillus strain capable of significantly preventing the progression of kidney disease and stabilizing renal function, and its uses. The strain of this invention has shown good efficacy in various kidney disease models, especially in a cisplatin-induced CKD model, significantly alleviating weight loss induced by platinum-based drugs in mice; it also provides excellent protection against platinum-based drug-induced intestinal inflammation and intestinal wall integrity; in the long term, it significantly alleviates platinum-based drug nephrotoxicity; it has a good stabilizing effect on renal function and can effectively prevent the progression of CKD. Therefore, the described strain can be used to prepare pharmaceutical compositions for stabilizing and improving renal function in acute and chronic kidney diseases, and can also be used to prepare drugs that reduce drug side effects, showing very broad application prospects.

This invention belongs to the field of drug synthesis, specifically relating to a mitochondrial-targeted chlordamine and cinnamaldehyde conjugated prodrug, its preparation method, and its application. The structural formula of the chlordamine and cinnamaldehyde conjugated prodrug is as follows. This invention provides a mitochondrial-targeted chlordamine and cinnamaldehyde conjugated prodrug that, through triphenylphosphine targeting mitochondria, delivers cinnamaldehyde and chlordamine to tumor cells, causing mitochondrial dysfunction and inhibiting tumor cell growth. By introducing various substituents onto the aromatic ring, the spatial conformation of the molecule is improved, enhancing its activity. Chlordamine acts on mitochondria, affecting mitochondrial energy metabolism; through triphenylphosphine targeting tumor cells and synergistic action with cinnamaldehyde, it reduces the side effects of anticancer drugs.

The invention discloses application of a peach kernel extract in preparation of a composition for preventing or treating intestinal diseases, and belongs to the technical field of food science and medical engineering. According to the application of the peach kernel extract in preparation of the composition for preventing or treating intestinal diseases, the peach kernel extract can effectively relieve diarrhea or hematochezia, improve colon length shortening and weight loss, repair intestinal tissue crypt atrophy and epithelial cell injury, inhibit inflammatory cell infiltration and reduce spleen indexes, and can be used for preventing and treating intestinal diseases. The release of inflammatory factors is inhibited, so that the effect of relieving or treating intestinal diseases is achieved; the peach kernel extract can overcome the defects of great side effect and high recurrence rate of the existing medicine.

This application relates to the field of biomedicine. Specifically, this application relates to *Lactobacillus paracasei*, compositions comprising the same, pharmaceutical compositions and cultures thereof, and uses thereof. The *Lactobacillus paracasei* of this application not only synergistically enhances the antitumor efficacy of paclitaxel but also effectively alleviates drug side effects, reverses tumor drug resistance, and exerts comprehensive probiotic effects by regulating gut microbiota and the immune microenvironment, demonstrating promising application prospects.