315 results about "Personalized medicine" patented technology

The present invention creates an objective methodology of quantitative accountability for medical device manufacturers, vendors, clinical providers, patients, and payers. In one embodiment, the standardized data received and stored in the medical device database can in turn be used for a variety of applications related to decision support (e.g., medical device selection), education and training (e.g., procedural performance), cost efficacy, evidence based medicine and best practice guidelines, personalized medicine, and comparative performance / safety analytics.

Disclosed are methods for detecting and / or prioritizing phenotype-causing genomic variants and related software tools. The methods include genomic feature based analysis and can combine variant frequency information with sequence characteristics such as amino acid substation. The methods disclosed are useful in any genomics study; for example, rare and common disease gene discovery, tumor growth mutation detection, personalized medicine, agricultural analysis, and centennial analysis.

Content delivery is provided responsive to mediacast content consumer requests by providing personalized mediacasts to each of a plurality of mediacast content consumers. Each of the personalized mediacasts includes a variety of replaceable programming and non-programming content segments and a variety of non-replaceable programming and non-programming content segments. Replacement programming and non-programming content segments may be targeted, for example selected based in part on one or more selection criterion associated with the mediacast content consumer, or provided by the broadcaster or Webcaster. A buffering scheme may be employed to inherently adjust asynchronicity between a broadcast or Webcast and a personalized mediacast. Actual insertion of replacement programming and non-programming content segments may occur upstream of a content consumer device or at the content consumer device.

Personalized medicine involves the use of a patient's molecular markers to guide treatment regimens for the patient. The scientific literature provides multiple examples of correlations between drug treatment efficacy and the presence or absence of molecular markers in a patient sample. Methods are provided herein that permit efficient dissemination of scientific findings regarding treatment efficacy and molecular markers found in patient tumors to health care providers.

The present invention provides compositions, kits, assemblies, libraries, arrays, and high throughput methods for large scale structural and functional characterization of gene expression regulatory elements in a genome of an organism, especially in a human genome. In one aspect of the invention, an array of expression constructs is provided, each of the expression constructs comprising: a nucleic acid segment operably linked with a reporter sequence in an expression vector such that expression of the reporter sequence is under the transcriptional control of the nucleic acid segment, the nucleic acid segment varying in the library and having a diversity of at least 50. The nucleic acid segments can be a large library of gene expression regulatory elements such as transcriptional promoters. The present invention can have a wide variety of applications such as in personalized medicine, pharmacogenomics, and correlation of polymorphisms with phenotypic traits.

Provided herein is a method and system for supporting behavior-changing decisions. The system solves the challenges encountered in identifying effective personalized behavior-changing recommendations, providing support for behavior-change in real time, and adhering with necessary steps towards an objective. The system can comprise a calendar platform and a messaging platform, thereby providing a user with an array of tools to track, send, and receive information, customized and personalized reminders, participate in a social network, and receive rewards. The system is also capable of building differentiated personalized profiles of antecedants, behaviors and rewards to develop highly targeted treatment indicators and better behavioral outcomes.

Provided herein are microfluidic devices that can be used as a 3D bioassay, e.g., for drug screening, personalized medicine, tissue engineering, wound healing, and other applications. The device has a series of channels {e.g., small fluid channels) in a small polymer block wherein one or more of the channels can be filled with a biologically relevant gel, such as collagen, which is held in place by posts. As shown herein, when the device is plated with cells such as endothelial cells, new blood vessels grow in the gel, which is thick enough for the cells to grow in three dimensions. Other channels, e.g., fluid channels, allow drugs or biological material to be exposed to the 3D cell growth. Cells, such as endothelial cells, can be cultured and observed as they grow on the surface of a 3D gel scaffold, where e.g., rates of angiogenesis can be measured, as well as intervascularization and extravascularization of cancerous cells.

The present invention provides compositions, kits, assemblies, libraries, arrays, and high throughput methods for large scale structural and functional characterization of gene expression regulatory elements in a genome of an organism, especially in a human genome, that are part of a common pathway. In one aspect of the invention, an array of expression constructs is provided, each of the expression constructs comprising: a nucleic acid segment operably linked with a reporter sequence in an expression vector such that expression of the reporter sequence is under the transcriptional control of the nucleic acid segment. The present invention can have a wide variety of applications such as in personalized medicine, pharmacogenomics, and correlation of polymorphisms with phenotypic traits.

The disclosure herein provides beneficial systems, methods, devices, and apparatuses that enhance and / or analyze images, and that can be configured to provide users an assessment and / or recommendation based on the enhanced and / or analyzed images. In an embodiment related to medicine, the assessment and / or recommendation is based on a patient situation, dimensions of patient organs / lumens, or the like in order to achieve personalized medicine.

A course guiding system based on non-zero start point and knowledge point in network education belongs to the field of computer technologies. The invention includes an initial knowledge domain construction module, an individualized knowledge domain generation module, an individualized learning route generation module, a history learning record module, a knowledge structure level evaluation module, and an individualized learning resource recommendation module. With knowledge point as the core, the invention constructs courses into the corresponding knowledge point tree and graph among knowledge points; learners are examined on knowledge points at each stage; by the analysis of learners' learning data and test of learning effect, the system obtains the learning status of learners at each knowledge point, their learning prediction result and knowledge point structure, recommends the corresponding learning resources and students to learners, and helps learners form the self-organized learning community to enhance the learning quality.

The methods and apparatus disclosed herein provide digital diagnostics and digital therapeutics to patients. The digital personalized medicine system uses digital data to assess or diagnose symptoms of a patient, and feedback from the patient response to treatment is considered to update the personalized therapeutic interventions. The methods and apparatus disclosed herein can also diagnose and treat cognitive function of a subject, with fewer questions, decreased amounts of time, and determine a plurality of behavioral, neurological or mental health disorders, and provide clinically acceptable sensitivity and specificity in the diagnosis and treatment.

The use of a medical software platform to collect, normalize, and aggregate clinical data. Supports clinical care and provides research and clinical tools for institutions, healthcare providers, researchers, and patients. The invention provides a graphical interface to customize searches in the database for specified subsets of conditions, treatments or outcomes. The invention also provides a system and method for searching through clinical databases for desired terms which may provide additional information to a physician regarding patient care. Furthermore, this invention facilitates personalized medicine-based practices as relationships between genetics, personal heath data from multiple sources, disease risk and drug response can be more easily visualized and utilized for patient care and research.

The disclosure herein provides beneficial systems, methods, devices, and apparatuses that enhance and / or analyze images, and that can be configured to provide users an assessment and / or recommendation based on the enhanced and / or analyzed images. In an embodiment related to medicine, the assessment and / or recommendation is based on a patient situation, dimensions of patient organs / lumens, or the like in order to achieve personalized medicine.

A system and method are presented for managing and using (e.g. for commercial or medical use) of a database. A verified database of a plurality of identified individuals is provided. The verified database comprises a plurality of individual-identifier data sets (IDSs) and relationship data. The verified database is processed in accordance with one or more parameters or conditions selected in accordance with at least one medical application, and a sub-group database is created including data records of the individuals from the verified database having said one or more selected parameters or conditions. This allows collection of data comprising the one or more selected parameters or conditions and delivery of at least part of the collected data to one or more users, and enables applying data from the verified database to provide personalized medicine service to at least one of the identified individuals.

A method for authenticating a user to a computer system is disclosed, comprising using a first input and a second input in producing a digital signature in response to a challenge. The digital signature is valid when the first input matches a personalized secret and the second input matches a trio comprising a public modulus, a public exponent, and a private-key-dependent exponent. Selection of the personalized secret is discretionary and changeable. A crypto-key generation process uses the personalized secret and two primes as input to produce the trio. The public modulus and public exponent of the trio form a public key used in digital signature validation. Also disclosed is a business method that replaces the conventional public-key certificate with an agreement on the user's public key.

This invention relates to computer systems for conducting drug and biomarker discovery, drug development, and personalized medicine, and more generally managing healthcare, and in particular to a system and method for predicting the therapeutic value of a treatment to an individual. The treatment is associated with a function that describes, in a population of individuals, the benefit from a treatment, generally in terms of occurrence of a medical event under treatment, as a function of the risk (e.g., the occurrence of the medical event) without said treatment.

The present invention discloses a method and means for providing specific dermocosmetic compositions designed to correspond to individual skin condition. The method comprises inter alia the steps of sampling the skin to be treated, so as to allow the analysis of defined sets of biomarkers relevant to the pathology under treatment; measuring quantitatively each biomarker in said sampled skin, so as to determine an individual profile of selected biomarkers, which defines the individual skin condition; analyzing the biomarker profile and designing a skin care protocol especially adapted to said individual skin condition; administrating a plurality of dermo-cosmetic compositions, in accordance with said individually adapted skin care protocol; wherein a personal correlation between said sampled patient's skin and said administrated treatment is provided.

Described herein are methods, devices and systems for simple organization, visualization and use of genome data (e.g. human genome data) on electronic devices (e.g. portable devices). In some embodiments, the data are organized and / or visualized according to phenotype traits, genes, and / or markers in a similar manner to the organization and / or visualization of digital music contents. This concept allows a new procedure for genomic data organization and facilitates the development of genomic data visualization tools. The methods described herein can be implemented with consumer-oriented software on electronic devices, computers, and portable devices, for the use of genomic related data in the field of personalized medicine for predictive, preventive and participative wireless healthcare.

The present invention relates to a novel algorithm that uses molecular profile signatures to extrapolate the physiological processes of one type of cell set (e.g., cell line, tissue, normal or diseased) to predict the activity of an agent or agents against another type of cell set that has never been exposed to the agent in question (drug efficacy prediction). The novel algorithm also allows one to predict the therapeutic response of a patient to a therapeutic regimen even though the patient (or patients) may have never been exposed to that agent before, thereby allowing for selecting a therapeutic agent or combination of agents that would best suit the patient (i.e., personalized medicine). The present invention also relates to methods of using the agents identified by the novel algorithm to treat a variety of diseases, including cancer.

Personalized medicine involves the use of a patient's molecular markers to guide treatment regimens for the patient. The scientific literature provides multiple examples of correlations between drug treatment efficacy and the presence or absence of molecular markers in a patient sample. Methods are provided herein that permit efficient dissemination of scientific findings regarding treatment efficacy and molecular markers found in patient tumors to health care providers.

The embodiments relate to improved skin quality, health and appearance using a new delivery method and certain bioactive compositions and formulations. The system incorporates microneedle delivery technology with unique compositions and formulations. Such development allows for the pursuit of personalized medicine, or treatment delivery that can expand to remote controlled environment, immediate compounding and ultimate personalization with a state of the art longitudinal data predictive analytics. Certain formulations described herein are unique, combinatory and synergistic. Secured by high-tech proprietary system, there are unlimited potentials using AQT technology including but not limited to 3-D printing of a biodegradable micro chips that can be delivered via injection, AQT or any other possible route.

Systems and methods for generating location-based retail pricing options are discussed herein. In an example, a method for generating location-based retail pricing options includes receiving, over a network from a user, a pricing request. The pricing request includes information identifying the user, a merchant, and an intended purchase. In this example, the method further includes determining a pricing option associated with the merchant and the intended purchase, and transmitting the pricing option to the user. The method still further includes processing a purchase transaction, associated with the user, for the intended purchase based on the pricing option.

Computing a personalized deal menu for a seller may be provided. The seller may operate one or more sales channels. A customer's willingness to wait in purchasing based on purchasing history of a customer may be determined. A purchase probability model that predicts a likelihood of the customer performing a purchase now compared to waiting to make the purchase may be formulated. A personalized price menu optimization model with one or more rules as constraints that jointly determines multiple prices, a price corresponding to a different purchase option with different lead time, may be solved. The personalized deal menu may be generated based on the solving.

The invention relates to a man-machine interactive system and a scheme which is composed of four parts: a man-machine interactive scheme (1) used for interacting medical information, a man-machine interactive hardware device (2) used for interacting medical information, a physical sign / symptom analysis software program (3), a medical information database and an inquire software program (4). The system can be assembled manufactured by using accessory random that is mass popularization manufactured in current social such as singlechip, computer, PDA, mobile phone and e-dictionary. The system realizes arranging inquire and multiple inquire to special information (the medical health type information having individuation requirement characteristic), provides target medical information service to broad masses of other specialty with culture standard more than middle. The system solves social requirement that ordinary masses obtains systematic and comprehensive medical health information guidance urgently who take medicine / health by experience at once because of lackness medical health information.

The invention provides personalized medicine management software for determining a series of recommended doses of a medication for a patient. The software contains code to receive information regarding a combination of at least one genetic factor and personal attributes for the patient that are predictive of the patient's reaction to a series of doses of the medication. Using a predictive mathematical model specific to the medication, the code calculates the series of recommended doses specific to the patient's genetic factor and personal attributes and specific to the medication. The series of recommended doses is outputted. In preferred embodiments, the output is the form of an interactive display. The interactive display permits a user, typically a health care professional, to input actual doses and actual patient responses. The subsequent series of recommended doses is preferably then adjusted, in real time, to account for the actual doses and actual patient responses.

The invention provides a telemarketing customer service system based on artificial intelligence and a business operation mode. According to records of various customer services and historical clients in a platform, a character model of every customer service and a character model of every historical client are generated based on emotion identification system. By adopting an artificial intelligence analysis technology, multidimensional analysis of every customer service, every task, and every client is carried out to generate the intelligent portrait of every customer service, the intelligent portrait of every task, and the intelligent portrait of every client are generated. The intelligent matching of the intelligent portrait of every customer service, the intelligent portrait of every task, and the intelligent portrait of every client is carried out according to a preset rule, and then a plurality of orders are generated, and accurate marketing among the customer services, the tasks, and the clients is realized, and therefore personalized service is provided for the clients. After the orders are finished, the intelligent vouching of the finished orders by adopting a speech recognition system and a preset vouching strategy, real-time quality inspection and real-time billing are realized, and finally, work load of workers is effectively reduced, vouching time is shortened, and the accuracy of the quality inspection is improved.

Methods for using focused light scattering techniques for the optical sensing of biological particles suspended in a liquid medium are disclosed. The optical sensing enables one to characterize particles size and / or distribution in a given sample. This, in turn, allows one to identify the biological particles, determine their relative particle density, detect particle shedding, and identify particle aggregation. The methods are also useful in screening and optimizing drug candidates, evaluating the efficacy and dosage levels of such drugs, and in personalized medicine applications.

Handwriting recognition techniques employing a personalized handwriting recognition engine. The recognition techniques use examples of an individual's previous writing style to help recognize new pen input from that individual. The techniques also employ a shape trainer to select samples of an individual's handwriting that accurately represent the individual's writing style, for use as prototypes to recognize subsequent handwriting from the individual. The techniques also alternately or additionally employ an intelligent combiner to combine the recognition results from the personalized recognition engine and the conventional recognition engine (or engines). The combiner may use a comparative neural network to combine the recognition results from multiple recognition engines. The combiner alternately may use a rule-based system based on prior knowledge of different recognition engines.