99 results about "Objective method" patented technology

The present invention creates an objective methodology of quantitative accountability for medical device manufacturers, vendors, clinical providers, patients, and payers. In one embodiment, the standardized data received and stored in the medical device database can in turn be used for a variety of applications related to decision support (e.g., medical device selection), education and training (e.g., procedural performance), cost efficacy, evidence based medicine and best practice guidelines, personalized medicine, and comparative performance / safety analytics.

Objective methods for detecting and diagnosing pancreatic cancer (PNC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of PNC-associated gene that discriminates between PNC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.

The present invention provides objective methods of diagnosis and behavioural treatments of neurological disorders such as autism spectral disorders and Parkinson's disease.

Objective methods for detecting and diagnosing small cell lung cancer (SCLC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of an SCLC-associated gene that discriminates between SCLC cells and normal cells. In another embodiment, the diagnostic method involves determining the expression level of an SCLC-associated gene that distinguishes two major histological types of lung cancer, non-small cell lung cancer (NSCLC) and SCLC. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of small cell lung cancer, methods of treating small cell lung cancer and method for vaccinating a subject against small cell lung cancer. Furthermore, the present invention provides chemotherapy resistant lung cancer- or SCLC-associated genes as diagnostic markers and / or molecular targets for therapeutic agent for these cancers. These genes are up-regulated in chemoresistant lung cancer or SCLC. Accordingly, chemoresistant lung cancer or SCLC can be predicted using expression level of the genes as diagnostic markers. As the result, any adverse effects caused by ineffective chemotherapy can be avoided, and more suitable and effective therapeutic strategy can be selected.

Non-invasive and objective methods for evaluating neurological conditions that are associated with impaired cortical plasticity using, e.g., Transcranial Magnetic Stimulation (TMS) or Theta Burst Stimulation (TBS).

Objective methods for detecting and diagnosing prostate cancer (PRC) or prostatic intraepithelial neoplasia (PIN) are described herein. In one embodiment, the diagnostic method involves the determining an expression level of PRC-associated gene that discriminate between PRC or PIN and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of either or both of PRC and PIN, methods of treating either or both of PRC and PIN and method of vaccinating a subject against either or both of PRC and PIN.

An objective method and system for dynamic analysis of prosthesis-bound subjects for determining optimal prosthesis alignment adjustments consists of a motion detection system, motion database, blending engine and algorithms, and a graphical user interface with suitable program controls whereby manual, semi-automatic, or fully automated analysis of a prosthesis-equipped subject's motion performance can be done in real time to determine objectively the optimal adjustments for the subject's prosthesis in a precise clinical protocol context.

Objective methods for detecting, diagnosing, treating and preventing hepatocellular carcinoma (HCC) are described herein. In particular, the present invention relates to two genes up-regulated in HCC cells as compared to normal cells, referred to herein as MGC47816 and HES6. In one embodiment, the diagnostic method involves the determining the expression level of MGC47816 or HES6 that discriminate between hepatocellular carcinoma cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of HCC, methods of treating HCC, and methods for vaccinating a subject against HCC.

The invention provides a seed maize field identification method and system based on multi-source and multi-temporal high resolution remote sensing data. The method comprises the steps of 1) getting the image of No. 1 multi-temporal high resolution Wild Field View (WFV) for the monitored maize field in maize growth season and the No. 2 high resolution panchromatic band image for key growth period; pre-processing the image of No. 1 multi-temporal high resolution Wild Field View (WFV) and getting xxx of No. 1 multi-temporal high resolution Wild Field View normalized difference vegetation index WFV NDVI Time Series Dataset and well-aligned High-Score 2# Panchromatic Band; S3: Application of Object-oriented Classification Method for Processing of WFV NDVI timing dataset of High-Score 1# in Maize Growing Season, to identify the cornfield block in the said monitoring area according to the phenological differences between crops; S4: to identify the seed maize field in the monitoring area based on the block acquired by S3 and according to the difference in spectrum and texture information between the seed maize field and the growing maize field on High-Score 2 panchromatic wave band. The present invention provides an accurate, economic and objective method for remote sensing and monitoring of seed maize breeding.

The invention discloses a flexible job-shop scheduling multi-objective method. The specific implementation procedures of the flexible job-shop scheduling multi-objective method are that: establishing a model for a multi-objective flexible job shop; optimizing the model by using an ant colony algorithm, and evaluating the result to check whether the scheme is the optimal scheme; and improving a pheromone updating rule according to the optimal scheme, and increasing convergence rate of the algorithm to obtain a Pareto optimal solution of a multi-objective flexible job shop scheduling problem. Compared with the prior art, the flexible job-shop scheduling multi-objective method effectively reduces workshop production cost, shortens the processing time, improves qualified rate of products, is high in practicability, and is easy to popularize.

Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells. In another embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS and IDC cells. The present invention further provides means for predicting and preventing breast cancer metastasis using BRC-associated genes having unique altered expression patterns in breast cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and method for vaccinating a subject against breast cancer.

The present invention relates to a full-reference (FR) objective method for assessing perceptual quality of decoded video frames in the presence of packet losses and coding artifacts. A method of assessing perceptual quality is provided. First, a value indicating an amount of distortion in a corresponding portion is accessed. Then, that value is classified as packet-loss distortion or coding-artifact distortion. Next, the classified value is modified to account for visibility differences of the human visual system, based on the classification, and then the modified values are combined for the multiple portions, to form a value indicating a total amount of distortion for the multiple portions.

A mathematical contouring algorithm that automatically determines the planning volume of a sarcoma prior to designing a brachytherapy treatment plan. The algorithm, utilizing computational geometry, numerical interpolation and artificial intelligence (AI) techniques, returns the planning volume in digitized and graphical forms in a matter of minutes. Such an automatic procedure reduces labor time and provides a consistent and objective method for determining planning volumes. In addition, a definitive representation of the planning volume allows for sophisticated brachytherapy treatment planning approaches to be applied when designing treatment plans, so as to maximize local tumor control and minimize normal tissue complications.

Prior methods of measuring diamond proportions in order to construct a complete model, such as a three dimensional virtual wire-frame model, of a diamond have been found to be inadequate. In particular, there has been no commercially available, automated and objective method for measuring the dimensions of a diamond with similar or greater accuracy as compared with the accuracy that can be achieved with manual gauges or micrometers. The present invention provides a method of measuring a physical characteristic of a facet of a diamond, such as the location of one or more points on an edge of a facet. The method comprises illuminating the diamond to visually distinguish a facet from adjacent facets when viewed from a predetermined location, and then capturing an image of the diamond as viewed from this predetermined location. The image is then analyzed to determine the location of at least one point located on an edge of a facet by identifying a discontinuity in the properties of light transmitted from the diamond to the viewing location.

Objective methods for diagnosing a predisposition to developing cancer, particularly bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer, are described herein. In one embodiment, the diagnostic method involves determining an expression level of PRMT1 gene. The present invention further provides methods of screening for therapeutic agents useful in the treatment of PRMT1 associated disease, such as a cancer, e.g. bladder cancer, gastric cancer, colorectal cancer, breast cancer, esophageal cancer, lung cancer, lymphoma, pancreatic cancer and testicular cancer. The present invention further provides methods of inhibiting the cell growth and treating or alleviating symptoms of PRMT1 associated diseases. The present invention also features products, including double-stranded molecules and vectors encoding thereof as well as to compositions comprising them.

Compositions and objective methods for detecting, diagnosing, and treating breast cancer (BRC) are described herein. In particular, the present invention describes three BRC-associated genes, referred to herein as A5657, B9769, and C7965, up-regulated in BRC cells as compared to normal cells. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells; in an alternate embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS cells and IDC cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and methods for vaccinating a subject against breast cancer.

Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells. In another embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS and IDC cells. The present invention further provides means for predicting and preventing breast cancer metastasis using BRC-associated genes having unique altered expression patterns in breast cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and method for vaccinating a subject against breast cancer.

A method for analyzing influence factors of production decline of an oil and gas field includes the following steps that A, an influence factor set is determined; B, an analysis sequence is determined according to historical data; C, non-quantity processing is conducted on analysis sequence data; D, by the adoption of an improved grey correlation analysis method, influence factor association degrees are obtained and ranked; E, by the adoption of a combined hierarchical analysis method, factor weights are calculated and ranked; F, comprehensive analysis is conducted on the sequence obtained in the step D and the sequence obtained in the step E, a final influence degree sequence is obtained, and comprehensive analysis of the influence factors of production decline of the oil and gas field is achieved. According to the method, the determining mode of an identification coefficient p of a conventional grey correlation analysis method is improved, and subjectivity brought by empirical selection is eliminated; by means of the combined hierarchical analysis method, the importance degrees of the influence factors are determined from the subjective aspect and combined with an objective result. Calculation results obtained through the subjective method and the objective method are combined, so that an analysis result is more scientific, accurate and reasonable.

Objective methods for detecting and diagnosing pancreatic cancer (PNC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of PNC-associated gene that discriminates between PNC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.

This invention provides method and system for measuring changes in the brain activity of an individual by functional brain imaging methods for investigative purposes, e.g., detecting and assessing whether an individual is being truthful or deceptive, and / or whether an individual has a prior knowledge of a certain face or object. The invention combines recent progress in medical brain imaging, computing and neuroscience to produce an accurate and objective method of detection of deception and concealed prior knowledge based on an automated analysis of the direct measurements of brain activity. Applying the paradigm developed from the deception model, and applying it to an individual viewing media information (e.g., audiovisual messages or movies, or announcements), the data is used to interpret the effect of the information on that individual. This permits the effective manipulation of the content of the media segments to achieve maximal desired impact in target populations or on specific individuals.

The invention discloses a tunnel risk evaluation method based on a fuzzy polymorphic Bayesian network. The invention provides an investigation method combining a confidence index, a weight index and aprobability interval based on expert judgment. According to the method, a tunnel risk accident tree is constructed according to an existing tunnel accident case, a basic event of a tunnel risk accident and the occurrence probability of each factor under the current technical level are obtained, and a polymorphic Bayesian network is constructed by the accident tree. The probability obtained by expert investigation and the probability obtained by case accidents are processed by a subjective and objective method to obtain a conditional probability, so that a polymorphic fuzzy Bayesian network conditional probability construction method and a tunnel risk probability calculation method are provided. According to the method, the subjectivity of risk factor identification can be reduced, the risk prediction accuracy is improved, informatization management and whole-process dynamic evaluation of underground engineering construction are realized, and the construction safety is ensured.

The invention provides a method and device for optimum design of oil field gathering and transportation systems. The method comprises the following steps of: determining an initial position of a booster station according to a gathering and transportation radium, a number of oil wells under administration of the station, a station yard processing scale and a length sum of pipelines of the oil wellsunder the administration of the station yard; optimizing the initial position of the booster station according to the length sum of the pipelines of the oil wells under the administration of the station yard and a weighting coefficient, so as to obtain an optimized position of the booster station; determining an optimum topological form of a series pipe network according to the optimized positionof the booster station and positions of the oil wells, so as to ensure that the length sum of the pipelines of the oil wells under the administration of the station yard is the shortest; and determining pipe diameters and wall thickness parameters of the pipelines according to the optimum topological form. According to the method and the device, an objective method and theoretical basis are provided for the layout of stations of series pipe network gathering and transportation systems and the optimum design and planning of pipeline connection and parameters, so that the defects of subjectivejudgment relaying on personal experiences and habits are avoided, and benefit is brought to reduce construction investment and operation expenses of the gathering and transportation systems.

The invention relates to a method for determining the feed liquid application uniformity in a cigarette charging process, which is characterized by comprising the following steps: taking 1,2-propanediol in a feed liquid as a label, representing the distribution of the feed liquid in the tobacco flake by utilizing the content of the 1,2-propanediol in a tobacco flake after charging, and determining the uniformity degree of the charging through detection, calculation and statistical analysis. The invention provides an integral and objective method for the quantitative evaluation of the feed liquid application uniformity in the cigarette charging process, and the method has very important meanings for improving charging equipment and the charging process, and promoting the quality and the stability of cigarette products.

The invention discloses an objective assessment method based on voice enhancement algorithm subjective assessment. The method is a new objective combination method proposed by utilizing multi-linear regression analysis based on five voice enhancement objective assessment methods as follows: PESQ, LLR, CEP, fwSNRseg and fwSNRsegVar. An objective score for assessing the quality of a voice signal, an objective score for assessing the quality of background noise and an objective score for assessing overall quality are obtained by the combinations of different weighting coefficients and five objective methods. The subjective and objective correlation coefficients of the method are superior to a plurality of other traditional objective algorithms, the standard deviation of error is lower, and the assessment of performance of the voice enhancement algorithm is easier, therefore, the invention has great practical value.

The invention discloses a workpiece scheduling method based on an ant colony optimization algorithm. The workpiece scheduling method is characterized in that workpieces are effectively selected in the scheduling process through the workpiece characteristics by using a Pareto multi-objective method, and production is performed by preferentially using the low-electricity-price period so that two objectives of optimizing electric power cost A and delay degree B can be realized. A better workpiece scheduling scheme is calculated under the environment of the parallel batch processor of the background of industrial time-of-use electricity price so that the utilization rate of enterprise resources and the energy use efficiency can be maximized, optimization of cost control and the production effect of the enterprise production process can be achieved and the market competitiveness of the enterprise can be enhanced.

The invention belongs to the field of wind-light-water multi-energy complementary joint scheduling, and discloses a multi-target tangent method for joint scheduling of a wind-light-water complementarypower generation system, which comprises the following steps: acquiring local wind speed, solar radiation intensity and hydropower station incoming water data; taking a reservoir water level value asa decision code according to the complementary characteristics of wind, light and water; analyzing power generation benefits and ecological benefits at the same time, and establishing a long-term multi-target scheduling model in the wind-light-water complementary power generation system; proposing and solving the established model by adopting a new multi-objective method to obtain a long-term optimal scheduling optimal solution set in the wind-solar-water complementary power generation system considering both power generation and ecology; and the solved multi-target scheme is analyzed. The method can be fully used for medium-and-long-term planning and scheduling scheme compilation of the wind-light-water complementary power generation system, the power generation target and the ecologicaltarget of the wind-light-water complementary power generation system are balanced, the comprehensive benefit of medium-and-long-term scheduling is improved to the maximum extent, and the method has certain reference significance.

The invention discloses a method and a device for determining dynamic weights of indexes. The method comprises the following steps: acquiring the weight of each index for the service quality, wherein the weight is an externally input preset value; acquiring sample data of each first index, wherein the first indexes are indexes which meet the preset conditions in all the indexes and the sample data comprises one or a plurality of sample values of the indexes and the value of the service quality corresponding to each sample value; according to the acquired sample data, respectively determining the weight of each first index for the service quality; and carrying out unitization processing on the weight of a second index in each index except for the first index and the determined weight of each first index and determining the weight of each index. By the method and the device, the combination of a subjective method and an objective method is realized, and the weight of each index for the influence on the service quality sensed by a user is determined by sufficiently utilizing the knowledge and experience of specialists and objective data acquired by operators.

Objective methods for detecting and diagnosing testicular seminoma (TS) arc described herein. In one embodiment, the diagnostic method involves the determining a expression level of TS -associated gene that discriminate between TS and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of TS, methods of treating TS and method of vaccinating a subject against TS.

Objective methods for detecting and diagnosing intestinal-type gastric cancers are described herein. Also described is method for predicting the presence or absence of lymph node metastasis (i.e., identifying the metastatic phenotype). In one embodiment, the diagnostic method involves the scoring of gene expression profiles that discriminate between lymph node positive tumors and lymph node negative tumors. The predictive score calculated acts as diagnostic indicator that can objectively indicate whether a sample tissue has the metastatic phenotype. The present invention further provides methods of diagnosing intestinal-type gastric cancer in a subject, methods of screening for therapeutic agents useful in the treatment of intestinal-type gastric cancer, methods of treating intestinal-type gastric cancer and method of vaccinating a subject against intestinal-type gastric cancer.