31 results about "Doxycycline Hyclate" patented technology

The invention discloses a doxycycline-hyclate-carried GTR (Guide Tissue Regeneration)/GBR (Guide Bone Regeneration) composite membrane and a preparation method thereof and belongs to the technical field of medicines. The GTR/GBR composite membrane adopts a three-layer structure, wherein the upper surface layer, the lower surface layer and the sandwich layer are all manufactured through sequence electrospinning; the upper surface layer and the lower surface layer are prepared from a natural polymer material and a mixed solution through which the polymer material is synthesized; the sandwich layer is a membrane layer prepared from a doxycycline-hyclate-carried solution through which the polymer material is synthesized. The uniaxial sequence electrospinning method is adopted to prepare the composite membrane adopting the three-layer structure, so that the medicine entrapment efficiency of fibers is improved, the preliminary burst effect of a medicine is reduced/eliminated, and continuously slow release of the medicine is realized. The two surface layers of the three-layer medicine-carried composite membrane can not only serve as porous barriers to control the medicine release rate so as to realize continuously slow release of the medicine but also prevent direct contact between the medicine and tissues to improve the compatibility between the tissues and the membrane so as to be more conducive to tissue repair and regeneration.

The invention discloses a compound doxycycline hyclate suspension injection and a preparation process thereof. The suspension injection is prepared by taking doxycycline hyclate and tilmicosin phosphate as main medicines and adding appropriate medical accessories. The compound doxycycline hyclate suspension injection comprises the following components: 5-20 percent (W/V) of doxycycline hyclate, 5-20 percent (W/V) of tilmicosin phosphate, 0.5-2 percent (W/V) of a suspending aid, 0.01-0.2 percent (W/V) of an antioxidant, 0.1-2 percent (V/V) percent of a thickening agent and injection oil which supplements the balance to reach 100 percent. According to the invention, the doxycycline hyclate and the tilmicosin phosphate are evenly suspended into a solvent by a special process, and therefore the compound doxycycline hyclate suspension injection has good dispersibility and high bioavailability. Meanwhile, a feasible approach is provided for broadened production, and the advantages of increasing medical efficacy, reducing medication frequency and saving manpower and material resources are achieved.

The invention discloses a doxycycline hyclate enteric-coated pellet which comprises the following components in percentage by weight from inside to outside: 48-58 blank core pellet, 35-40 medicinal layer and 4-13 enteric-coated layer. The invention also discloses a method for preparing the doxycycline hyclate enteric-coated pellet. The doxycycline hyclate enteric-coated pellets prepared by the method are filled into a capsule, and an obtained enteric-coated preparation has the advantages of increased contact area with the intestinal tract, high bioavailability, good stability, steady release in vitro and vivo, no influence by gastrointestinal peristalsis and food intake, uniform absorption, smaller difference of bioavailability among individuals, and the like.

The invention discloses a preparation method of doxycycline hyclate freeze-dried powder injection. The method includes steps of material preparing, freeze drying and the like, wherein pre-freezing is performed in three steps, the temperature of materials is fast decreased to about minus 20 DEG C, then the temperature of the materials is decreased to about minus 30 DEG C at a constant speed, and the temperature of the materials is finally fast decreased to about minus 40 DEG C and the temperature is kept; sublimation is performed in two steps, the temperature of the materials is increased to about minus 20 DEG C and the temperature is kept for 5-10 hours, and then the temperature of the materials is increased to about minus 5 DEG C and the temperature is kept for 1-3 hours. The method has the advantages that the special freeze drying process is used to solve the technical problem that the doxycycline hyclate liquid is difficult in freeze drying, doxycycline hyclate liquid solid content can reach above 50%, freeze drying efficiency is increased, freeze drying cycle is shortened, and products are full in appearance, free of atrophy, collapse, fracture and the like, and good in re-dissolving performance and mass stability.

The invention discloses soluble compound doxycycline hyclate powder for animals and a preparation method thereof, which aim to provide compound doxycycline hyclate powder which is used for treating the mixed infection of swine plague mycoplasma pneumonia, has quick effect and can treat both symptoms and root causes, lighten stress reactions when pigs fall ill and improve the weight growth ratio, and a preparation method which has simple process and is easy to realize. The soluble powder comprises the following components by the weight percent: 1-20 of doxycycline hyclate, 0.5-5 of ofloxacin, 5 of aminophylline and the balance of anhydrous dextrose. The soluble compound doxycycline hyclate powder adopts antibiotics, antibacterial drugs and antiasthmatic drugs in a reasonable proportion so as to have multiple actions, can quickly ease clinic symptoms caused by the swine plague and the mycoplasma pneumonia, reduce damages caused by the two diseases to organisms, quicken the recovery, kill pathogens fundamentally, reduce the probability of the drug resistance of pathogenic microorganisms and treat both the symptoms and the root causes, and has quick effect.

The invention provides a preparation method of doxycycline hyclate and doxycycline hyclate prepared through the method. Through a reaction between chlorinated acetanilide and oxytetracycline, raw materials are provided. The yield of doxycycline hyclate is increased, production of by-products is reduced, and meanwhile, acetanilide, ethyl alcohol, methyl alcohol and the like generated in a preparation process can be recycled. Therefore, environmental pollution and resource waste are reduced, the production cost is decreased, and the yield of products in the preparation process is stable. Additionally, doxycycline hyclate prepared through the preparation method is high in purity and great in luster.

A veterinary medicine for treating the infection of the mixture of mould body and other bacteria to chicken and pig contains florfenicol, fumarate trevisin, doxycycline hyclate and lactate TMP.

The invention relates to an ointment, in particular to an ointment for treating acne and a preparation method and application thereof. The ointment for treating acne comprises a base material and active pharmaceutical ingredients, wherein the active pharmaceutical ingredients comprise 500-2000 parts of doxycycline hyclate, 800-2500 parts of chloramphenicol, 500-2000 parts of triamcinolone acetonide acetate, 500-2000 parts of vitamin C, 10-100 parts of glucocorticoid, 10-100 parts of vitamin B2 and 5-100 parts of cyproheptadine hydrochloride. The ointment for treating acne is unique in composition and significant in therapeutic effect; through the unique compatibility of the composition, various medicines in the active pharmaceutical ingredients not only can achieve effects of the original medicine but also can be further improved in clinical effect after being combined; sebum secretion is effectively regulated, toxins and hazardous substances in hair follicles are discharged, and symptoms such as acne and comedo can be eliminated fundamentally; and meanwhile the ointment has significant therapeutic effects on acne mark fading and acne pit smoothing.

The invention discloses a device and method for recycling ethyl alcohol in a refined mother solution of doxycycline hyclate. The specific device for recycling ethyl alcohol comprises a pressure reduction distillation kettle, a neutralization kettle, a press filter, a to-be-recycled ethyl alcohol intermediate tank, a distillation tower, a vaporization membrane separation device and a finished product tank which are connected in sequence; the distillation tower is connected with a side material solution inlet of the vaporization membrane separation device, and a side material solution outlet ofthe vaporization membrane separation device is connected with the finished product tank. According to the device and method for recycling the ethyl alcohol in the refined mother solution of the doxycycline hyclate, the rate of recycling absolute ethyl alcohol reaches 85% or above, the content of the recycled ethyl alcohol reaches 99.5% or above, the moisture content is smaller than 0.5%, the content of chloroethane is lower than 200 ppm, and the recycle device and method accord with the standard of recycle application. The technology is stable, the recycle rate is high, the production cost isgreatly lowered, low-temperature pressure reduction distillation is adopted, the energy is saved, the emission amount of the ethyl alcohol is lowered, and the environmental pollution is reduced.

Provided is a ureaplasma urealyticum/mycoplasma hominis combined rapid culture and drug sensitivity detection kit. The kit can complete detection in 8-24 h, and meanwhile, drug-resistant detection of various antibiotics can be performed. The combined rapid culture kit is mainly composed of pork stomach digestive juice or lung digestive juice, a beef extracting solution or a beef heart extracting solution, cattle serum or horse serum or other animal serum, sodium chloride, peptone, yeast powder, urea, L-arginine, phenol red indicator or cresol red indicator, and penicillin or other antibiotics. The drug detection kit can detect doxycycline hyclate, roxithromycin, acetylspiramycin, gatifloxacin, clarithromycin, azithromycin, clindamycin, erythromycin, kitasamycin, ofloxacin, levofloxacin hydrochloride, sparfloxacin, ciprofloxacin, doxycycline, erythromycin cydocarbonate and various other antibiotics. By means of the detection kit, not only is the mycoplasma detection time shortened, but also drug-resistant detection can be performed at the same time so that clinical medication can be guided. The detection kit has the beneficial effects of being high in sensitivity, high in specificity, high in detection rate, easy and convenient to operate and the like.

A dental composition comprising a therapeutically effective amount of doxycycline hyclate and a therapeutically effective amount of triamcinolone acetonide and use in dental treatment.

The invention belongs to the technical field of veterinary medicine and discloses doxycycline hyclate injection and a preparation process thereof.Every 100ml of the doxycycline hyclate injection comprises 4.2-12.4g of magnesium chloride complexing agent, 5-15g of doxycycline hyclate, 20-30ml of alpha-pyrrolidone, 10-20ml of dimethyl formamide, 10-20ml of glycerin methylal, 0.1-0.2g of antioxidant, 5-10g of cosolvent and the balance of injection water.The prepared doxycycline hyclate injection has the advantages that the doxycycline hyclate injection is light in color, good in stability, quick in action, definite in curative effect, convenient in veterinary clinical application and easy in dose control, the doxycycline hyclate injection has a certain long-acting effect and cannot be easily affected by other medicine, and the treatment effect and efficiency are increased.

The invention belongs to the technical field of medicine and particularly relates to a doxycycline hyclate enteric-coated tablet and a preparation method thereof. The enteric-coated tablet is prepared from, by weight, 28-32% of doxycycline hyclate enteric-coated pellets, 55-65% of lactose anhydrous, 4-8% of corn starch, 0.1-5% of cross-linking povidone and 0.1-1% of magnesium stearate. The diameter of the doxycycline hyclate enteric-coated pellets ranges from 0.35 mm to 1.00 mm, lactose anhydrous includes lactose anhydrous bodies with two different particle sizes, the particle size of the small-particle-size lactose anhydrous ranges from 45 microns to 150 microns, and the particle size of the large-particle-size lactose anhydrous ranges from 250 microns to 400 microns. The doxycycline hyclate enteric-coated tablet has the advantages that the preparation technology is simple, hardness is moderate, disintegration is quick, content uniformity is good and the release degree accords to quality standards, the treatment effect is good, and adverse effects are small.

The invention relates to a compound Chinese medicine injection for treating a porcine respiratory disease. The compound Chinese medicine injection mainly comprises common andrographis herb and Alpha-asarin. The compound doxycycline hyclate suspension injection has the functions of clearing away fever and detoxicating, relieving cough and asthma, calming and relieving spasm and the like, has the advantages of simple and convenience preparation process and stable performance and is suitable for industrial production.

The invention discloses a substance related to doxycycline hyclate as well as an analysis and detection method thereof. The invention discovers a novel photodegradation product of doxycycline hyclate, and the structure of the photodegradation product is reported for the first time. The invention provides a preparation method of the photodegradation product, the method is simple and easy to operate, and a large number of the photodegradation products can be prepared. A liquid phase analysis method is provided for rapidly detecting the photodegradation products, and a maximum absorption wavelength of the photodegradation products is used as a detection wavelength, so that the detection rate of the photodegradation products is improved, and the result is accurate and reliable; the photodegradation products can be used for detecting substances related to doxycycline hyclate and preparations thereof, further improving quality standards of doxycycline hyclate and preparations thereof, and improving safety and controllability thereof.

The invention relates to a preparation technology for improving the purity of a doxycycline hyclate injection. The preparation technology comprises following steps: grinding doxycycline hyclate into powder by the use of a ball mill, and dissolving the powder in water so as to form a solution A; dissolving ethyl cellulose in an organic solvent so as to form a solution B; pouring the solution A into the solution B under a stirring condition, wherein an emulsion is formed after the solution A disperses in the solution B; dissolving gelatin in distilled water under a water-bath condition at 60-80 DEG C so as to prepare a protection solution D which is standby at the constant temperature of 30 DEG C; drooping the emulsion C into the protection solution D under a stirring condition so as to form a solution E, and stirring the solution under a condition that the temperature of the water-bath is raised to 50 DEG C from 30 DEG C so that the organic solvent volatilizes; and then performing suction filtration on the solution E, washing the solution E, and drying the solution E so as to obtain the white powder doxycycline hyclate. According to the invention, problems that the dissolving speed is relatively slow in a conventional preparation process of doxycycline hyclate preparations and the doxycycline hyclate for injection contains impurities in the conventional preparation process are solved.