Compound florfenicol injection and preparation method thereof

A technology of compound florfenicol and florfenicol, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of slow onset of action and long course of treatment, and achieve release Slow absorption, high cure rate, enhanced synergy effect

Active Publication Date: 2012-10-31
山东中牧兽药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the course of oral administration is long and the onset is slow, so it is not suitable for acute porcine infectious pleuropneumonia

Method used

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  • Compound florfenicol injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Formulation Example 1 Preparation of 10 L Compound Florfenicol Injection

[0042] prescription:

[0043] Florfenicol 0.2kg,

[0044] Doxycycline hydrochloride 0.2kg,

[0045] Ofloxacin 0.01kg,

[0046] Dimethylacetamide DMAC 2L,

[0047]Propylene Glycol 3L,

[0048] The balance is absolute ethanol.

[0049] Preparation:

[0050] Step 1: Weigh 0.2kg of florfenicol, add it to 2L dimethylacetamide, stir and dissolve for 15min;

[0051] Step 2: Weigh 0.2 kg of doxycycline hydrochloride, add it to 3 L of propylene glycol, heat to 68 degrees Celsius, stir and dissolve for 15 minutes;

[0052] Step 3: Cool the solution obtained in step 2 to normal temperature, add the solution obtained in step 1, stir and mix for 10 minutes, then add 0.01 kg ofloxacin, and stir for 15 minutes.

[0053] Step 4: Add absolute ethanol to the solution obtained in Step 3 to make up to 10 L, and stir to dissolve for 10 min.

[0054] Step 5: Filter the solution obtained in Step 4, pot it, an...

Embodiment 2

[0055] Formulation Example 2 Preparation of 10 L Compound Florfenicol Injection

[0056] prescription:

[0057] Florfenicol 2kg,

[0058] Doxycycline hydrochloride 0.05kg,

[0059] Ofloxacin 0.02kg,

[0060] Dimethylacetamide DMAC 4L,

[0061] Propylene Glycol 2L,

[0062] The balance is absolute ethanol.

[0063] Preparation:

[0064] Step 1: Weigh 2kg of florfenicol, add it to 4L dimethylacetamide, stir and dissolve for 20min;

[0065] Step 2: Weigh 0.05 kg of doxycycline hydrochloride, add it to 2 L of propylene glycol, heat to 65 degrees Celsius, and stir to dissolve for 20 minutes;

[0066] Step 3: Cool the solution obtained in step 2 to normal temperature, add the solution obtained in step 1, stir and mix for 10 minutes, then add 0.02 kg ofloxacin, and stir for 15 minutes.

[0067] Step 4: Add absolute ethanol to the solution obtained in step 3 to make up to 10 L, and stir to dissolve for 15 minutes.

[0068] Step 5: Filter the solution obtained in Step 4, pot...

Embodiment 3

[0069] Formulation Example 3 Preparation of 10 L Compound Florfenicol Injection

[0070] prescription:

[0071] Florfenicol 0.5kg,

[0072] Doxycycline hydrochloride 0.2kg,

[0073] Ofloxacin 0.02kg,

[0074] Dimethylacetamide DMAC 3L,

[0075] Propylene Glycol 3L,

[0076] The balance is absolute ethanol.

[0077] Preparation:

[0078] Step 1: Weigh 0.5kg of florfenicol, put it into 3L dimethylacetamide, stir and dissolve for 30min;

[0079] Step 2: Weigh 0.2 kg of doxycycline hydrochloride, put it into 3 L of propylene glycol, heat to 65 degrees Celsius, stir and dissolve for 15 minutes;

[0080] Step 3: Cool the solution obtained in step 2 to normal temperature, add the solution obtained in step 1, stir and mix for 20 minutes, then add 0.02 kg ofloxacin, and stir for 30 minutes.

[0081] Step 4: Add absolute ethanol to the solution obtained in step 3 to make up the full amount, and stir to dissolve for 30 minutes.

[0082] Step 5: Filter the solution obtained in ...

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Abstract

The invention discloses compound florfenicol injection and relates to the field of veterinary medicine preparation. The compound florfenicol injection is prepared from florfenicol, doxycycline hyclate, ofloxacin, dimethylacetamide (DMAC), propylene glycol and absolute ethyl alcohol. The invention also provides a preparation method of the compound florfenicol injection. As a novel veterinary compound preparation, the compound florfenicol injection has the characteristics of strong synergistic effect and low dosage, can effectively treat porcine infectious pleuropneumonia and has the important significance for sustainable development of the animal husbandry.

Description

technical field [0001] The invention relates to the field of veterinary drug preparations, in particular to a compound florfenicol injection. Background technique [0002] Porcine contagious pleuropneumonia is a highly contagious respiratory disease of pigs caused by Actinobacillus pleuropneumoniae. It is characterized by acute hemorrhagic fibrinous pleuropneumonia and chronic fibrinous necrotizing pleuropneumonia. One of the major epidemics of bacterial respiratory diseases. The occurrence of this disease has obvious seasonality, mostly occurring in April-May and September-November. The disease most commonly occurs in breeding pigs and adult pigs, but it can be caused by stress factors such as sudden changes in the breeding environment, transfer or mixing of pigs, crowding or long-distance transportation, poor ventilation, high humidity, and sudden changes in temperature. Or accelerate the spread of disease, increasing morbidity and mortality. [0003] The most acute typ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/65A61K47/16A61K9/08A61P11/00A61P31/04A61K31/165A61K31/5383
Inventor 王统高
Owner 山东中牧兽药有限公司
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