Doxycycline-hyclate-carried GTR/GBR composite membrane and preparation method thereof

A technology of doxycycline hydrochloride and composite membrane, which is applied in the field of medicine, can solve problems such as application limitations and unresolved problems, and achieve the effects of improving tissue affinity, avoiding drug contact, and improving affinity

Inactive Publication Date: 2015-11-11
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the initial burst release of 40%-50% of the drug inhibits the growth and proliferation of cells to a certain extent. The problem of the initial burst release of the drug has not been solved so far, which greatly limits the application of this technology.

Method used

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  • Doxycycline-hyclate-carried GTR/GBR composite membrane and preparation method thereof
  • Doxycycline-hyclate-carried GTR/GBR composite membrane and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] A preparation method of a GTR / GBR composite membrane loaded with doxycycline hydrochloride, comprising the following steps:

[0037] 1) Mix gelatin and polycaprolactone with an average molecular weight of 80,000 in a mass ratio of 1:1 and dissolve them in hexafluoroisopropanol to prepare a surface electrospinning solution with a mass fraction of 8%, and ultrasonically degas 5min;

[0038] 2) Polycaprolactone and doxycycline hydrochloride are mixed in a mass ratio of 1:0.25 and then dissolved in hexafluoroisopropanol to prepare a core layer electrospinning solution with a mass fraction of 10%, and ultrasonically degassed for 5 ~8min;

[0039]3) The surface layer electrospinning solution and the core layer electrospinning solution obtained in step 1) and step 2) are respectively injected into two syringes of the electrospinning device, and uniaxial sequence electrospinning is performed to obtain hydrochloric acid-loaded polyamide. GTR / GBR three-layer composite diaphragm...

Embodiment 2

[0046] A preparation method of a GTR / GBR composite membrane loaded with doxycycline hydrochloride, comprising the following steps:

[0047] 1) Mix polycaprolactone and gelatin in a mass ratio of 1:0.5 and dissolve them in hexafluoroisopropanol to prepare a surface electrospinning solution with a mass fraction of 10%, and ultrasonically degas for 8 min; polycaprolactone The average molecular weight is 100,000;

[0048] 2) Polycaprolactone and doxycycline hydrochloride are mixed in a mass ratio of 1:0.2 and then dissolved in hexafluoroisopropanol to prepare a core layer electrospinning solution with a mass fraction of 8%, and ultrasonically degassed for 8min ;

[0049] 3) The surface layer electrospinning solution and the core layer electrospinning solution obtained in step 1) and step 2) are respectively injected into two syringes of the electrospinning device, and uniaxial sequence electrospinning is performed to obtain hydrochloric acid-loaded polyamide. GTR / GBR three-layer...

Embodiment 3

[0054] A preparation method of a GTR / GBR composite membrane loaded with doxycycline hydrochloride, comprising the following steps:

[0055] 1) Mix polycaprolactone and gelatin in a mass ratio of 1:0.2 and dissolve them in hexafluoroisopropanol to prepare a surface electrospinning solution with a mass fraction of 12%, and ultrasonically degas for 8 min; polycaprolactone The average molecular weight is 80,000;

[0056] 2) Polycaprolactone and doxycycline hydrochloride are mixed in a mass ratio of 1:0.1 and then dissolved in hexafluoroisopropanol to prepare a core layer electrospinning solution with a mass fraction of 12%, and ultrasonically degassed for 6min ;

[0057] 3) The surface layer electrospinning solution and the core layer electrospinning solution obtained in step 1) and step 2) are respectively injected into two syringes of the electrospinning device, and uniaxial sequence electrospinning is performed to obtain hydrochloric acid-loaded polyamide. GTR / GBR three-layer...

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Abstract

The invention discloses a doxycycline-hyclate-carried GTR (Guide Tissue Regeneration)/GBR (Guide Bone Regeneration) composite membrane and a preparation method thereof and belongs to the technical field of medicines. The GTR/GBR composite membrane adopts a three-layer structure, wherein the upper surface layer, the lower surface layer and the sandwich layer are all manufactured through sequence electrospinning; the upper surface layer and the lower surface layer are prepared from a natural polymer material and a mixed solution through which the polymer material is synthesized; the sandwich layer is a membrane layer prepared from a doxycycline-hyclate-carried solution through which the polymer material is synthesized. The uniaxial sequence electrospinning method is adopted to prepare the composite membrane adopting the three-layer structure, so that the medicine entrapment efficiency of fibers is improved, the preliminary burst effect of a medicine is reduced/eliminated, and continuously slow release of the medicine is realized. The two surface layers of the three-layer medicine-carried composite membrane can not only serve as porous barriers to control the medicine release rate so as to realize continuously slow release of the medicine but also prevent direct contact between the medicine and tissues to improve the compatibility between the tissues and the membrane so as to be more conducive to tissue repair and regeneration.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a drug-loaded GTR / GBR composite membrane and a preparation method thereof, in particular to a doxycycline hydrochloride-loaded multilayer GTR / GBR composite membrane and a preparation method thereof. Background technique [0002] Peri-implantitis is inflammation of the soft and hard tissues around the implant, with an incidence ranging from 28% to 56%. Compared with traditional curettage and topical medication, membrane-induced tissue regeneration and bone transplantation can effectively fill bone defects, improve soft tissue morphology, increase the amount of new bone and re-osseointegration rate of bone tissue around implants, and improve the stability of implants. be improved. [0003] The oral cavity is a bacterial environment. The colonization of bacteria on the surface of the implant affects the formation of the osseointegration between the implant and the surrounding bone ti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/40A61F2/28
Inventor 贾骏贾列妮徐宏宇胡详刚谢乔王伟
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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