5results about How to "Long-lasting release" patented technology

The invention relates to paclitaxel ganoderma lucidum spore oil self-nanoemulsion composite particles with ganoderma lucidum spores as a carrier and a preparation method of the paclitaxel ganoderma lucidum spore oil self-nanoemulsion composite particles, and belongs to the technical field of medicines. Pretreated Ganoderma lucidum spores (GLS) are obtained through process screening and serve as a drug carrier, and paclitaxel-loaded Ganoderma lucidum spore oil self-nanoemulsion (PGS) is loaded into the Ganoderma lucidum spores (GLS) to obtain paclitaxel-loaded composite particles (PGS (at) GLS). An in-vitro release curve shows that the PGS-atGLS has the characteristic of slow release after reaching the intestinal tract; in-vivo pharmacodynamic experiments show that PGS-atGLS can significantly inhibit development and metastasis of mouse colorectal cancer; tumor tissue slice immunofluorescence analysis shows that PGS-atGLS can effectively play a role in treating colon cancer. The paclitaxel self-nanoemulsion-loaded ganoderma lucidum spore composite particles synergistically promote cancer immune circulation by inducing immunogen cell death and immunoregulation, significantly improve the treatment effect of colon cancer, and have good biological safety.

The invention belongs to the technical field of medicines, and particularly relates to a linarin targeted slow-release nano drug-loading system as well as a preparation method and application thereof. A polylactic acid-polyglycolic acid copolymer is used as a matrix, polyvinyl alcohol is used as a cross-linking agent, and coated drug-loaded microspheres are formed through cross-linking and grafting of the matrix and the cross-linking agent; and then chitosan is used as a protective agent, chitosan and the coated drug-loaded microspheres are crosslinked and grafted to form double-coated composite drug-loaded microspheres, the chitosan in the composite drug-loaded microspheres is used as a shell, the coated drug-loaded microspheres are used as a core, and the linarin targeted slow-release nano drug-loaded system is obtained. Through the double-target design, the targeting property to cornea and lacrimal gland is enhanced, the treatment efficiency of the medicine is improved, stable release and continuous release of linarin are realized, and the problem of unstable release of the medicine is solved; in addition, the targeted slow-release nano drug-loading system is combined with the anti-inflammatory activity and the mitochondrial protection function of linarin, so that the side effects on eyes are reduced, and the safety is improved.

The application discloses a multifunctional antibacterial coating bone implant device based on a selective vacuum perfusion process and a preparation method thereof. The method comprises the following steps: 1) pretreating a titanium alloy base; 2) performing anodic oxidation treatment on the pretreated titanium alloy base to construct a nanotube structure on the surface of the titanium alloy base; 3) selectively coating the treated titanium alloy base with a hydrogel adhesive, then immersing the titanium alloy base in a povidone iodine mixed solution to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a bone growth promoting factor to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a blood vessel growth promoting factor to perform vacuum perfusion, and performing post-treatment; and 4) encapsulating the obtained sample surface with an in-situ self-polymerized polydopamine layer, washing and freeze-drying. The bone implant device has antibacterial, bone growth promoting and blood vessel growth promoting functions, and can greatly improve the curative effect on bone fracture symptoms accompanied by infection.

Provided is a bladder that can provide long-lasting releasability and a sustained and improved service life thereof even by vulcanization molding of a rubber product made of an unvulcanized rubber compound containing halogenated butyl rubber and a coating material used for the bladder. The bladder for vulcanization molding of a rubber product made of an unvulcanized rubber compound containing halogenated butyl rubber includes a silicone rubber layer on an outermost surface thereof. The silicone rubber layer is made of a cured product containing condensation-curable silicone rubber and an organic acid metal compound dissolved therein. 0.001 to 3 parts by mass of the organic acid metal compound as a metal amount is contained per 100 parts by mass of the condensation-curable silicone rubber.

The invention belongs to the technical field of drug-loaded adhesive hydrogel, and particularly relates to injectable drug-loaded adhesive hydrogel as well as a preparation method and application thereof. According to the hydrogel, dopamine hydrochloride modified biological macromolecules with amino groups and biological macromolecules with aldehyde groups serve as matrixes, a long-chain network structure is formed through a Schiff base reaction, and then iron ions serve as a complexing agent, so that the hydrogel is prepared. And complexing and cross-linking the dopamine hydrochloride modified carboxymethyl-beta-cyclodextrin and the long-chain network structure to form an ion dissipation network, thereby obtaining the injectable drug-loading adhesive hydrogel. Wherein the dopamine hydrochloride modified carboxymethyl-beta-cyclodextrin is loaded with antibacterial, anti-inflammatory or anti-tumor hydrophobic drug molecules. The hydrogel prepared by the invention consists of two networks, namely a long-chain network and an ion dissipation network, and has excellent bonding performance, drug-loading slow release is realized on the molecular level through hydrophilic molecule carboxymethyl-beta-cyclodextrin, and an injectable strong tissue bonding hydrogel drug-loading system is developed.