2results about How to "Long-lasting release" patented technology

The application discloses a multifunctional antibacterial coating bone implant device based on a selective vacuum perfusion process and a preparation method thereof. The method comprises the following steps: 1) pretreating a titanium alloy base; 2) performing anodic oxidation treatment on the pretreated titanium alloy base to construct a nanotube structure on the surface of the titanium alloy base; 3) selectively coating the treated titanium alloy base with a hydrogel adhesive, then immersing the titanium alloy base in a povidone iodine mixed solution to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a bone growth promoting factor to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a blood vessel growth promoting factor to perform vacuum perfusion, and performing post-treatment; and 4) encapsulating the obtained sample surface with an in-situ self-polymerized polydopamine layer, washing and freeze-drying. The bone implant device has antibacterial, bone growth promoting and blood vessel growth promoting functions, and can greatly improve the curative effect on bone fracture symptoms accompanied by infection.

Provided is a bladder that can provide long-lasting releasability and a sustained and improved service life thereof even by vulcanization molding of a rubber product made of an unvulcanized rubber compound containing halogenated butyl rubber and a coating material used for the bladder. The bladder for vulcanization molding of a rubber product made of an unvulcanized rubber compound containing halogenated butyl rubber includes a silicone rubber layer on an outermost surface thereof. The silicone rubber layer is made of a cured product containing condensation-curable silicone rubber and an organic acid metal compound dissolved therein. 0.001 to 3 parts by mass of the organic acid metal compound as a metal amount is contained per 100 parts by mass of the condensation-curable silicone rubber.