121results about How to "Improve freeze-drying efficiency" patented technology

The invention discloses a method for preparing fresh grosvener siraitia freeze-dried superfine powder, relates to processing technology for fruits and vegetables, and provides a method for preparing fresh grosvener siraitia freeze-dried superfine powder, which combines vacuum freeze drying technology with superfine grinding technology to protect effective components of the grosvener siraitia and realize full utilization of the grosvener siraitia. The method comprises the following steps: carrying out pretreatments such as selecting, cleaning, sterilization and the like on the fresh grosvener siraitia; putting the grosvener siraitia on a tray for prefreezing after crushing; putting the prefreezed grosvener siraitia in a vacuum environment for heating and drying at the temperature of between 40 and 120 DEG C; controlling the moisture content of the freeze-dried product to less than 6 percent; and finally, grinding the dried grosvener siraitia until the particle size of the powder reaches 10 to 40 meshes, and then carrying out superfine grinding on the powder by a superfine grinding machine until the particle size of the powder reaches less than 40 microns. Because the product is superfine powder, thus, the fresh grosvener siraitia freeze-dried superfine powder has the advantages of small powder particle, big surface area, delicate taste, quicker absorption and wider application, the superfine powder can be eaten directly, and can also be used as the raw materials of other foods, health-care products, medicaments and cosmetics.

The invention discloses maca powder with bioactivity fully reserved, and a preparation method and a preparation of the maca powder. The maca powder is prepared by conducting refrigerating, freeze drying and smashing on fresh maca; moisture content of the maca powder is below 5%; and the maca powder contains glucosinolate accounting for 1.1-2.75wt% of the total weight of the maca powder. The preparation method comprises the processes of preparing materials, refrigerating, conducting freeze drying, and smashing. The preparation is characterized in that the maca powder is matched with auxiliary materials accepted in the field of pharmacy, and prepared into a tablet, power, dissolved medicine or a capsule. The preparation method adopts a vacuum freeze drying technology, and the activity of myrosinase in the maca is inhibited during the course of storage and drying; a hydrolysis reaction condition for myrosinase and glucosinolate is destroyed by crystallization of moisture in the maca; oxidation of active components of the maca is reduced due to the low-temperature drying; and characteristic substances-glucosinolate, the bioactive components such as protein, and other volatile components are reserved to the greatest extent.

The invention provides improvement on a method for preparing complex of a polyvinylpyrrolidone copolymer grafted with a natural polymer or a water-soluble derivate thereof and an iodine derivate. The effective iodine content in the complex of the graft copolymer of the natural polymer or the water-soluble derivate thereof and iodine, the stability of the complex iodine and the freezing and drying working efficiency of the concentrate of the complex or the compounds thereof are improved by improved means of compounding a long-chain alkyl anion surfactant or a long-chain alkyl nonionic surfactant and the polyvinyl-containing natural polymer or the water-soluble derivate-grafted polyvinylpyrrolidone chain segment, compounding iodide and iodine, and replacing ethanol with an organic solvent with a high freezing point, high volatility and capability of dissolving in water and dissolving the iodine to a certain degree to improve the freezing and drying speed of the concentrate the complex of the graft copolymer and the iodine or compounds thereof, and the like.

The invention discloses a freeze-dry process preparation method of a bulk vegetable egg flower soup base, and belongs to the technical field of vacuum freeze-dry processing of the vegetable egg flower soup base. Various vegetables and egg flower needed by the freeze-dried soup base disclosed by the invention are independently freeze-dried according to respective freeze-dry process curves, the seasonings which do not need to be freeze-dried are added according to the formulation of the soup base, and the mixture of the vegetables, the egg flower and the seasonings is packaged to obtain the bulk vegetable egg flower soup base, which is different from an original block type soup base. The vegetables are fresh in color and luster, and the egg flower and the seasonings are rewatered rapidly and more delicious in taste after the soup base prepared by using the method disclosed by the invention is brewed by using hot water; and simultaneously, experimental data and practical application data in large-scale production prove that at least 40% of energy consumption is reduced.

The invention belongs to the field of pharmacy, more specifically, the invention relates to a medicinal composition containing reactive pro-urokinase, its cryodesiccation method and freeze-dried preparation.

The invention discloses a flavor Maillard peptide-containing Islamic barbecue seasoning and a production method thereof. Anti-freeze polypeptides which substantially improve the anti-freeze effect of food materials, delay and prevent formation of ice crystals in the freezing storage process of the food materials, prevent the structure, the quality and the flavor of foods from being destroyed and prolong the market circulation period of the food materials are scientifically compounded with composite Maillard peptides which endow the food materials with special aroma, taste and color and generate a strong anti-oxidation effect, and an osmotic agent which has a rapid osmosis effect and shortens the pickling time, potato flour, sweet potato flour and tomato powder which reduce generation of barbecue carcinogenic substances, dietary fiber powder for promoting digestion and other functional raw materials are added to finally produce the Islamic barbecue seasoning with the advantages of substantial anti-freeze effect, prolongation of the market circulation period of the food materials, maintenance of the quality and the flavor of the food materials, strong osmosis effect, shortening of the pickling and barbecuing time, reduction of the generation of the barbecue carcinogenic substances, and suitableness for commercial running modes.

The invention relates to a levocarnitine composition for injection and a preparation method of the levocarnitine composition; the levocarnitine composition is lyophilized powder containing levocarnitine and mannitol, wherein the weight ratio of the levocarnitine to the mannitol is 1:(0.75-1.25); the average particle diameter of the lyophilized powder is 90-130 nm, and the porosity is 94-98%. The preparation method comprises the steps of: 1) preparing: weighing levocarnitine and mannitol, putting the levocarnitine and the mannitol in a preparing tank, adding injection water, agitating to enable the levocarnitine and the mannitol to be completely dissolved and uniformly mixing, regulating the pH to 5.7-6.3 through a 0.1mol/L hydrochloric acid solution; 2) decarburizing and sterile filtering; 3) sterile packaging; 4) vacuum freeze drying to obtain the levocarnitine composition . The levocarnitine composition has the advantages of simple preparation, advanced technique, uniform quality, excellent stability, better redissolution capability and clinic medicine application safety.

The invention belongs to the field of pharmaceutical preparations, and relates to tedizolid phosphate for injection. The freeze-drying preparation for injection is prepared by the steps of taking tedizolid phosphate as an effective ingredient, adding a freeze-drying protective agent and a pH regulator, and carrying out medical solution preparation, filling and freeze-drying to obtain the tedizolid phosphate powder injection for injection. The freeze-drying process provided by the invention is designed according to the tedizolid phosphate property characteristics; the process is simple and convenient to operate and short in production cycle, and adapts to industrialized mass production; and besides, low-moisture products can be provided, the problem that tedizolid phosphate for injection is hydrolyzed in the storage process is overcome, and the product quality and stability are increased.

The invention discloses a spicy cumin halal barbecue condiment and a preparation method thereof. The preparation method comprises the following steps of: scientifically compounding an antifreeze polypeptide which can remarkably improve anti-freezing effects of a food material, delay and prevent ice crystal formation and recrystallization of the food material during frozen storage, prevent the food structure, the quality and the flavor of the food material from being destroyed, and prolong the market circulation time limit of the food material, and a composite flavor maillard peptide which can endow the food material with special fragrance, taste and color and produce strong antioxidant effects; adding penetrating agents which have rapid penetration effects and shorten the pickling time, potato powder, sweet potato powder and tomato powder which can reduce the production of barbecue carcinogens, and functional raw materials such as dietary fibers and the like which can prolong the shelf life of a condiment and promote digestion to finally prepare a halal barbecue condiment which is more suitable for a commercial operation mode, has remarkable anti-freezing effects, can prolong the circulation time limit of the food material during frozen storage, keep the quality and flavor of the food material, shorten the pickling and barbecuing time and reduce the production of barbecue carcinogens, and is strong in penetration effects.

The invention relates to a clindamycin phosphate composition for injection. The composition is freeze-dried powder which consists of clindamycin phosphate and sodium hydroxide, wherein the weight ratio of the clindamycin phosphate to the sodium hydroxide is (24-26):1; the average grain diameter of the freeze-dried powder is 70-130nm; and the porosity is 92-98 percent. A preparation method of the composition comprises the following steps of: (1) preparing: weighing the clindamycin phosphate and the sodium hydroxide, filling in a preparation tank, adding water for injection, stirring to fully dissolve the clindamycin phosphate and the sodium hydroxide and uniformly mixing; (2) decarbonizing and performing sterile filtration; (3) performing sterile subpackaging; and (4) freeze-drying under vacuum. The composition has the advantages of simple formula, advanced process, uniform quality and superior stability and meanwhile has better redissolving performance and clinical medication safety.

The invention discloses high-solubility compound protein powder and a preparation method thereof. Soybean protein isolate, whey protein concentrate and phospholipid are taken as main raw materials, stevia rebaudiana is processed into a stevia rebaudiana extract at low temperature, the effective ingredients and the bioactive ingredients of the stevia rebaudiana can be maximumly retained, the extraction rate is high, the flavor is pure, the color and cluster are natural, no licorice taste exists, the stevia rebaudiana extract is scientifically compounded with main materials, antifreeze polypeptides, dietary fiber flour, bee pupa hydrolysates and wheat malt powder are added, and then the compound protein powder which is appropriate in mouthfeel, good in solubility, comprehensive in nutrition, high in bioactivity and wide in suitable crowd is prepared. According to the preparation method, a non-thermal processing technique is adopted, the working efficiency is high, energy consumption is little, environmental friendliness is achieved, no pollution is generated, introduction of food additives and chemical auxiliaries is reduced, the food safety is effectively improved, the product quality is improved, the production cost is reduced, the low-carbon production objective is achieved, and large-scale and industrialized development can be achieved.

The invention discloses a halal barbecue seasoning which can shorten the marinating time and a preparation method thereof. The scientific compounding can significantly improve the antifreeze effect of food materials, delay and prevent the formation of ice crystals and recrystallization of food materials during frozen storage, and prevent the food structure of food materials , the quality and flavor are destroyed, the antifreeze polypeptide that prolongs the market circulation of food materials and the special aroma, taste and color can be given to food materials, and the compound flavor Maillard peptide with strong anti-oxidation effect can be produced, and the addition of fast penetration Functional raw materials such as osmotic agent that shortens pickling time, potato powder, sweet potato powder, tomato powder that can reduce carcinogens produced by barbecue, and dietary fiber powder that can prolong the shelf life of seasonings and promote digestion, and finally prepare a kind of food with significant anti-inflammatory properties. The halal barbecue seasoning is more suitable for commercial operation mode because of its freezing effect, prolonging the circulation period of frozen ingredients, maintaining the quality and flavor of ingredients, strong penetration, shortening pickling and grilling time, and reducing the production of barbecue carcinogens.

The invention discloses an automatic freeze drying machine with high heat uniformity. The automatic freeze drying machine comprises a machine shell. The machine shell comprises a freeze drying box anda cold trap box. The bottom of the freeze drying box and the top of the cold trap box are connected through bolts. Through holes are formed between the bottom of the freeze drying box and the top ofthe cold trap box. A lifting drive device is mounted at the inner top end of the freeze drying box. Mechanical clamping hands for clamping a freeze drying tray are correspondingly arranged at the twoends of the lifting drive device so that the input and output of freeze-drying materials from the freeze drying box can be realized. A freeze drying partition is horizontally placed, the two ends of the freeze drying partition are embedded and fixed on the inner wall of the freeze drying box, and the freeze drying tray is placed on the freeze drying partition. According to the automatic freeze drying machine with the high heat uniformity, through the structural design of the freeze drying partition and the freeze drying tray, the heat transfer effect of different positions of the whole freezedrying tray and the freeze drying partition is uniform, so that the freeze drying efficiency of freeze drying articles is improved, the freeze drying effect of the same batch of freeze-drying articlesis improved, and the comprehensive performance is excellent.

The invention discloses a loop-mediated isothermal amplification reagent capable of being transported at a normal temperature as well as a preparation method and application of the reagent. The reagent comprises Bst DNA Polymerase, dNTP, a primer mixture, an indicator, a protective agent and an aerosol pollution preventive. The preparation method comprises the following steps: mixing the previouscomponents, and performing freeze drying at a temperature of 70-80 DEG C below zero for 8-16 hours, thereby obtaining the loop-mediated isothermal amplification reagent. A loop-mediated isothermal amplification reagent used for nucleic acid test is prepared in the invention, can be transported and preserved at the normal temperature, and is convenient to transport and excellent in stability; meanwhile, the problem that popularization of a LAMP (Loop-mediated Isothermal Amplification) technology is limited by aerosol pollution is solved, and the application and popularization difficulty of theLAMP technology is greatly reduced. The activity of the Bst DNA Polymerase in the reagent is 150%, the reagent can be preserved at the normal temperature of one year or longer, only a buffer solutionneeds to be added during use, the operation is simple, the activity of DNA polymerase is high, the detection sensitivity is loss-free, the interference of the protective agent is low, and the cost islow.

The invention discloses a probiotic freeze-dried powder of extracts from food with the same origin of medicine and food. The food with the same origin of medicine and food is used as the raw material, and a low-temperature extraction process is adopted in the whole process. Color, flavor and taste; the antifreeze agent with significant antifreeze effect prepared from natural plant raw materials is used to replace the traditional and existing cryoprotectant in the vacuum freeze-drying process of the extract, which further greatly reduces the freeze loss caused by the freeze-drying process , which effectively improves the biological activity and nutritional value of the extract freeze-dried powder, and scientifically compounded with functional dietary fiber powder, prebiotics and plant Lactobacillus powder, which significantly enhances the medicinal and nutritional balance of the extract freeze-dried powder and Functionality, solubility and probiotics prolong the shelf life of the product, and finally produce a probiotic medicine and food homologous food with high content of nutrients and biologically active substances, strong function, good antifreeze effect and solubility, and low cost Extract lyophilized powder.

The invention provides a heat-resisting protective agent for a TGEV and PEDV bigeminy freeze-drying live vaccine and a preparing method and application of the heat-resisting protective agent.The heat-resisting protective agent is prepared from, by weight, 1-3% of gelatin, 2-10% of lactose, 0.5-3% of lactoalbumin hydrolysate, 1-6% of trehalose, 0.1-3% of L-arginine, 1-3% of sodium glutamate, 2-8% of polyvinyl pyrrolidone and the balance water.Compared with a heat-resisting protective agent with a conventional saccharose gelatin ingredient, the TGEV and PEDV bigeminy freeze-drying live vaccine prepared from the heat-resisting protective agent is safe, effective, high in stability, low in virus antigen freeze-drying loss ratio, good in heat resistance and long in retention period.Due to the fact that a proper freeze-drying technology is matched with the heat-resisting protective agent, the protection effect of the heat-resisting protective agent on antigens is further promoted, and the freeze-drying efficiency is improved.After the prepared vaccine is placed for 14 days at 37 DEG C, the decrease of the virus content is not larger than 0.5 titer; after the prepared vaccine is stored for 30 months at 2-8 DEG C, the freezing-dried appearance is still maintained, and the virus content is still larger than or equal to 105.0 TCID50; the vacuum degree, the remaining moisture and other detection items of the vaccine are all qualified.

The invention discloses a composite protein powder capable of improving immunity and a preparation method thereof. Using soybean protein isolate, concentrated whey protein and phospholipids as main raw materials, stevia is processed into stevia extract at low temperature, which can retain Active ingredients and bioactive ingredients of stevia, high extraction rate, pure flavor, natural color, no licorice taste, scientifically compounded with main ingredients, and added antifreeze polypeptide, dietary fiber powder, bee chrysalis enzymatic hydrolyzate, wheat germ Powder, to prepare a compound protein powder with suitable taste, good solubility, comprehensive nutrition, strong biological activity, suitable for a wide range of people, and capable of improving immunity. The preparation method adopts non-thermal processing technology, which has high work efficiency, low energy consumption, environmental friendliness, no pollution, reduces the introduction of food additives and chemical additives, effectively improves food safety, improves product quality and reduces production costs , achieved the goal of low-carbon production, and can be scaled and industrialized.

The present invention refers to a recombinant koi herpesvirus (KHV) or Cyprinid herpesvirus 3 (CyHV-3), which is immunogenic in fish, preferably in carps, more preferably in Cyprinus carpio, and to a vaccine for preventive and/or therapeutic treatment of a disease caused by koi herpesvirus (KHV) or CyHV-3. The 5 recombinant herpesvirus is used to confer immunity on fish, preferably on carps, more preferably on Cyprinus carpio, against a disease caused by koi herpesvirus (KHV) or Cyprinid herpesvirus 3 (CyHV-3).

The invention discloses a dog interferon freeze-dried product, and relates to the technical field of freeze-dried biological products.The dog interferon freeze-dried product is prepared by freeze-drying a dog interferon stock solution and a freeze-drying protecting agent, wherein a freeze-drying protecting agent base solution is composed of a pH buffer agent and a protein protecting agent, and the freeze-drying protecting agent comprises a heat-resisting protective agent, a filling agent and a freeze-drying accelerating agent.The prepared dog interferon freeze-dried product can be stored for a long term at 2 DEG C-8 DEG C; due to the fact that the freeze-drying accelerating agent is added, the freeze-drying time of a freeze-drying technological link in large-scale industrialized production is shortened, the freeze-drying efficiency is improved, it is guaranteed that freeze-drying is full, and the stability of products of different batches is guaranteed; through combination of the preferable heat-resisting protective agent and filling agent, the anti-fracture strength of a dog interferon protein chain is improved, the biological activity of the dog interferon freeze-dried product is improved, and the product yield ratio of the dog interferon freeze-dried product is increased.

The invention relates to the field of medicines, and particularly discloses an ultrasonic contrast agent with ultra-long duration time and a preparation method of the ultrasonic contrast agent. The contrast agent has the advantage that the contrast duration time for the organs such as the liver, the kidney and the spleen reaches 2 hours or a longer time, the longest duration time can reach 6 hours or a longer time, and the ultrasonic contrast agent belongs to the contrast agent with the longest ultrasonic contrast duration time in the micro-bubble type ultrasonic contrast agents reported at present. In addition, the preparation process of the contrast agent is simple and controllable, the large-scale production can be easily realized, the production raw materials are injectable medicinal auxiliary materials which are approved at present, and thus the clinical application prospect is broad.

The present invention discloses medicinal and edible food extract freeze-dried powder. The preparation method uses medicinal and edible food as raw materials and a low temperature extraction technology in the whole process, and the obtained extract maximally maintains the nature color and luster, tastes and mouthfeel of the medicinal and edible food. In the vacuum freeze-drying process of the extract, an antifreeze agent prepared by using natural plant raw materials and having significant antifreeze effects is used to replace traditional and existing cryoprotectants, which further greatly reduces the freeze losses caused by the freeze-drying technology and effectively improves the biological activity and nutritional value of the extract freeze-dried powder. The antifreeze agent is scientifically combined with functional dietary fiber powder, probiotic factors and lactobacillus plantarum powder, which significantly enhances the medicinal and edible nutritional balance and functionality, solubility and probiotic properties of the extract freeze-dried powder, and extends the shelf life of the products. Finally, the medicinal and edible food extract freeze-dried powder is obtained, high in contents of the nutrients and bioactive substances, strong in functions, good in anti-freeze effects and solubility, and low in cost .

The invention discloses instant medicinal and edible food extract freeze-dried powder. Medicinal and edible foods are used as raw materials, a low-temperature extraction technology is adopted in the whole process, and an obtained extract furthest reserves natural color, natural flavor and natural mouth feel of the medicinal and edible foods; in the vacuum freeze drying process of the extract, an anti-freezing agent which is prepared from natural plant raw materials and has remarkable anti-freezing effects is used for replacing conventional existing cryoprotectants, so that further freezing loss caused by a freeze-drying technology is greatly reduced, and the biological activity and the nutritive value of the extract freeze-dried powder are effectively improved; besides, when the extract, functional dietary fiber powder, prebiotic factors and lactobacillus plantarum powder are scientifically compounded, the medicinal and edible nutrition balance, the functionality, the solubility and the prebiotics of the extract freeze-dried powder are obviously strengthened, the guarantee period of products is prolonged, and finally the instant medicinal and edible food extract freeze-dried powder which is high in content of nutrient substances, high in content of biological active substances, powerful in functions, good in anti-freezing effects, good in solubility and low in cost is prepared.

The invention discloses a temperature-resistant halal barbecue seasoning and a preparation method thereof. The scientific compounding can significantly improve the antifreeze effect of food materials, delay and prevent the formation and recrystallization of ice crystals when food materials are frozen, and prevent food structure, quality and flavor of food materials. Antifreeze polypeptides that are damaged and prolong the market circulation of food materials, as well as special aroma, taste and color can be given to food materials, and compound flavor Maillard peptides with strong anti-oxidation effects can be produced. time penetrating agent, potato powder, sweet potato powder, tomato powder that can reduce carcinogens produced by barbecue, and functional raw materials such as dietary fiber powder that can prolong the shelf life of seasonings and promote digestion, and finally prepare a kind of antifreeze effect that can The halal barbecue seasoning is more suitable for commercial operation mode, which prolongs the circulation period of frozen storage of ingredients, maintains the quality and flavor of ingredients, has strong penetration, can shorten the time of pickling and grilling, and reduces the production of barbecue carcinogens.

The invention discloses a highly stable halal barbecue seasoning and a preparation method thereof. The scientific compounding can significantly improve the antifreeze effect of food materials, delay and prevent the formation and recrystallization of ice crystals when food materials are frozen, and prevent food structure, quality and Flavor is destroyed, antifreeze peptides that prolong the market circulation of food materials and food materials can be endowed with special fragrance, taste and color, and can produce compound flavor Maillard peptide with strong anti-oxidation effect, and add fast penetration, shorten Penetrating agent for pickling time, potato powder, sweet potato powder, tomato powder that can reduce carcinogens in barbecue, and dietary fiber powder that can prolong the shelf life of seasonings and promote digestion. It is a halal barbecue seasoning that is more suitable for commercial operation mode, which can prolong the circulation period of frozen storage of ingredients, maintain the quality and flavor of ingredients, have strong penetration, shorten the time of pickling and grilling, and reduce the production of barbecue carcinogens.