228results about How to "Shorten freeze-drying time" patented technology

The invention discloses aerogel micro powder and a preparation method thereof. The method comprises the following steps: a hydrogel is provided, and fragmentation is carried out on the hydrogel and dispersing the hydrogel to obtain gel fluid or gel dispersion liquid; an atomizing device is employed for performing atomization on the gel fluid or the gel dispersion liquid, gel droplets are formed, the gel droplets are collected by a low-temperature container, and the gel freezing particles are obtained; the freeze drying is carried out, and the aerogel micro powder is obtained. The aerogel micropowder can realize integration of granulation and refrigeration, pre-refrigeration is not required, rapid and continuous production of the aerogel micro powder can be realized, organic solvent displacement is not required, the preparation method has the advantages of simple process, short production period, low cost, energy saving, and environmental protection, the preparation process can be amplified to industrial production, and the obtained aerogel micro powder has the excellent physical properties of controllable morphology, uniform particle size, large specific surface area, high porosity amount, and low thermal conductivity.

The invention relates to a freeze-dried powder injection of L-oxiracetam and a process for preparing the freeze-dried powder injection. The freeze-dried powder injection comprises, by weight, 1 part of the L-oxiracetam, 0.1 to 10 parts of an excipient, 0.01 to 1 part of an antisticking agent and 0.01 to 0.5 part of a pH regulator, wherein polyethylene glycol (PEG) series of products serve as the antisticking agent preferably. The freeze-dried powder injection which is prepared on the basis of a prescription according to the process has the advantages of being short in freeze-drying time, attractive in appearance, short in redissolving time and high in stability.

The invention discloses a method for preparing fresh grosvener siraitia freeze-dried superfine powder, relates to processing technology for fruits and vegetables, and provides a method for preparing fresh grosvener siraitia freeze-dried superfine powder, which combines vacuum freeze drying technology with superfine grinding technology to protect effective components of the grosvener siraitia and realize full utilization of the grosvener siraitia. The method comprises the following steps: carrying out pretreatments such as selecting, cleaning, sterilization and the like on the fresh grosvener siraitia; putting the grosvener siraitia on a tray for prefreezing after crushing; putting the prefreezed grosvener siraitia in a vacuum environment for heating and drying at the temperature of between 40 and 120 DEG C; controlling the moisture content of the freeze-dried product to less than 6 percent; and finally, grinding the dried grosvener siraitia until the particle size of the powder reaches 10 to 40 meshes, and then carrying out superfine grinding on the powder by a superfine grinding machine until the particle size of the powder reaches less than 40 microns. Because the product is superfine powder, thus, the fresh grosvener siraitia freeze-dried superfine powder has the advantages of small powder particle, big surface area, delicate taste, quicker absorption and wider application, the superfine powder can be eaten directly, and can also be used as the raw materials of other foods, health-care products, medicaments and cosmetics.

The invention discloses a polypeptide freeze-drying composition with skin activity and a preparation method thereof and belongs to the technical field of beauty polypeptide. The composition is prepared from polypeptide with skin activity, an excipient, a solubilizer and a pH buffer agent. The preparation method of the composition disclosed by the invention comprises the following steps: dissolving, mixing, filtering, sterilizing and filling all the ingredients; setting freeze drying according to a freeze-dry curve to obtain the polypeptide freeze-drying composition with the skin activity. Thepreparation method has the advantages of simple operation and mature and controllable technologies; furthermore, freeze drying is finished within 18h, so that the product quality is ensured; simultaneously, the production energy consumption is reduced, and the production cost is reduced. The polypeptide freeze-drying composition with skin activity prepared by the method has the advantages of goodstability, easiness in storage and no preservative addition. The composition disclosed by the invention is mainly applied to removing wrinkles, resisting senility, whitening the skin, removing freckles, relieving and resisting allergy, removing eye bags, developing hair and fixing hair, so that varieties of skin problems can be improved.

A process for preparing thymic peptide includes such steps as homogenizing fresh thymus gland, adding buffering solution (pH=2-4) for suppressing enzyme activity, breaking cell under 10 deg.C by ultrasonic waves, homogenizing machine and superfine technique, freeze centrifugalizing, ultrafiltering, nano filtering and concentrating. Its advantages are high output rate, high percentage of natural polypeptide, high activity and low cost.

The invention which is suitable for the technical field of drying provides a fruit vacuum freeze drying method. The method comprises the following steps: prefreezing: refrigerating fruits to be dried; and carrying out five-stage drying under vacuum conditions. The fruit vacuum freeze drying method of the invention, which adopts a five-step gradient cooling mode of the heating temperature, allows heat required by water sublimation to be guaranteed, cooling to be timely, the basic balance of the heat supply and demand to maintained, the material dissolving caused by too fast heating to be prevented, and the water sublimation rate to be accelerated.

The invention discloses a method for producing freeze-dried whole donkey milk powder, belonging to the technical field of food deep processing. The freeze-dried whole donkey milk powder is obtained through the steps of raw and fresh donkey milk inspection, milk purification, refrigeration, standardization, homogenization, sterilization concentration, prefreezing, vaccum drying, power recovery, pulverization, mixing and inspection. The donkey milk powder produced by using the method has small nutrient loss, good solubility, high rehydration, uniform product, attractive color and good taste.

The invention belongs to the field of pharmacy, more specifically, the invention relates to a medicinal composition containing reactive pro-urokinase, its cryodesiccation method and freeze-dried preparation.

The invention discloses a vacuum freeze drying processing method of shrimp meat. The vacuum freeze drying processing method comprises the following steps: 1, blanching shrimp meat with hot water, and immediately cooling the blanched shrimp meat with cold water; 2, soaking the blanched and cooled shrimp meat in a seasoning solution for seasoning, and then performing second direct mixing for seasoning after draining; 3, putting the seasoned and drained shrimp meat on a dish, and pre-freezing in a quick-freezing refrigerator; and 4, reducing the temperature in a condensation cylinder to -25 DEG C, starting vacuumizing to perform vacuum freeze drying, keeping negative pressure for 6h-8h after the temperature in a drying bin rises to 30-35 DEG C and the vacuum degree reaches 4Pa below, slowly pressurizing to normal pressure, and then taking the shrimp meat out. The shrimp meat is subjected to vacuum freeze drying, the shapes and tissue structures of the shrimp meat can be kept, the quality and the mouth feel of the cooked shrimp meat are basically kept after the shrimp meat is soaked in hot water to be rehydrated, and thus the shrimp meat is especially suitable for being added into a convenient food as an important auxiliary material or an ingredient.

The invention relates to a drying process of a specific plant. The process comprises the following steps of: 1. pretreatment: sorting prepared fresh pseudo-ginsengs; after separating and removing pruning openings, fibrous roots and flocking roots attached to the fresh pseudo-ginseng roots, obtaining main pseudo-ginseng roots; cleaning and removing surface attachments and leaching surface water; 2. pre-freezing: directly placing the whole main pseudo-ginseng roots into a pre-freezing chamber at minus 15-minus 20 DEG C and pre-freezing for 6-7 hours; 3. sublimation drying: spreading the pre-frozen main pseudo-ginseng roots on a table disk made of heat conducting materials, controlling the thickness of a paving material to be below 5cm and shifting to a vacuum drying chamber; after sealing, vacuumizing, maintaining internal vacuum pressure at 30-70Pa, setting the temperature of the table disk to be 40 DEG C, continuously supplying heat to the table disk and carrying out sublimation drying in vacuum for 10-15 hours till the table disk is heated to 40 DEG C; 4. analysis: maintaining the temperature of the table disk to be 40 DEG C and continuously supplying heat to the table disk and vacuumizing for 10-12 hours till the material is heated to 40 DEG C and material water is controlled to be below 3 percent; and 5. discharging and packaging. The invention provides a method for preparing active pseudo-ginseng.

The invention relates to panax notoginseng saponins freeze-dried powder injection and a preparation method thereof. The freeze-dried powder injection is prepared by panax notoginseng saponins and water for injection. The panax notoginseng saponins freeze-dried powder injection is free of auxiliary materials or stent agents, good in re-dissolubility, low in water content and good in appearance forming.

The utility model discloses an ultrasonic freeze drying process, relating to the technical field of the freeze drying agent, mainly comprising that after the materials are dissolved in a suitable solvent, the material can be handled with the continuous ultrasonic assistance; under the vacuum freezing condition, the solvent are deeply frozen into solid state; the heat energy is continuously supplied, making the solvent in the materials sublimed into vapor state directly from the solid state; the drying process is completed after the vapor is pumped out by the vacuum system. The equipment of the utility model comprises a closed vessel, a cooling and heating system, a vacuum system, an ultrasonic device, and the relating heat insulation and sealing device. The ultrasonic freeze drying process is characterized in rapid drying speed, high production efficiency, and small labor intensity. The process and the equipment can be applied to the drying fields of the medicine, food, chemistry and other respects.

The invention discloses netilmicin sulfate lyophiled powder injection and a preparation method of the netilmicin sulfate lyophiled powder injection. Netilmicin sulfate and additives are added with water to be prepared into netilmicin sulfate injectable suspension, and the netilmicin sulfate lyophiled powder injection is obtained through freeze drying, wherein the additives are inclusion moleculesand pH conditioning agents, the inclusion molecules are selected from bletilla striata polysaccharide, beta-cyclodextrin, urea, thiourea, beta-cyclodextrin derivatives, deoxycholic acid and starch, and the pH conditioning agents are selected from sodium carbonate, sodium bicarbonate, ammonia water, sulfuric acid and phosphoric acid. Required auxiliary materials are few, the preparation process issimple, the freeze drying process is particularly screened and optimized, and the netilmicin sulfate lyophiled powder injection and the preparation method has the characteristics that the stability is high, the biological availability is high, the production cost is low, the quality is safe and reliable, and the like.

The invention discloses lyophilized parecoxib sodium powder and a preparation method thereof. The lyophilized parecoxib sodium powder comprises, by mass, 40 parts of parecoxib sodium, 1-3 parts of stabilizers, 5-30 parts of lyophilization excipients and 0.1-0.5 part of pH (potential of hydrogen) regulators. The preparation method includes the steps of 1) mixing the lyophilization excipients, water and medicinal carbon with stirring, and filtering to obtain a solution I; 2) mixing the stabilizers, the water and the parecoxib sodium with stirring so as to obtain a solution II; 3) mixing the solution I with the solution II and filtering to obtain a solution III; 4) lyophilizing the solution III to obtain the lyophilized parecoxib sodium powder. A lyophilized parecoxib sodium composition prepared by the preparation method has the advantages that since the parecoxib sodium is degraded difficultly, 'degradation product' content is extremely low and stability during long-term storage is high; treatment effect and safety of the lyophilized parecoxib sodium composition during clinical application are greatly improved.

This invention relates to a preparation method of freeze-dried injection of nedaplatin.nedaplatin freeze-dried injection prepared with the inventive method can be used as therapeutic drug of cancer. The invention improves the stability of nedaplatin during lyophilization and shortens the period of lyophilization through adding ethanol during preparation process. the preparation method comprises adding water for injection 80% of nedaplatin into nedaplatin, stirring for dissolving, adding dextran, stirring for dissolving, determing the content of intermediate, adding ethanol 1-10% of the cumulative volume of the solution, adding water for injection to full dose, filtrating with 0.22 mu m millipore filter under aseptic condition, encapsulating in sirin bottle, plugging, freeze drying, rolling the opening, testing, and packaging. The optimum amount of ethanol is 1-5% of cumulative volume of the solution.

Injectable pharmaceutical compositions containing 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione dimalcate as active ingredient in the form of a lyophilised powder with a carrier selected from lactose and dextran, mixed with sodium chloride.

The invention provides roxatidine acetate hydrochloride used for injection and a preparation method thereof. The roxatidine acetate hydrochloride is prepared by taking the roxatidine acetate hydrochloride as a raw material; adding glycine or mannitol as an excipient; and freezing and drying after preparing the raw material and the excipient into a liquid medicament. The prepared roxatidine acetate hydrochloride used for the injection is used for upper gastrointestinal hemorrhage caused by gastric ulcer, stress ulcer and hemorrhagic gastritis and preanesthetic medication. The product obtained by the method has good quality, exact curative effect and stable quality.

The invention discloses high-solubility compound protein powder and a preparation method thereof. Soybean protein isolate, whey protein concentrate and phospholipid are taken as main raw materials, stevia rebaudiana is processed into a stevia rebaudiana extract at low temperature, the effective ingredients and the bioactive ingredients of the stevia rebaudiana can be maximumly retained, the extraction rate is high, the flavor is pure, the color and cluster are natural, no licorice taste exists, the stevia rebaudiana extract is scientifically compounded with main materials, antifreeze polypeptides, dietary fiber flour, bee pupa hydrolysates and wheat malt powder are added, and then the compound protein powder which is appropriate in mouthfeel, good in solubility, comprehensive in nutrition, high in bioactivity and wide in suitable crowd is prepared. According to the preparation method, a non-thermal processing technique is adopted, the working efficiency is high, energy consumption is little, environmental friendliness is achieved, no pollution is generated, introduction of food additives and chemical auxiliaries is reduced, the food safety is effectively improved, the product quality is improved, the production cost is reduced, the low-carbon production objective is achieved, and large-scale and industrialized development can be achieved.

The invention discloses a low-temperature and low-pressure freeze-drying method of pseudo-ginseng chewable tablets. The low-temperature and low-pressure freeze-drying method comprises the steps of (1) preprocessing, namely cleaning fresh pseudo-ginseng main roots and draining off the moisture content, slicing and spraying tea polyphenol aqueous solution and sweet aqueous solution onto the pseudo-ginseng slices, (2) pre-freezing, namely putting the pseudo-ginseng slices obtained in the step (1) into a vacuum drier, reducing the temperature to the range of -30 to -40 DEG C and freezing the pseudo-ginseng slices, (3) vacuum freeze-drying, namely vacuumizing the vacuum dryer to keep the pressure within the range of 10-20Pa, keeping for 1-2 hours, heating to increase the temperature to 0 DEG C from the range of -30 to -40 DEG C within 20-30 hours, reheating, and increasing the temperature to 20 DEG C from 0 DEG C within 2-4 hours; taking out the obtained pseudo-ginseng chewable tablets from the vacuum dryer. The low-temperature and low-pressure freeze-drying method of the pseudo-ginseng chewable tablets is low in cost, and capable of effectively keeping the content of effective constituents of the prepared pseudo-ginseng chewable tablets and guaranteeing excellent freeze-dried product appearance and good taste.

The invention discloses probiotics powder and a production method thereof. The probiotics powder is prepared from, by mass, 17-55 parts of probiotics freeze-dried powder, 2-15 parts of zinc gluconateand 3-23 parts of water-soluble dietary fibers; wherein the probiotic freeze-dried powder comprises probiotics, silicon dioxide aerogel and a freeze-drying protective agent. According to the preparation method, the silicon dioxide hydrogel is used as a base material of a probiotic culture medium, the probiotics can be uniformly distributed and grow in a porous structure of the hydrogel, the product uniformity is high, a three-dimensional network structure of the silicon dioxide hydrogel can play a role in protecting probiotics thalli in the freeze drying process, and the survival rate of the probiotics is increased.