Roxatidine acetate hydrochloride used for injection and preparation method thereof

Abstract

The invention provides roxatidine acetate hydrochloride used for injection and a preparation method thereof. The roxatidine acetate hydrochloride is prepared by taking the roxatidine acetate hydrochloride as a raw material; adding glycine or mannitol as an excipient; and freezing and drying after preparing the raw material and the excipient into a liquid medicament. The prepared roxatidine acetate hydrochloride used for the injection is used for upper gastrointestinal hemorrhage caused by gastric ulcer, stress ulcer and hemorrhagic gastritis and preanesthetic medication. The product obtained by the method has good quality, exact curative effect and stable quality.

Description

technical field

[0001] The invention relates to a preparation method of freeze-dried powder injection, in particular to a preparation method of roxatidine hydrochloride acetate for injection. The roxatidine hydrochloride acetate for injection prepared by the method is used for upper gastrointestinal bleeding caused by gastric ulcer, stress ulcer and hemorrhagic gastritis and administration before anesthesia. Background technique

[0002] Digestive system disease is one of the common frequently-occurring diseases, among which peptic ulcer is the main one, which is mainly caused by smoking, drinking, emotional stress, and drug stimulation. According to the statistics of the World Health Organization (WHO), the incidence of peptic ulcer accounts for about More than 10% of the world's population. With the development of society and the accelerated pace of life, the incidence of gastrointestinal diseases is still increasing year by year. In response to this situation, the develo...

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