The invention discloses a donkey-hide gelatin vitality-consolidating paste and a preparation method for the nano paste. The vitality-consolidating paste includes donkey-hide gelatin, black sesame, walnut kernels, red dates, barbary wolfberry fruits, roses, brown sugar, collagen peptide, yellow rice wine, maltodextrin, malt syrup and water. Through the adoption of smashing, colloid milling and other technologies to prepare, the nutritional ingredients and functional components of raw materials can be completely reserved; through a cryogenic freezing and pulverizing technology, problems of the local overheating of equipment, material bonding and equipment blocking can be solved, the nutritional ingredients and functional components of the raw materials cannot be damaged, so that the particlefineness and activity of the materials can be guaranteed; and the particle size of the prepared vitality-consolidating paste can reach a nano scale (the particle size range being 200-400 nm), so thatthe solubility of the raw materials (especially some functional components that are poor in water solubility or extremely difficult to dissolve) can be significantly enhanced, the components of the vitality-consolidating paste can be easier to absorb by human bodies, efficacy can be greatly increased, and therefore, the best efficacy of the vitality-consolidating paste can be achieved.