The invention discloses maca life-nourishing and health-care liquor and a making method thereof. The maca life-nourishing and health-care liquor comprises, by weight, 20-50 parts of maca, 5-20 parts of kudzu vine roots, 5-15 parts of momordica grosvenori and 5-15 parts of stigma croci. The raw materials are cleaned, dried in air, smashed and mixed according to proportion, then are soaked, deposited and filtered through pure grain brewed liquor with the alcoholic strength higher than 50, and maca original pulp liquor is made; the maca original pulp liquor is mixed with corresponding sorghum liquor, barley liquor, corn liquor, rice liquor, wine and the like, then edible auxiliary materials are added for seasoning, secondary precipitation, filtering and sterilization are performed, packaging is performed after sterilization, and then the maca life-nourishing and health-care liquor is made. The made maca life-nourishing and health-care liquor is good in taste and safe to drink. The health-care effects of the maca, the kudzu vine roots, the momordica grosvenori and the stigma croci are fully guaranteed, human body vigor can be enhanced, body immunity is improved, and the maca life-nourishing and health-care liquor can be used for preventing male prostatic diseases, relieving female climacteric syndromes, resisting aging and has other synergistic effects.