The invention discloses a production process of an organic and inorganic compound fertilizer; the organic and inorganic compound fertilizer is prepared by mixing straw with a phosphatic fertilizer, a nitrogenous fertilizer, livestock manure, an inorganic salt, an efficient rotten bacterium agent and a conditioner for fermentation reaction to obtain organic matter, mixing the organic matter with an inorganic fertilizer produced by mixing urea, monoammonium phosphate and potassium chloride; the produced inorganic organic compound fertilizer is simple in production process, easy to operate, suitable for all kinds of vegetables, fruit trees, flowers, and the like, and quick in effect, can enable products to come into the market earlier, is better in quality, and is a pure natural green fertilizer with high quality, high content and high utilization rate.