Doxycycline hyclate liposome and production thereof

Abstract

A doxycycline hydrochloride liposome with high optical and thermal stability, high power to pass through skin and mucosa, and high antibacterial effect is prepared from phosphatide, cholesterol, doxycycline hydrochloride and emulsifier by film dispersing method, injection method, or reverse evaporation method.

Description

technical field The invention relates to a doxycycline hydrochloride liposome and a preparation method thereof. Background technique Doxycycline hydrochloride (doxycycline hydrochloride, doxycycline hydrochloride) is a tetracycline antibiotic. It can be widely used in respiratory, urinary, reproductive system and biliary tract infections, and has certain curative effects on skin and soft tissue infections, sepsis, acne, brucellosis, trachoma, gonorrhea, etc., and can effectively control subgingival plaque in periodontal pockets, Inhibit periodontal disease pathogenic bacteria. But the current doxycycline hydrochloride crude drug is unstable to light and heat, and is not easy to store. And doxycycline hydrochloride preparation mainly contains tablet and capsule at present, because the water solubility of doxycycline hydrochloride is better prepared into topical preparation, then the permeability to skin, mucous membrane is poor, local drug action time and antibacterial effe...

AI Technical Summary

Problems solved by technology

However, the local action time and effect of specific drugs are related to the preparation method of liposomes and the components of liposomes; and for different drug active ingredients, especially for doxycycline hydrochloride water-soluble drugs, the lipid The encapsulation efficiency of the body, increasing the drug loading is also a problem

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