219 results about "Trachoma" patented technology

The invention relates to immunogenic compositions comprising combinations of Chlamydia trachomatis antigens and their use in vaccines. The composition may comprise at least two components, one component of which comprises Chlamydia trachomatis antigens for eliciting a Chlamydia trachomatis specific TH1 immune response and another component of which comprises antigens for eliciting a Chlamydia trachomatis specific TH2 immune response. The invention further relates to an immunogenic composition comprising a Chlamydia trachomatis Type III secretion system (TTSS) regulatory protein and a Chlamydia trachomatis Type III secretion system (TTSS) secreted protein or a fragment thereof. The invention further relates to the use of combinations of adjuvants for use with antigens associated with a sexually transmissible disease, such as Chlamydia trachomatis antigens. Preferred adjuvant combinations include mineral salts, such as aluminium salts and oligonucleotides comprising a CpG motif. The invention further provides a combination of Chlamydia trachomatis antigens comprising a Chlamydia trachomatis antigen that is conserved over at least two serovars.

A dripping pill of Chloromycetin eye drops for treating trachnoma, keratitis, conjunctivitis, eyelid inflammation, etc is proportionally prepared from polyethanediol as matrix and Chloromycetin. It is applied in conjunction with the buffer liquid prepared from borax, boric acid, hydroxyphenyl ethylether and the water for injection. Its preparing process is also disclosed.

A soft, pliable cellulose acetate phthalate (CAP)—hydroxypropyl cellulose (HPC) composite film is provided which is generated by casting from organic solvent mixtures containing ethanol. The film rapidly reduces the infectivity of several sexually transmitted disease pathogens, including the human immunodeficiency virus (HIV-1), herpesvirus (HSV), non-viral sexually transmitted disease pathogens (such as Neisseria gonorrhoeae, Haemophilus ducreyi, Chlamydia trachomatis and Treponema pallidum) and bacteria associated with bacterial vaginosis (BV). The film is converted into a gel/cream and thus does not have to be removed following application and use. In addition to being a topical microbicide, the film can be employed for the mucosal delivery of pharmaceuticals other than cellulose acetate phthalate.

The present invention provides novel methods for determining the presence or absence of Chlamydia in a patient, as well as diagnostic kits useful in practicing the methods of the invention. The methods of the invention are based on nucleic acid amplification reactions to detect both Chlamydia genomic and cryptic plasmid sequences. In one embodiment, the methods involve using nucleic acid primers to specifically amplify the Chlamydia trachomatis ompA gene and cryptic plasmid. These methods provide both enhanced reliability and sensitivity of detection, thereby providing an accurate determination of the presence or absence of Chlamydia trachomatis in a patient.

The invention relates to a fluorescence PCR (polymerase chain reaction) detection method for diagnosing infection of Chlamydia trachomatis (CT), neisseria gonorrhoeae (NG) and ureaplasma urealyticum (UU), which belongs to the field of nucleic acid in vitro diagnosis. The method comprises a polymerase chain reaction (PCR) system based on fluorescence PCR technology, contains a forward primer and areverse primer aiming at the CT/the NG/the UU and a fluorescent probe, and can detects DNA of three pathogens such as the CT, the NG, the UU and the like simultaneously in a reaction tub under suitable PCR condition. The method can diagnosing the infection of the CT/the NG/the UU in a clinical sample simply, conveniently and rapidly, has high sensitivity and specificity, and has important clinical value to early control and prevention of relevant genitourinary tract infections, blocking of an infection sources, and infection reduction of related pathogen.

An ocular Jiatishaxing gel for treating eyelid inflammation, stye, conjunctivitis, dacryocystitis, keratitis, corneal ulcer and trachoma is prepared from Jiatishaxing, HPMC as matrix, antiseptic, isotonic regulator, osmotic promoter, pH regulator and water through dissolving Jiatishaxing in water, adding others, stirring, regulating pH=5-9, filter and adding water.

The invention provides a composition containing an effective dose of antofloxacin or a pharmaceutically acceptable salt thereof or/and an effective dose of an anti-inflammatory steroid or non-steroidanti-inflammatory medicine or/and an effective dose of a water-retaining or wetting agent or an anti-xerophthalmia medicine, and an application of the composition in the preparation of an externally used antofloxacin medicine for local eyes or ears or noses or skins, used for preventing or treating conjunctivitis, angular blepharitis, keratitis, scleritis, trachoma, xerophthalmia, cataract, otitisexterna, otitis media, folliculitis and impetigo in humans or mammals. The medicine obtained in the invention has good curative effects or good therapeutic compliance.

Methods and compositions for the treatment or prevention of ocular Chlamydia trachomatis infection. Compositions comprise one or more Chlamydia trachomatis proteins, immunogenic fragments thereof or polynucleotides encoding such proteins or fragments.

The invention provides an application of etimicin and pharmacologically acceptable salt or inclusion compounds thereof in preparation of a local eye medicine or medicine composition for preventing ortreating eye diseases, xerophthalmia or dry eye syndromes, caused by conjunctivitis, angular blepharitis, keratitis, scleritis, trachoma and sensitive bacterium infection, of people or mammals. Eye preparations comprise eye drops, eye gel and the like. The medicine has better safety and effectiveness in a certain range.

The present invention relates to a staining kit and its preparation method, staining method and its application in several detection items for detecting canceration cell, red blood cell, campylobacteriosis, vaginal cleaning degree, estrogen level, garlandosus, trichomoniasis, mycosis, diplococcus gonorrhoeae and chlamydi trachomatis on a cervical smear. Said invented kit is formed from fixatino fluid, staining solution and differentiatino solution. Its staining method includes the steps of fixation, staining, differentiation and water-washing. Its film-making speed is quick, only has need oftwo main, and its detection accuracy rate is high, can be up to 98%.

Disclosed are peptides or a mixture of peptides, or analogs thereof, derived from the variable domains of the Chlamydia trachomatis (C. trachomatis) immunodominant major outer membrane protein (MOMP). The peptides or mixtures of peptides are characterized by having specificity only to C. trachomatis anti-MOMP antibodies and being non-cross reactive with anti-MOMP antibodies of other Chlamydia species Specific peptides are described (SEQ ID Nos. 1 to 8) as well as their analogs, which have essentially the same biological activity.

The present invention relates to primers and probes that can be used in various assays to detect a new strain of Chlamydia trachomatis. The invention further provides for the simultaneous detection of other diseases, especially Neisseria gonorrhoeae.

The present invention provides nucleic acids, proteins and vectors for a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. trachomatis. The method employs a vector containing a nucleotide sequence encoding a polypeptide of a strain of Chlamydia operably linked to a promoter to effect expression of the gene product in the host. The polypeptides are derived from the Chalmydia gene 60kCRMP gene including truncated forms of the gene. The invention further provides recombinant 60kCRMP protein useful for protecting against disease caused by infection with Chlamydia.

The present invention provides a composition containing an effective dose of etimicin or a pharmaceutically acceptable salt thereof and an anti-inflammatory effective dose of dexamethasone or a pharmaceutically acceptable derivative thereof, and applications of the composition in preparation of topical ophthalmic or aural or nasal or skin external application drugs for prevention or treatment of human or mammalian conjunctivitis, angular blepharitis, keratitis, scleritis, trachoma, xerophthalmia, otitis externa, otitis media, folliculitis, furuncle, impetigo and the like. According to the present invention, the drug has good safety and good efficacy compared to etimicin.

The invention relates to the detection of three different bacterial species which are responsible for sexually-transmitted diseases, i.e., Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Mycoplasma genitalium (MG). The invention more particularly relates to the detection of these three species in real-time PCR, in multiplex PCR and in real-time multiplex PCR. The invention provides reference templates sequences, which are especially adapted to the design of primers and probes, which can be used together in the same tube to detect CT and/or MG and/or NG by real-time multiplex amplification.

The present invention relates to an eye preparation for curing trachoma. It is prepared by using 10 Chinese medicinal materials of calcined smithsonite, borneol, musk, prepared frankincense, prepared myrrh and others.

The invention relates to a method and a device for detecting battery separator paper trachoma, wherein the method comprises shielding an external light source, leading only one surface of separator paper to be illuminated by the light source on one position of a transmission line, and then detecting whether the surface of the separator paper which is not illuminated has light to transmit or not, and then judging whether the separator paper has trachoma or not. The device for achieving the method comprises a detection box whose periphery is closed, and a light source and a photoreceptor which are respectively arranged on both sides of a plane wherein the separator paper is crossed over in the detection box, wherein the two lateral surfaces which are opposite of the detection box body are both provided with at least one permeating hole for the separator paper to cross over whose width is equal to the width of the separator paper, and the width of the permeating hole is equal to the width of the separator paper. The method can automatically, rapidly, effectively, efficiently and continuously detect battery separator paper trachoma, which overcomes the shortcomings of artificial naked eye detection which has big randomness, bad accuracy, low efficiency and the like, and can be widely used in the field of scroll trachoma detection.

Disclosed are isolated Chlamydia trachomatis proteins, methods of fusion protein and associated antibody production, and methods of using isolated proteins and antibodies in diagnosis and detection. Also disclosed are compositions comprising isolated proteins, wherein the compositions can further comprising pharmaceutically acceptable carriers, an adjuvant and/or an immunostimulant, and methods using the pharmaceutical compositions for treating or preventing an infection by Chlamydia in a subject. The compositions may also comprise a protein or immunogenic fragment of a pathogenic organism other than Chlamydia trachomatis.

Compositions and methods for detecting Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are provided. The present invention also provides methods and compositions for screening for infection/inflammation based on genomic copy number. Described herein is a method that entails assaying a sample obtained from the urogenital tract of the mammal for an indicator of genomic copy number, wherein a genomic copy number level that is higher than a control genomic copy number level is indicative of the presence of infection or inflammation of the urogenital tract. Also described in a kit of the invention that includes a primer and/or probe for detecting or sequencing an indicator of genomic copy number, wherein the indicator of genomic copy number comprises a nucleic acid sequence that is expected to be present in the genome of the mammal in one or two copies; and a primer and/or probe for detecting or sequencing a nucleic acid sequence that is indicative of a pathogen that infects the urogenital tract or a miRNA correlated with inflammation.

The invention provides a composition comprising an effective dose of etimicin or a pharmaceutically acceptable salt thereof, an anti-inflammatorily effective dose of steroids or non-steroid anti-inflammatory drugs, and an effective dose of a water-retaining or wetting agent or anti-xerophthalmia drug, and application of the composition to preparation of external drugs for local administration of the eyes, the nose or skin and for prevention and treatment of conjunctivitis in human beings or mammals, angular blepharitis, keratitis, scleritis, trachoma, xerophthalmia, cataract, otitis externa, otitis media, folliculitis, furuncle, pustule and the like. The composition provided by the invention has better curative effect or treatment compliance.

The invention discloses a Tibetan medicine for treating conjunctivitis and a preparation method thereof. The Tibetan medicine consists of an active component or an active component and pharmaceutically acceptable accessories, wherein the active component is prepared from horehound, herba artemisiae adamsii, carum carvi, hypecoum erectum, caraway and bear gall powder in a certain percentage by weight. The Tibetan medicine, which can be prepared into a preparation for eyes, has functions of clearing away heat, reducing fire, removing nebula and improving eyesight, and the medicine is applicable to hot eyes and eye pain, lacrimation, trachoma and conjunctivitis.