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226 results about "Trachoma" patented technology
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A bacterial infection of the eye.
Nanosilver-containing antibacterial and antifungal granules and methods for preparing and using the same
Owner:LEGEND WIN FINANCE
Immunogenic compositions for Chlamydia trachomatis
PendingUS20060034871A1Enhance immune responseAntibacterial agentsBacterial antigen ingredientsDiseaseAdjuvant
The invention relates to immunogenic compositions comprising combinations of Chlamydia trachomatis antigens and their use in vaccines. The composition may comprise at least two components, one component of which comprises Chlamydia trachomatis antigens for eliciting a Chlamydia trachomatis specific TH1 immune response and another component of which comprises antigens for eliciting a Chlamydia trachomatis specific TH2 immune response. The invention further relates to an immunogenic composition comprising a Chlamydia trachomatis Type III secretion system (TTSS) regulatory protein and a Chlamydia trachomatis Type III secretion system (TTSS) secreted protein or a fragment thereof. The invention further relates to the use of combinations of adjuvants for use with antigens associated with a sexually transmissible disease, such as Chlamydia trachomatis antigens. Preferred adjuvant combinations include mineral salts, such as aluminium salts and oligonucleotides comprising a CpG motif. The invention further provides a combination of Chlamydia trachomatis antigens comprising a Chlamydia trachomatis antigen that is conserved over at least two serovars.
Owner:NOVARTIS AG
Drop pill type eye drip fluid of chloramphenicol, and preparation method
InactiveCN1872038AEnsure stable qualityImprove stabilityOrganic active ingredientsSenses disorderDiseasePolyethylene glycol
A dripping pill of Chloromycetin eye drops for treating trachnoma, keratitis, conjunctivitis, eyelid inflammation, etc is proportionally prepared from polyethanediol as matrix and Chloromycetin. It is applied in conjunction with the buffer liquid prepared from borax, boric acid, hydroxyphenyl ethylether and the water for injection. Its preparing process is also disclosed.
Owner:济宁光明制药有限公司
Cranberry extract eye ophthalmic preparation and preparation method and uses thereof
InactiveCN103860625AGood effectMeet the strong demand for eye protectionSenses disorderAnthropod material medical ingredientsLingonberry extractDisease
The invention relates to a cranberry extract eye ophthalmic preparation and a preparation method and uses thereof, and belongs to the technical field of eye ophthalmic preparations. The technical problem to be solved is to provide a cranberry extract eye ophthalmic preparation. The cranberry extract eye ophthalmic preparation comprises an active ingredient of cranberry extract. The cranberry extract eye ophthalmic preparation can effectively treat, prevent or alleviate cataract, glaucoma, vitreous opacity, macular degeneration, retinopathy, optic atrophy, keratitis, epiphora induced by wind, presbyopia, myopia, visual fatigue, blurred vision, conjunctival burn, conjunctivitis, corneal ulcer, palpebral ecgema, floaters or trachoma and other eye diseases. A novel preparation is provided for treating cataract, glaucoma, vitreous opacity, macular degeneration, retinopathy, optic atrophy, keratitis, epiphora induced by wind, presbyopia, myopia, visual fatigue, blurred vision, conjunctival burn, conjunctivitis, corneal ulcer, palpebral ecgema, floaters or trachoma and other eye diseases, and meets the strong demand of people for loving and protecting eyes.
Owner:CHENGDU JIANKABIN SCI & TECH
Water dispersible film
InactiveUS20050070501A1Avoid difficultyAntibacterial agentsOrganic active ingredientsDiseaseComposite film
Owner:NEW YORK BLOOD CENT
Methods and compositions for the detection of Chlamydia trachomatis
InactiveUS20070065837A1High stringency conditionSugar derivativesMicrobiological testing/measurementOmpa geneChlamydia trachomatis
The present invention provides novel methods for determining the presence or absence of Chlamydia in a patient, as well as diagnostic kits useful in practicing the methods of the invention. The methods of the invention are based on nucleic acid amplification reactions to detect both Chlamydia genomic and cryptic plasmid sequences. In one embodiment, the methods involve using nucleic acid primers to specifically amplify the Chlamydia trachomatis ompA gene and cryptic plasmid. These methods provide both enhanced reliability and sensitivity of detection, thereby providing an accurate determination of the presence or absence of Chlamydia trachomatis in a patient.
Owner:QIAGEN DIAGNOSTICS
Fluorescence PCR method for diagnosing infection of Chlamydia trachomatis, neisseria gonorrhoeae and ureaplasma urealyticum
ActiveCN101613763AMicrobiological testing/measurementMicroorganism based processesForward primerFluorescence
The invention relates to a fluorescence PCR (polymerase chain reaction) detection method for diagnosing infection of Chlamydia trachomatis (CT), neisseria gonorrhoeae (NG) and ureaplasma urealyticum (UU), which belongs to the field of nucleic acid in vitro diagnosis. The method comprises a polymerase chain reaction (PCR) system based on fluorescence PCR technology, contains a forward primer and areverse primer aiming at the CT / the NG / the UU and a fluorescent probe, and can detects DNA of three pathogens such as the CT, the NG, the UU and the like simultaneously in a reaction tub under suitable PCR condition. The method can diagnosing the infection of the CT / the NG / the UU in a clinical sample simply, conveniently and rapidly, has high sensitivity and specificity, and has important clinical value to early control and prevention of relevant genitourinary tract infections, blocking of an infection sources, and infection reduction of related pathogen.
Owner:CITY UNIVERSITY OF HONG KONG
Gatiflxacin eye gels based on HPMC medium and its preparing method
InactiveCN1562030AExtended stayNot easy to loseOrganic active ingredientsSenses disorderTreatment effectIrritation
An ocular Jiatishaxing gel for treating eyelid inflammation, stye, conjunctivitis, dacryocystitis, keratitis, corneal ulcer and trachoma is prepared from Jiatishaxing, HPMC as matrix, antiseptic, isotonic regulator, osmotic promoter, pH regulator and water through dissolving Jiatishaxing in water, adding others, stirring, regulating pH=5-9, filter and adding water.
Owner:SHENYANG PHARMA UNIVERSITY
Externally used antofloxacin medicine for local eyes or ears or noses or skins, and composition thereof
The invention provides a composition containing an effective dose of antofloxacin or a pharmaceutically acceptable salt thereof or / and an effective dose of an anti-inflammatory steroid or non-steroidanti-inflammatory medicine or / and an effective dose of a water-retaining or wetting agent or an anti-xerophthalmia medicine, and an application of the composition in the preparation of an externally used antofloxacin medicine for local eyes or ears or noses or skins, used for preventing or treating conjunctivitis, angular blepharitis, keratitis, scleritis, trachoma, xerophthalmia, cataract, otitisexterna, otitis media, folliculitis and impetigo in humans or mammals. The medicine obtained in the invention has good curative effects or good therapeutic compliance.
Owner:刘力
Vaccines Against Chlamydial Infection
InactiveUS20100172927A1Improving immunogenicityAntibacterial agentsBacterial antigen ingredientsPolynucleotideImmunogenicity
Owner:CORIXA CORP +1
Local delivery eye medicine composition
The invention provides an application of etimicin and pharmacologically acceptable salt or inclusion compounds thereof in preparation of a local eye medicine or medicine composition for preventing ortreating eye diseases, xerophthalmia or dry eye syndromes, caused by conjunctivitis, angular blepharitis, keratitis, scleritis, trachoma and sensitive bacterium infection, of people or mammals. Eye preparations comprise eye drops, eye gel and the like. The medicine has better safety and effectiveness in a certain range.
Owner:刘力
Staining kit and preparation method, staining method, and use thereof
InactiveCN1434127AMany inspection itemsPlay a role in promotingMicrobiological testing/measurementDiseaseStaining
The present invention relates to a staining kit and its preparation method, staining method and its application in several detection items for detecting canceration cell, red blood cell, campylobacteriosis, vaginal cleaning degree, estrogen level, garlandosus, trichomoniasis, mycosis, diplococcus gonorrhoeae and chlamydi trachomatis on a cervical smear. Said invented kit is formed from fixatino fluid, staining solution and differentiatino solution. Its staining method includes the steps of fixation, staining, differentiation and water-washing. Its film-making speed is quick, only has need oftwo main, and its detection accuracy rate is high, can be up to 98%.
Owner:裴芳君
Chlamydia trachomatis specific peptides and their use in diagnostic assays
InactiveUS6699678B1High sensitivityStrong specificityPeptide/protein ingredientsMicroorganismsAntiendomysial antibodiesDrug biological activity
Disclosed are peptides or a mixture of peptides, or analogs thereof, derived from the variable domains of the Chlamydia trachomatis (C. trachomatis) immunodominant major outer membrane protein (MOMP). The peptides or mixtures of peptides are characterized by having specificity only to C. trachomatis anti-MOMP antibodies and being non-cross reactive with anti-MOMP antibodies of other Chlamydia species Specific peptides are described (SEQ ID Nos. 1 to 8) as well as their analogs, which have essentially the same biological activity.
Owner:SAVYON DIAGNOSTICS
Chlamydia trachomatis antigens for vaccine and diagnostic use
InactiveUS20090304722A1High expressionImprove abilitiesAntibacterial agentsOrganic active ingredientsGamma interferonWhole cell lysate
The present invention is related to antigens from Chlamydia trachomatis which are recognized by specific antibodies from individuals infected with Chlamydia or which can induce T cells from the same individuals to secrete gamma-interferon. The T cell reactive antigens are present in a whole-cell lysate and have apparent molecular weights of 5-12, 16-20, 25-35 and 58-74 kDa as determined by SDS-PAGE. The antigens of the invention are useful in vaccines but also as diagnostic compositions.
Owner:STATENS SERUM INST
Immunisation against Chlamydia trachomatis
InactiveUS20060216308A1Stable maintenanceAntibacterial agentsBacterial antigen ingredientsChlamydia trachomatisAntigenic protein
The present invention provides antigenic proteins of Chlamydia trachomatis. The proteins of the present invention are useful for eliciting an immune response to Chlamydia in a patient. For example, an effective amount of protein of the present invention or fraction thereof may be administered to a patient for eliciting a Chlamydia specific immune response. In another example, a method of raising an antibody specific for Chlamydia trchomatis elementary bodies (EB) is provided in which a protein of the present invention is administered to a patient.
Owner:CHIRON CORP
Primer and probe sequences for detecting chlamydia trachomatis
ActiveUS20080299567A1Easy to detectSugar derivativesMicrobiological testing/measurementChlamydia trachomatisDisease cause
Owner:ABBOTT MOLECULAR INC
Primer, probe and method for detecting human urological genital tract causal agent
InactiveCN101117646AImprove early detection rateSave operating timeMicrobiological testing/measurementDiseaseChlamydia trachomatis
The present invention discloses a guiding object and a probe for testing the human urogenital tract pathogens, and a method for testing the human urogenital tract pathogens using the guiding object and the probe. The present invention can test three different pathogens including Neisseria gonorrhoeae, mycoplasma ureaplasma and chlamydia trachomatis in a same reaction tube simultaneously. The present invention not only can increase the early detection rate of the sexually transmitted diseases, but also can reduce the operating time of the medical personnel, lower the cost, and lighten the economic burden of the patient.
Owner:SHANGHAI SHENYOU JIANHAI BIOLOGICAL TECH LIABILITY
Immunization Against Chlamydia Infection
The present invention provides nucleic acids, proteins and vectors for a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. trachomatis. The method employs a vector containing a nucleotide sequence encoding a polypeptide of a strain of Chlamydia operably linked to a promoter to effect expression of the gene product in the host. The polypeptides are derived from the Chalmydia gene 60kCRMP gene including truncated forms of the gene. The invention further provides recombinant 60kCRMP protein useful for protecting against disease caused by infection with Chlamydia.
Owner:BRUNHAM ROBERT +3
Topically administered pharmaceutical composition
The present invention provides a composition containing an effective dose of etimicin or a pharmaceutically acceptable salt thereof and an anti-inflammatory effective dose of dexamethasone or a pharmaceutically acceptable derivative thereof, and applications of the composition in preparation of topical ophthalmic or aural or nasal or skin external application drugs for prevention or treatment of human or mammalian conjunctivitis, angular blepharitis, keratitis, scleritis, trachoma, xerophthalmia, otitis externa, otitis media, folliculitis, furuncle, impetigo and the like. According to the present invention, the drug has good safety and good efficacy compared to etimicin.
Owner:刘力
Triple nucleic acid detection kit for neisseria gonorrhoeae / ureaplasma urealyticum/ chlamydia trachomatis
ActiveCN103409508ASimple and fast operationAvoid pollutionMicrobiological testing/measurementFluorescence/phosphorescenceSynechococcusPositive control
The invention discloses a triple nucleic acid detection kit for neisseria gonorrhoeae / ureaplasma urealyticum / chlamydia trachomatis. The kit comprises an RT-PCR (Reverse Transcription-Polymerase Chain Reaction) reaction liquid, an enzyme mixed liquid, a triple reaction liquid for neisseria gonorrhoeae / ureaplasma urealyticum / chlamydia trachomatis, positive control and negative control. The kit disclosed by the invention overcomes the deficiencies that in the prior art, neisseria gonorrhoeae / ureaplasma urealyticum / chlamydia trachomatis is poor in specificity, lower in sensitivity and the like, effectively prevents pollution, has the advantages of high sensitivity, good specificity, strong repeatability, quick and objective detection result and the like, and has good application prospect for detecting neisseria gonorrhoeae / ureaplasma urealyticum / chlamydia trachomatis.
Owner:JIANGSU BIOPERFECTUS TECH CO LTD
Real-Time Multiplex Detection of Three Bacterial Species Responsible for Sexually Transmitted Diseases
The invention relates to the detection of three different bacterial species which are responsible for sexually-transmitted diseases, i.e., Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Mycoplasma genitalium (MG). The invention more particularly relates to the detection of these three species in real-time PCR, in multiplex PCR and in real-time multiplex PCR. The invention provides reference templates sequences, which are especially adapted to the design of primers and probes, which can be used together in the same tube to detect CT and / or MG and / or NG by real-time multiplex amplification.
Owner:BIO RAD EURO GMBH
Preparation for treating trachoma
ActiveCN1775232AHighlight substantive specificSignificant progressSenses disorderPharmaceutical delivery mechanismMyrrhSmithsonite
The present invention relates to an eye preparation for curing trachoma. It is prepared by using 10 Chinese medicinal materials of calcined smithsonite, borneol, musk, prepared frankincense, prepared myrrh and others.
Owner:武汉五景药业有限公司
Kit for detecting sexually transmitted diseases
InactiveCN102080123AHigh sensitivitySimple stepsMicrobiological testing/measurementDNA/RNA fragmentationPathogenExact results
The invention discloses a kit for detecting sexually transmitted diseases. The kit comprises 1 to 3 pairs of primers which can specifically amplify genes of pathogens such as gonococcus, chlamydia trachomatis and / or ureaplasma urealyticum respectively; and the nucleotide sequences of the primers are shown as SEQ ID NO:1-6. The kit has high specificity and high sensitivity, can be used for detecting a single pathogen and detecting various pathogens at the same time, is convenient to use, provides exact results and has an extremely good clinical application prospect.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV
Primer, probe, kit and detection method for multiple detection of chlamydia trachomatis, neisseria gonorrhoeae and ureaplasma
InactiveCN109825615AImprove accuracyHigh sensitivityMicrobiological testing/measurementDNA/RNA fragmentationPathogenic microorganismFluorescence
The invention relates to the technical field of detection of pathogenic microorganisms, in particular to primers, a probe, a kit and a detection method for multiple detection of chlamydia trachomatis,neisseria gonorrhoeae and ureaplasma. The kit comprises a CT / NG / UU conserved region-specific primer pair and the Taqman fluorescent probe. The kit can accurately detect CT / NG / UU infected samples by real-time fluorescent quantitative PCR, and is convenient and quick to use, high in sensitivity, good in specificity and high in repeatability.
Owner:中生方政生物技术股份有限公司
Azithromycin ultrafine powder in-situ gel eye drops and preparation method thereof
InactiveCN102106812AHelps maintain effective concentrationImprove topical bioavailabilityAntibacterial agentsOrganic active ingredientsBacterial keratitisEye drop
The invention provides azithromycin ultrafine powder in-situ gel eye drops and a preparation method thereof. The method comprises the following steps of: firstly, micronizing a medicament by using a proper method to remarkably improve the dissolution rate and solubility of the medicament; and secondly, preparing an ophthalmic preparation which is in a liquid state in vitro and is in a gel state when dripped into eyes by adopting sodium alginate as an ion-sensitive gel matrix or adopting poloxamer 407 and poloxamer 188 as thermosensitive gel matrixes. The eye drops are steady in storage at 4 DEG C and uniform in content, and are not required for secondary preparation so as to reduce contamination. In the method, azithromycin ultrafine powder and in-situ gel are combined for the treatment of bacterial keratitis and trachoma; and by the dual effects of the ultrafine powder and the gel, the sustained release effect is achieved when the retention time of the preparation in the eyes is prolonged, so that the local bioavailability of the medicament and the compliance of patients are improved, and the medicament absorption of the cornea is increased to reduce the toxic or side effect caused by the systemic absorption of ophthalmic medicaments.
Owner:SHENYANG PHARMA UNIVERSITY
Immunogenic compositions for chlamydia trachomatis
The invention relates to compositions comprising combinations of Chlamydia trachomatis antigens and their use in vaccines. Specific combinations may be selected from a first antigen group of PepA, LcrE, ArtJ, DnaK, and CT398, and a second antigen group of PepA, LcrE, ArtJ, DnaK, CT398, OmpH-like, L7 / L12, OmcA, AtoS, CT547, Eno, HtrA and MurG. The invention further relates to the use of combinations of adjuvants for use with antigens associated with a sexually transmissible disease, such as Chlamydia trachomatis antigens. Preferred adjuvant combinations include mineral salts, such as aluminium salts and oligonucleotides comprising a CpG motif.
Owner:CHIRON CORP
Method and apparatus for detecting battery diaphragm paper sand hole
ActiveCN101349653AOvercoming the defect of sampling randomnessRealize detection automationOptically investigating flaws/contaminationElectrical batteryPulp and paper industry
The invention relates to a method and a device for detecting battery separator paper trachoma, wherein the method comprises shielding an external light source, leading only one surface of separator paper to be illuminated by the light source on one position of a transmission line, and then detecting whether the surface of the separator paper which is not illuminated has light to transmit or not, and then judging whether the separator paper has trachoma or not. The device for achieving the method comprises a detection box whose periphery is closed, and a light source and a photoreceptor which are respectively arranged on both sides of a plane wherein the separator paper is crossed over in the detection box, wherein the two lateral surfaces which are opposite of the detection box body are both provided with at least one permeating hole for the separator paper to cross over whose width is equal to the width of the separator paper, and the width of the permeating hole is equal to the width of the separator paper. The method can automatically, rapidly, effectively, efficiently and continuously detect battery separator paper trachoma, which overcomes the shortcomings of artificial naked eye detection which has big randomness, bad accuracy, low efficiency and the like, and can be widely used in the field of scroll trachoma detection.
Owner:SHENZHEN BAK POWER BATTERY CO LTD
Methods and Compositions for Chlamydial Antigens for Diagnosis and Treatment of Chlamydial Infection and Disease
ActiveUS20110256094A1Reduce the possibilityReduce morbidityAntibacterial agentsBacterial antigen ingredientsAdjuvantTreatment chlamydia
Disclosed are isolated Chlamydia trachomatis proteins, methods of fusion protein and associated antibody production, and methods of using isolated proteins and antibodies in diagnosis and detection. Also disclosed are compositions comprising isolated proteins, wherein the compositions can further comprising pharmaceutically acceptable carriers, an adjuvant and / or an immunostimulant, and methods using the pharmaceutical compositions for treating or preventing an infection by Chlamydia in a subject. The compositions may also comprise a protein or immunogenic fragment of a pathogenic organism other than Chlamydia trachomatis.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Methods of detecting chlamydia and gonorrhea and of screening for infection/inflammation based on genomic copy number
ActiveUS20160257998A1Microbiological testing/measurementAntiinfectivesNucleic acid sequencingChlamydiae
Compositions and methods for detecting Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are provided. The present invention also provides methods and compositions for screening for infection / inflammation based on genomic copy number. Described herein is a method that entails assaying a sample obtained from the urogenital tract of the mammal for an indicator of genomic copy number, wherein a genomic copy number level that is higher than a control genomic copy number level is indicative of the presence of infection or inflammation of the urogenital tract. Also described in a kit of the invention that includes a primer and / or probe for detecting or sequencing an indicator of genomic copy number, wherein the indicator of genomic copy number comprises a nucleic acid sequence that is expected to be present in the genome of the mammal in one or two copies; and a primer and / or probe for detecting or sequencing a nucleic acid sequence that is indicative of a pathogen that infects the urogenital tract or a miRNA correlated with inflammation.
Owner:CEPHEID INC
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