Veterinary compound florfenicol injection and preparation method thereof

Abstract

The invention discloses compound florfenicol injection and a preparation method thereof. The compound florfenicol injection comprises the following components: 500g of florfenicol, 500g of doxycycline hyclate, 500g of tilmicosin phosphate, 3,000g of polyvinylpyrrolidone, 4,000g of N, N-dimethylacetylamide, 200g of magnesium chloride, 20g of sodium formaldehyde sulphoxylate and 10,000 milliliters of water for injection. The preparation method comprises the following steps of: (1) preparing; (2) adding doxycycline into the polyvinylpyrrolidone, heating to 80 DEG C, stirring until a mixture is clarified, adding the tilmicosin phosphate, and stirring until a mixture is clarified; (3) heating dimethylacetylamide to 50 DEG C, adding the florfenicol, and stirring for dissolving; (4) adding 1,000 milliliters of water for injection, adding the magnesium chloride and the sodium formaldehyde sulphoxylate in turn, and stirring for dissolving; and (5) mixing solution prepared in the step (2) and the step (3), gradually adding solution prepared in the step (4) under stirring, replenishing the water for injection until the total volume of the water for injection is 10,000 milliliters, uniformly stirring, filtering, filling nitrogen, encapsulating, and sterilizing at the temperature of between 110 and 115 DEG C for 30 minutes to prepare the compound florfenicol injection.

Description

technical field [0001] The invention belongs to a compound florfenicol injection for treating swine asthma and a preparation method thereof. Background technique [0002] At present, the most important drugs for the treatment of asthma at home and abroad are kanamycin, enrofloxacin, oxytetracycline, etc. These drugs have a certain control effect in the treatment of swine asthma, but they have relatively large toxic and side effects and strong drug resistance. , after 3 days of continuous medication, the original drug sensitivity was greatly reduced. In addition, the pathogen of swine asthma, mycoplasma, attaches to the cilia of the respiratory tract, and the pathogen proliferates further, destroying the integrity of the cilia of the epithelial cells of the respiratory tract, and other bacteria such as Eperythrozoon will break through the first cilium barrier of the respiratory system to defend against germs, and drive straight into the lungs The combination of porcine asthm...

AI Technical Summary

Problems solved by technology

[0002] At present, the most important drugs for treating asthma at home and abroad are kanamycin, enrofloxacin, oxytetracycline, etc. These drugs have a certain control effect in the treatment of swine asthma, but they have relatively large toxic and side effects and strong drug resistance. , after 3 days of continuous medication, the original drug sensitivity is greatly reduced

In addition, the pathogen of swine asthma, mycoplasma, adheres to the cilia of the respiratory tract, and the pathogen proliferates further, destroying the integrity of the cilia of the epithelial cells of the respiratory tract, and other bacteria such as Eperythrozoon will break through the first cilium barrier of the respiratory system to defend against pathogens, and drive straight into the lungs The combination of porcine asthma and eperythrozoonosis will further damage the lungs, cause lung necrosis or degeneration, greatly reduce the body's immunity, and greatly increase the mortality of pigs

Now the main drug for the treatment of swine asthma only has a certain control effect on swine asthma, can not control the infection of eperythrozoonosis, can not remove the swine asthma pathogen attached to the respiratory cilia, and can not improve the immunity of pigs

Common drugs used to treat swine asthma do not reduce pig mortality very well

The most important thing is that the commonly used drugs for the treatment of asthma have high toxicity and side effects. After treatment, the growth and weight gain of pigs are seriously affected, and they are often transformed into dead pigs after being cured, and the growth rate is significantly reduced.

Therefore, the common drugs for the treatment of swine asthma are clinically limited

Images