Application of total glycosides of eucommia ulmoides in preparing medicine for treating osteoporosis

Abstract

The invention relates to application of effective component eucommia total glycoside in the medicament preparation for curing osteoporosis. The medicament for curing osteoporosis which is prepared from effective component eucommia total glycoside can be used in the form of soft capsules and hard capsules, wherein soft capsules are proportioned by one part by weight of eucommia total glycoside and 0.5-8 parts by weight of sea-buckthorn seed oil or edible vegetable oil or polyethylene glycol 400 and are prepared by applying conventional process for preparing soft capsules. Hard capsules are prepared by filling eucommia total glycoside into capsules. Proved by pharmacological test, eucommia total glycoside can not affect weight increasing of animals and no obvious effect is found on organ index. Eucommia total glycoside can obviously increase bone mineral density, greatly strengthen femoral fracture stress and femoral crushing stress, and increase bone length reduce which is caused by vitamin A acid and bone weight reduce. Eucommia total glycoside can not obviously affect serum estrogen level and has good function on osteoporosis of rats which is caused by vitamin A acid resistance.

Description

technical field

[0001] The invention belongs to the technical field of medical preparations containing raw materials or their reaction products with unknown structures, and specifically relates to materials derived from plants. Background technique

[0002] Osteoporosis is a systemic skeletal disease characterized by decreased bone mass and degeneration of bone microstructure, resulting in increased bone fragility and susceptibility to fractures. Menopausal women are particularly prominent and are in the top ten of the current disease spectrum. With the intensification of the aging trend of the world's population, osteoporotic fractures, as a serious complication, have increasingly attracted people's attention to the impact on the health of the elderly. Osteoporosis is one of the most important public health problems in developed countries, and it is also a very prominent problem in developing countries. Osteoporosis is listed as a major chronic disease in the 21st century...

Examples

Embodiment 1

[0034] Taking the production of 1000 soft capsules as an example, the used Chinese medicine raw materials and auxiliary materials and their weight ratios are:

[0035] Total glucosides of Eucommia ulmoides 200g

[0036] Sea Buckthorn Seed Oil 400g

[0037] In the above proportion, the content of aucubin in the total glucosides of eucommia kernels is not less than 50%.

[0038] Its preparation method is as follows:

[0039] Take 200g of the total glucosides of Eucommia ulmoides, add 400g of seabuckthorn seed oil, add 1g of anhydrous sodium carbonate, and anhydrous sodium carbonate is used to absorb the water in seabuckthorn seed oil, mix evenly, grind, pass through a 100-mesh sieve, and Add materials on the soft capsule machine to make 1000 capsules, each containing 100mg of total glucosides of Eucommia ulmoides (calculated as aucubin).

Embodiment 2

[0041] Taking the production of 1000 soft capsules as an example, the used Chinese medicine raw materials and auxiliary materials and their weight ratios are:

[0042] Total glucosides of Eucommia ulmoides 200g

[0043] Sea Buckthorn Seed Oil 50g

[0044] In the above proportion, the content of aucubin in the total glucosides of eucommia kernels is not less than 50%.

[0045] Its preparation method is the same as that of Example 1, and 1000 capsules are made by a soft capsule machine, and each capsule contains 100 mg of total glucosides of Eucommia ulmoides (calculated as aucubin).

Embodiment 3

[0047] Taking the production of 1000 soft capsules as an example, the used Chinese medicine raw materials and auxiliary materials and their weight ratios are:

[0048] Total glucosides of Eucommia ulmoides 200g

[0049] Sea Buckthorn Seed Oil 800g

[0050] In the above proportion, the content of aucubin in the total glucosides of eucommia kernels is not less than 50%.

[0051]Its preparation method is the same as that of Example 1, and 1000 capsules are made by a soft capsule machine, and each capsule contains 100 mg of total glucosides of Eucommia ulmoides (calculated as aucubin).

technical field

[0001] The invention belongs to the technical field of medical preparations containing raw materials or their reaction products with unknown structures, and specifically relates to materials derived from plants. Background technique

[0002] Osteoporosis is a systemic skeletal disease characterized by decreased bone mass and degeneration of bone microstructure, resulting in increased bone fragility and susceptibility to fractures. Menopausal women are particularly prominent and are in the top ten of the current disease spectrum. With the intensification of the aging trend of the world's population, osteoporotic fractures, as a serious complication, have increasingly attracted people's attention to the impact on the health of the elderly. Osteoporosis is one of the most important public health problems in developed countries, and it is also a very prominent problem in developing countries. Osteoporosis is listed as a major chronic disease in the 21st century...

Examples

Embodiment 1

[0034] Taking the production of 1000 soft capsules as an example, the used Chinese medicine raw materials and auxiliary materials and their weight ratios are:

[0035] Total glucosides of Eucommia ulmoides 200g

[0036] Sea Buckthorn Seed Oil 400g

[0037] In the above proportion, the content of aucubin in the total glucosides of eucommia kernels is not less than 50%.

[0038] Its preparation method is as follows:

[0039] Take 200g of the total glucosides of Eucommia ulmoides, add 400g of seabuckthorn seed oil, add 1g of anhydrous sodium carbonate, and anhydrous sodium carbonate is used to absorb the water in seabuckthorn seed oil, mix evenly, grind, pass through a 100-mesh sieve, and Add materials on the soft capsule machine to make 1000 capsules, each containing 100mg of total glucosides of Eucommia ulmoides (calculated as aucubin).

Embodiment 2

[0041] Taking the production of 1000 soft capsules as an example, the used Chinese medicine raw materials and auxiliary materials and their weight ratios are:

[0042] Total glucosides of Eucommia ulmoides 200g

[0043] Sea Buckthorn Seed Oil 50g

[0044] In the above proportion, the content of aucubin in the total glucosides of eucommia kernels is not less than 50%.

[0045] Its preparation method is the same as that of Example 1, and 1000 capsules are made by a soft capsule machine, and each capsule contains 100 mg of total glucosides of Eucommia ulmoides (calculated as aucubin).

Embodiment 3

[0047] Taking the production of 1000 soft capsules as an example, the used Chinese medicine raw materials and auxiliary materials and their weight ratios are:

[0048] Total glucosides of Eucommia ulmoides 200g

[0049] Sea Buckthorn Seed Oil 800g

[0050] In the above proportion, the content of aucubin in the total glucosides of eucommia kernels is not less than 50%.

[0051]Its preparation method is the same as that of Example 1, and 1000 capsules are made by a soft capsule machine, and each capsule contains 100 mg of total glucosides of Eucommia ulmoides (calculated as aucubin).