Postbiotic preparation and composition for improving activity of gamma-aminobutyric acid and promoting calcium absorption and application of postbiotic preparation and composition in sleep improvement and bone health

By improving the intestinal environment through specific postbiotic preparations, GABA activity and calcium absorption are enhanced, solving the problems of low GABA utilization and poor calcium absorption, and achieving the dual benefits of improved sleep and bone health.

CN121801732AActive Publication Date: 2026-04-07SHANDONG NICE HEALTH TECHNOLOGY CO LTD
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Patent Information

Application Number
CN202511980410.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-25
Publication Date
2026-04-07
Estimated Expiration
2045-12-25

AI Technical Summary

Technical Problem

In the current technology, the oral bioavailability of γ-aminobutyric acid (GABA) is low, the absorption efficiency of calcium preparations is poor, and there is a lack of products that promote the synergistic effect of the two, which cannot meet the dual needs of sleep improvement and bone health.

Method used

Using specific postbiotic formulations containing Lactobacillus reuteri Nice-xt and Lactobacillus reuteri Nice-06 and their fermentation metabolites, GABA activity and calcium absorption are enhanced by improving intestinal barrier function and regulating intestinal pH.

Benefits of technology

It significantly improves the bioavailability of GABA and the absorption rate of calcium, achieving a dual-functional synergistic effect of improving sleep and bone health, shortening latency, increasing the proportion of deep sleep, and enhancing bone density.

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Abstract

The invention belongs to the technical field of microorganisms and compound nutrients, and particularly relates to a postbiotic preparation and composition for improving activity of gamma-aminobutyric acid and promoting calcium absorption and application of the postbiotic preparation and composition in sleep improvement and bone health. Through the synergistic effect of the specific metagen preparation and the gamma-aminobutyric acid, the multi-dimensional technical breakthrough is realized, and the physiological activity and the application value are remarkably improved. In the aspect of bioavailability, the intestinal barrier function is improved and the pH value of the intestinal tract is adjusted to be weakly acidic through the postbiotics, so that the concentration of serum GABA is increased by 2-3 times compared with that of single use, and the calcium absorption rate is increased from 30% to 55-60%. And on the aspect of function synergy, the limitation of single effect in the prior art is broken through, dual-function synergy of'sleep regulation-bone health 'is realized, meanwhile, the vicious circle of'poor sleep-calcium loss' is improved, and good practical application value is achieved.
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