The invention discloses a multi-tug cooperative open caisson floating transportation manipulation simulation control method. The method is in allusion to that scale parameters of a pipe section are very special, the floating transportation process is affected by multiple factors such as channel conditions, the floating transportation distance, the hydrology, the meteorology and the like, and difficulties of heavy water transportation and cooperative towing of multiple tugs are required to be overcome at the same time. According to the invention, the whole process of immersed pipe floating transportation manipulated and towed in a cooperative mode by six tugs under different wind, wave and flow sea conditions is simulated through continuously changing the towing power and the position of the tugs, stress analysis is carried out on the towing force for the immersed pipe every time when the position of the immersed pipe is changed, the manipulating modes of different tugs are adjusted, the single and total tug stresses and a resultant force received by the immersed pipe are calculated, moving postures of the immersed pipe are displayed in an immersed pipe floating transportation towing system, and curves of the cycle time, the track belt width, the tug service power and the like are acquired. The method disclosed by the invention can realize selection and tests for channels, steering areas, foundation trench towing modes and turning modes of each tug, evaluates the controllability, gives an advice on the size of a steering water area and the towing cable length, and judges whether configuration of the tugs is reasonable or not.