The invention relates to an intelligent video tracking method based on immune genetic particle filtering, which comprises the following steps: initializing and sampling particles, calculating the weighted value of the particles, estimating and outputting the state, calculating the number of effective particles, and if the number of effective particles is smaller than the preset threshold, optimizing the set of immune genetic particles, otherwise, directly sampling particles again. The invention adopts the principle of the immune genetic algorithm, and realizes the optimization of the particle set through fitness calculation, memory unit updating, inhibition of the antibody concentration, promotion, crossover, variation and other types of operation, so that novel particles can be generated on the premise that the effectiveness of particles with high weighted values is maintained, thereby improving the diversity of particle sets and the number of effective particles. The novel particles can better express the true state of the target, thereby enhancing the robustness and effectiveness of the intelligent video tracking and reducing the risk of mistaken tracking.