The invention discloses a method for optimizing the natural gas liquefaction process technological parameters based on the genetic algorithm. According to the method for optimizing the natural gas liquefaction process technological parameters based on the genetic algorithm, on the basis of an original technological process, the genetic algorithm is introduced, a corresponding original genus, a fitness judgment formula, the cross-over rate, the aberration rate and the end condition are established for each set of parameters based on the genetic algorithm in the process of optimization of the process technological parameters, genetic algorithm optimization operation is conducted, and finally the optimal genes are obtained and used as the optimal technological parameters of the natural gas liquefaction process. Under the condition that the inherent characteristics of all devices of a system and other design regulations are met, the energy consumption generated in the natural gas liquefaction process is reduced. Meanwhile, the method for optimizing the natural gas liquefaction process technological parameters based on the genetic algorithm has the advantages of being supermatic in intelligent optimization, capable of improving the optimization efficiency, and high in global superiority and universality. According to the method for optimizing the natural gas liquefaction process technological parameters based on the genetic algorithm, the optimization range covers all the technological parameters of the process, and global optimization is really achieved through interrelation of the parameters. The method for optimizing the natural gas liquefaction process technological parameters based on the genetic algorithm can also be applied to various optimization objects, and therefore the universality of natural gas liquefaction technological parameter optimization is improved.