Aspects of the present disclosure generally relate to systems and methods for managing and optimizing end-to-end communication sessions involving the delivery of application data (e.g., audio data, audio/video data, electronic file download data, etc.) over third party networks using an optimized communication system (OCS), as described herein. Embodiments of the disclosed system enable optimal quality (e.g., reduced delay, packet loss, jitter, etc.) of communication sessions. In one example, the system provides a real-time or close to real-time evaluation of network conditions, e.g., network congestion, nodes best-suited for application data transfer, etc., and other factors associated with geographically diverse and unpredictable routing infrastructure characteristics of the Internet to enable optimized communication sessions.