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Traditional Chinese and western medicine compound oral liquid for treating porcine respiratory disease, and preparation method and application of compound oral liquid

A porcine respiratory disease, Chinese and Western medicine technology, applied in the field of veterinary medicine, can solve the problems of pigs' living habits affecting waste, driving up the use cost of pig farms, and poor water solubility of tilmicosin, so as to achieve small feed intake and growth traits of pigs , Delay the process of drug resistance, the best effect on the treatment of porcine respiratory diseases

Inactive Publication Date: 2018-05-08
FUJIAN AONONG BIOLOGICAL TECH GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The tilmicosin premix has serious problems of poor palatability caused by poor water solubility and bitter taste of tilmicosin, and the clinical efficacy is relatively poor
The use method of tilmicosin phosphate soluble powder is to dissolve in drinking water, and the waste is very large due to the influence of the living habits of pigs
Moreover, the price of tilmicosin phosphate soluble powder is high, which further increases the use cost of pig farms

Method used

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  • Traditional Chinese and western medicine compound oral liquid for treating porcine respiratory disease, and preparation method and application of compound oral liquid
  • Traditional Chinese and western medicine compound oral liquid for treating porcine respiratory disease, and preparation method and application of compound oral liquid
  • Traditional Chinese and western medicine compound oral liquid for treating porcine respiratory disease, and preparation method and application of compound oral liquid

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Experimental program
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preparation example Construction

[0038] In addition, the embodiment of the present invention also provides a preparation method of the above-mentioned Chinese and Western medicine compound oral liquid for treating porcine respiratory diseases, for example, it may include the following steps: dissolving loquat leaf extract, Fritillaria sichuanensis extract, tilmicol phosphate according to the proportion Star, menthol, essence, sucrose and auxiliary materials, sterilized.

[0039] Further, the above-mentioned raw materials can be mixed with reference to the following method: dissolve loquat leaf extract, Chuan Fritillaria extract, menthol, essence, sucrose and auxiliary materials under heating conditions to obtain the first mixed solution, and then replace it with the dissolved phosphoric acid Micosin was mixed to obtain the second mixture, which was dried and sterilized.

[0040] The heating is carried out under the condition of 50-60° C., so that the extract of loquat leaves, extract of Fritillaria chinensis,...

Embodiment 1

[0046] 2 parts by weight of loquat leaf extract, 2 parts by weight of Chuan Fritillaria extract, 1 part by weight of menthol, 1 part by weight of essence, 1 part by weight of sucrose and 1 part by weight of auxiliary materials and water at 50 ° C Dissolved under the conditions to obtain the first mixed solution. Then mix the first mixed solution with 2 parts by weight of dissolved tilmicosin phosphate to obtain a second mixed solution. Sterilize, get the Chinese and Western medicine compound oral liquid of treating porcine respiratory disease.

[0047] Wherein, the loquat leaf extract is based on its dry product, and the mass fractions of elemol and α-pichengol are equal to 85wt% in total. The mass ratio of elemol to α-picubitol is 1:5. The Fritillaria siberiana extract is calculated on the basis of its dry product, and the mass fractions of the coniferine and the coniferine are equal to 90wt% in total. The mass ratio of Songbei base and Fube base is 1:3. Excipients contai...

Embodiment 2

[0049] 95 parts by weight of loquat leaf extract, 95 parts by weight of Chuan Fritillaria extract, 30 parts by weight of menthol, 30 parts by weight of essence, 30 parts by weight of sucrose and 50 parts by weight of auxiliary materials and water at 60 ° C Dissolved under the conditions to obtain the first mixed solution. Then the first mixed solution was mixed with 95 parts by weight of dissolved tilmicosin phosphate to obtain a second mixed solution. Sterilize, get the Chinese and Western medicine compound oral liquid of treating porcine respiratory disease.

[0050] Wherein, the mass fraction of the loquat leaf extract is equal to 95wt% in total of elemol and α-pichengol in terms of its dry product. The mass ratio of elemenol to α-pichengol is 3:5. The mass fraction of the Fritillaria sichuanensis extract is 98wt% in total on the basis of its dry product. The mass ratio of Songbei base and Fube base is 2:8. Excipients contain sodium bisulfite.

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Abstract

The invention relates to traditional Chinese and western medicine compound oral liquid for treating a porcine respiratory disease, and a preparation method and an application of the compound oral liquid, and belongs to the field of veterinary medicines. The preparation method of the traditional Chinese and western medicine compound oral liquid comprises the following steps of dissolving a folium eriobotryae extract, a fritillaria cirrhosa extract, tilmicosin phosphate, menthol, essence, sucrose and an auxiliary material. The preparation method is simple, good in condition controllability, lowin production cost and high in stability and has good application prospects. The traditional Chinese and western medicine compound oral liquid prepared by the method can effectively cover bitterness of an ordinary tilmicosin medicine, overcome the great difficulty of serious reduction of porcine feed intake caused by an ordinary tilmicosin pharmaceutical preparation and avoid resistance to the tilmicosin medicine, and has the advantages that the oral liquid takes effect quickly, is absorbed well, and is low in waste and cost. The oral liquid is used for preparing a medicine for treating or preventing the porcine respiratory disease, and has a better treatment effect on the porcine respiratory disease and only smaller influence on the porcine feed intake.

Description

technical field [0001] The invention relates to the field of veterinary medicine, and in particular to a Chinese and western medicine compound oral liquid for treating porcine respiratory diseases, a preparation method and application thereof. Background technique [0002] With the rapid development of animal husbandry and intensive farming, pig farms are getting bigger and bigger, resulting in more concentrated pigs, poor air conditions in pig houses, and easier cross-contamination. The frequency of pig farms in my country has risen sharply in 2010, especially porcine respiratory disease syndrome (PRDC) and porcine reproductive and respiratory syndrome (PRRS, commonly known as blue ear disease), which have had a very large impact on the production of pig farms. [0003] At present, the drug of choice for the treatment of porcine respiratory diseases is tilmicosin, and the drugs approved by the Ministry of Agriculture of my country are mainly tilmicosin premix and tilmicosin ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/08A61K47/26A61K47/10A61P11/00A61P31/14A61K31/706
CPCA61K36/8966A61K9/0095A61K31/706A61K36/73A61K47/10A61K47/26A61K2300/00
Inventor 谢伟杰王庆福吴有林柒启恩戴多亮梁世仁
Owner FUJIAN AONONG BIOLOGICAL TECH GRP CO LTD
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