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A kind of tilmicosin phosphate soluble powder preparation and preparation method thereof

A tilmicosin phosphate and soluble technology, which is applied in the fields of pharmaceutical formulation, powder delivery, organic active ingredients, etc., can solve the problems of reducing therapeutic effect, drug caking, deliquescence, etc., and achieve good palatability, low production cost, and grain time fast effect

Active Publication Date: 2019-08-20
HUBEI LONGXIANG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Soluble powder is a powder dosage form mixed with a drug and suitable auxiliary materials. It is mainly used for poultry drinking water administration. Soluble powder prepared by traditional mixing process is easy to cause drug agglomeration, deliquescence and deterioration, which ultimately reduces the therapeutic effect

Method used

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  • A kind of tilmicosin phosphate soluble powder preparation and preparation method thereof
  • A kind of tilmicosin phosphate soluble powder preparation and preparation method thereof
  • A kind of tilmicosin phosphate soluble powder preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The weight ratio of each component of tilmicosin phosphate soluble powder is:

[0049]

[0050] Sieve the above raw and auxiliary materials and put them into the high-speed mixing granulator according to the above formula ratio for mixing, add an appropriate amount of purified water to granulate, the mixing speed of the high-speed mixing granulator is 1400r / min, the cutter speed is 800r / min, and then Dry and sieve with an 80-mesh sieve to obtain tilmicosin phosphate soluble powder.

Embodiment 2

[0052] The weight ratio of each component of tilmicosin phosphate soluble powder is:

[0053]

[0054]

[0055] Sieve the above raw and auxiliary materials and put them into a high-speed mixing granulator according to the above formula ratio for mixing, add an appropriate amount of purified water to granulate, the mixing speed of the high-speed mixing granulator is 1000r / min, the cutter speed is 600r / min, and then Dry and sieve with an 80-mesh sieve to obtain tilmicosin phosphate soluble powder.

Embodiment 3

[0057] The weight ratio of each component of tilmicosin phosphate soluble powder is:

[0058]

[0059] Sieve the above raw and auxiliary materials and put them into the high-speed mixing granulator according to the above formula ratio for mixing, add an appropriate amount of purified water to granulate, the mixing speed of the high-speed mixing granulator is 1200r / min, the cutter speed is 700r / min, and then Dry and sieve with an 80-mesh sieve to obtain tilmicosin phosphate soluble powder.

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Abstract

The invention relates to a tilmicosin phosphate soluble powder preparation and a preparation method thereof. The soluble powder preparation is prepared from the following components in parts by weight: 5-30 parts of tilmicosin phosphate, 2-30 parts of a sweetening agent, 2-20 parts of an adhesive and 20-91 parts of parts of a water-soluble diluent. The tilmicosin phosphate soluble powder provided by the invention has mobility, solubility and palatability; moisture absorption and agglomeration are not easily generated; and the stability is obviously superior to that of existing soluble powder.

Description

technical field [0001] The invention relates to a tilmicosin phosphate soluble powder preparation and a preparation method thereof. Background technique [0002] Tilmicosin is a semi-synthetic macrocyclic lipid antibiotic for livestock and poultry. It has strong antibacterial activity and a wide antibacterial spectrum. It is effective against all Gram-positive bacteria and some Gram-negative bacteria, mold Shape, spirochete, mycoplasma, etc. have inhibitory effect. Especially for Actinobacillus pleuropneumoniae, Pasteurella, Staphylococcus aureus, Streptococcus pyogenes, Corynebacterium pyogenes and Mycoplasma of livestock and poultry, the activity is stronger than Tylosin. [0003] The drug has been approved for clinical use in Australia, Brazil, France, Malaysia, Spain, the United States and other countries for the treatment of infectious diseases in cattle, goats, dairy cows, pigs, chickens and other animals. my country has now approved tilmicosin drugs for clinical tre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/706A61P31/04
Inventor 陈清平汪敦辉王铭宏吴东林
Owner HUBEI LONGXIANG PHARMA TECH CO LTD
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