The present invention discloses traditional Chinese medicine granules for avian colibacillosis treatment, wherein raw materials comprise, by crude drug, 30-90 g of gypsum, 3-20 g of honeysuckle, 2-30 g of figwort root, 2-15 g of baikal skullcap root, 2-15 g of unprocessed rehmannia root, 2-15 g of weeping forsythia fruit, 2-15 g of cape jasmine, 2-15 g of Chinese gentian root, 2-30 g of manyflower gueldenstaedtid herb, 2-40 g of indigowoad root, 2-15 g of common anemarrhena, 2-15 g of creeping liriope, and a proper amount of an excipient. The preparation method for the cooling-relieving therapy granules comprises: (1) adopting enzyme extraction on the drugs in the formula to prepare extract powder, (2) adding the excipient and mixing, and (3) carrying out granulation, drying and sub-packaging to obtain the finished product. The granule agent has functions of heat clearing, detoxication, yin nourishing and dysentery treatment, and has characteristics of high active ingredient content, significant therapy effect, easy taking and no toxic and side-effect.