148 results about "Colistin Sulfate" patented technology

This invention relates to a method of treating otitis externa using a topical combination medication, including one or more antifungal agent such as, for example fluconazole, voriconazole, itraconazole, clotrimazole, amphotericin B, caspofungin, micafungin, terbinafine, naftifine, butenafine, amorolfine, ravuconazole, posaconazole, flucytosine, econazole, enilaconazole, miconazole, oxiconazole, saperconazole, sulconazole, terconazole, tioconazole, nikkomycin Z, anidulafungin (LY303366), nystatin, pimaricin, griseofulvin, ciclopirox, haloprogin, tolnaftate, and undecylenate and one or more antibacterial agent such as neomycin sulfate, polymyxin B sulfate, colistin sulfate, gentamycin, tobramycin, chloramphenicol, Ciprofloxacin, Ofloxacin, a penicillin compound, a cephalosporin compound, a macrolide compound, a fluoroquinolone compound, streptomycin, or kanamycin.

The invention discloses a shoat feed and a preparation method. The shoat feed is prepared from the following raw materials in a ratio: northeast corn, soybean meal CP43, rice bran meal, puffed soybean meal, Ronggang molasses yeast, citric acid residue meal, calcium hydrophosphate, calcium formate, 0.5 percent shoat premix, salt, 98.5 percent L-lysine hydrochloride, granular acidifying agent-II, 99 percent DL-methionine, 97 percent betaine hydrochloride Betaine [C5H11NO2], 98.5 percent L-threonine, Mycofix-Plus3.0, blue copperas, 98 percent L-tryptophan, phytase 5,000mu/g, 10 percent colistin sulfate, coated acetyl kitasamycin*500, and 1806Z-LUCTA. The preparation method comprises the following steps of: A, proportioning the raw materials according to the components and the weight ratio; B, crushing: crushing the raw materials by using a crusher respectively; C, mixing the crushed raw materials; D, drying and packing; E, inspecting; and F, metering and packing. The shoat feed has the advantages of reasonable formula, rich nutritional components, good taste and easy digestion, improves the immunologic function of shoats and is suitable for large-scale breeding.

The invention discloses an amoxicillin colistin sulphate granule and a preparation method thereof. The amoxicillin colistin sulphate granule comprises the following ingredients in parts by weight: 1-25 parts of amoxicillin, 0.5-50 parts of colistin sulphate and 50-90 parts of additives, as well as an adhesive accounting for 0.5-8 parts of the weight sum of the ingredients, and the amoxicillin colistin sulphate granule is prepared by such steps as sieving, dissolving, mixing, drying and pelletizing. The amoxicillin and colistin sulphate in the invention can be uniformly mixed, thereby improving the solubility of the product in water, reinforcing the efficacy, ensuring the treatment effect, facilitating the quick recovery of animals, guaranteeing easy storage and low by-effect and reinforcing the treatment effect by drug combination; the amoxicillin colistin sulphate granule can be not only used for treating mixed infection of pigs, but also being conveniently applied on clinic and facilitating the prevention and treatment of group animal diseases so as to alleviate animal stress reactions and reduce the labor intensity of manual drug use.

The invention relates to a bacillus amyloliquefaciens insecticide-fertilizer for farm onsite fermentation, a preparation method and applications thereof. The insecticide-fertilizer comprises the following raw materials: bacillus amyloliquefaciens, colistin sulfate, natamycin, L-alanine, asparagine, yeast extract powder, peptone, disodium hydrogen phosphate, sodium chloride, glucose, fructose, and brown sugar. The colistin sulfate and natamycin in the insecticide-fertilizer can inhibit the growth of fungi (such as pathogenic fungi, yeast, etc.) and gram negative bacteria (such as colibacillus, salmonella, etc.) during the fermentation process. The spore germinator (alanine, fructose, and asparagine) can rapidly promote the germination of spores of bacillus amyloliquefaciens and improve the germination rate of spores. The provided insecticide-fertilizer can be applied to the onsite fermentation and propagation in a simple and crude farm. The required equipment is simple. The using amount of bacterium is little. The cost is low. The fermentation broth obtained through onsite fermentation has the advantages of high content and good activity. The insecticide-fertilizer can prevent disease, promote growth, and increase output and improve quality, and can be used as a microbial pesticide, and the effect is stable.

The invention discloses a process for extracting colistin sulfate through a precipitation method. The process comprises the following steps of: (a) adjusting pH of fermentation liquor containing polymyxin E with oxalic acid or concentrated sulfuric acid, and filtering with a filtering device; (b) adding 0 metal complexing agent and inorganic flocculant to the filtrate, and reacting at normal temperature for 0.5 to 4.0h; (c) heating, cooling, and vacuum-filtering the reactive liquid; (d) adjusting pH of the filtrate above with aqueous alkali, separating the solid from the liquid to obtain a filter cake, dissolving the filter cake with sulfuric acid solution so as to obtain acidizing fluid, adding potassium permanganate and activated carbon to the acidizing fluid respectively, agitating for0.5 to 2.0 hours, and then vacuum-filtering to obtain colistin sulfate liquid; and (e) centrifugally spray-drying the colistin sulfate liquid. With the adoption of the process, the common problems ofthe existing process for purifying fermentation liquor that the steps are complicated, the period is long, the labor intensity is relatively high, and the wastewater is difficult to treat and the like can be overcame.

The invention relates to a paenibacillus polymyxa pesticide-fertilizer for farm onsite fermentation, a preparation method, and applications thereof. The pesticide-fertilizer comprises the following raw materials: paenibacillus polymyxa powder, colistin sulfate, natamycin, L-alanine, valine, yeast powder, corn steep liquor powder, disodium hydrogen phosphate, sodium chloride, fructose, and brown sugar. The colistin sulfate and natamycin in the insecticide-fertilizer can inhibit the growth of fungi (such as pathogenic fungi, yeast, etc.) and gram negative bacteria (such as colibacillus, salmonella, etc.) during the fermentation process. The spore germinator (alanine, fructose, and valine) can rapidly promote the germination of spores of paenibacillus polymyxa and improve the germination rate of spores. The provided pesticide-fertilizer can be applied to the onsite fermentation and propagation in a simple and crude farm. The required equipment is simple. The using amount of bacterium is little. The cost is low. The fermentation broth obtained through onsite fermentation has the advantages of high content and good activity. The insecticide-fertilizer can prevent disease, promote growth, and increase output and improve product quality, and can be used as a microbial pesticide, and the effect is stable.

The invention discloses an environment-friendly ecological broiler feed which comprises, by weight, 528 parts of corn, 100 parts of wheat, 275 parts of 46% soybean meal, 5 parts of soya-bean oil, 50 parts of 60% high protein powder, 15 parts of stone flour, 3 parts of salt, 13.5 parts of calcium hydrogen phosphate, 1.3 parts of 99% methionine, 4.05 parts of 65% lysine, 0.25 part of anti-oxidants, 0.31 part of vitamin for chicken, 0.13 part of colistin sulfate, 0.11 part of phytase, 0.9 part of probiotics, 0.15 part of kemzyme, 2.5 parts of choline, 0.5 part of salinomycin, 1 part of broiler multi-minerals, 0.5 part of 10% bacitracin zinc, and 0.5 part of Youpuding. The breeding method using the broiler feed is a broiler breeding method for reducing broiler manure nitrogen phosphorus discharge; because of the addition of phytase and probiotics in the feed, the nitrogen and phosphorus utilization rates of broilers are effectively improved, the excretion amounts of nitrogen and phosphorus are decreased, and the utilization rate of the feed is improved.

The invention relates to a compound preparation for controlling the diseases of aquaculture fish, and especially relates to a compound preparation for controlling the bacillary enteritis of young sea bass. The compound preparation comprises 10-20wt% of garlicin, 10-20wt% of colistin sulfate, 10-15wt% of Isatis Root, 10-20wt% of Radix Scutellariae, 10-20wt% of honeysuckle flower, 10-15wt% of licorice root and 10-15wt% of Chinese angelica. The compound preparation can substantially inhibit the growth of pathogenic bacteria comprising Escherichia coli, Aeromonas hydrophila and the like in the intestinal tract of young sea bass, can enhance the body immunity of the young sea bass, effectively prevents and treats the bacillary enteritis of the young sea bass, and improves the survival rate of the young sea bass to above 70%. The compound preparation has the advantages of stable sources and low prices of raw materials, simple production technology, wide application prospect, and easy industrialized production.

The invention discloses a concentrated feed for promoting the healthy growth of piglets and a preparation method of the concentrated feed. The concentrated feed mainly comprises extruded soybeans, fish meal, wheat shorts, whey powder, milk replacer, dicalcium phosphate, stone powder, table salt, lysine, methionine, threonine, selenium yeast, choline chloride, multi-vitamins, multi-minerals, olaquindox, colistin sulfate and the like; organic zinc and the selenium yeast are added in the concentrated feed, and the high protein feed fish meal, the whey powder, the milk replacer and the extruded soybean meal are further added, and thus the nutrition is reasonable, the absorption rate and the utilization rate of the feed are increased, and the concentrated feed is green, organic and free of pollution; probiotics and an acidifier are further added, so that the intestinal health of the piglets is promoted and the digestion rate and the utilization rate of the piglets on the feed are increased, so as to promote the healthy growth of the piglets.

The invention discloses a preparation method of colistin sulfate premixing agents. The PH of the colistin sulfate fermentation liquid is regulated to 4.5 to 5.0 by sulfuric acid, the plate frame filtering and the re-filtering are carried out to obtain wet germ slag and filter liquid, the filter liquid is concentrated by a dual-effect concentrator, and the concentration liquid is obtained; the concentration liquid and the wet germ slag are mixed into mixed liquid, ground limestone and defatted rice bran are added into the mixed liquid, the materials are uniformly mixed, and a mixture is obtained; and the mixture is subjected to expansion drying, the air inlet temperature of expansion drying agents is controlled to be 125 to 135 DEG C, the air outlet temperature is 60 to 70 DEG C, and finished products of the colistin sulfate premixing agents are obtained. The preparation method provided by the invention has the advantages that the utilization rate is high, the yield is high, and the operation is easy.

The invention discloses a method for detecting whether antibiotic filter residues are doped in rapeseed meal, comprising the following steps: detecting whether rapeseed meal contains characteristic markers of antibiotic filter residues, and detecting the characteristic markers. That is to say, antibiotic filter residues are doped in the rapeseed meal. The method of the invention specifically contains the following steps: pretreatment of samples, collection of volatile components, gas chromatography separation, and ion mobility spectrum detection for detecting whether there are characteristic markers of antibiotic filter residues in a sample so as to determine whether antibiotic filter residues are doped in rapeseed meal. The method of the invention has high separating power of gas chromatography and high sensitivity of ion mobility spectrum. Meanwhile, by a static headspace sampling mode, accurate and nondestructive testing of trace volatile components can be achieved. The method can be adopted to detect characteristic markers of streptomycin filter residue, cephalosporins filter residue and colistin sulfate filter residue to identify adulteration of rapeseed meal.

The invention discloses an oil suspension. Every 100 mL of the oil suspension contains 10 g of amoxicillin, 1 g of colistin sulfate, 0.9-1.0 g of surfactant, 1.0-4.0 g of colloid protective agent, 3.0-15.0 g of suspending agent, 0.075-0.1 g of antioxidant and the balance oil phases. Under the condition of adopting specific auxiliary types and dosage ratios, the prepared suspension is good in physical stability, permeability and re-dispersity; the mass of the suspension is not reduced after the suspension is stored in a 4-60 DEG C environment for three months, which indicates that the mass of the suspension is stable.

The invention relates to veterinary compound apramycin sulfate soluble powder and application thereof. The veterinary compound apramycin sulfate soluble powder is characterized by being prepared by mixing the following components according to unit weight of 100g: 3-25g of apramycin sulfate, 5-10g of colistin sulfate, 0.1-0.2g of atropine sulfate, 2-5mg of epidermal growth factor, and the balance of medically applicable auxiliary materials. The components with optimal contents are as follows: 15g of apramycin sulfate, 5g of colistin sulfate, 0.15g of atropine sulfate, 3mg of epidermal growth factor, and the balance of medically applicable auxiliary materials, wherein the auxiliary materials comprise more than one of sucrose, anhydrous glucose and oral glucose. The invention also discloses the application of the veterinary compound apramycin sulfate soluble powder to treatment of piglet yellow-white scour. By adopting the compound preparation of antibiotics, anticholinergics and epidermal growth factors, the invention has effective treatment effect for piglet yellow-white scour, has the efficacy of treating both the symptoms and root cause and reduces the bacterial resistance probability with simple preparation, obvious effect and wide application.

The invention relates to the field of veterinary medicines and particularly relates to a Chinese and western medicine composition for treating piglet diarrhea and a preparation method thereof. The Chinese and western medicine composition for treating piglet diarrhea is mainly prepared from 10-50 parts by weight of gallnut, 1-9 parts of bacitracin zinc and 0.5-1.5 parts of colistin sulfate. The Chinese and western medicine composition is enhanced in synergetic effect of raw materials, has an efficient prevention and treatment effect on piglet diarrhea, is nearly free from toxic and side effects, and further is capable of promoting growth of livestock and poultry and improving the feed conversion ratio. The invention further provides a preparation method of fast buccal disintegrating micropowder. The method comprises the following steps: dissolving out active ingredients in the gallnut by virtue of a water decocting method and mixing the obtained liquid medicine with other ingredients so as to facilitate fusion among the active ingredients. The prepared medicine is uniform in active ingredient distribution; the preparation method is simple, energy consumption is saved and the prepared medicine is excellent in palatability and disintegration speed performances.

The invention relates to a compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as a preparation method of the compound doxycycline hydrochloride composition. The compound doxycycline hydrochloride composition is prepared by uniformly mixing the following components by weight: 10-15 parts of doxycycline hydrochloride, 10-20 parts of colistin sulfate, 5-15 parts of tylosin tartrate, 5-10 parts of trimethoprim lactate and 40-70 parts of anhydrous dextrose. The compound doxycycline hydrochloride composition has the beneficial effects of reasonable formula, easiness in preparation, remarkable treatment effect and clinically proven special effect for treating colibacillosis and chronic respiratory disease of the poultry.

The invention relates to high-ration fiber piglet compound feed. The high-ration fiber piglet compound feed consists of the following ingredients in parts by weight: 250 to 400 parts of corns, 250 to 350 parts of wheat, 80 to 150 parts of extracted soybean meal, 50 to 75 parts of fermented soybean meal, 50 to 100 parts of extruded soybeans, 30 to 100 parts of brown rice, 30 to 60 parts of 65% fish meal, 30 to 70 parts of whey powder, 20 to 80 parts of flour, 10 to 20 parts of soybean oil, 5 to 10 parts of calcium hydrogen phosphate, 5 to 10 parts of stone powder, 4 to 5 parts of piglet micro-mineral premixed material, 5 to 10 parts of citric acid, 3 to 6 parts of 99% lysine, 3 to 5 parts of sodium chloride, 1 to 2 parts of 50% choline chloride, 1 to 2 parts of methionine, 1 to 2 parts of threonine, 4 to 5 parts of self-compounding multi-dimensional premixed material, 0.3 to 0.6 part of tryptophan, 0.3 to 0.5 part of an antioxidant, 0.5 to 0.7 part of origanum oil, 0.05 to 0.1 part of 50% kitasamycin and 0.15 to 0.2 part of colistin sulfate. The ratio of soluble ration fiber to insoluble fiber in the ration is adjusted, so that the weanling stress syndrome of the piglet can be controlled, the intestine health of the piglet can be improved, the diarrhea is reduced, the dependence of the piglet on the antibiotics and the pharmaceutical dose zinc oxide can be alleviated, and the effect is remarkable.

The invention discloses a nosiheptide-colistin sulfate premixed agent which comprises 0.5-4 portions of nosiheptide, 1-10 portions of colistin, and the carriers of calcium carbonate, zeolite powder, corn flour, etc. for the rest in every 100 weight portions. The preparation method is as following. The raw materials are added in a mixing machine by the sequence of the carriers, the colistin sulfate, the nosiheptide and the carriers, and mixed evenly to make into powdery nosiheptide-colistin sulfate premixed agent. Or the nosiheptide and the carriers can be mixed fully firstly, then the colistin sulfate is dissolved in the water and sprinkled evenly on the mixture of the nosiheptide and the carriers. After being granulated, dried and screened, the mixture is made into the granular-typed nosiheptide-colistin sulfate premixed agent, the granularity of which is 30-60 mesh. The nosiheptide-colistin sulfate premixed agent of the invention is added in feedstuffs. The content range of the nosiheptide in every kilogram of overhead price feedstuff is 0.5-20mg, and the content range of the colistin sulfate in every kilogram of overhead price feedstuff is 2-40mg.

The invention relates to the field of veterinary drug formulations, and in particular relates to a compound formulation for treating bacterial infection of the digestive tract of livestock and poultry. The compound formulation comprises the following components in every 100ml: 2-10g of ciprofloxacin on ciprofloxacin basis, 1-9g of colistin sulfate on synthesized pure medicine, and 0.03-0.1g of atropine sulfate. The compound formulation is prepared by adopting ciprofloxacin and colistin sulfate with high bacteria sensitivity and strong synergetic bacteria resistance and combining symptomatic treatment medicines by a method for treating both symptom and root cause, so that a remarkable synergetic sterilization effect can be achieved, the drug dosage can be reduced, the cure rate can be improved, the treatment cost can be reduced, and the compound formulation is stable; occurrence of drug resistance of pathogenic bacteria of the digestive tract of livestock and poultry can be effectively avoided; the compound formulation is low in prescription price and convenient to popularize and apply.

A creep feed is a special high-nutrition feed for feeding suckling pigs in one week after the suckling pigs are born and in 1-2 weeks after the suckling pigs are weaned, and the creep feed is commonly known as a milk replacer or artificial milk and is a feeder prepared for replacing full milk. Main raw materials of the creep feed are byproducts of the milk industry. The invention relates to a creep feed which consists of extruded corn, fermented soybean meal, whey powder, whey protein meal, imported steamed fish meal, cane sugar, membrane protein meal, plasma protein powder, plant essential oil, compound vitamins, composite amino acids, mineral substances, salt, colistin sulfate, enramycin, sodium selenite, a flavoring agent, an acidifying agent, probiotics and the like. According to the creep feed, animal protein raw materials are used as much as possible, the fermented soybean meal is used for replacing conventional soybean meal, the extruded corn is used for replacing conventional corn and simultaneously, the acidifying agent and the probiotics are added, so anti-nutritional factors in the raw materials are farthest reduced, the palatability and digestibility of the feed are improved, the appetite of the suckling pigs is stimulated, food intake is increased, growth of intestinal tracts is promoted, immunity is enhanced, the diarrhea rate of the suckling pigs in a creep stage is reduced, the survival rate of nursery pigs is increased, weaning stress is reduced and finally, targets of successful creeping and increment of daily gain are achieved.

The invention discloses a culture medium for selectively separating and culturing group B streptococci and a preparation method thereof. Culture supernatant fluid of group B streptococci at the logarithmic phase and an antibiotic combination are added to a group B streptococcus selective developing basic culture medium. The culture supernatant fluid contains quorum sensing substances capable of accelerating the growth of bacteria and facilitating the speed of color development reaction and color development intensity, thereby greatly shortening the detection time; and the antibiotic combination comprises amethopterin, colistin sulfate and metronidazole, which can inhibit the growth of mixed bacterium, except the group B streptococci, thereby achieving a purpose of selectively separating and culturing the group B streptococci. When the culture medium is used for detecting the group B streptococci, the characteristics of high specificity and sensitivity, convenience in observation and the like are provided, and the culture medium can be effectively applied to rapid detection to clinic samples.

The invention discloses compound doxycycline hydrochloride injection for treating intestinal diseases of animals, and the injection comprises principle agent, addition agent and solvent, wherein the principle agent is prepared by the following raw materials in parts by weight: 10-100 parts of doxycycline hydrochloride and 25-250 parts of sulfamethoxazole, or 10-100 parts of mequindox, or 10-100 parts of colistin sulfate, the addition agent is prepared by the following materials in parts by weight: 1-2 parts of antioxidant and 0.1-0.2 part of ethylene diamine tetraacetic acid-2Na, and the solvent is prepared by 650-980 parts of solvent for injection by weight. Clinical tests prove that the compound doxycycline hydrochloride injection for treating intestinal diseases of animals has better treating effects than unilateral preparations which respectively include each medicine and has the characteristics of wide antimicrobial spectrum, strong antibacterial activity, safe use and approval treating effects.

The invention discloses animal norfloxacin nicotinate compound injection for treating intestinal diseases and a preparation method of the injection. The animal norfloxacin nicotinate compound injection includes main drugs, additives and a solvent, wherein the main drugs are prepared from the following materials in parts by weight: 10-100 parts of norfloxacin nicotinate and 5-50 parts of berberine sulphate or 10-100 parts of mequindox or 10-100 parts of colistin sulfate; the additives are prepared from 1-2 parts of antioxidant and 0.1-0.2 part of ethylenediamine tetraacetic acid disodium; and the solvent is prepared from 650-980 parts of injection solvent. According to the clinical test, the animal norfloxacin nicotinate compound injection for treating intestinal diseases has the characteristics of being better in curative effect than that of single preparation of each drug, extensive in antibacterial spectrum, strong in antibacterial activity, safe to use, and precise in curative effect.