Veterinary suspension containing amoxicillin, colistin sulfate and prednisolone and preparation method thereof

A technology of colistin sulfate and amoxicillin, which is applied in the direction of medical preparations containing active ingredients, antibacterial drugs, liquid delivery, etc., can solve the problems of unsatisfactory mixed infectious diseases and narrow application range, and save manpower , avoid limitations, and delay the effects of drug resistance

Inactive Publication Date: 2011-01-26
CHINA AGRI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above existing two compound preparations are mainly suitable for the treatment of dairy cow mastitis, and the scope of application is narrow, so they cannot meet the mixed infectious diseases of various animals (especially pigs).

Method used

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  • Veterinary suspension containing amoxicillin, colistin sulfate and prednisolone and preparation method thereof
  • Veterinary suspension containing amoxicillin, colistin sulfate and prednisolone and preparation method thereof
  • Veterinary suspension containing amoxicillin, colistin sulfate and prednisolone and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The present invention contains the formula of the veterinary suspension of amoxicillin, colistin sulfate and prednisolone as follows:

[0051] Amoxicillin 20kg,

[0052] Colistin Sulfate 1.5kg,

[0053] Prednisolone 0.04kg,

[0054] Aluminum stearate 1kg,

[0055] Span-80 1L,

[0056] Propyl gallate 0.02kg,

[0057] Benzyl alcohol 0.5kg

[0058]

[0059] Add soybean oil for injection to 100L.

[0060] Prepare the veterinary suspension containing amoxicillin, colistin sulfate and prednisolone with the present invention, and concrete method comprises the following steps:

[0061] 1) Adding the formulated amount of aluminum stearate and propyl gallate into 2L of soybean oil for injection, heating and stirring to dissolve them completely, adding the formulated amount of benzyl alcohol to obtain liquid A;

[0062] 2) Take 60L of soybean oil for injection and pour it into the colloid mill, start the colloid mill, then slowly a...

Embodiment 2

[0066] The present invention contains the formula of the veterinary suspension of amoxicillin, colistin sulfate and prednisolone as follows:

[0067] Amoxicillin 20kg,

[0068] Colistin Sulfate 1kg,

[0069] Prednisolone 0.03kg,

[0070] Hydrogenated castor oil 1kg,

[0071] Span-60 0.5L,

[0072] Propyl gallate 0.02kg,

[0073] Methylparaben 0.05kg,

[0074]

[0075] Isopropyl myristate Add to 100L.

[0076] Prepare the veterinary suspension containing amoxicillin, colistin sulfate and prednisolone with the method of the present invention, concrete method comprises the following steps:

[0077] 1) Add hydrogenated castor oil, propyl gallate and methylparaben in 2L of isopropyl myristate into 2L of isopropyl myristate, heat and stir to completely dissolve to obtain liquid A;

[0078] 2) Take 40L of isopropyl myristate and pour it into the colloid mill, start the colloid mill, then slowly add the above liquid A, wait until i...

Embodiment 3

[0082] The present invention contains the formula of the veterinary suspension of amoxicillin, colistin sulfate and prednisolone as follows:

[0083] Amoxicillin 10kg,

[0084] Colistin Sulfate 1kg,

[0085] Prednisolone 0.05kg,

[0086] Hydrogenated castor oil 0.5kg,

[0087] Vaseline 0.25kg,

[0088] Span-80 0.2L,

[0089] Thiourea 0.2kg,

[0090] Methylparaben 0.05kg,

[0091] Ethyl oleate 30L,

[0092]

[0093] Add soybean oil for injection to 100L.

[0094] Prepare the veterinary suspension containing amoxicillin, colistin sulfate and prednisolone with the method of the present invention, concrete method comprises the following steps:

[0095] 1) Add hydrogenated castor oil, vaseline, thiourea and methylparaben in 2L of soybean oil for injection into 2L of soybean oil, heat and stir to dissolve completely, and obtain liquid A;

[0096]2) Pour the prescribed amount of ethyl oleate and 30L soybean oil for injection into the ...

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PUM

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Abstract

The invention discloses a veterinary suspension containing amoxicillin, colistin sulfate and prednisolone and a preparation method thereof. The veterinary suspension adopts the amoxicillin, the colistin sulfate and the prednisolone as active ingredients. The preparation method of the veterinary suspension containing the amoxicillin, the colistin sulfate and the prednisolone comprises the following steps of: (1) dissolving or dispersing a suspending agent, an antioxidant and a preservative in a hot dispersion medium to obtain a solution (A); (2) adding 40-80 percent of dispersion medium in a formula ratio in a colloid mill, starting the colloid mill, then slowly adding the solution (A) and adding a wetting agent while stirring after the solution (A) is fully added; (3) sequentially adding the amoxicillin, the colistin sulfate and the prednisolone after fully adding all the accessories, and grinding by adopting two alternate modes, i.e. an endless grinding mode and a non-endless grinding mode; and (4) detecting the grain fineness, stopping grinding when the grain fineness accords with the requirement, adding the dispersion medium to the formula ratio, mixing, canning, sealing and sterilizing to obtain the veterinary suspension containing the amoxicillin, the colistin sulfate and the prednisolone.

Description

technical field [0001] The invention belongs to the field of animal husbandry pharmaceutical preparations, and in particular relates to a veterinary compound suspension containing amoxicillin, colistin sulfate and prednisolone and a preparation method thereof. Background technique [0002] With the rapid development of my country's livestock and poultry breeding industry, various pathogenic bacteria have become more and more complicated in veterinary clinics in recent years. Negative bacterial infection brings great difficulties to veterinary prevention and control work. Due to the lack of mature compound preparations that have good effects on various pathogenic bacteria, veterinary workers often need to use a variety of single drug preparations in combination to treat mixed infectious diseases, and often use glucocorticoids such as Splash in the early stage of infection. Nisolone, dexamethasone and other adjuvant therapy. Therefore, to treat a disease, it is often necessar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K38/12A61P31/04A61K31/43A61K31/573
Inventor 肖希龙沈建忠汤树生何家康李兰张朝明
Owner CHINA AGRI UNIV
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