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Amoxicillin and colistin sulfate oil suspension and preparation method thereof

A technology of colistin sulfate and oil suspension, which is applied in the field of medicine and can solve problems such as easy caking, poor redispersibility, and unusable medicines

Active Publication Date: 2017-01-04
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the experiment, it was found that the above-mentioned oil suspension was easy to agglomerate after centrifugation or long-term storage, and the redispersibility was poor, which made the medicine unusable

Method used

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  • Amoxicillin and colistin sulfate oil suspension and preparation method thereof
  • Amoxicillin and colistin sulfate oil suspension and preparation method thereof
  • Amoxicillin and colistin sulfate oil suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 Preparation of amoxicillin colistin sulfate oil suspension of the present invention

[0025] Take 40ml of soybean oil, add 30ml of benzyl benzoate (or 30ml of isopropyl myristate), heat (60°C-70°C) and mix well, then add vitamin C palmitate (0.01%-0.02%w / v), Colloidal protective agent (1.0g of magnesium aluminum silicate magnesium stearate 1:1 mixture), suspending agent (poloxamer 188 5.0g, polyethylene glycol 6000 2.5g), suspending agent is melted and stirred evenly, add Surfactant (soybean lecithin 0.3g, Tween-80 0.3g and Span-80 0.3g), after cooling to room temperature (15~25℃), add suspending agent (sodium carboxymethylcellulose 1.0g), stir Evenly, add 10 g of amoxicillin and 1 g of colistin sulfate, stir evenly, and then set the volume to 100 ml with soybean oil, and homogenize to obtain the oil suspension of amoxicillin sulfate and colistin sulfate of the present invention.

[0026] The beneficial effects of the present invention are demonstrated thr...

experiment example 1

[0040] Experimental example 1 The influence of the type of oil phase on the quality of amoxicillin colistin sulfate suspension

[0041] Soybean oil, rapeseed oil, peanut oil, corn oil, white oil, ethyl oleate, benzyl benzoate, isopropyl myristate, soybean oil-benzyl benzoate (volume ratio 50%: 50%) , soybean oil-isopropyl myristate (volume ratio 50%: 50%), soybean oil-ethyl oleate (volume ratio 50%: 50%) are used as the oil phase, and the surfactant Span-80 ( 5% w / v), antioxidant p-hydroxytert-butyl anisole (BHA) (0.02% w / v), thickener aluminum stearate (1% w / v) and main drug amoxicillin (10% w / v), colistin sulfate (1% w / v) to prepare different suspensions, and investigate their sedimentation volume ratio, needle penetration, and dispersion after centrifugation. The results are shown in Table 1.

[0042] Table 1 The quality evaluation results of suspensions prepared by using different types of oil phases

[0043]

[0044] It can be concluded from Table 1 that the amoxicilli...

experiment example 2

[0045] Experimental Example 2 Effect of the Composition Ratio of the Composite Oil Phase on the Quality of Amoxicillin Colistin Sulfate Suspension

[0046] Composite oil phases were prepared according to the ratio shown in Table 2, and combined with surfactant Span-80 (5% w / v), antioxidant p-hydroxytert-butyl anisole (BHA) (0.02% w / v), Thickener aluminum stearate (1% w / v) and the main drug amoxicillin (10% w / v), colistin sulfate (1% w / v) to prepare different suspensions, investigate their sedimentation volume See Table 2 for the results of ratio, puncture, and dispersion after centrifugation.

[0047] Table 2 The quality evaluation results of the suspension prepared according to the composition ratio of different composite oil phases

[0048]

[0049] Can draw in conjunction with the test result of table 1 and table 2, when benzyl benzoate, isopropyl myristate and soybean oil prepare composite oil phase respectively, benzyl benzoate ratio is 30%-50%v / v, Or when the ratio ...

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Abstract

The invention discloses an oil suspension. Every 100 mL of the oil suspension contains 10 g of amoxicillin, 1 g of colistin sulfate, 0.9-1.0 g of surfactant, 1.0-4.0 g of colloid protective agent, 3.0-15.0 g of suspending agent, 0.075-0.1 g of antioxidant and the balance oil phases. Under the condition of adopting specific auxiliary types and dosage ratios, the prepared suspension is good in physical stability, permeability and re-dispersity; the mass of the suspension is not reduced after the suspension is stored in a 4-60 DEG C environment for three months, which indicates that the mass of the suspension is stable.

Description

technical field [0001] The invention relates to an amoxicillin sulfate colistin oil suspension and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Amoxicillin, also known as amoxycillin or amoxycillin, is a white powder with a half-life of about 61.3 minutes, stable under acidic conditions, and a gastrointestinal absorption rate of 90%. Amoxicillin has a strong bactericidal effect and a strong ability to penetrate cell membranes. It is one of the most widely used oral semi-synthetic penicillins. Colistin sulfate is easily soluble in water, slightly soluble in methanol, ethanol, soluble in acetone, ether, etc., free base is slightly soluble in water. It has strong antibacterial effect on Gram-negative bacteria, is used to treat intestinal diseases caused by Gram-negative bacteria, and is used as a feed additive, and has obvious growth-promoting effect. Colistin sulfate has a narrow antibacterial spectrum and has strong antibac...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K38/12A61K31/43A61K47/44A61K47/14A61K47/26A61K47/34A61K47/38A61P31/04
CPCA61K9/0019A61K9/10A61K31/43A61K38/12A61K47/10A61K47/14A61K47/26A61K47/38A61K47/44A61K2300/00
Inventor 杨海涵房春林黄兴唐华侨吴学渊
Owner CHENGDU QIANKUN VETERINARY PHARMA
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