Compound formulation for treating bacterial infection of digestive tract of livestock and poultry and preparation method of compound formulation

A compound preparation, digestive tract technology, applied in the directions of digestive system, antibacterial drugs, medical preparations containing active ingredients, etc.

Active Publication Date: 2014-04-16
湖南慧谷农业生态研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because gram-negative bacteria are prone to produce drug-resist

Method used

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  • Compound formulation for treating bacterial infection of digestive tract of livestock and poultry and preparation method of compound formulation
  • Compound formulation for treating bacterial infection of digestive tract of livestock and poultry and preparation method of compound formulation
  • Compound formulation for treating bacterial infection of digestive tract of livestock and poultry and preparation method of compound formulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The compound preparation of this example contains the following components: ciprofloxacin lactate (calculated as ciprofloxacin) 5g, colistin sulfate (calculated as a pure drug) 4g, atropine sulfate 0.07g, procaine hydrochloride For 0.9g, 0.8g of sodium chloride, 5g of nicotinamide, 0.04g of edetate disodium, and appropriate amount of lactic acid, add water for injection to 100ml.

[0032] Described preparation method comprises the steps:

[0033] (1) Take 40% water for injection and heat it to 50°C, add colistin sulfate and stir to dissolve; then add pre-dissolved procaine hydrochloride and sodium chloride respectively, and fully stir to form A liquid;

[0034] (2) Take 30% water for injection, heat it to 60°C, put in ciprofloxacin lactate to dissolve, then put in pre-dissolved atropine sulfate and disodium edetate and stir to form B liquid;

[0035] (3) Combine liquid A and liquid B, add nicotinamide and stir evenly, add water for injection to 98%, adjust the pH value...

Embodiment 2

[0037] The compound preparation of this example contains the following components: ciprofloxacin lactate (calculated as ciprofloxacin) 2.5g, colistin sulfate (calculated as pure medicine) 2g, atropine sulfate 0.05g, profloxacin hydrochloride Caine 0.8g, sodium chloride 0.7g, nicotinamide 2.5g, edetate disodium 0.03g, lactic acid amount, water for injection was added to 100ml.

[0038] Described preparation method comprises the steps:

[0039] (1) Take 40% water for injection and heat it to 50°C, add colistin sulfate and stir to dissolve; then add pre-dissolved procaine hydrochloride and sodium chloride respectively, and fully stir to form A liquid;

[0040] (2) Take 30% water for injection, heat it to 60°C, put in ciprofloxacin lactate to dissolve, then put in pre-dissolved atropine sulfate and disodium edetate and stir to form B liquid;

[0041] (3) Combine liquid A and liquid B, add nicotinamide and stir evenly, add water for injection to 98%, adjust the pH value to 3.8-4.5...

Embodiment 3

[0043] The compound preparation of this example contains the following components: ciprofloxacin lactate (calculated as ciprofloxacin) 4g, colistin sulfate (calculated as pure medicine) 3g, atropine sulfate 0.05g, proca For 0.8g, 0.6g of sodium chloride, 4g of nicotinamide, 0.03g of edetate disodium, and appropriate amount of lactic acid, add water for injection to 100ml.

[0044] Described preparation method comprises the steps:

[0045] (1) Take 40% water for injection and heat it to 50°C, add colistin sulfate and stir to dissolve; then add pre-dissolved procaine hydrochloride and sodium chloride respectively, and fully stir to form A liquid;

[0046] (2) Take 30% water for injection, heat it to 60°C, put in ciprofloxacin lactate to dissolve, then put in pre-dissolved atropine sulfate and disodium edetate and stir to form B liquid;

[0047] (3) Combine liquid A and liquid B, add nicotinamide and stir evenly, add water for injection to 98%, adjust the pH value to 3.8-4.5 wit...

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Abstract

The invention relates to the field of veterinary drug formulations, and in particular relates to a compound formulation for treating bacterial infection of the digestive tract of livestock and poultry. The compound formulation comprises the following components in every 100ml: 2-10g of ciprofloxacin on ciprofloxacin basis, 1-9g of colistin sulfate on synthesized pure medicine, and 0.03-0.1g of atropine sulfate. The compound formulation is prepared by adopting ciprofloxacin and colistin sulfate with high bacteria sensitivity and strong synergetic bacteria resistance and combining symptomatic treatment medicines by a method for treating both symptom and root cause, so that a remarkable synergetic sterilization effect can be achieved, the drug dosage can be reduced, the cure rate can be improved, the treatment cost can be reduced, and the compound formulation is stable; occurrence of drug resistance of pathogenic bacteria of the digestive tract of livestock and poultry can be effectively avoided; the compound formulation is low in prescription price and convenient to popularize and apply.

Description

technical field [0001] The invention relates to the field of veterinary drug preparations, in particular to a compound preparation for treating bacterial infection of the digestive tract of livestock and poultry and a preparation method thereof. Background technique [0002] In recent years, my country's animal husbandry industry has developed rapidly, and the number of breeding has increased year by year. However, the incidence of bacterial gastrointestinal infectious diseases in the form of enteritis, diarrhea, and dysentery has remained high. Great loss. The common clinical diseases of this kind mainly include piglet yellow and white scour, diarrhea and diarrhea, piglet paratyphoid fever, calf diarrhea, calf paratyphoid fever, poultry colibacillosis, etc. The pathogens are Escherichia coli, Salmonella, Pasteurella, etc. Lambert-negative bacteria. Because Gram-negative bacteria are prone to drug-resistant strains, some drugs will have poor efficacy after a period of use. ...

Claims

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Application Information

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IPC IPC(8): A61K38/12A61P31/04A61P1/00A61K31/46A61K31/496
Inventor 熊以宓曹典军谭武贵张雄敏石磊蔡浩
Owner 湖南慧谷农业生态研究院有限公司
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