67 results about "Procaine Hydrochloride" patented technology

A drug which is preferably usable for inhibiting inflammation in chronic and autoimmune inflammatory processes and/or produces vasodilating and sympathicolytic effects.This use is achieved through a drug from a mixture containing a local anesthetic of the ester type or amide type, preferably procaine hydrochloride, water, and at least one substance for adjusting the pH of the mixture in the range of 7.6 to 8.6. It is possible by this drug to significantly increase the injectable amount of local anesthetic compared with commercially available and known drugs containing a local anesthetic as active ingredient. The mixture can be applied continuously by subcutaneous or intravenous infusion.

Neuro-metabolic and endocrine-function regulating/modulating compositions, are disclosed. The compositions of the present invention comprise Selegiline Hydrochloride, Procaine Hydrochloride, Vinpocetine, trimethylglycine, and an ingredient selected from a group consisting of N-nicotinoyl-gamma-aminobutyric acid (N-GABA), niacin, niacinamide, gamma-aminobutyric acid (GABA), and combinations thereof. Methods of using the compositions, compositions, and compositions of the present invention are also disclosed.

The diluent for hemocyte analyzer includes sodium hydroxide 430-470 g/L, dimethylol urea 0.8-1.2 g/L, phosphoric acid 430-470 ml/L, non-ionic surfactant 0.3-0.7 g/L, procaine hydrochloride 0.09-0.13 g/L, anhydrous sodium sulfate 1.0-9.5 g/L, and sodium chloride 0.3-0.7 g/L except water. The diluent of the present invention may be used in various kinds of hemocyte analyzer.

The invention discloses a composite drug of traditional Chinese medicine and western medicine for treating coronary artery disease and hyperlipidemia and resisting aging. The drug is prepared from the following raw materials in weight portion: 10 to 37 portions of ginseng, 26 to 77 portions of polygonum multiflorum, 26 to 77 portions of rhizoma polygonati, and 15 to 51 portions of procaine hydrochloride. The drug can effectively treat the coronary artery disease and the hyperlipidemia, and can simultaneously achieve the aim of resisting aging. Besides, the drug does not have toxic side effects.

Optimum compounding composition of a local injection preparation for treating rectal submucous lesioned abnormal tissue with local anesthetic is decided to provide a medical composition kit. In a composition kit for the treatment where respective containers are unsealed upon being used and respective contents are mixed to obtain a preparation for injection, a medical composition kit which is characterized in that respective single doses of a therapeutic preparation and local anesthetic are fractionally charged in containers, the said therapeutic preparation contains 1˜10% of a water-soluble aluminum compound and 0.01˜2% of tannic acid and the said local anesthetic contains 0.1˜1% of lidocaine hydrochloride or 0.5˜5% of procaine hydrochloride.

The invention relates to a preparation method of granules for diminishing inflammation, relieving pain and promoting gastric mucosa repair. The preparation method comprises the following steps of: crushing procaine hydrochloride and cane sugar till the particle sizes of the two components can be 80 meshes; dosing and weighing, wherein gelatin is taken, and the weight ratio of gentamycin sulfate (calculated by anhydride) to procaine hydrochloride (calculated by anhydride) to vitamin B12 to the cane sugar is 20mg: 0.1g: 0.02mg: 4.81g; preparing a binding agent; granulating, wherein the procaine hydrochloride and the cane sugar are sequentially poured into a fluidized bed drying granulator, solution of the gentamycin sulfate and the vitamin B12 is sprayed into the mixture after the procaine hydrochloride and the cane sugar are fully mixed for 15 minutes, then aqueous solution of the gelatin is taken as the binding agent for spraying fluidized granulation, the granulation temperature is controlled in a range of 50+/-5 DEG C, the drying temperature is controlled in a range of 65+/-5 DEG C, the drying lasts for 20 minutes and stops after the granules are formed and then the granules are obtained; granulating; and totally mixing the granules. The preparation method has the advantage of obtaining the granules with good quality.

The invention discloses a method for producing compound procaine hydrochloride capsules. According to the method, procaine hydrochloride, glutamic acid and starch are premixed and then smashed and screened, and potassium metbisulphite, talcum powder and benzoic acid are premixed and then smashed and screened; monopotassium phosphate is dissolved in purified water to serve as a bonding agent, then a soft material is made with an efficient wet granulation machine by means of procaine hydrochloride, vitamin B6, inositol, glutamic acid and starch, granulation is conducted with a swing type granulation machine, drying is conducted, and the potassium metbisulphite, the benzoic acid and the talcum powder are added during total blending. By the adoption of the method, the problem of traditional methods that a large amount of irritating odor is generated during production is solved, prepared granules are high in mobility and dissolution rate, filling is smooth, and the manufacturing technique is more stable. Operation is easy, preparation is convenient, cost is low, and the method is suitable for industrial large-scale production.

The invention discloses a western medicine ointment for eliminating abscess. The ointment is prepared from, by weight, 5-15 parts of erythromycin; 20-30 parts of ciprofloxacin; 10-20 parts of mupirocin; 8-15 parts of polyethylene glycol; 8-15 parts of benzalkonium chloride; 5-10 parts of triethanolamine; 10-15 parts of glycerin; 5-10 parts of laurocapram; 0.1-0.5 part of ethylparaben, 1-3 parts ofsodium lauryl sulfate, 5-15 parts of benzalkonium chloride; 5-10 parts of methyl salicylate; 2-10 parts of diphenhydramine hydrochloride; 5-15 parts of procaine hydrochloride; 100-150 parts of water.The ointment is simple in formula and has effects of promoting ulcer wound healing and eliminating abscess. The ointment has the advantages of exquisite appearance, easy application, moderate consistence, heat resistance, cold resistance, rapid effect and short treatment period and meets the current use requirements.

The invention relates to the field of traditional Chinese medicines, and provides a Chinese and western medicine external patch for treating scapulohumeral periarthritis. An emplastrum is prepared from the following active ingredients and auxiliary materials in parts by weight; the active ingredients comprise 0.1 to 0.3 part of moschus, 100 to 200 parts of radix notoginseng, 50 to 100 parts of safflower, 50 to 100 parts of radix salviae miltiorrhizae, 1.2 to 1.8 parts of boric acid, 1.2 to 1.8 parts of root of cinnamomum camphora, 3 to 6 parts of dragon's blood, 1 to 5 parts of urea, 10 to 20 parts of extractum belladonnae liquidum, 0.5 to 1.5 parts of diphenhydramine hydrochloride, and 1 to 3 parts of procaine hydrochloride; the auxiliary materials comprise 280 to 350 parts of rubber, 120 to 160 parts of rosin, 350 to 450 parts of zinc oxide, 30 to 50 parts of lanolin, and 10 to 20 parts of vaseline. The emplastrum has the advantages that the effects of activating blood circulation and dredging collaterals, and sterilizing bacteria and relieving pain are realized, the emplastrum quickly takes effect, the curative effect is obvious, any side effect is avoided, the safety is high, the convenience in use is realized, and the like; the effect of treating the scapulohumeral periarthritis is obvious, and the curative rate is 92%.

The invention is a new method for measuring the content of procaine hydrochloride solution. The method is: pipetle the procaine hydrochloride solution 1.0ml precisely, and put into 100ml cylinder, adds in purified water to dilute them to the scale and acquires the sample solution, the sample solution and purified water are put into two color comparators, carries on measurement according to the operation demands of ultraviolet spectrum device UV-2550, the wavelength of the device is set as 308nm, measures the amplitude D between its first order of derivative valley and zero, then the D is substituted in the formula D=0.00252C+0.0001, the C is the content of procaine hydrochloride in solution. The method is accurate and quick.

The invention discloses a procaine hydrochloride drug intermediate p-nitrobenzoic acid synthesis method, which comprises: adding 4-nitro-6-hydroxybenzyl alcohol in a reaction container, increasing thetemperature of the solution, controlling the stirring, adding a 3-methyl-2-butanone solution and samarium oxide powder, increasing the temperature of the solution, continuously carrying out the reaction, reducing the temperature of the solution, filtering, washing multiple times with a potassium sulfate solution, washing multiple times with an oxalic acid solution, washing multiple times with a 2-chloro-2-methylpropane solution, re-crystallizing in a thiodiglycol solution, and dehydrating with a dehydrating agent to obtain the finished product p-nitrobenzoic acid.

The invention relates to musk cream for promoting blood circulation to remove blood stasis and a hot press molding method thereof. The musk cream for promoting blood circulation to remove blood stasisis prepared from the following components in parts by weight: 1-3 parts of muskone, 8-12 parts of boric acid, 5-8 parts of camphor, 30-35 parts of sanguis draconis, 15-20 parts of urea, 110-120 partsof belladonna fluid extract, 4-7 parts of diphenhydramine hydrochloride, 10-14 parts of procaine hydrochloride, 400-500 parts of an extract for promoting blood circulation to remove blood stasis, 2000-2100 parts of rubber, 900-1000 parts of rosin, 2600-2700 parts of zinc oxide, 210-230 parts of lanolin, 90-110 parts of petroleum jelly and 260-280 parts of 95% ethanol. The hot press method comprises the steps of cutting a sizing material, refining the sizing material, kneading, filtering, baking the sizing material and gluing. The musk cream for promoting blood circulation to remove blood stasis, prepared by the method disclosed by the invention, is easy for gluing because the sizing material is soft, a product has great cohesive force and strengthened adhesion, and has no residual residueon skin after application, and the curative effect is good; a preparation process is simple, achieves high production efficiency and low cost, can meet safe production conditions, and is suitable formass production.

The invention discloses a swelling and pain relieving ointment, relates to the technical field of external ointment and aims to solve the problems that existing ointments have single components and cannot remove root causes. The ointment is prepared from raw materials as follows: Vaseline, erythromycin, mupirocin, borneol, iodine tincture, glycerin, laurocapram, procaine hydrochloride, diphenhydramine hydrochloride and traditional Chinese medicine composition. The invention also discloses a preparation method of the swelling and pain relieving ointment. The prepared ointment is fine in appearance, easy to coat, medium in thickness and resistant to cold and heat and has the functions of promoting healing of ulcer wounds and removing abscess, Vaseline is used as a matrix, borneol fully playsthe role in relieving pain and promoting granulation, iodine tincture and erythromycin inhibit bacteria and diminish inflammation, traditional Chinese medicines are added for matched use, so that theointment has effects of dredging collaterals, reducing phlegm, resolving masses, promoting blood circulation to remove blood stasis and relieving swelling and pain, western medicines and traditionalChinese medicines have a synergistic effect, the swelling and pain relieving effect is better, and the ointment has wide market prospects.

The invention aims at providing a preparation method of a medicine for treating respiratory system infection of livestock and poultry. The medicine has rapid and accurate treatment effects on respiratory system infection and complications of livestock and poultry. The medicine is prepared by the following steps: mixing and crushing 0.2 part of trimethoprim and 0.2 part of a cosolvent, and then sieving the mixture through a 120-mesh sieve or a finer sieve; and uniformly mixing the sieved product with 1 part of tylosin tartrate, 1 part of kanamycin sulfate and 0.05-0.1 part of a pain reliever by a method of progressively increasing by equal quantity, wherein the cosolvent is citric acid, succinic acid or a compound of the two, and the pain reliever is procaine hydrochloride, lidocaine hydrochloride or a compound of the two. The synergism compound tylosin tartrate for livestock injection provided by the invention contains three components, namely the tylosin tartrate, kanamycin sulfate and trimethoprim; the problem that secondary infection cannot be well controlled due to the narrow antibacterial spectrum of the tylosin tartrate when mycoplasma infection is treated can be solved; the problem that the trimethoprim is poorly soluble in water can be solved, a synergism effect of the tylosin tartrate and kanamycin sulfate can be achieved, and the medicine has an obvious treatment effect.

The invention provides a pharmaceutical composition for treating piles, which is a suppository. The invention also provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following components in parts by weight: 80-120 parts of berberine hydrochloride, 7-20 parts of procaine hydrochloride, 1.5-4.2 parts of hydrocortisone, 7-18 parts of borneol, 3.5-6.5 parts of menthol and 1000 parts of fat-soluble matrix. The pharmaceutical composition can directly reach piles infected part through rectal administration, thus the side effect of enterohepatic circulation due to oral administration is reduced. The pharmaceutical composition for treating piles provided by the invention can be used for solving the defect that oral administration is slow in acting for diseases in intestine, can substitute for the traditional operative treatment, is convenient to use and does not damage organisms.

The present invention discloses an anesthetic oral liquid for gastric surgery, and a preparation method thereof. The anesthetic oral liquid for the gastric surgery comprises the following raw materials in parts by weight: 0.5 part-1 part of cannabidiol, 0.6 part-0.8 part of propofol, 3 parts-4 parts of a traditional Chinese medicine extract, 0.2 part-0.4 part of procaine hydrochloride, 2 parts-3 parts of vitamin E, 4 parts-6 parts of ascorbic acid, 0.5 part-1 part of sodium hydrogencarbonate, 0.5 part-1 part of anhydrous lactose, 5-8 parts of phospholipids, 1 part-3 parts of a co-solvent and 66 parts-75 parts of purified water. The present invention relates to the technical field of the gastric surgery. The anesthetic oral liquid for the gastric surgery has a very good local anesthetic effect on the stomach, is also very small in side effects, reduces harms caused by anesthetic medicines to patients, reduces unsafety of the patients during use, improves therapeutic effects of the patients to a certain extent, has strong practicability, and is high in raw material solubility during the preparation and long in storage time.

The invention provides a gastrodin injection and a preparation process thereof, and the gastrodin injection can be used for reducing white spots and white blocks occurring during storage, improving the clarity, guaranteeing the safety of medication and meanwhile guaranteeing better stability. According to the gastrodin injection and the preparation process thereof, lactose, procaine hydrochloride, sodium hyposulfite, niacinamide and glycine are used as auxiliary materials; the white spots and the white blocks occurring during storage can be reduced, the clarity can be improved and the safety of medication can be guaranteed after proportioning; but meanwhile, we found that the gastrodine content is obviously reduced after the gastrodin injection is stored for a period of time after the auxiliary materials are added; after the addition sequence of the auxiliary material is adjusted by using the special technology, the content of the gastrodine in the gastrodin injection is still stable after long-time storage, so that the validity of the clinical medication is guaranteed.

The invention provides procaine penicillin as well as a preparation method, an impurity and an impurity control method thereof. The content of an RRT 0.24 impurity in the procaine penicillin is less than 0.13%. According to the preparation method, the content of an RRT0.24 impurity in a used raw material procaine hydrochloride is controlled to be not higher than 0.05%, and the RRT0.24 impurity is 2-{[2-(4-aminobenzoyloxy) ethyl] (ethyl) amino} ethyl-4-aminobenzoate. The content y of the RRT 0.24 impurity in the product procaine penicillin and the content x of the RRT 0.24 impurity in the raw material procaine hydrochloride meet a linear relation model y = 2.4835 x, wherein the model R2 = 0.9546. The invention discloses a novel impurity of procaine penicillin, which plays an important role in quality control of procaine penicillin.