33 results about "Enterohepatic circulation" patented technology

The invention discloses an artificial bear bile powder and a preparation method thereof. The preparation method comprises the following steps: a) dissolving poultry bile powder with a buffer solution of pH=7-9 and then filtering to obtain filter residue and filtrate; b ) adding the filtrate to a reactor equipped with 7α-hydroxysteroid dehydrogenase, 7β-hydroxysteroid dehydrogenase and coenzyme I or coenzyme II for reaction; c) freeze-drying the reaction solution after the reaction and combining with the The filter residue is mixed to obtain artificial bear bile powder. The present invention completely uses natural sources of poultry bile as the raw material for artificial bear bile, without adding other chemical substances, and adopts common animal bile, and its bile source is easy to collect, obtain, and process; through in vitro simulation of the enterohepatic circulation process , to bioconvert poultry bile into artificial bear bile powder that is chemically equivalent to natural bear bile powder, as a substitute for natural bear bile, to protect the endangered Asian black bear, and to promote the healthy development of the bear bile industry.

The invention discloses traditional Chinese medicine fructus sophorae suppository for treating the hemorrhoid hematochezia, which is prepared by mixing 650-900 parts of suppository base with alcohol extracts as medicinal active ingredients, wherein the alcohol extracts are prepared from stir-baked fructus sophorae, charred radix sanguisorbae, baikal skullcap root, stir-baked fruit of trifoliate orange, angelica and divaricate saposhnikovia root. The fructus sophorae suppository disclosed by the invention is modern novel traditional Chinese medicine preparation prepared by the prescription of the traditional fructus sophorae pill preparation, and has the effects of clearing intestine and dispelling wind, and dispelling heat from blood and stopping bleeding. The traditional Chinese medicinefructus sophorae suppository has local functions, mainly has the effects of lubrication, antibiosis, inflammation diminishing, itching relieving and the like and is convenient to use, nonirritant, easy to be accepted by sufferers. In addition, the traditional Chinese medicine fructus sophorae suppository can be further absorbed by chamber mucous membranes to join the blood circulation so as to realize the general action, such as analgesia, stimulation and the like; furthermore, the traditional Chinese medicine fructus sophorae suppository can not be subjected to enterohepatic circulation, thefirst pass effect of medicines is avoided, and the toxic or side effect of the medicines on the liver is also avoided.

The invention discloses a mangiferin cholic acid derivative, its preparation method and application, and discloses its chemical structure and chemical synthesis method. The mangiferin derivatives prepared by the present invention have liver-targeting properties, and can be targetedly accumulated in the liver and gallbladder through the enterohepatic circulation mechanism of cholic acid, thereby increasing the drug concentration and improving the ability of the mangiferin cholic acid derivatives to inhibit hepatobiliary inflammation. Effect.