33 results about "Enterohepatic circulation" patented technology

The invention discloses artificial bear gall powder and a preparation method thereof. The preparation method comprises the following steps: step (a) dissolving livestock gall powder by using a buffer solution of which the pH value is equal to 7-9 and then filtering to obtain filter residues and a filtrate; step (b) adding the filtrate into a reactor filled with 7alpha-hydroxyl steroid dehydrogenase, 7beta-hydroxyl steroid dehydrogenase and coenzyme I or coenzyme II and reacting; step (c) after the reaction ends, freeze-drying a reaction liquid and then mixing the freeze-dried reaction liquid with the filter residues to obtain the artificial bear gall powder. According to the preparation method disclosed by the invention, completely natural livestock gall is taken as a raw material for preparing the artificial bear gall, no other chemical substances are added, common animal gall is adopted and a gall source is easy to pick, obtain and process; through an in-vitro enterohepatic circulation simulation process, the livestock gall is biologically transformed into the artificial bear gall powder which is equivalent to natural bear gall powder in chemistry, and the artificial bear gall powder is used as a natural bear gall replacement to protect the endangered animal Asian black bear and promote healthy development of the bear gall industry.

The invention belongs to the technical field of biological medicine, and particularly relates to an oral surface modification bile acid granule, composition of entrapped treatment medicine in the granule and a preparation method. Firstly, a positively charged compound of entrapped treatment medicine is prepared; then, a bile acid polymer with negative ions is used for coupling to form granules. Abile acid-phospholipid compound is inserted into a wrapped granule surface to form the bile acid modified granule. The medicine wrapped granule can be lipidosome, micelle, emulsion, microspheres, nanometer particles and the like. After the granule is orally taken in the body, the granule is selectively absorbed into blood in the intestinal tract under the effect of enterohepatic circulation; the bioavailability of oral medicine can be improved. The medicine is prepared from gene, protein, polypeptide, antibodies, nucleic acid, viruses and small molecule medicine.

The invention provides an assorted feed for preventing the liver of a tilapia from becoming yellow. The assorted feed has balanced nutrition, and has good growth promotion effect to the tilapia on the basis of meeting normal growth nutrition demands of the tilapia, feed coefficient is reduced, and water deterioration or standard exceeding of water quality cannot be caused easily; meanwhile, serum bilirubin content of the tilapia in a high-temperature feeding period can be reduced effectively, and hepatoenteral circulation of bile is promoted; and activities of glutamic oxalacetic transaminase and glutamic-pyruvic transaminase of serum of the tilapia in the high-temperature feeding period are reduced, and activity of lysozyme of the serum is increased.

The present invention pertains to the technical field of pharmaceutical preparations. The present invention provides a kind of nano calcium carbonate enteric-coated bioadhesive tablets and their preparation method. The enteric-coated bioadhesive tablets contain the following ingredients: a) the tablet core made from nano calcium carbonate and usable minor ingredients; b) the enteric coating layer made from polyacrylic resin enteric coating material and the minor ingredients that can be used as pharmaceuticals. There are two types of tablet cores. One is bioadhesive prescription granule and the other is disintegrating granule. The nano calcium carbonate enteric-coated bioadhesive tablets prepared by the present invention possess the features of positioning, fast disintegration and bioadhesion. The main medicine is not released in stomach. After entering duodenum, the coating layer will be quickly removed. The disintegrating granule in tablet core makes the tablet core disintegrated in a short time, and the bioadhesive granule clings to the upper section of small intestine for a long time and plays a role of interrupting the enterohepatic circulation of lead; in addition, this nano calcium carbonate enteric-coated bioadhesive tablet has very good extraneous releasing effect and stability and may be developed into a new-type lead removing pharmaceutical.

A preparation comprising a compound which essentially prevents the enterohepatic circulation of nucleotide synthesis inhibitors or antagonizes the action of the nucleotide synthesis inhibitors with a displacement in time, and a nucleotide synthesis inhibitor such as brequinar, mycophenolatemofetil (2-morpholinoethyl (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-4-methyl-4-hexenoate), methotrexate, mizoribine and compounds of formulae (I) and (II)

is suitable for the treatment of immunological disorders, cancer, or in transplantations.

The invention discloses traditional Chinese medicine fructus sophorae suppository for treating the hemorrhoid hematochezia, which is prepared by mixing 650-900 parts of suppository base with alcohol extracts as medicinal active ingredients, wherein the alcohol extracts are prepared from stir-baked fructus sophorae, charred radix sanguisorbae, baikal skullcap root, stir-baked fruit of trifoliate orange, angelica and divaricate saposhnikovia root. The fructus sophorae suppository disclosed by the invention is modern novel traditional Chinese medicine preparation prepared by the prescription of the traditional fructus sophorae pill preparation, and has the effects of clearing intestine and dispelling wind, and dispelling heat from blood and stopping bleeding. The traditional Chinese medicine fructus sophorae suppository has local functions, mainly has the effects of lubrication, antibiosis, inflammation diminishing, itching relieving and the like and is convenient to use, nonirritant, easy to be accepted by sufferers. In addition, the traditional Chinese medicine fructus sophorae suppository can be further absorbed by chamber mucous membranes to join the blood circulation so as to realize the general action, such as analgesia, stimulation and the like; furthermore, the traditional Chinese medicine fructus sophorae suppository can not be subjected to enterohepatic circulation, the first pass effect of medicines is avoided, and the toxic or side effect of the medicines on the liver is also avoided.

The invention relates to a synthetic method of 13C marked glycocholic acid, and the method comprises the following steps: under the protection of nitrogen, 13C marked glycine benzyl ester hydrochloride and cholic acid are mixed and dissolved in a polar solvent, then coupling reagent is added, the reaction temperature is controlled between minus 20 and 150DEG C, the reaction time is 0.1 to 120h, and then the product is obtained after separation and purification by a silica gel column. The method adopts the coupling agent to synthesize the 13C marked glycocholic acid, the yield of the glycocholic acid can achieve above 80 percent, the abundance of 13C can achieve 99atm%, the optical purity can achieve 98 percent, and the chemical purity can achieve 98 percent. The obtained 13C marked glycocholic acid can be used as medical diagnosis reagent and can be used for enterohepatic circulation of the cholic acid, overgrowth of intestinal bacteria, activity evaluation of bacterial metabolism andthe like.

The present invention belongs to the field of food production and specifically discloses a nutritional composition for lowering blood lipids. The nutritional composition comprises the following components in percentages by mass: 40-60% of cured cereal flour and maltodextrin, 15-35% of trachinotus ovatus peptide powder and defatted milk powder, 10-20% of fruit and vegetable powder, and 2-5% of sodium carboxymethylcellulose. Trachinotus ovatus is subjected to enzymatic hydrolysis, the zymolytic trachinotus ovatus is centrifuged, the centrifuged trachinotus ovatus is ultra-filtered, and the ultra-filtered trachinotus ovatus is dried to obtain the trachinotus ovatus peptide powder. The provided cured cereal flour and fruit and vegetable powder are rich in dietary fibers, the added sodium carboxymethylcellulose can further enhance the colloidal system of dietary fibers in the intestinal tract and is compounded with the trachinotus ovatus peptide powder, so that the nutritional composition can obviously reduce the hepatoenteral circulation of bile acids, increase the discharge of the bile acids with faeces, and achieve the purpose of lowering blood lipids. The nutritional composition can be used as health-care food, special medical use recipe food and common food, and is suitable for the use of high blood lipid and sub-health populations who are busy in work and tense in life paces.

The invention discloses infant jaundice removing Yao medicine bubble bath liquid, which is prepared from the following ingredients in parts by weight: 30 to 120 parts of beautiful phyllodium branchlet and leaves, 20 to 100 parts of fructus gardeniae, 20 to 100 parts of herba boltoniae indicae, 30 to 120 parts of honeysuckle stems, 30 to 120 parts of cortex nauclea officinalis and 30 to 120 parts of herba artemisiae capillaris. The invention also discloses a preparation method of the infant jaundice removing Yao medicine bubble bath liquid. The matching of the whole recipe is precise and appropriate; the efficacies of clearing heat, promoting diuresis and removing toxicity and jaundice are achieved; warm water bubble bath is combined, so that the functions of promoting the gastrointestinal peristalsis, promoting the defecation and reducing the bilirubin enterohepatic circulation are realized; a better jaundice removing effect is achieved. In the whole recipe, the liniment is used as the major ingredient; the wind-dispelling and liniment effects are achieved; the evil is eliminated without body resistance damage; the idea of wind deficiency and liniment fullness and the fullness and deficiency balance of Yao medicine is sufficiently realized.

The invention relates to an internal lead removal oral preparation, in particular to a weakly agglomerated carbonate powdery oral preparation and an administration method thereof. A main component of the oral preparation is carbonate capable of performing precipitation and displacement reaction with lead ions. After the preparation is swallowed, nanometer calcium carbonate is distributed on the endomembrane of the intestine, precipitation and displacement reaction is performed on calcium ions and the lead ions to generate lead carbonate with low water solubility to block the lead ions from being recovered by means of enterohepatic circulation, and the lead carbonate is excreted along with feces in the intestinal tract. According to the oral preparation, a lead removal medicament or a lead removal healthcare product is prepared from the calcium carbonate, is free of obvious toxic or side effects on a human body, and has a good dispersion effect and a good lead removal effect.

The invention discloses application of prevotella in preparation of a medicine for treating cholestatic diseases. The cholestatic diseases include, but is not limited to, primary sclerosing cholangitis. After the inventor constructs a PSC animal model, it is determined that the abundance of P.copri in mice is consistently reduced in the same population, then intervention effects of P.copri on inflammation, fibrosis, cholestasis and the like of the PSC model are observed and evaluated through intragastric administration for one week and daily supplementation of 1*10<8> CFU of P.copri bacterial liquid, bile acid metabolism changes are determined through total bile acid determination and targeted bile acid detection analysis, and the action mechanism is analyzed. Experiments prove that the P.copri can obviously relieve cholestasis in hepatointestinal circulation of PSC mice and obviously improve liver fibrosis, which is of great significance to prevention or treatment of cholestatic diseases.

The invention provides a pharmaceutical composition for treating piles, which is a suppository. The invention also provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following components in parts by weight: 80-120 parts of berberine hydrochloride, 7-20 parts of procaine hydrochloride, 1.5-4.2 parts of hydrocortisone, 7-18 parts of borneol, 3.5-6.5 parts of menthol and 1000 parts of fat-soluble matrix. The pharmaceutical composition can directly reach piles infected part through rectal administration, thus the side effect of enterohepatic circulation due to oral administration is reduced. The pharmaceutical composition for treating piles provided by the invention can be used for solving the defect that oral administration is slow in acting for diseases in intestine, can substitute for the traditional operative treatment, is convenient to use and does not damage organisms.

The invention discloses a traditional Chinese medicine enema for treating non-alcoholic steatohepatitis as well as a preparation method and application method of the traditional Chinese medicine enema. The traditional Chinese medicine enema consists of the following raw material drugs: herba artemisiae scopariae, radix paeoniae rubra, radix salviae miltiorrhizae, flos carthami, semen persicae, radix bupleuri, radix paeoniae alba, rheum officinale, radix scutellariae, radix astragali, poria cocos, roasted rhizome atractylodis macrocephalae, rhizoma corydalis and fructus toosendan. The drugs aredirectly absorbed through intestinal mucosae by virtue of a retention enema method based on a ''gut-liver axis'' theory, so that damage caused by gastric acid and digestive juice to the drugs is reduced, and the utilization rate of drugs is increased; toxic metabolites and toxins in enteric cavities and on the intestinal mucosae can be directly eliminated, intestinal florae can be regulated, thesituation that toxic substances enter livers through enterohepatic circulation can be avoided, clinical symptoms and signs of patients can be effectively relieved, liver functions and blood lipid parameters of can be reduced, the intestinal florae can be improved, and the non-alcoholic steatohepatitis can be effectively prevented and treated. Besides, the traditional Chinese medicine enema can beindependently used and can be combined with other drugs and treatment methods for use.

The invention relates to a radiation resistant lozenge developed through compatibility of a medicinal and edible herbal essence extract of sea-tangle, wolfberry fruit, Folium Ginkgo, cassia seed, chrysanthemum, dahurian angelica root, Corsvenor Momordica Fruit and licorice root with edible glucose. The main component flavonoid compound of the radiation resistant lozenge has the functions of oxidation resistance, free radical removal, body immunity enhancement, cardiovascular and cerebrovascular circulation improvement, platelet aggregation enzyme (PAF), mutation resistance and ageing resistance. The radiation resistant lozenge is obtained by using the radiation resistance strength and the functions and effects of traditional Chinese medicines according to a traditional Chinese medicinal monarch, minister, assistant and guide principle, and has comprehensive efficacies and effects. The dosage form in the invention is lozenge because the extracted radiation resistant herbal essence and the edible glucose can be directly absorbed into bodies through oral mucosa capillary vessels, and the lozenge can directly act on throat, head and face, and can reduce and avoid the consumption of enterohepatic circulation due to oral administration.

The invention, which belongs to the medicine field, relates to development for a tanshinol-naringenin composite pellet. Tanshinol being a water-soluble component of the root of red-rooted salvia being Chinese medicine is effective in treating angina pectoris. At present, most of tanshinol preparations being available in the market are immediate-release dosage forms that can not satisfy the demand of long-term therapy for angina pectoris; the bioavailability, being lower than 10%, of the preparation is low and the metabolism is fast, wherein t1/2 is equal to 0.5h approximately; and the pure sustained-release pellet can not keep enough blood concentration for long time and thus is not effective in treating angina pectoris. Besides, naringenin is capable of inhibiting activity of P450enzymeCYP3A4; and after taking of the naringenin with tanshinol, the metabolic process of the tanshinol in vivo can be inhibited, so that the bioavailability of tanshinol is enhanced and the plasma clearance is reduced. Therefore, according to development provided by the invention, tanshinol and naringenin are prepared into a composite pellet. In addition, enterohepatic circulation exists during oral naringenin taking and thus a long-acting effect can be realized by an immediate-release dosage form, so that the naringenin is prepared into an immediate-release pellet and the tanshinol is prepared into a sustained-release pellet.

The invention provides an animal in-vitro loading device which comprises a base body, a first flow guide pipe, a second flow guide pipe and a surface-enhanced Raman substrate; at least two channels penetrating through the base body are arranged in the base body; the first flow guide pipe is connected to the base body, communicates with one ends of the channels and is used for introducing fluid into the channels; the second flow guide pipe is connected to the base body, communicates with the other ends of the channels and is used for leading out fluid in the channels; the surface-enhanced Raman substrate is arranged on the inner wall of one of the passages, so that a target component in the fluid is attached to the surface of the surface-enhanced Raman substrate; and a transparent window is formed in the position, corresponding to the surface-enhanced Raman substrate, of the base body, so that Raman spectrum laser beams can penetrate through the transparent window to detect target components attached to the surface-enhanced Raman substrate. According to the invention, the bile liquid retention property is good, the influence on the liver-intestine circulation is small, the surface enhanced Raman spectrum technology is combined, a drug target component in the bile can be rapidly detected, and the efficient bile sampling and detection integration is achieved.

The present invention relates to the synthesis and use of a novel trifluorinated bile acid analog, that being, CA-sar-TFMA which is useful as an imaging probe, diagnostic agent or contrast agent and is resistant to bacterial deconjugation, wherein the trifluorinated bile acid analog can be used as a ¹⁹F MRI tracer exhibiting an increased half-life due to its resistance to choloylglycine hydrolase.

The invention discloses a metabolic method of a human body fat-soluble substance, which belongs to the technical field of human body substance metabolism, and the method comprises the following steps:a fat-soluble substance is converted from a solid state to a liquid state; the liquefied fat-soluble substances are dissolved in the blood, so that the transportation of the fat-soluble substances bythe blood is facilitated; the fat-soluble substance leaves the blood vessel and enters the gallbladder through the liver; fiber food is eaten before meal, liver and intestine circulation is broken, reabsorption of the fat-soluble substances is reduced, and the fat-soluble substances are discharged out of the body through the intestinal tract. The problem that the metabolic effect of fat-soluble substances in a human body is poor is solved, the fat-soluble substances can be metabolized out of a human body, so that the occurrence of vascular embolism is reduced, and the incidence probability ofcardiovascular diseases is reduced; the damage of the fat-soluble substances to the human body is reduced, and meanwhile, the fat metabolism capability can be remarkably improved.

The invention discloses the use of a silicon dioxide mesoporous material in the preparation of an antidote for treating heavy metal poisoning, and provides the use of a new medicament for stopping enterohepatic circulation for treating heavy metal poisoning. The silicon dioxide material has a mesoporous structure; the internal and external surfaces of the mesopores are modified and connected withfunctional groups having sulfydryls; and the silicon dioxide mesoporous material is prepared into the antidote for absorbing heavy metals in the gastrointestinal tract.

The invention provides a pharmaceutical composition and an application thereof. The pharmaceutical composition comprises the following components in parts by weight: 10-100 parts of Indian damnacanthus herb and 10-100 parts of cichorium intybus; the pharmaceutical composition containing Indian damnacanthus herb and cichorium intybus is used for treating fatty liver; the Indian damnacanthus herb and the cichorium intybus have a synergistic effect, liver and intestine circulation is obviously improved, on one hand, the Indian damnacanthus herb repairs the liver, on the other hand, the cichoriumintybus prevents enterotoxin from further damaging the liver, liver and intestine treatment is achieved, and the effect of the pharmaceutical composition is larger than the sum of the Indian damnacanthus herb effect and the cichorium intybus effect; furthermore, the pharmaceutical composition has no dependence, and is safe, reliable, low in cost and easy to popularize and apply.