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37 results about "Enterohepatic circulation" patented technology
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Enterohepatic circulation refers to the circulation of biliary acids, bilirubin, drugs or other substances from the liver to the bile, followed by entry into the small intestine, absorption by the enterocyte and transport back to the liver. Enterohepatic circulation is an especially important concept in the field of toxicology as many lipophilic xenobiotics undergo this process causing repeated liver damage.
Artificial bear gall powder and preparation method thereof
ActiveCN104382941AEasy to processGallbladder source is easy to getSenses disorderAntipyreticEnterohepatic circulationNatural source
The invention discloses artificial bear gall powder and a preparation method thereof. The preparation method comprises the following steps: step (a) dissolving livestock gall powder by using a buffer solution of which the pH value is equal to 7-9 and then filtering to obtain filter residues and a filtrate; step (b) adding the filtrate into a reactor filled with 7alpha-hydroxyl steroid dehydrogenase, 7beta-hydroxyl steroid dehydrogenase and coenzyme I or coenzyme II and reacting; step (c) after the reaction ends, freeze-drying a reaction liquid and then mixing the freeze-dried reaction liquid with the filter residues to obtain the artificial bear gall powder. According to the preparation method disclosed by the invention, completely natural livestock gall is taken as a raw material for preparing the artificial bear gall, no other chemical substances are added, common animal gall is adopted and a gall source is easy to pick, obtain and process; through an in-vitro enterohepatic circulation simulation process, the livestock gall is biologically transformed into the artificial bear gall powder which is equivalent to natural bear gall powder in chemistry, and the artificial bear gall powder is used as a natural bear gall replacement to protect the endangered animal Asian black bear and promote healthy development of the bear gall industry.
Owner:SHANGHAI KAIBAO PHARMA
A kind of artificial bear bile powder and preparation method thereof
ActiveCN104382941BEasy to processGallbladder source is easy to getSenses disorderAntipyreticEnterohepatic circulationNatural source
Owner:SHANGHAI KAIBAO PHARMA
Bile acid modified oral granule
InactiveCN108379230AOrganic active ingredientsPeptide/protein ingredientsEnterohepatic circulationOral Granules
The invention belongs to the technical field of biological medicine, and particularly relates to an oral surface modification bile acid granule, composition of entrapped treatment medicine in the granule and a preparation method. Firstly, a positively charged compound of entrapped treatment medicine is prepared; then, a bile acid polymer with negative ions is used for coupling to form granules. Abile acid-phospholipid compound is inserted into a wrapped granule surface to form the bile acid modified granule. The medicine wrapped granule can be lipidosome, micelle, emulsion, microspheres, nanometer particles and the like. After the granule is orally taken in the body, the granule is selectively absorbed into blood in the intestinal tract under the effect of enterohepatic circulation; the bioavailability of oral medicine can be improved. The medicine is prepared from gene, protein, polypeptide, antibodies, nucleic acid, viruses and small molecule medicine.
Owner:北京凯宾鸿生物医药科技有限公司
Micro-fluidic chip for screening hepatoenteral circulation drugs
InactiveCN103981094AMiniaturizationAchieve integrationLaboratory glasswaresTissue/virus culture apparatusEnterohepatic circulationHigh flux
The invention belongs to the fields of the biochemistry, the analysis chemistry, machining and drug screening, and relates to a micro-fluidic chip for screening hepatoenteral circulation drugs. The micro-fluidic chip is formed by four basic units, each of the basic units comprises a fluid inlet, a fluid outlet and a cell culture pool; the cell culturing pool of each of the basic unit I, the basic unit II and the basic unit III is a circle with the diameter of 5mm, and the cell culture pool of the basic unit IV is provided with cylindrical fences; and the micro-fluidic chip concretely comprises, from top to bottom, the basic unit I, a colon cancer cell film, a blood vessel endothelial cell film, the basic unit II, the basic unit III, a blood vessel endothelial cell film, the basic unit IV, a hepatocyte film and a chip. The micro-fluidic hepatoenteral circulation chip adopts multi-layer basic unit integration, complex fluid control and multiple microstructure design to realize the micromation, the integration and the rapid high flux of the screening of the hepatoenteral circulation drugs.
Owner:DALIAN UNIV OF TECH
Assorted feed for preventing liver of tilapia from becoming yellow
InactiveCN105724839AGood growth promoting effectLower serum bilirubin levelsClimate change adaptationAnimal feeding stuffEnterohepatic circulationGrowth promotion
The invention provides an assorted feed for preventing the liver of a tilapia from becoming yellow. The assorted feed has balanced nutrition, and has good growth promotion effect to the tilapia on the basis of meeting normal growth nutrition demands of the tilapia, feed coefficient is reduced, and water deterioration or standard exceeding of water quality cannot be caused easily; meanwhile, serum bilirubin content of the tilapia in a high-temperature feeding period can be reduced effectively, and hepatoenteral circulation of bile is promoted; and activities of glutamic oxalacetic transaminase and glutamic-pyruvic transaminase of serum of the tilapia in the high-temperature feeding period are reduced, and activity of lysozyme of the serum is increased.
Owner:GUANGZHOU PANYU DACHUAN FEED
Nano calcium carbonate enteric-coated bioadhesive tablets and their preparation method
InactiveCN101543482ADisintegrates quicklyProlong the displacement reaction timeAntinoxious agentsPharmaceutical delivery mechanismEnterohepatic circulationAdditive ingredient
The present invention pertains to the technical field of pharmaceutical preparations. The present invention provides a kind of nano calcium carbonate enteric-coated bioadhesive tablets and their preparation method. The enteric-coated bioadhesive tablets contain the following ingredients: a) the tablet core made from nano calcium carbonate and usable minor ingredients; b) the enteric coating layer made from polyacrylic resin enteric coating material and the minor ingredients that can be used as pharmaceuticals. There are two types of tablet cores. One is bioadhesive prescription granule and the other is disintegrating granule. The nano calcium carbonate enteric-coated bioadhesive tablets prepared by the present invention possess the features of positioning, fast disintegration and bioadhesion. The main medicine is not released in stomach. After entering duodenum, the coating layer will be quickly removed. The disintegrating granule in tablet core makes the tablet core disintegrated in a short time, and the bioadhesive granule clings to the upper section of small intestine for a long time and plays a role of interrupting the enterohepatic circulation of lead; in addition, this nano calcium carbonate enteric-coated bioadhesive tablet has very good extraneous releasing effect and stability and may be developed into a new-type lead removing pharmaceutical.
Owner:THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
Preparation having improved therapeutic breadth comprising nucleotide synthesis inhibitors
InactiveUS20050255071A1Reduce actionImprove toleranceBiocideCosmetic preparationsEnterohepatic circulationDisease
A preparation comprising a compound which essentially prevents the enterohepatic circulation of nucleotide synthesis inhibitors or antagonizes the action of the nucleotide synthesis inhibitors with a displacement in time, and a nucleotide synthesis inhibitor such as brequinar, mycophenolatemofetil (2-morpholinoethyl (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-4-methyl-4-hexenoate), methotrexate, mizoribine and compounds of formulae (I) and (II) is suitable for the treatment of immunological disorders, cancer, or in transplantations.
Owner:AVENTIS PHARMA DEUTLAND
Traditional Chinese medicine fructus sophorae suppository for treating hemorrhoid hematochezia and preparation method thereof
ActiveCN102078417AAvoid first pass effectAvoid side effectsDigestive systemSuppositories deliveryEnterohepatic circulationSide effect
The invention discloses traditional Chinese medicine fructus sophorae suppository for treating the hemorrhoid hematochezia, which is prepared by mixing 650-900 parts of suppository base with alcohol extracts as medicinal active ingredients, wherein the alcohol extracts are prepared from stir-baked fructus sophorae, charred radix sanguisorbae, baikal skullcap root, stir-baked fruit of trifoliate orange, angelica and divaricate saposhnikovia root. The fructus sophorae suppository disclosed by the invention is modern novel traditional Chinese medicine preparation prepared by the prescription of the traditional fructus sophorae pill preparation, and has the effects of clearing intestine and dispelling wind, and dispelling heat from blood and stopping bleeding. The traditional Chinese medicine fructus sophorae suppository has local functions, mainly has the effects of lubrication, antibiosis, inflammation diminishing, itching relieving and the like and is convenient to use, nonirritant, easy to be accepted by sufferers. In addition, the traditional Chinese medicine fructus sophorae suppository can be further absorbed by chamber mucous membranes to join the blood circulation so as to realize the general action, such as analgesia, stimulation and the like; furthermore, the traditional Chinese medicine fructus sophorae suppository can not be subjected to enterohepatic circulation, the first pass effect of medicines is avoided, and the toxic or side effect of the medicines on the liver is also avoided.
Owner:SHANXI ZHENDONG PHARMA
Synthetic method of 13C marked glycocholic acid
The invention relates to a synthetic method of 13C marked glycocholic acid, and the method comprises the following steps: under the protection of nitrogen, 13C marked glycine benzyl ester hydrochloride and cholic acid are mixed and dissolved in a polar solvent, then coupling reagent is added, the reaction temperature is controlled between minus 20 and 150DEG C, the reaction time is 0.1 to 120h, and then the product is obtained after separation and purification by a silica gel column. The method adopts the coupling agent to synthesize the 13C marked glycocholic acid, the yield of the glycocholic acid can achieve above 80 percent, the abundance of 13C can achieve 99atm%, the optical purity can achieve 98 percent, and the chemical purity can achieve 98 percent. The obtained 13C marked glycocholic acid can be used as medical diagnosis reagent and can be used for enterohepatic circulation of the cholic acid, overgrowth of intestinal bacteria, activity evaluation of bacterial metabolism andthe like.
Owner:SHANGHAI RES INST OF CHEM IND
Nutritional composition for lowering blood lipids and application thereof
ActiveCN106173853ADecreased enterohepatic circulationEasy dischargePeptide/protein ingredientsMetabolism disorderEnterohepatic circulationFeces
The present invention belongs to the field of food production and specifically discloses a nutritional composition for lowering blood lipids. The nutritional composition comprises the following components in percentages by mass: 40-60% of cured cereal flour and maltodextrin, 15-35% of trachinotus ovatus peptide powder and defatted milk powder, 10-20% of fruit and vegetable powder, and 2-5% of sodium carboxymethylcellulose. Trachinotus ovatus is subjected to enzymatic hydrolysis, the zymolytic trachinotus ovatus is centrifuged, the centrifuged trachinotus ovatus is ultra-filtered, and the ultra-filtered trachinotus ovatus is dried to obtain the trachinotus ovatus peptide powder. The provided cured cereal flour and fruit and vegetable powder are rich in dietary fibers, the added sodium carboxymethylcellulose can further enhance the colloidal system of dietary fibers in the intestinal tract and is compounded with the trachinotus ovatus peptide powder, so that the nutritional composition can obviously reduce the hepatoenteral circulation of bile acids, increase the discharge of the bile acids with faeces, and achieve the purpose of lowering blood lipids. The nutritional composition can be used as health-care food, special medical use recipe food and common food, and is suitable for the use of high blood lipid and sub-health populations who are busy in work and tense in life paces.
Owner:SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
Infant jaundice removing Yao medicine bubble bath liquid and preparation method thereof
InactiveCN107095922APowerful medicineMedicinal and calmDigestive systemPharmaceutical delivery mechanismEnterohepatic circulationAdditive ingredient
The invention discloses infant jaundice removing Yao medicine bubble bath liquid, which is prepared from the following ingredients in parts by weight: 30 to 120 parts of beautiful phyllodium branchlet and leaves, 20 to 100 parts of fructus gardeniae, 20 to 100 parts of herba boltoniae indicae, 30 to 120 parts of honeysuckle stems, 30 to 120 parts of cortex nauclea officinalis and 30 to 120 parts of herba artemisiae capillaris. The invention also discloses a preparation method of the infant jaundice removing Yao medicine bubble bath liquid. The matching of the whole recipe is precise and appropriate; the efficacies of clearing heat, promoting diuresis and removing toxicity and jaundice are achieved; warm water bubble bath is combined, so that the functions of promoting the gastrointestinal peristalsis, promoting the defecation and reducing the bilirubin enterohepatic circulation are realized; a better jaundice removing effect is achieved. In the whole recipe, the liniment is used as the major ingredient; the wind-dispelling and liniment effects are achieved; the evil is eliminated without body resistance damage; the idea of wind deficiency and liniment fullness and the fullness and deficiency balance of Yao medicine is sufficiently realized.
Owner:广西艳日辉瑶药瑶浴产品开发有限公司
Internal lead removal oral preparation and administration method thereof
ActiveCN107496447ANovel Application IdeasImprove bioavailabilityPharmaceutical delivery mechanismAntinoxious agentsIntestinal structureSolubility
The invention relates to an internal lead removal oral preparation, in particular to a weakly agglomerated carbonate powdery oral preparation and an administration method thereof. A main component of the oral preparation is carbonate capable of performing precipitation and displacement reaction with lead ions. After the preparation is swallowed, nanometer calcium carbonate is distributed on the endomembrane of the intestine, precipitation and displacement reaction is performed on calcium ions and the lead ions to generate lead carbonate with low water solubility to block the lead ions from being recovered by means of enterohepatic circulation, and the lead carbonate is excreted along with feces in the intestinal tract. According to the oral preparation, a lead removal medicament or a lead removal healthcare product is prepared from the calcium carbonate, is free of obvious toxic or side effects on a human body, and has a good dispersion effect and a good lead removal effect.
Owner:XIANGYA HOSPITAL CENT SOUTH UNIV
Synthetic method of 13C marked glycocholic acid
The invention relates to a synthetic method of 13C marked glycocholic acid, and the method comprises the following steps: under the protection of nitrogen, 13C marked glycine benzyl ester hydrochloride and cholic acid are mixed and dissolved in a polar solvent, then coupling reagent is added, the reaction temperature is controlled between minus 20 and 150DEG C, the reaction time is 0.1 to 120h, and then the product is obtained after separation and purification by a silica gel column. The method adopts the coupling agent to synthesize the 13C marked glycocholic acid, the yield of the glycocholic acid can achieve above 80 percent, the abundance of 13C can achieve 99atm%, the optical purity can achieve 98 percent, and the chemical purity can achieve 98 percent. The obtained 13C marked glycocholic acid can be used as medical diagnosis reagent and can be used for enterohepatic circulation of the cholic acid, overgrowth of intestinal bacteria, activity evaluation of bacterial metabolism andthe like.
Owner:SHANGHAI RES INST OF CHEM IND
Application of prevotella in preparation of medicine for treating cholestatic diseases
PendingCN113509494AReduce sedimentationImprove fibrosisBacteria material medical ingredientsDigestive systemEnterohepatic circulationBile Juice
The invention discloses application of prevotella in preparation of a medicine for treating cholestatic diseases. The cholestatic diseases include, but is not limited to, primary sclerosing cholangitis. After the inventor constructs a PSC animal model, it is determined that the abundance of P.copri in mice is consistently reduced in the same population, then intervention effects of P.copri on inflammation, fibrosis, cholestasis and the like of the PSC model are observed and evaluated through intragastric administration for one week and daily supplementation of 1*10<8> CFU of P.copri bacterial liquid, bile acid metabolism changes are determined through total bile acid determination and targeted bile acid detection analysis, and the action mechanism is analyzed. Experiments prove that the P.copri can obviously relieve cholestasis in hepatointestinal circulation of PSC mice and obviously improve liver fibrosis, which is of great significance to prevention or treatment of cholestatic diseases.
Owner:NANJING MEDICAL UNIV
Pharmaceutical composition for treating piles as well as preparation method and application thereof
ActiveCN102579569AAnti-inflammatoryHas pain reliefHydroxy compound active ingredientsCardiovascular disorderIntestinal structureDisease
The invention provides a pharmaceutical composition for treating piles, which is a suppository. The invention also provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following components in parts by weight: 80-120 parts of berberine hydrochloride, 7-20 parts of procaine hydrochloride, 1.5-4.2 parts of hydrocortisone, 7-18 parts of borneol, 3.5-6.5 parts of menthol and 1000 parts of fat-soluble matrix. The pharmaceutical composition can directly reach piles infected part through rectal administration, thus the side effect of enterohepatic circulation due to oral administration is reduced. The pharmaceutical composition for treating piles provided by the invention can be used for solving the defect that oral administration is slow in acting for diseases in intestine, can substitute for the traditional operative treatment, is convenient to use and does not damage organisms.
Owner:BEIJING RECTUM HOSPITAL
Traditional Chinese medicine enema for treating non-alcoholic steatohepatitis as well as preparation method and application method of traditional Chinese medicine enema
ActiveCN111375004ASmall toxicityNo side effectsDigestive systemPharmaceutical delivery mechanismMetaboliteWolfiporia extensa
The invention discloses a traditional Chinese medicine enema for treating non-alcoholic steatohepatitis as well as a preparation method and application method of the traditional Chinese medicine enema. The traditional Chinese medicine enema consists of the following raw material drugs: herba artemisiae scopariae, radix paeoniae rubra, radix salviae miltiorrhizae, flos carthami, semen persicae, radix bupleuri, radix paeoniae alba, rheum officinale, radix scutellariae, radix astragali, poria cocos, roasted rhizome atractylodis macrocephalae, rhizoma corydalis and fructus toosendan. The drugs aredirectly absorbed through intestinal mucosae by virtue of a retention enema method based on a ''gut-liver axis'' theory, so that damage caused by gastric acid and digestive juice to the drugs is reduced, and the utilization rate of drugs is increased; toxic metabolites and toxins in enteric cavities and on the intestinal mucosae can be directly eliminated, intestinal florae can be regulated, thesituation that toxic substances enter livers through enterohepatic circulation can be avoided, clinical symptoms and signs of patients can be effectively relieved, liver functions and blood lipid parameters of can be reduced, the intestinal florae can be improved, and the non-alcoholic steatohepatitis can be effectively prevented and treated. Besides, the traditional Chinese medicine enema can beindependently used and can be combined with other drugs and treatment methods for use.
Owner:黑龙江省医院
Radiation resistant lozenge
The invention relates to a radiation resistant lozenge developed through compatibility of a medicinal and edible herbal essence extract of sea-tangle, wolfberry fruit, Folium Ginkgo, cassia seed, chrysanthemum, dahurian angelica root, Corsvenor Momordica Fruit and licorice root with edible glucose. The main component flavonoid compound of the radiation resistant lozenge has the functions of oxidation resistance, free radical removal, body immunity enhancement, cardiovascular and cerebrovascular circulation improvement, platelet aggregation enzyme (PAF), mutation resistance and ageing resistance. The radiation resistant lozenge is obtained by using the radiation resistance strength and the functions and effects of traditional Chinese medicines according to a traditional Chinese medicinal monarch, minister, assistant and guide principle, and has comprehensive efficacies and effects. The dosage form in the invention is lozenge because the extracted radiation resistant herbal essence and the edible glucose can be directly absorbed into bodies through oral mucosa capillary vessels, and the lozenge can directly act on throat, head and face, and can reduce and avoid the consumption of enterohepatic circulation due to oral administration.
Owner:谢金魁 +1
A nutritional composition for reducing blood fat and its application
ActiveCN106173853BIncrease contentGood effect of lowering blood fatPeptide/protein ingredientsMetabolism disorderBiotechnologyCellulose
The present invention belongs to the field of food production and specifically discloses a nutritional composition for lowering blood lipids. The nutritional composition comprises the following components in percentages by mass: 40-60% of cured cereal flour and maltodextrin, 15-35% of trachinotus ovatus peptide powder and defatted milk powder, 10-20% of fruit and vegetable powder, and 2-5% of sodium carboxymethylcellulose. Trachinotus ovatus is subjected to enzymatic hydrolysis, the zymolytic trachinotus ovatus is centrifuged, the centrifuged trachinotus ovatus is ultra-filtered, and the ultra-filtered trachinotus ovatus is dried to obtain the trachinotus ovatus peptide powder. The provided cured cereal flour and fruit and vegetable powder are rich in dietary fibers, the added sodium carboxymethylcellulose can further enhance the colloidal system of dietary fibers in the intestinal tract and is compounded with the trachinotus ovatus peptide powder, so that the nutritional composition can obviously reduce the hepatoenteral circulation of bile acids, increase the discharge of the bile acids with faeces, and achieve the purpose of lowering blood lipids. The nutritional composition can be used as health-care food, special medical use recipe food and common food, and is suitable for the use of high blood lipid and sub-health populations who are busy in work and tense in life paces.
Owner:SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
A traditional Chinese medicine enema for treating non-alcoholic steatohepatitis and its preparation method and application method
ActiveCN111375004BSmall toxicityNo side effectsDigestive systemPharmaceutical delivery mechanismEnterohepatic circulationMetabolite
The invention discloses a traditional Chinese medicine enema for treating non-alcoholic steatohepatitis and its preparation method and application method. . Based on the theory of "gut-liver axis", the present invention adopts the method of retention enema to make the drug directly absorbed through the intestinal mucosa, reduce the damage to the drug by gastric acid and digestive juice, and increase the utilization rate of the drug; it can also directly remove the intestinal cavity and intestinal mucosa Toxic metabolites and toxins in the body, adjust the intestinal flora, and prevent toxic substances from entering the liver through the enterohepatic circulation, which can effectively relieve the clinical symptoms and signs of patients, reduce liver function and blood lipid indicators, improve intestinal flora, and effectively prevent and treat non-alcoholic Steatohepatitis. In addition, the traditional Chinese medicine enema of the present invention can be used alone or in combination with other medicines and treatment methods.
Owner:黑龙江省医院
Development for tanshinol-naringenin composite pellet
InactiveCN106474091APromote dissolutionGuaranteed uniformityOrganic active ingredientsPharmaceutical delivery mechanismEnterohepatic circulationSalvia miltiorrhiza
The invention, which belongs to the medicine field, relates to development for a tanshinol-naringenin composite pellet. Tanshinol being a water-soluble component of the root of red-rooted salvia being Chinese medicine is effective in treating angina pectoris. At present, most of tanshinol preparations being available in the market are immediate-release dosage forms that can not satisfy the demand of long-term therapy for angina pectoris; the bioavailability, being lower than 10%, of the preparation is low and the metabolism is fast, wherein t1 / 2 is equal to 0.5h approximately; and the pure sustained-release pellet can not keep enough blood concentration for long time and thus is not effective in treating angina pectoris. Besides, naringenin is capable of inhibiting activity of P450enzymeCYP3A4; and after taking of the naringenin with tanshinol, the metabolic process of the tanshinol in vivo can be inhibited, so that the bioavailability of tanshinol is enhanced and the plasma clearance is reduced. Therefore, according to development provided by the invention, tanshinol and naringenin are prepared into a composite pellet. In addition, enterohepatic circulation exists during oral naringenin taking and thus a long-acting effect can be realized by an immediate-release dosage form, so that the naringenin is prepared into an immediate-release pellet and the tanshinol is prepared into a sustained-release pellet.
Owner:CHINA PHARM UNIV
Pharmaceutical composition for treating piles as well as preparation method and application thereof
ActiveCN102579569BAnti-inflammatoryHas pain reliefHydroxy compound active ingredientsCardiovascular disorderDiseaseEnterohepatic circulation
The invention provides a pharmaceutical composition for treating piles, which is a suppository. The invention also provides a preparation method and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following components in parts by weight: 80-120 parts of berberine hydrochloride, 7-20 parts of procaine hydrochloride, 1.5-4.2 parts of hydrocortisone, 7-18 parts of borneol, 3.5-6.5 parts of menthol and 1000 parts of fat-soluble matrix. The pharmaceutical composition can directly reach piles infected part through rectal administration, thus the side effect of enterohepatic circulation due to oral administration is reduced. The pharmaceutical composition for treating piles provided by the invention can be used for solving the defect that oral administration is slow in acting for diseases in intestine, can substitute for the traditional operative treatment, is convenient to use and does not damage organisms.
Owner:BEIJING RECTUM HOSPITAL
Traditional Chinese medicine monomer nanoparticle oral delivery system based on intestinal liver circulation and preparation method and application thereof
The invention discloses a traditional Chinese medicine monomer nanoparticle oral delivery system based on intestinal liver circulation and a preparation method thereof, spherical nanoparticles (SA NPs) with the particle size of 194 + / -20 nm are formed through self-assembly of threat resin acid (SA), and the limitation of a traditional nano carrier is broken through: the oral bioavailability reaches 34.7% by utilizing an ASBT-mediated intestinal liver circulation mechanism; the gastric acid environment is tolerated (the pH is stable at 1.5), and after penetrating through the intestinal epithelium, the drug is targeted to ischemic brain tissues; the medicine has carrier-medicine dual functions, and the cerebral infarction volume is reduced by 34.1% when the medicine is singly used; after the neuroprotective peptide NA1 is loaded (the drug loading capacity is 5.8 wt%), the infarct volume is reduced by 68.7% through synergism. The system is suitable for pre-hospital first aid of cerebral apoplexy, and the freeze-dried powder can be stored at normal temperature for 12 months. The delivery system has a great application prospect in preparation of drugs for treating acute ischemic stroke needing rapid brain targeting.
Owner:HUBEI PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE (AFFILIATED HOSPITAL OF HUBEI UNIV OF TRADITIONAL CHINESE MEDICINE HUBEI INST OF TRADITIONAL CHINESE MEDICINE)
Animal in-vitro loading device
PendingCN114062341AEfficient sampling and detection integrationSolve easy lossRaman scatteringEnterohepatic circulationSurface-enhanced Raman spectroscopy
The invention provides an animal in-vitro loading device which comprises a base body, a first flow guide pipe, a second flow guide pipe and a surface-enhanced Raman substrate; at least two channels penetrating through the base body are arranged in the base body; the first flow guide pipe is connected to the base body, communicates with one ends of the channels and is used for introducing fluid into the channels; the second flow guide pipe is connected to the base body, communicates with the other ends of the channels and is used for leading out fluid in the channels; the surface-enhanced Raman substrate is arranged on the inner wall of one of the passages, so that a target component in the fluid is attached to the surface of the surface-enhanced Raman substrate; and a transparent window is formed in the position, corresponding to the surface-enhanced Raman substrate, of the base body, so that Raman spectrum laser beams can penetrate through the transparent window to detect target components attached to the surface-enhanced Raman substrate. According to the invention, the bile liquid retention property is good, the influence on the liver-intestine circulation is small, the surface enhanced Raman spectrum technology is combined, a drug target component in the bile can be rapidly detected, and the efficient bile sampling and detection integration is achieved.
Owner:SHANGHAI INST OF PLANNED PARENTHOOD RES
Traditional Chinese medicine fructus sophorae suppository for treating hemorrhoid hematochezia and preparation method thereof
ActiveCN102078417BLittle side effectsReduce first pass effectDigestive systemSuppositories deliveryEnterohepatic circulationSide effect
Owner:SHANXI ZHENDONG PHARMA
Compositions and methods to evaluate hepatobiliary/gastrointestinal health, enterohepatic circulation, and drug interactions
ActiveUS9597417B2Improve efficiencyOrganic active ingredientsNMR/MRI constrast preparationsEnterohepatic circulationDrug interaction
The present invention relates to the synthesis and use of a novel trifluorinated bile acid analog, that being, CA-sar-TFMA which is useful as an imaging probe, diagnostic agent or contrast agent and is resistant to bacterial deconjugation, wherein the trifluorinated bile acid analog can be used as a 19F MRI tracer exhibiting an increased half-life due to its resistance to choloylglycine hydrolase.
Owner:THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
Novel intestinal probiotic butyric acid monad and application thereof
The invention discloses a novel intestinal probiotic butyric acid monad and application thereof, the novel intestinal probiotic butyric acid monad is preserved in Guangdong Microbiological Culture Collection Center, and the preservation number is GDMCC No.67648. A mouse model proves that the butyric acid monad can promote synthesis of intestinal TMP (Trimethoprim) by remodeling intestinal steady state, and then the TMP is converted into thiamine. Through intestinal liver circulation, thiamine accumulates in the liver and is further converted into TPP. The process promotes the degradation of BCAs, further regulates the lipid metabolism of the liver, and obviously alleviates the progress of metabolic dysfunction related fatty liver diseases induced by high fat diet.
Owner:QINGDAO UNIV +1
Medicinal and edible formula detoxification powder as well as preparation method and application thereof
The invention provides detoxification powder with a medicinal and edible formula as well as a preparation method and application of the detoxification powder, and relates to the technical field of detoxification powder preparation. The detoxifying powder comprises the following components in parts by weight: 9-10 parts of coffee, 3-5 parts of dandelions, 3-4 parts of oysters, 3-4 parts of honeysuckle flowers, 1-3 parts of Chinese wolfberry fruits, 1-2 parts of cape jasmine fruits, 1-2 parts of rhizoma polygonati, 1-2 parts of dried ginger, 1-2 parts of cinnamon, 1-2 parts of peach kernels, 1-2 parts of Chinese yams, 1-1.5 parts of dried orange peel and 1-1.5 parts of licorice roots. The invention also provides a preparation method of the medicinal and edible formula detoxification powder. The preparation method comprises the following steps: screening raw materials, removing impurities, cleaning, drying, crushing, sieving, mixing, sterilizing, filling and packaging. The detoxification powder developed by the invention breaks through the limitation of single detoxification, realizes triple synergistic removal of enterotoxin, liver toxin and blood toxin, and solves the problem of incomplete local detoxification in the prior art by utilizing a liver-intestine circulation physiological pathway.
Owner:CHONGQING BAISUI HEALTH TECHNOLOGY CO LTD
A kind of oral preparation for removing lead in vivo and administration method thereof
ActiveCN107496447BNo side effectsGood dispersionAntinoxious agentsPharmaceutical delivery mechanismEnterohepatic circulationLead carbonate
The invention relates to an internal lead removal oral preparation, in particular to a weakly agglomerated carbonate powdery oral preparation and an administration method thereof. A main component of the oral preparation is carbonate capable of performing precipitation and displacement reaction with lead ions. After the preparation is swallowed, nanometer calcium carbonate is distributed on the endomembrane of the intestine, precipitation and displacement reaction is performed on calcium ions and the lead ions to generate lead carbonate with low water solubility to block the lead ions from being recovered by means of enterohepatic circulation, and the lead carbonate is excreted along with feces in the intestinal tract. According to the oral preparation, a lead removal medicament or a lead removal healthcare product is prepared from the calcium carbonate, is free of obvious toxic or side effects on a human body, and has a good dispersion effect and a good lead removal effect.
Owner:XIANGYA HOSPITAL CENT SOUTH UNIV
Application of tribaquidone sulfonate and its geniposide composition in the preparation of medicines
ActiveCN106866696BSolve the problem of poor curative effect in single applicationLittle side effectsNervous disorderOrganic chemistryEnterohepatic circulationSide effect
The invention relates to sauchinone sulfonate or sauchinone and geniposide (or jasminoidin) composition and application thereof in preparing liver protection medicine or senile dementia medicine. The sauchinone or geniposide has the problems of poor absorption, quick elimination, low enterohepatic circulation and bioavailability and the like when being independently applied to pharmacological activity of protecting liver or treating senile dementia; thus, sauchinone sulfonate or sauchinone and geniposide are pharmacologically combined and applied; the problems that the sauchinone and the geniposide have poor curative effects when being independently applied are solved; the sauchinone sulfonate or sauchinone and geniposide composition has an accurate curative effect and a small side effect, especially sodium sauchinone sulfonate and geniposide injection has a very accurate curative effect for treating hepatitis or liver damage or senile dementia, and the sodium sauchinone sulfonate or sauchinone and geniposide composition can be applied to intravenous administration.
Owner:张忠立
A kind of mangiferin cholic acid derivative and its preparation method and application
ActiveCN110540572BEasy to synthesizeHas liver-targeting propertiesAntipyreticDigestive systemEnterohepatic circulationCholic acid
The invention discloses a mangiferin cholic acid derivative, its preparation method and application, and discloses its chemical structure and chemical synthesis method. The mangiferin derivatives prepared by the present invention have liver-targeting properties, and can be targetedly accumulated in the liver and gallbladder through the enterohepatic circulation mechanism of cholic acid, thereby increasing the drug concentration and improving the ability of the mangiferin cholic acid derivatives to inhibit hepatobiliary inflammation. Effect.
Owner:GUANGXI UNIV OF CHINESE MEDICINE