54 results about "Gut dysbiosis" patented technology

The invention belongs to the technical field of intestinal flora regulation composition, and provides a preparation for increasing probiotics in intestinal tract and modifying intestinal flora in order to solve the problem of imbalanced intestinal flora and reduction of ratio of beneficial bacteria in intestine tracts. The preparation is prepared from dendrobium officinale, astragalus membranaceus, lily, red dates, white peony roots, fructus psoraleae and herba epimedii according to certain ratio. The preparation can be processed into oral liquids and also can be processed into other dose forms, such as effervescent tablets. The preparation can effectively increase the quantity of probiotics in intestinal tract, effectively reducing pathogenic bacteria and vibrio desulphuricans causing inflammation and obesity, and Clostridum XIVa causing intestinal necrosis of animals. In the formula, plant polysaccharides, such as dendrobium officinale polysaccharides, red date polysaccharides and astragalus polysaccharides, are compounded, so that the preparation has effects of balancing Yin-Yang and modifying the structure of the intestinal flora. The preparation is suitable for middle-aged andsenior people and sub-health people, and also is suitable for modification on disordered intestinal flora in diabetic patients, especially type-II diabetic patients.

The present invention provides methods for determining if a patient is likely to benefit from a cancer treatment, by determining if said patient has a gut dysbiosis with an over representation of certain bacterial species. The present invention also provides probiotic strains to improve the efficacy of a cancer treatment, especially chemotherapy, in patients in need thereof.

The invention provides application of a wild jujube leaf total flavonoid extract in preparation of a medicine for preventing and treating alteration of intestinal flora. According to the invention, rats with alteration of intestinal flora caused by D-galactose are taken as research objects, and the intestinal flora regulation effect of the wild jujube leaf total flavone extract is studied. Rat experiment results show that supplementing of the wild jujube leaf total flavonoid extract can prevent alteration of intestinal flora in the D-galactose induced aging process, for example, increase of intestinal flora diversity, rise of bacteroides, decrease of phylum palustre, and decrease of lactobacillus are realized, and the proportion and composition of phylum palustre and bacteroides tend to anormal control group.

The invention relates to metabolism of enteric microorganisms and phenylalanine and phenylpyruvic acid of the enteric microorganisms, and provides a composition containing phenyllactic acid or salts of phenyllactic acid and phenylpyruvic acid or salts of phenylpyruvic acid and used for preventing or / and treating insulin resistance and related diseases, use of the composition in preparation of a medicine or food for improving, preventing or treating insulin resistance and related diseases, and a method for preventing or treating insulin resistance and related diseases. The related diseases include intestinal dysbacteriosis, metabolic syndrome, obesity, diabetes, podagra and tumors.

The invention provides a preparation method of a mice intestinal flora alteration ERIC-PCR (Enterobacterial Repetitive Intergenic Consensus sequence-based Polymerase Chain Reaction) fingerprint spectrum. The preparation method comprises the steps: moulding mice intestinal flora alteration caused by antibacterial-associated diarrhea, extracting a cecum content DNA, eliminating humic acid in the cecum content DNA, eliminating a PCR inhibitor in the cecum content DNA, performing ERIC-PCR amplification and native polyacrylamide gel electrophoresis (Native-PAGE), and comparing with a conventional flora analysis result so as to establish the ERIC-PCR fingerprint spectrum of the mice intestinal flora alteration. According to the preparation method, with a pure-series mice as a research object, the defect caused when a conventional bacterium culturing method is applied to the microflora analysis is solved. The preparation method can be used for rapid detection of the laboratory mice intestinal flora alteration, prevents the defects of complicated operation, long time consumption, large workload and the like of conventional bacterium separation and culturing, and is capable of accurately, rapidly and effectively detecting the mice intestinal flora distribution condition.

The invention discloses lactobacillus plantarum H6 for efficiently lowering an in-vivo cholesterol level. The lactobacillus plantarum H6 is collected in General Microorganisms Center of China Committee for Culture Collection of Microorganisms and has a collection number of CGMCC No. 18205. The lactobacillus plantarum H6 can be used for effectively improving alteration of intestinal florae and liver injury induced by high-cholesterol diets.

The invention discloses a probiotic preparation for conditioning intestinal flora imbalance of tumor patients after radiotherapy and chemotherapy and an application thereof, and relates to the technical field of probiotic preparations. The probiotic preparation comprises probiotics, vitamins, trace elements, proteins, traditional Chinese medicine extract, sugar and auxiliary components. The probiotics comprise the following components in parts by mass: 10 to 25 parts of bifidobacterium longum, 10 to 15 parts of bifidobacterium breve, 10 to 35 parts of bifidobacterium bifidum, 10 to 25 parts ofbifidobacterium adolescentis, 10 to 25 parts of lactobacillus acidophilus, 10 to 35 parts of lactobacillus fermentum, 10 to 20 parts of lactobacillus paracasei, 10 to 30 parts of lactobacillus plantarum, 10 to 15 parts of lactobacillus rhamnosus and 5 to 10 parts of streptococcus thermophilus.

The invention discloses application of bacillus coagulans in preparation of food or medicine for improving body function decline caused by hyperglycemia and hyperlipidemia, and belongs to the field of microbial strains. The invention discloses bacillus coagulans which is preserved in China General Microbiological Culture Collection Center (CGMCC) on November 10, 2021, the preservation number is CGMCC No.23766, and the preservation address is Institute of Microbiology, Chinese Academy of Sciences, No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The strain has a certain effect on relieving weight rise, inflammatory response, tissue fat accumulation, memory ability decline, intestinal short-chain fatty acid reduction and intestinal flora imbalance caused by high-glucose and high-fat diet, and provides a new raw material and direction for screening food, health care products or medicines for regulating and controlling body function decline caused by hyperlipidemia and hyperglycemia.

The invention relates to application of an Ovularia raphanipes extract in pharmaceutical field, in particular to application of the Ovularia raphanipes extract in preparation of preparations used for treating and / or preventing diseases related to alteration of an intestinal florae. The Ovularia raphanipes extract not only can be obviously beneficial to structure recovery of dominant florae in intestinal tracts and beneficial to flora diversification but also shows obvious treatment and / or prevention effect on diseases related to structure of the intestinal flora, for example, expression of an inflammatory factor can be effectively inhibited, deterioration of inflammation is effectively alleviated, and various immunity-associated physiological and pathological indexes are improved. Meanwhile, in a main body with the structure of the intestinal florae destroyed due to factors such as containing of excessive antibiotics, symptoms such as ulceration and inflammation exacerbation of the intestines are observed, and the Ovularia raphanipes extract can effectively alleviate symptoms such as ulcerative colitis of the main body, maintain integrity of the intestinal florae of the main body, has obvious repairing effect, can be used in various fields such as medicines, health products and the like and has economic and social values.

The invention relates to an application of an edible fungus extract in preparing a preparation for treating and / or preventing intestinal flora disorder and related diseases, in particular to an application of a birch mushroom extract in preparing a preparation for treating and / or preventing intestinal flora disorder and related diseases. The preparation method is simple and easy to implement, and low in operation cost; and an extraction solvent in the preparation method can be recycled, so that the residual risk of an organic reagent is avoided, the natural quality of the birch mushroom extract is ensured, and the method is environment-friendly, and belongs to a green manufacturing technology. According to the invention, the raw materials are completely extracted, the raw materials are fully utilized, and the utilization rate of the raw materials is high. The birch mushroom extract not only can obviously contribute to the recovery of the dominant flora structure in an intestinal tract and the diversity of a flora, but also has obvious treatment and / or prevention effects on diseases related to the flora structure of the intestinal tract, can be used in various fields such as medicines, health care products and the like, and has great economic and social values.

The invention relates to a use of an edible fungus extract in preparing a preparation for treating and / or preventing intestinal flora disorder and related diseases, in particular to a use of a russuleextract in preparing a preparation for treating and / or preventing the intestinal flora disorder and related diseases. The preparation method is simple and easy to implement and low in operation cost;and an extraction solvent in the preparation method can be recycled, so that the residual risk of an organic reagent is avoided, the natural quality of the ressule extract is ensured, the preparationmethod is environment-friendly, and the preparation method belongs to a green manufacturing technology. According to the invention, the raw materials are completely extracted, the raw materials are fully utilized, and the utilization rate of the raw materials is high. The russule extract not only can obviously contribute to the recovery of the dominant flora structure in a intestinal tract and the diversity of the flora, but also has obvious treatment and / or prevention effects on diseases related to the flora structure of the intestinal tract, can be used in various fields such as medicines,health care products and the like, and has great economic and social values.

The invention refers to the use of pharmaceutical and food compositions containing Melatonin, a yeast (belonging to the Saccharomyces family) and a bacterium (belonging to the Lactobacillus, Bifidobacterium, Streptococcus families) for use in the treatment of disorders associated with vaginal and intestinal diseases caused by altered balance in the flora (dysbiosis), which are useful for reducing inflammation due to local and systemic infections caused by the excessive growth of pathogenic microorganisms.

The invention relates to a microecological preparation and a preparation method and application thereof. The microecological preparation comprises the following components in parts by mass of 2-35 parts of a rosa roxburghii tratt extract, 2-35 parts of a fig extract, 1-20 parts of composite microorganism bacterium powder, 5-45 parts of composite oligosaccharide, 20-50 parts of auxiliary protective carriers and 0.05-0.3 part of essence. According to the microecological preparation disclosed by the invention, the rosa roxburghii tratt extract and the fig extract are added, so that growth and propagation of probiotics can be promoted, further the probiotics can always maintain sufficient viable count in the quality guarantee period, the quality guarantee period is prolonged, the probiotics have longer strain vitality period, the microecological environment of the whole intestine can be better improved, and the digestion promoting effect can be better improved; and the microecological preparation has the effects of preventing and treating intestinal tract diseases and treating diarrhea caused by disorder of intestinal flora, chronic diarrhea, diarrhea refractory through antibiotics, constipation, dyspepsia, abdominal distension and the like, can recover intestinal flora balance, protect livers and strengthen the functions of the livers for removing toxicity and expelling toxin, and has various disease-preventing and disease-resisting functions of reducing blood sugar, reducing blood lipid, strengthening human body resistibility and the like.

The invention relates to the technical field of food. The composition for regulating and improving intestinal flora imbalance is prepared by mixing isomaltooligosacharide, inulin, lactitol, fructo-oligosaccharide, lactobacillus plantarum, stachyose, resistant dextrin, bifidobacterium lactis, bifidobacterium bifidum, lactobacillus acidophilus, bifidobacterium longum, bifidobacterium breve and lactobacillus rhamnosus. Compared with the prior art, the composition disclosed by the invention has the following beneficial effects that the composition disclosed by the invention starts from reasons such as constant value of probiotics in intestinal tracts and repair of intestinal mucosal barrier injury, and achieves the purpose of effectively regulating and improving diseases related to intestinal dysbacteriosis through mutual cooperation and synergistic effect of all the components; auxiliary materials such as cane sugar, maltodextrin, pigment and essence are not added, meanwhile, prebiotics and dietary fibers are added, colonization of probiotics in intestinal tracts is promoted, and the functional food is safe and reliable and can be used as functional food for improving intestinal flora disorder diseases after being eaten for a long time.

The invention relates to a pueraria flower extract for improving intestinal microecological imbalance. Specifically, the invention provides an application of the pueraria flower extract, the pueraria flower extract is used for preparing a composition, and the composition is used for improving intestinal microecological imbalance. The pueraria flower extract can be used for preventing and treating intestinal flora imbalance caused by oral administration of antibiotics.

The invention relates to low-calorie baking food with a healthcare function and a preparation method thereof. The low-calorie baking food is prepared by mixing the following raw materials in parts by weight: 50-65 parts of flour, 5-10 parts of rice protein powder, 1-3 parts of corn peptide, 5-10 parts of egg liquid, 1-3 parts of trehalose, 1-3 parts of fructo-oligosaccharide, 1-3 parts of sorbitol, 0.5-1 part of erythritol, 0.2-0.4 part of baking powder and 5-10 parts of liquid butter. The low-calorie baking food which is prepared by scientifically and effectively mixing the formula tastes sweet, fresh and cool, is not sweet greasy, is low-calorie, and has the functions of promoting the digestion, adjusting the alteration of intestinal flora and improving the memory; meanwhile, the auxiliary protection effect on cardiovascular diseases such as hypertension, hyperlipidemia and hyperglycemia can be achieved, the immunity of a human body is improved, and the low-calorie baking food has the healthcare function, so that a new healthier food choice is provided for masses of consumers.

The present invention relates to methods of enhancing the potency of incretin-based drugs in subjects in need thereof. Through different animal models, the inventors identified that a specific gut microbiota signature impairs GLP-1-activated gut-brain axis which could be transferred to germ free mice. The dysbiotic gut microbiota induces enteric neuropathy, reduces GLP-1 receptor and nNOS mRNA concentration, GLP-1-induced nitric oxide production for the control of insulin secretion and gastric emptying. The frequency of Lactobacilli in the ileum microbiota was tightly correlated with nMOS mRNA concentration, which is a mode of action of GLP-1, of the enteric nervous system opening a novel route for the improvement of GLP-1 based therapies in type 2 diabetic patients. In particular, the present invention relates to a method of enhancing the potency of an incretin-based drug administered to a diabetic subject as part of a treatment regimen.

The invention provides application of a mesona chinensis extract in preparation of drugs or health-care products for regulating intestinal flora and relates to the technical field of traditional Chinese medicines. According to the application, experiments prove that the mesona chinensis extract can be used for regulating an intestinal flora structure of a high-fat rat, promoting growth of beneficial bacteria, i.e., akkermansia muciniphila, improving a ratio of firmicutes / bacteroidetes, regulating the content of short-chain fatty acids, improving disorder of the intestinal florae, promoting metabolism of fats and inhibiting accumulation of the fats, thereby playing a role in reducing blood fat and protecting liver.

The invention relates to use of an edible fungi extract in preparing a preparation for treatment and / or prevention of alteration of intestinal flora and related diseases, in particular to the use of acordyceps sobolifera alkaline water extract in preparing the preparation for treatment and / or prevention of alteration of intestinal flora and related diseases. A preparation method is simple and easy to operate and low in operation cost. An extraction solvent in the preparation method uses only alkaline water, no risk of residual organic reagents exists, the natural quality of a cordyceps sobolifera is ensured, and the extract is environmentally friendly and belongs to the green manufacturing technology. The cordyceps sobolifera alkaline water extract not only can obviously contribute to therecovery of the dominant flora structure in the intestinal tract and the diversification of the flora, but also shows an obvious treatment and / or prevention effect on related diseases of the intestinal flora structure, for example, the extract can effectively alleviate the deterioration of inflammation, improve various physiological and pathological indicators related to immunity, can be used invarious fields such as medicines and health care products and have great economic and social value.

The invention discloses an antibiotic-free feed additive for preventing and controlling calf diarrhea as well as a preparation method and a use method of the antibiotic-free feed additive, and relates to the antibiotic-free feed additive for preventing and controlling the calf diarrhea as well as the use method of the antibiotic-free feed additive. The invention aims to solve the technical problems that in the current prevention and control of calf diarrhea, the drug resistance of bacteria is gradually increased, beneficial microorganisms in digestive tracts can be inhibited or killed by using antibiotics, intestinal flora imbalance is caused, the resistance of calves is reduced, visceral organs such as livers and kidneys are damaged, and the illness state is aggravated. The sodium humate and the attapulgite powder have high adsorption capacity, and can effectively inhibit reproduction of enteropathogenic bacteria and adsorb toxins generated by the enteropathogenic bacteria; glutamine provides energy for proliferation and development of intestinal epithelial cells; and the xylooligosaccharide and the probiotics can regulate the intestinal microenvironment, improve the intestinal flora, increase the intestinal probiotics and reduce the number of intestinal pathogenic bacteria. Therefore, the product can effectively prevent and control calf diarrhea by improving the physical barrier and the biological barrier of the calf intestinal tract to protect the intestinal tract health.

Described herein are compositions and methods for delivering microbial therapeutic agents useful for the treatment of conditions associated with dysbacteriosis of intestinal flora. In various aspects, the present invention provides compositions and methods useful for treating or preventing inflammatory bowel disease (IBD) in a subject in need thereof. For example, the present invention relates, in part, to a plurality of bacterial isolates wherein at least two of the plurality of bacterial isolates are isolated from faeces of different human donors.

The present invention discloses an application of a pleurotus eryngii mycelium polysaccharide from solid-state fermentation (PESF). The active polysaccharide (PESF) with a hypolipidemic function is produced by a solid-state fermentation method of pleurotus eryngii mycelia. In a mouse model in vivo hypolipidemic mechanism, an oral administration of a certain dose of the PESF can regulate intestinalmicroflora, significantly promotes growth of Lactobacillus and inhibits major micro-organism genus of staphylococcus, corynebacterium, aerococcus, etc., thus restores intestinal flora imbalance caused by a high-fat diet to a certain degree, finally inhibits absorption of exogenous lipids in intestinal tract, and thus reduces accumulation of blood lipids and liver lipids in body. The pleurotus eryngii polysaccharide is analyzed and confirmed to have biofunctional activity of regulating structure and functions of the intestinal microflora, and a significant correlation is found between polysaccharide hypolipidemic activity and polysaccharide intestinal microflora-regulating function.

Described herein are compositions and methods for delivering microbial therapeutic agents useful for the treatment of conditions associated with dysbacteriosis of intestinal flora. Described herein are compositions and methods for protecting the gastrointestinal microbiome in a subject. In various embodiments, provided herein are pharmaceutical compositions comprising isolated or purified bacterial isolates and / or mixtures of isolated or purified bacterial isolates (e.g., faeces from humans, e.g., from healthy humans).

The invention belongs to the technical field of probiotic fermented foods, and particularly discloses a probiotic fermented food for regulating intestinal health and a preparation method thereof. The probiotic fermented food is prepared from, by weight, 60-80 parts of broomcorn millet powder, 10-30 parts of plum powder, 5-15 parts of mango peel and 0.2-6 parts of zymophyte powder; the zymophyte powder is prepared by mixing lactobacillus fermentum powder, lactobacillus plantarum powder, lactobacillus reuteri and lactobacillus acidophilus powder according to the mass ratio of 1:1:(0.5-2):(0.5-2). The probiotic fermented food is good in taste, low in fat content and low in raw material cost, through the synergistic effect of all the components, the problem of alteration of intestinal flora is solved, gastrointestinal motility is promoted, digestion is promoted, meanwhile, the probiotic fermented food is rich in multiple nutrient substances, and the effects of resisting oxidation, whitening and resisting aging are achieved.

The invention relates to application of ectoine substances and drinking wine containing the ectoine substances. Specifically, the invention provides an application of ectoine substances to preparationof a composition, and the composition is used for one or more applications selected from the following group: (a) dispelling the effects of alcohol; (b) preventing and / or treating liver injury; and (c) ameliorating intestinal dysbiosis. The ectoine substance comprises ectoine, or a salt thereof, or an ester thereof, and / or hydroxyl ectoine, or a salt thereof, or an ester thereof. The ectoine substances provided by the invention can effectively prevent and treat drunkenness, alcoholic liver injury and intestinal flora imbalance caused by drinking.

The invention relates to the field of traditional Chinese medicine. A traditional Chinese medicinal composition for treating intestinal dysbacteriosis is prepared from the following medicinal raw materials in parts by weight: 120-360 parts of radix astragali, 100-300 parts of fructus ligustri lucidi, 30-95 parts of ginseng, 30-95 parts of lucid ganoderma, 65-195 parts of rhizoma curcumae, 30-90 parts of rhizoma atractylodis macrocephalae, 65-195 parts of herba scutellariae barbatae, 120-360 parts of gynostemma pentaphyllum, 30-95 parts of poria cocos, 15-45 parts of endothelium corneum gigeriae galli, 65-195 parts of duchesnea indica, 65-195 parts of solanum lyratum thunb, 65-195 parts of herba artemisiae scopariae, 65-195 parts of radix cynanchi panicullati, 10-30 parts of ground beeltlesand 65-195 parts of oldenlandia diffusa. The medicine can be used for effectively treating intestinal dysbacteriosis. Tests prove that the traditional Chinese medicinal composition has exact curativeeffect and relatively good market prospect.

The invention discloses a gastrointestinal flora determination method, which relates to the technical field of microbiological detection, and comprises the following steps: preparing a sample solution, shaking, diluting, culturing, carrying out a confirmation test, carrying out water bath, carrying out gas production contrast, carrying out taxonomic analysis and sequencing. The measuring method is more scientific and reasonable, the number of microorganisms in a liquid sample and the intestinal flora structure can be accurately measured through the number of gas production pipes, an intestinal flora sequencing report can be obtained, the human health development trend can be scientifically predicted, people health management can be guided, deviation of bacterial microbiota can be quantitatively measured, and treatment that can make up or at least partially address a gastrointestinal dysbiosis or extent thereof in an individual.

The invention provides application of a radix puerariae extract in preparation of a medicine or health care product for regulating intestinal flora and reducing blood fat, and relates to the technical field of traditional Chinese medicine. Experiments prove that the radix puerariae extract can regulate the intestinal flora structure of a high-fat rat, further regulate the content of short-chain fatty acid, improve the disorder of the intestinal flora, promote the metabolism of fat and inhibit the accumulation of the fat, thereby playing roles in reducing the blood fat and protecting the liver.