Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Use of cordyceps sobolifera alkaline water extract in preparing preparation for treatment and/or prevention of alteration of intestinal flora and related diseases

A technology of intestinal flora imbalance and alkaline water extraction, applied to plant/algae/fungus/moss components, metabolic diseases, blood diseases, etc., can solve the problem of unclear functional factors and quality control indicators, functional scope and market publicity confusion , the function is not significant enough, etc., to achieve the effect of helping the recovery of the structure of the dominant flora, improving the physiological and pathological indicators, and helping the diversification of the flora

Inactive Publication Date: 2019-06-14
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY +1
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the improvement of the health quality of consumers, there is an even greater requirement for the refinement of health products. However, most of the existing edible and medicinal fungus health products have a confusing range of functions and market promotion. Functional factors and quality control indicators are not clear, and the functions are not significant enough. Medicinalization

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of cordyceps sobolifera alkaline water extract in preparing preparation for treatment and/or prevention of alteration of intestinal flora and related diseases
  • Use of cordyceps sobolifera alkaline water extract in preparing preparation for treatment and/or prevention of alteration of intestinal flora and related diseases
  • Use of cordyceps sobolifera alkaline water extract in preparing preparation for treatment and/or prevention of alteration of intestinal flora and related diseases

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0049] In the fifth aspect of the present invention, a kind of preparation method of cicadaline aqueous extract is provided, comprising:

[0050] After pulverizing the fruiting body of Cicada chinensis, use 12-16 times the amount of alkaline aqueous solution, ultrasonically extract for 1-2 hours to obtain the extraction solution, concentrate under reduced pressure, adjust the pH to 4-5, refrigerate, precipitate, and freeze-dry the precipitate to obtain Cicadaline water extract.

[0051] Preferably, the alkaline aqueous solution comprises NaOH and / or NaHCO with a pH of 9-10 3 aqueous solution.

[0052] Preferably, the pH adjustment is adding acetic acid to adjust the pH.

[0053] Preferably, the cold storage is cold storage for 24 hours.

[0054] A preparation method of cicadaline water extract, comprising:

[0055] Cicada flower fruiting bodies are crushed, and 12-16 times the amount of sodium hydroxide alkaline aqueous solution with a pH of 9-10 is used for ultrasonic ext...

Embodiment 1

[0062] Embodiment 1: the preparation method of cicadaline water extract, the steps are as follows:

[0063] After crushing the cicadae fruiting body, use 12-16 times the amount of pH 9-10 sodium hydroxide alkaline aqueous solution, ultrasonically extract for 1-2 hours to obtain the extraction solution, concentrate under reduced pressure to an appropriate volume, add acetic acid to adjust the pH to 4-5 , refrigerated for 24 hours, a precipitate was precipitated, and the precipitate was freeze-dried to obtain a cicadaline aqueous extract.

[0064] Protein content was determined by the Kjeldahl method. Table 1 is the protein content in the cicadaline water extract.

[0065] Protein content in table 1 cicadaline water extract

[0066]

Embodiment 2

[0067] Example 2: The improvement effect of cicadaline water extract on indicators related to intestinal flora imbalance in mice induced by high-fat diet

[0068] 1. Reagents:

[0069] Total cholesterol (T-CHO) test kit: Nanjing Jiancheng Institute of Bioengineering.

[0070] Triglyceride (TG) test kit: Nanjing Jiancheng Institute of Bioengineering.

[0071] Low-density lipoprotein cholesterol (LDL-C) test kit: Nanjing Jiancheng Bioengineering Institute.

[0072] High-density lipoprotein cholesterol (HDL-C) test kit: Nanjing Jiancheng Bioengineering Institute.

[0073] Thirty female C57 mice, SPF grade, weighing 12-14 g, and 28-30 days old, were purchased from Guangdong Medical Experimental Animal Center with license number SCXK (Guangdong) 2013-0002.

[0074] Rats and mice maintained feed: Guangdong Medical Experimental Animal Center, license number SCXK (Guangdong) 2013-0002.

[0075] The high-fat and high-cholesterol feed formula is shown in Table 2.

[0076] Table 2 M...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to use of an edible fungi extract in preparing a preparation for treatment and / or prevention of alteration of intestinal flora and related diseases, in particular to the use of acordyceps sobolifera alkaline water extract in preparing the preparation for treatment and / or prevention of alteration of intestinal flora and related diseases. A preparation method is simple and easy to operate and low in operation cost. An extraction solvent in the preparation method uses only alkaline water, no risk of residual organic reagents exists, the natural quality of a cordyceps sobolifera is ensured, and the extract is environmentally friendly and belongs to the green manufacturing technology. The cordyceps sobolifera alkaline water extract not only can obviously contribute to therecovery of the dominant flora structure in the intestinal tract and the diversification of the flora, but also shows an obvious treatment and / or prevention effect on related diseases of the intestinal flora structure, for example, the extract can effectively alleviate the deterioration of inflammation, improve various physiological and pathological indicators related to immunity, can be used invarious fields such as medicines and health care products and have great economic and social value.

Description

technical field [0001] The present invention relates to the use of an edible fungus extract in the preparation of preparations for the treatment and / or prevention of intestinal flora disorders and related diseases, in particular to the use of cicadaline water extracts in the preparation of treatment and / or prevention of intestinal flora Use in the preparation of disorders and related diseases. Background technique [0002] In recent years, studies on gut microbiota have been emerging, and the role of gut microbiota in human health has attracted more and more attention. Gut flora is the sum of all microorganisms in the human intestinal tract. There are many types (including bacteria, fungi and viruses), and the number is even more amazing. It is estimated that in a normal adult, the total weight of intestinal bacteria can reach 1-1.5kg. They can affect body weight, digestion and absorption capacity, and resist the risk of infection and autoimmune diseases; in addition, they...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/068A61P37/04A61P3/06A61P3/04A61P1/00A61P7/04A61P29/00A61P37/08A23L33/00A23L31/00A61K35/64
Inventor 陈地灵唐晓萃郭殷锐吴清平谢意珍帅欧杨柏华
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com