An absorbable semi-fluid cross-linked polypeptide biosurgical hemostat

A hemostatic material and fluidity technology, applied in surgical adhesives, drug delivery, medical science, etc., can solve the problems of high price, heavy burden on patients, etc., and achieve good compatibility, good cross-linking effect, and human body compatibility good sex effect

Active Publication Date: 2020-07-14
北京纳什国际生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, there is also a non-biologically derived artificial synthetic glue used for hemostasis in surgical operations on the domestic market. It is a fully imported product. Although it avoids the risk of infection caused by blood products, it is expensive and causes excessive weight to most patients. burden

Method used

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  • An absorbable semi-fluid cross-linked polypeptide biosurgical hemostat
  • An absorbable semi-fluid cross-linked polypeptide biosurgical hemostat
  • An absorbable semi-fluid cross-linked polypeptide biosurgical hemostat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The weight ratio of animal gelatin to crosslinking agent (acrylamide and trimethylpropane) is 95:5. First, dissolve animal gelatin in deionized water, increase the temperature to accelerate the dissolution, add a cross-linking agent after dissolution, and then add 0.05M ferric ion and 0.05M divalent calcium ion respectively, at 200nm wavelength, 6000μW / cm 2 Stir under strong ultraviolet light for 8 hours, and then filter with filter paper. It can be seen that the transparent jelly is blocked by the filter paper, and then rinsed several times to wash off excessive cross-linking agent and metal ions. After more than 90%, the product is harvested, ground into tiny particles, and passed through a fine sieve to make the product particles uniform. After mixing the hemostatic substance with 0.9% sodium chloride aqueous solution, a uniform, semi-fluid and granular light yellow jelly is formed .

Embodiment 2

[0035] The weight ratio of animal gelatin to crosslinking agent (acrylamide and polyethylene glycol) is 99:1. First, dissolve animal gelatin in deionized water, increase the temperature to accelerate the dissolution, add a cross-linking agent after dissolution, and then add 0.05M ferric ions and 0.05M divalent calcium ions respectively, at a wavelength of 300nm, 8000μW / cm 2 Stir under strong ultraviolet light for 12 hours, and then filter with filter paper. It can be seen that the transparent jelly is blocked by the filter paper, and then rinsed several times to wash off excessive cross-linking agent and metal ions. After more than 90%, the product is harvested, ground into tiny particles, and passed through a fine sieve to make the product particles uniform. After mixing the hemostatic substance with 0.9% sodium chloride aqueous solution, a uniform white jelly with semi-fluidity and granular texture is formed.

Embodiment 3

[0037] The weight ratio of animal gelatin to crosslinking agent (trimethylpropane) is 90:10. First, dissolve animal gelatin in deionized water, increase the temperature to accelerate the dissolution, add a cross-linking agent after dissolution, and then add 0.05M ferric ion and 0.05M divalent calcium ion respectively, at 300nm wavelength, 6000μW / cm 2 Stir under strong ultraviolet light for 16 hours, and then filter with filter paper. It can be seen that the transparent jelly is blocked by the filter paper, and then rinsed several times to wash off the excessive cross-linking agent and metal ions. After more than 90%, the product is harvested, ground into tiny particles, and passed through a fine sieve to make the product particles uniform. After mixing the hemostatic substance with 0.9% sodium chloride aqueous solution, a uniform, semi-fluid and granular light yellow jelly is formed .

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Abstract

The present invention provides an absorbable semi-flowing cross-linked polypeptide biological surgical bleeding-stopping substance, which comprises a gelatin and a cross-linking agent, wherein a cross-linking agent is added to a gelatin solution to make high-reactivity amino acid side chains react with each other so as to form a cross-linking structure, and iron-calcium ions are added to increase the cross-linking degree so as to finally form the three-dimensional network cross-linked macromolecular polypeptide. According to the present invention, the absorbable semi-flowing cross-linked polypeptide biological surgical bleeding-stopping substance can be safely absorbed by human tissues, has characteristics of semi-fluidity, viscosity and adhesion, can promote the coagulation process of human body through physical and chemical principles, can rapidly stop bleeding, can treat surgical bleeding in the case of no damage on tissues so as to improve the convenience and the flexibility of surgical hemostasis and improve the safety and the effectiveness of surgical hemostasis, and can achieve the satisfactory bleeding-stopping effect in the cases of multi-point bleeding, large-area errhysis, bleeding in the narrow lacuna, hidden bleeding point or difficultly distinguished bleeding point, and bleeding difficultly operated and controlled by the existing bleeding-stopping methods.

Description

technical field [0001] The invention belongs to the hemostatic material used for surgical operations in the category of medical instruments, and in particular relates to an absorbable semi-fluid cross-linked polypeptide biosurgical hemostat and a preparation method thereof. Background technique [0002] Tissue and organ bleeding in surgical operations is almost inevitable. Intraoperative bleeding can lead to prolongation of operation time, unclear surgical field of view and operation errors. Intraoperative ischemia can lead to tissue hypoxia, blood pressure instability and coagulation disorders, and even patients with hemorrhagic shock or die. Postoperative complications can increase, the patient recovers slowly after surgery, and the hospital stay is prolonged. In addition, due to the decline of natural hemostatic function among surgical patients in recent years and the continuous increase of elderly people who take anticoagulant drugs for cardiovascular and cerebrovascula...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/10A61L24/12A61L24/00A61L24/02A61L24/04
CPCA61L24/001A61L24/0042A61L24/02A61L24/046A61L24/104A61L24/12A61L2300/252A61L2300/418A61L2400/04C08L71/02
Inventor 江涛何迎辉
Owner 北京纳什国际生物科技有限公司
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